Article
Medicine, Research & Experimental
Jingwen Yuan, Shahid Ullah Khan, Junfeng Yan, Jiatong Lu, Chen Yang, Qiang Tong
Summary: Baicalin inhibits gastric cancer and enhances the efficacy of 5-Fu by promoting ROS-related ferroptosis in gastric cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Qiang Liu, Qiu Peng, Bin Zhang, Yueqiu Tan
Summary: Genomic instability is a common feature of tumors, and the XRCC gene family plays an important role in tumor development and therapeutic sensitivity. Studying XRCC can help us better understand the mechanisms of tumor formation and potential treatments.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Jingyi Hu, Anqi Li, Yueyang Guo, Ting Ma, Siqi Feng
Summary: This review summarizes the main tumor metabolic alterations linked with 5-FU resistance and proposes potential chemotherapy combinations from the perspective of intervening tumor metabolism to overcome 5-FU resistance.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Oncology
Yansong Zheng, Hengce Zhang, Yueting Guo, Yuan Chen, Hanglong Chen, Yingchun Liu
Summary: The study found that knockdown of XRCC1 significantly increased beta-lap-induced DNA double-strand breaks, comet tail lengths, and cell death in PDA cells. Furthermore, combining XRCC1 knockdown with beta-lap treatment switched programmed necrosis with beta-lap monotherapy to caspase-dependent apoptosis.
Article
Oncology
Yen-Yun Wang, Pen-Tzu Fang, Chang-Wei Su, Yuk-Kwan Chen, Joh-Jong Huang, Ming-Yii Huang, Shyng-Shiou F. Yuan
Summary: Oral cancer is the fourth most common cancer among males in Taiwan, with poor prognosis for advanced-stage oral squamous cell carcinoma. Research found that high expression of ERCC2 may be a risk factor for OSCC recurrence, and high levels of XRCC1, ERCC1, and ERCC2 proteins are associated with lower survival rates.
Article
Pharmacology & Pharmacy
Eric S. Christenson, Anthony Gizzi, Junru Cui, Matthew Egleston, Kyle J. Seamon, Michael DePasquale, Benjamin Orris, Ben H. Park, James T. Stivers
Summary: Selective inhibition of hUNG catalytic activity in cancer cell lines leads to increased sensitivity to FdU in colorectal cancer cells, indicating a potential therapeutic strategy. The mechanism of FdU differs from FU and hUNG inhibition does not correlate with p53 or TDG expression.
MOLECULAR PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Haniyeh Ghasemizadeh, Mehrab Pourmadadi, Fatemeh Yazdian, Hamid Rashedi, Mona Navaei-Nigjeh, Abbas Rahdar, Ana M. Diez-Pascual
Summary: This study synthesized a pH-responsive nanocomposite based on halloysite nanotube (HNT) coated with carboxymethyl cellulose (CMC)/polyethylene glycol (PEG) hydrogel using the water-in-oil-in-water (W/O/W) technique for the controlled delivery of 5-Fluorouracil (5-FU), a hydrophobic chemotherapy drug prescribed for different types of cancers. The nanocomposite showed high drug entrapment and loading efficiency, and demonstrated improved and sustained release of 5-FU in an acid environment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Karim Kheiri, Negin Sohrabi, Reza Mohammadi, Mohammad Sadegh Amini-Fazl
Summary: Chemotherapy, while effective, has the drawback of affecting healthy tissues. Designing new drug delivery systems with controlled release is a major challenge in cancer treatment. In this study, Fe3O4 magnetic nanogel core-shell encapsulated with chitosan-polyacrylic acid was synthesized to deliver anticancer drug 5-fluorouracil. The release of the drug was found to be enhanced under tumor tissue conditions compared to physiological environments, and the mechanism was identified as Fickian diffusion.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Mariana Pereira, Nuno Vale
Summary: The study found that saquinavir (SAQ) in combination with 5-fluorouracil (5-FU) had a better synergistic effect in treating prostate cancer cells (PC-3) than in treating lung cancer cells (A549).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Medicinal
Anai A. Valencia-Lazcano, Dilawar Hassan, Mehrab Pourmadadi, Amin Shamsabadipour, Razieh Behzadmehr, Abbas Rahdar, Dora I. Medina, Ana M. Diez-Pascual
Summary: This study reviews the applications of 5-Fluorouracil (5-FU) as an anticancer drug for various types of cancers. Different approaches, such as nanoparticles loaded with 5-FU, co-delivery systems with other drugs, have been described to overcome the limitations of 5-FU therapy. This review provides the latest progress on 5-FU-loaded nanocarriers and their potential as an advanced tool for cancer therapy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Jung Ho Han, MinJeong Kim, Hyeon Jin Kim, Se Bok Jang, Sung-Jin Bae, In-Kyu Lee, Dongryeol Ryu, Ki-Tae Ha
Summary: Resistance to anticancer therapeutics is a major challenge in cancer treatment, with altered cancer metabolism, such as the Warburg effect, playing a pivotal role. The use of antiglycolytic agents, such as catechin, may help overcome resistance to 5FU in gastric cancer cells by limiting LDHA expression and lactate production, providing a potential novel adjuvant drug option.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Tz-Feng Lin, Shih-Hsuan Yeh
Summary: Chemotherapy is a crucial method in cancer treatment that often requires high concentrations of drugs. Research on using polymer composites for local and sustained drug release has been developed to minimize side effects caused by high-concentration chemotherapy drugs.
Article
Multidisciplinary Sciences
Qingqing Hu, Jiajia Xu, Jingshu Ke, Ziye Zhang, Ting Chu
Summary: This study assessed the adverse events associated with S-1 and 5-fluorouracil (5-FU) and provided focused healthcare approaches to improve patient compliance and quality of survival. The results showed a higher incidence of stomatitis, hypokalemia, mucosal inflammation, and hypophosphatemia in the 5-FU group compared to the S-1 group.
Article
Multidisciplinary Sciences
Li Wang, Xuemei Cao, Yanyan Yang, Cansu Kose, Hiroaki Kawara, Laura A. Lindsey-Boltz, Christopher P. Selby, Aziz Sancar
Summary: Nucleotide excision repair is the principal mechanism for removing bulky DNA adducts from the mammalian genome. The widely used thymidine analog EdU was found to be a substrate for excision repair in replicating cells. The repair of EdU was observed throughout the genome and showed higher rates in the transcribed strand of transcriptionally active genes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Abhimanyu K. Singh, Sergio E. Martinez, Weijie Gu, Hoai Nguyen, Dominique Schols, Piet Herdewijn, Steven De Jonghe, Kalyan Das
Summary: The authors discovered a transient P-pocket created by HIV reverse transcriptase while sliding over a DNA substrate and developed a cryo-EM platform for lead optimization. By screening 300 drug-like fragments, they identified two leads that bind to the P-pocket, which is resilient to drug-resistance mutations and composed of structural elements from polymerase active site, primer grip, and template-primer. An engineered RT/DNA aptamer complex was utilized to trap the transient P-pocket and structures of the RT/DNA complex in the presence of an inhibitory fragment were determined.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Shun-Fu Chang, Cheng-Nan Chen, Jung-Chung Lin, Hsin-Ell Wang, Shigetarou Mori, Jia-Je Li, Chia-Kuang Yen, Ching-Yun Hsu, Chang-Phone Fung, Pele Choi-Sing Chong, Chih-Hsiang Leng, Yi-Jun Ding, Feng-Yee Chang, L. Kristopher Siu
Article
Biochemistry & Molecular Biology
Kuo-Chin Huang, Po-Yao Chuang, Rong-Ze Hsieh, Cheng-Nan Chen, Shun-Fu Chang, Yu-Ping Su
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Cheng-Ming Hsu, Ming-Yu Yang, Ming-Shao Tsai, Geng-He Chang, Yao-Hsu Yang, Yao-Te Tsai, Ching-Yuan Wu, Shun-Fu Chang
Summary: HNSCCs, the most common cancers of the head and neck, present a clinical challenge due to high recurrence rates and treatment resistance. This study explored the potential anticancer effects of DT, a compound in danshen, on HNSCCs, showing promising results in inducing cell apoptosis and reducing tumor size.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Shun-Fu Chang, Kuo-Chin Huang, Kuan-Han Lee, Yao-Chang Chiang, Wei-Ru Lee, Rong-Ze Hsieh, Yu-Ping Su, Shun-Chi Wu
Summary: The study reveals the damaging effects of visfatin on human primary chondrocytes, impacting mechanical changes and intracellular biochemical reactions, providing a more comprehensive understanding of osteoarthritis development. The inactivation of GSK3 beta and subsequent regulation of intracellular mechanics may serve as theranostic targets for future drug development for OA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Ting-Chung Wang, Sheng-Jie Luo, Shun-Fu Chang
Summary: The study reveals that BMP7 promotes the transmigration and migration abilities of glioblastoma cells through the Smad5-p75NTR signaling pathway, with the underlying mechanisms requiring further investigation.
Article
Biochemistry & Molecular Biology
Yu-Sheng Lin, Tzu-Hao Chang, Wan-Chun Ho, Shun-Fu Chang, Yung-Lung Chen, Shih-Tai Chang, Huang-Chung Chen, Kuo-Li Pan, Mien-Cheng Chen
Summary: The study suggests that the altered cytoskeletons in VPC-induced cardiomyopathy, particularly involving the Rac2/cofilin pathway, play a crucial role in sarcomere morphology and Z-line arrangement disarray.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Ko-Chao Lee, Kuen-Lin Wu, Chia-Kung Yen, Cheng-Nan Chen, Shun-Fu Chang, Wen-Shih Huang
Summary: This study elucidated the role of the adipocyte-containing microenvironment in the development of 5-FU resistance in CRC, and highlighted the potential of 6-shogaol and AMPK signaling in CRC therapy.
Article
Biology
Kuen-Lin Wu, Ko-Chao Lee, Chia-Kuang Yen, Cheng-Nan Chen, Shun-Fu Chang, Wen-Shih Huang
Summary: The study found that visfatin significantly reduces CRC sensitivity to capecitabine by controlling TYMS expression, while resveratrol can significantly alleviate the visfatin effect on capecitabine-treated CRC cells. These results provide new insights into understanding capecitabine susceptibility of CRC under a visfatin-containing environment and suggest a potential therapeutic application of resveratrol in CRC patients with obesity.
Article
Chemistry, Medicinal
Ko-Chao Lee, Kuen-Lin Wu, Chia-Kung Yen, Shun-Fu Chang, Cheng-Nan Chen, Ying-Chen Lu
Summary: The drug resistance of colorectal cancer cells against 5-fluorouracil therapy is a major challenge. This study found that resistin induced ERK activation and increased NLRP3 expression in CRC cells via Toll-like receptor 4, which is associated with the development of drug resistance to 5-FU. In addition, fermented quercetin enhanced the cytotoxicity of 5-FU in resistin-treated CRC cells.
Article
Biochemistry & Molecular Biology
Shun-Fu Chang, Hsiao-En Tsai, Jong-Tar Kuo, Yu-Rong Ruan, Chiu-Yen Chen, Shin-Yi Wang, Po-Yu Liu, Ding-Yu Lee
Summary: This study elucidates the relationship between blood reflux and epigenetic factors HDACs and DNMTs, as well as their roles in chronic venous disease (CVD). The results show that blood reflux leads to increased expression of HDACs and DNMTs, inhibiting metabolic regulation and promoting venous endothelial cell dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ko-Chao Lee, Kuen-Lin Wu, Shun-Fu Chang, Hsin- Chang, Cheng-Nan Chen, Yih-Yuan Chen
Summary: Ginger extracts have beneficial effects and can enhance bioactivity. Fermentation of NaDES-ginger extract using Lactobacillus reuteri increases antioxidant activity and enhances anticancer effects on oxaliplatin-resistant CRC cells.
Article
Biology
Te-Chuan Chen, Chen-Wei Huang, Chih-Yu Lo, Cheng-Nan Chen, Shun-Fu Chang, Yih-Yuan Chen
Summary: The present study investigated the impact of obesity and adipokines on renal cell carcinoma (RCC) cells' resistance to sunitinib. The study found that visfatin increased SREBP-1 expression in RCC cells, leading to sunitinib resistance. Simvastatin attenuated the effects of visfatin and enhanced the cytotoxicity of sunitinib in RCC cells.
Article
Engineering, Biomedical
Kuo-Chin Huang, Ding-Yu Lee, Po-Yao Chuang, Tien-Yu Yang, Yu-Ping Su, Shun-Fu Chang
Summary: This study investigates the osteoinductive capability of chitosan scaffolds cross-linked with different doses of glucose. The results show that scaffolds with higher glucose contents improve cell adhesion, survival, differentiation, and mineralization. The study also reveals the primary adhesion molecule and signaling pathway involved in osteoinduction.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2023)
Article
Medicine, General & Internal
I-Yun Lee, Shun-Fu Chang, Chin-Yuan Wu, Yu-Shi Lin, Hui-Chen Su, Yao-Te Tsai, Ming-Shao Tsai, Geng-He Chang, Ming-Yu Yang, Yao-Hsu Yang, Pei-Rung Yang, Cheng-Ming Hsu
Summary: This study retrospectively reviewed patients with vocal fold nodules who received traditional Chinese medicine treatments and found that herbs like Glycyrrhiza glabra and Platycodon grandifloras may offer beneficial outcomes as alternative treatments. The clinical and in vitro results supported this conclusion.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Medicine, General & Internal
Shun-Fu Chang, Wei-Hsun Yang, Chun-Yu Cheng, Sheng-Jie Luo, Ting-Chung Wang
Summary: Inhibition of gamma-secretase activity promotes glioma cell migration by downregulating E-cadherin expression, with Smad5 playing a role in regulating this process independently. Additionally, endogenous Smad1 in glioma cells is involved in regulating E-cadherin expression and cell migration, but does not affect the effects of gamma-secretase inhibitor DAPT. These findings provide insights into the molecular mechanisms of gamma-secretase activity regulation in controlling glioma cell malignancy.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)