Review
Biochemistry & Molecular Biology
Jhansi Nathan, Arunkumar Ramachandran
Summary: Marine biomolecules with antiangiogenic properties show potential for cancer treatment, with small molecular drug screening using the zebrafish model as an advantage in recent cancer research.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Ling Sun
Summary: Silencing FBXW7 upregulates the HIF-1α/VEGF signaling pathway, promoting angiogenesis in neonatal rats with hypoxic-ischemic brain damage (HIBD) after brain injury, reducing infarct volume and improving recovery of nerve function in HIBD rats.
Article
Medicine, Research & Experimental
Mariko Miyashita-Ishiwata, Malak El Sabeh, Lauren D. Reschke, Sadia Afrin, Mostafa A. Borahay
Summary: This study reveals an aberrant response of leiomyoma cells to hypoxia, characterized by increased cell proliferation and secretion of angiogenic factors. This abnormal response may contribute to the development and growth of leiomyoma.
Article
Multidisciplinary Sciences
Zhiyang Li, Heng Zhang, Yujie Sun, Zhuangzhuang Feng, Bijia Cui, Jingxia Han, Yinan Li, Huijuan Liu, Tao Sun
Summary: Angiogenesis plays a crucial role in embryologic development, growth, and tissue repair, but dysregulation of this process is a hallmark of various pathologies, including cancer. Existing methods for evaluating cell vascular formation are often limited to static analysis, leading to bias. Researchers have developed code scripts to study the dynamic angiogenesis process, allowing for the screening of drugs that can affect various parameters of vascular formation. Animal experiments have confirmed the efficacy of these drugs in inhibiting blood vessel formation, providing a new perspective for angiogenesis research and drug development.
Article
Dermatology
Qicheng Lan, Kaitao Wang, Zhefeng Meng, Hang Lin, Taotao Zhou, Yi Lin, Zhikai Jiang, Jianpeng Chen, Xuao Liu, Yuting Lin, Dingsheng Lin
Summary: This study investigated the effects of RXD on the survival of random skin flaps. The results showed that RXD promoted flap survival, increased angiogenesis, and decreased inflammation and oxidative stress.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Environmental Sciences
Meriam N. N. Rezk, Gerges M. Beshreda, Dalia Abdelrahman Meshref, Walaa Yehia Abdelzaher, Gaber El-Saber Batiha, Amin A. Hafiz, Duaa Althumairy, Nada H. Aljarba, Nermeen N. Welson
Summary: This study aimed to investigate the role of hypoxiainducible factor-1 alpha (HIF-1 alpha) in the diagnosis, prediction, and follow-up of Dormex-intoxicated patients. The results showed that HIF-1 alpha can effectively predict and follow up patients within 24 hours after admission. Additionally, blood-related indicators were also significantly abnormal in patients with Dormex intoxication.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Ophthalmology
Minsup Lee, Wendy Leskova, Randa S. Eshaq, Norman R. Harris
Summary: The study revealed that METH administration resulted in increased retinal hypoxia, HIF-1α, VEGFa, and angiogenesis.
EXPERIMENTAL EYE RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Diego Rodriguez, Deepika Watts, Diana Gaete, Sundary Sormendi, Ben Wielockx
Summary: The vascular network is crucial for sensing oxygen levels and hypoxia triggers a cascade of cellular signals, including angiogenesis, regulated by transcription factors such as HIFs and oxygen sensors like PHDs. Understanding how vascular cells respond to hypoxia under varying conditions is important for potential therapeutic targets in vascular dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Physiology
Xueli Liu, Bin Zhu, Yujie Li, Xinyue Liu, Sheng Guo, Chenglong Wang, Sen Li, Dingxuan Wang
Summary: Angiogenesis and VEGF play crucial roles in tendon healing, but the effects of exogenous VEGF application are controversial and require further research.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Cell Biology
Nasim Kheshtchin, Jamshid Hadjati
Summary: Hypoxia, a common characteristic of solid tumors, contributes to different aspects of tumor progression and limits the efficacy of immunotherapies. Developing new immunotherapy strategies involving therapeutic targeting of HIF-1 molecules associated with hypoxia may enhance the clinical effectiveness of immunotherapy. Targeting hypoxia presents a potential opportunity to improve the clinical benefit of cancer immunotherapy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Christina M. Termini, Amara Pang, Tiancheng Fang, Martina Roos, Vivian Y. Chang, Yurun Zhang, Nicollette J. Setiawan, Lia Signaevskaia, Michelle Li, Mindy M. Kim, Orel Tabibi, Paulina K. Lin, Joshua P. Sasine, Avradip Chatterjee, Ramachandran Murali, Heather A. Himburg, John P. Chute
Summary: Ionizing radiation and chemotherapy deplete hematopoietic stem cells and damage the vascular niche, leading to the secretion of SEMA3A from bone marrow endothelial cells. Inhibition of NRP1 promotes vascular and hematopoietic regeneration through increased expression of R spondin 2, suggesting a potential therapeutic target for improving hematopoietic recovery after myeloablation.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Yi-Hsun Huang, Cheng-Hsiang Kuo, I-Chen Peng, Yi-Sheng Chang, Sung-Huei Tseng, Edward M. Conway, Hua-Lin Wu
Summary: The study reveals that rTMD1 not only inhibits VEGF-induced angiogenesis in vitro, but also significantly reduces retinal neovascularization in an OIR animal model while sparing normal physiological vessel growth. Furthermore, loss of TMD1 promotes PA in OIR.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Oncology
Bich Phuong Bui, Phuong Linh Nguyen, Kyeong Lee, Jungsook Cho
Summary: This review discusses the crucial role of hypoxia-inducible factor-1 (HIF-1) in tumor biology, particularly in hypoxic environments. Despite numerous identified HIF-1 inhibitors as potential therapeutic agents for various cancers, none of them have been successfully translated into clinically available cancer treatments. The review summarizes the roles of the HIF-1 pathway in tumor proliferation, angiogenesis, metastasis, drug resistance, and cancer-related pain. Additionally, it highlights the current status of HIF-1 inhibitors in clinical trials and their future perspectives. HIF-1 inhibitors may be promising combinational therapeutic interventions to improve the efficacy of current cancer treatments and reduce drug resistance and cancer-related pain.
Article
Biochemistry & Molecular Biology
Marina Sakai, Nobuaki Takahashi, Hiroaki Ikeda, Yutaka Furutani, Shoko Higuchi, Takehiro Suzuki, Naoshi Dohmae, Sayaka Kobayashi, Hiroshi Harada, Soichi Kojima, Tomokazu Matsuura, Akira Hattori, Hideaki Kakeya
Summary: HIF-1 is a promising drug target for cancer chemotherapy, with KUSC-5037 identified as an effective inhibitor under hypoxic conditions. KUSC-5037 suppresses HIF-1 signaling and reduces the expression of HIF-1 target genes, showing potential as a lead molecule for cancer treatment.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
Ka Lin Heck-Swain, Jiwen Li, Wei Ruan, Xiaoyi Yuan, Yanyu Wang, Michael Koeppen, Holger K. Eltzschig
Summary: The myeloid-expressed HIF1A plays a functional role in providing cardioprotection during ischemia and reperfusion injury by inducing the neuronal guidance molecule netrin-1 in neutrophils.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)