Disruption of SOX6 gene using CRISPR/Cas9 technology for gamma-globin reactivation: An approach towards gene therapy of β-thalassemia

Gene therapy and gene editing strategies for hemoglobinopathies

(2018) Maria Rosa Lidonnici et al.   BLOOD CELLS MOLECULES AND DISEASES

Inducing indel mutation in the SOX6 gene by zinc finger nuclease for gamma reactivation: An approach towards gene therapy of beta thalassemia

(2017) Mehran Modares Sadeghi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Comparison of different methods for erythroid differentiation in the K562 cell line

(2016) Laleh Shariati et al.   BIOTECHNOLOGY LETTERS

Genetic disruption of theKLF1gene to overexpress the γ-globin gene using the CRISPR/Cas9system

(2016) Laleh Shariati et al.   JOURNAL OF GENE MEDICINE

Genome-Editing Technologies: Principles and Applications

(2016) Thomas Gaj et al.   Cold Spring Harbor Perspectives in Biology

Zinc Finger Nuclease: A New Approach to Overcome Beta-Lactam Antibiotic Resistance

(2016) Mansoureh Shahbazi Dastjerdeh et al.   Jundishapur Journal of Microbiology

Current and future alternative therapies for beta-thalassemia major

(2016) Edouard de Dreuzy et al.   Biomedical Journal

Editing the genome to introduce a beneficial naturally occurring mutation associated with increased fetal globin

(2015) Beeke Wienert et al.   Nature Communications

Application of gene-editing technologies to HIV-1

(2015) Mary Jane Drake et al.   Current Opinion in HIV and AIDS

Non-transfusion-dependent thalassemias

(2013) K. M. Musallam et al.   HAEMATOLOGICA

Ineffective Erythropoiesis inβ-Thalassemia

(2013) Jean-Antoine Ribeil et al.   TheScientificWorldJOURNAL

The HDAC inhibitor Givinostat modulates the hematopoietic transcription factors NFE2 and C-MYB in JAK2V617F myeloproliferative neoplasm cells

(2012) Ariel Amaru Calzada et al.   EXPERIMENTAL HEMATOLOGY

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

Transfusion-related biologic effects and free hemoglobin, heme, and iron

(2012) Caroline P. Ozment et al.   TRANSFUSION

Sox6 enhances erythroid differentiation in human erythroid progenitors

(2011) C. Cantu et al.   BLOOD

Transcriptional regulation of fetal to adult hemoglobin switching: new therapeutic opportunities

(2011) A. Wilber et al.   BLOOD

Expression of miR-210 during erythroid differentiation and induction of γ-globin gene expression

(2011) Nicoletta Bianchi et al.   BMB Reports

MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13

(2011) V. G. Sankaran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Advances in the understanding of haemoglobin switching

(2010) Vijay G. Sankaran et al.   BRITISH JOURNAL OF HAEMATOLOGY

Update on fetal hemoglobin gene regulation in hemoglobinopathies

(2010) Daniel E Bauer et al.   CURRENT OPINION IN PEDIATRICS

Transcriptional silencing of  -globin by BCL11A involves long-range interactions and cooperation with SOX6

(2010) J. Xu et al.   GENES & DEVELOPMENT

Targeting DNA Double-Strand Breaks with TAL Effector Nucleases

(2010) M. Christian et al.   GENETICS

Thalassemia: An Overview of 50 Years of Clinical Research

(2010) Vijay G. Sankaran et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin

(2010) Joseph Borg et al.   NATURE GENETICS

KLF1 regulates BCL11A expression and γ- to β-globin gene switching

(2010) Dewang Zhou et al.   NATURE GENETICS

Reversing the Hemoglobin Switch

(2010) Vijay G. Sankaran et al.   NEW ENGLAND JOURNAL OF MEDICINE

Control of fetal hemoglobin: new insights emerging from genomics and clinical implications

(2009) S. L. Thein et al.   HUMAN MOLECULAR GENETICS

Developmental and species-divergent globin switching are driven by BCL11A

(2009) Vijay G. Sankaran et al.   NATURE