NEFA-induced ROS impaired insulin signalling through the JNK and p38MAPK pathways in non-alcoholic steatohepatitis

Obesity and metabolic dysfunction severely influence prostate cell function: role of insulin and IGF1

(2017) Fernando L-López et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Pre-conditions for eliminating mitochondrial dysfunction and maintaining liver function after hepatic ischaemia reperfusion

(2017) Chenxia Hu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Acetoacetate induces hepatocytes apoptosis by the ROS-mediated MAPKs pathway in ketotic cows

(2017) Xiliang Du et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Upregulation of miR-181a impairs hepatic glucose and lipid homeostasis

(2017) Xiliang Du et al.   Oncotarget

Alpha-lipoic acid attenuates endoplasmic reticulum stress-induced insulin resistance by improving mitochondrial function in HepG2 cells

(2016) Lin Lei et al.   CELLULAR SIGNALLING

Mitochondrial quality control in insulin resistance and diabetes

(2016) Jonathan Wanagat et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Glutaredoxins concomitant with optimal ROS activate AMPK through S-glutathionylation to improve glucose metabolism in type 2 diabetes

(2016) Kelei Dong et al.   FREE RADICAL BIOLOGY AND MEDICINE

PGC-1α overexpression via local transfection attenuates mitophagy pathway in muscle disuse atrophy

(2016) Chounghun Kang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hepatocyte-specific Keap1 deletion reduces liver steatosis but not inflammation during non-alcoholic steatohepatitis development

(2016) Pierluigi Ramadori et al.   FREE RADICAL BIOLOGY AND MEDICINE

Mitofusin-2 knockdown increases ER-mitochondria contact and decreases amyloid β-peptide production

(2016) Nuno Santos Leal et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Adaptation of Hepatic Mitochondrial Function in Humans with Non-Alcoholic Fatty Liver Is Lost in Steatohepatitis

(2015) Chrysi Koliaki et al.   Cell Metabolism

SREBP-1c overactivates ROS-mediated hepatic NF-κB inflammatory pathway in dairy cows with fatty liver

(2015) Xinwei Li et al.   CELLULAR SIGNALLING

Redox modulation of adipocyte differentiation: hypothesis of “Redox Chain” and novel insights into intervention of adipogenesis and obesity

(2015) Xin Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

1-Methylnicotinamide ameliorates lipotoxicity-induced oxidative stress and cell death in kidney proximal tubular cells

(2015) Yuki Tanaka et al.   FREE RADICAL BIOLOGY AND MEDICINE

The effects of mitochondrial complex I blockade on ATP and permeability in rat pulmonary microvascular endothelial cells in culture (PMVEC) are overcome by coenzyme Q1 (CoQ1)

(2015) Robert D. Bongard et al.   FREE RADICAL BIOLOGY AND MEDICINE

Aldehyde dedydrogenase-2 plays a beneficial role in ameliorating chronic alcohol-induced hepatic steatosis and inflammation through regulation of autophagy

(2015) Rui Guo et al.   JOURNAL OF HEPATOLOGY

ER stress induces NLRP3 inflammasome activation and hepatocyte death

(2015) C Lebeaupin et al.   Cell Death & Disease

Redox control of protein degradation

(2015) Marta Pajares et al.   Redox Biology

MicroRNA-149 Inhibits PARP-2 and Promotes Mitochondrial Biogenesis via SIRT-1/PGC-1α Network in Skeletal Muscle

(2014) Junaith S. Mohamed et al.   DIABETES

Effects of nonesterified fatty acids on the synthesis and assembly of very low density lipoprotein in bovine hepatocytes in vitro

(2014) Lei Liu et al.   JOURNAL OF DAIRY SCIENCE

Mitofusin 2 deficiency leads to oxidative stress that contributes to insulin resistance in rat skeletal muscle cells

(2014) Qian Nie et al.   MOLECULAR BIOLOGY REPORTS

Mitochondrial Reactive Oxygen Species (ROS) and ROS-Induced ROS Release

(2014) Dmitry B. Zorov et al.   PHYSIOLOGICAL REVIEWS

Impaired Mitochondrial Dynamics and Bioenergetics in Diabetic Skeletal Muscle

(2014) Ruohai Liu et al.   PLoS One

Nox-derived ROS are acutely activated in pressure overload pulmonary hypertension: indications for a seminal role for mitochondrial Nox4

(2013) Giovanna Frazziano et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Mfn2 modulates the UPR and mitochondrial function via repression of PERK

(2013) Juan Pablo Muñoz et al.   EMBO JOURNAL

Mitochondrial dysfunction in non-alcoholic fatty liver disease and insulin resistance: Cause or consequence?

(2013) C. García-Ruiz et al.   FREE RADICAL RESEARCH

Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease

(2013) Karima Begriche et al.   HEPATOLOGY

PGC-1α overexpression results in increased hepatic fatty acid oxidation with reduced triacylglycerol accumulation and secretion

(2012) E. Matthew Morris et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Mitofusin 2 (Mfn2) links mitochondrial and endoplasmic reticulum function with insulin signaling and is essential for normal glucose homeostasis

(2012) D. Sebastian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of insulin resistance in mice lacking PGC-1  in adipose tissues

(2012) S. Kleiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protection from Palmitate-Induced Mitochondrial DNA Damage Prevents from Mitochondrial Oxidative Stress, Mitochondrial Dysfunction, Apoptosis, and Impaired Insulin Signaling in Rat L6 Skeletal Muscle Cells

(2011) Larysa V. Yuzefovych et al.   ENDOCRINOLOGY

Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis

(2011) Anabela P. Rolo et al.   FREE RADICAL BIOLOGY AND MEDICINE

The inhibitory effect of dexamethasone on platelet-derived growth factor-induced vascular smooth muscle cell migration through up-regulating PGC-1α expression

(2010) Wei Xu et al.   EXPERIMENTAL CELL RESEARCH

Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: distinct clinicopathologic meanings

(2010) Elizabeth M. Brunt et al.   HEPATOLOGY

The Effects of Palmitate on Hepatic Insulin Resistance Are Mediated by NADPH Oxidase 3-derived Reactive Oxygen Species through JNK and p38MAPKPathways

(2010) Dan Gao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial dysfunction precedes insulin resistance and hepatic steatosis and contributes to the natural history of non-alcoholic fatty liver disease in an obese rodent model

(2010) R. Scott Rector et al.   JOURNAL OF HEPATOLOGY

Increased Expression and Activity of the Transcription Factor FOXO1 in Nonalcoholic Steatohepatitis

(2008) L. Valenti et al.   DIABETES

Differential pattern of lipid droplet-associated proteins andde novoperilipin expression in hepatocyte steatogenesis

(2008) Beate Katharina Straub et al.   HEPATOLOGY

Epidemiology of non-alcoholic fatty liver disease in China

(2008) Jian-Gao Fan et al.   JOURNAL OF HEPATOLOGY

Paradoxical effects of increased expression of PGC-1  on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism

(2008) C. S. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA