The feedback loop between miR-21, PDCD4 and AP-1 functions as a driving force for renal fibrogenesis

miR-21 is involved in norepinephrine-mediated rat granulosa cell apoptosis by targeting SMAD7

(2017) Li Zhang et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

miR-21 promotes renal fibrosis in diabetic nephropathy by targeting PTEN and SMAD7

(2015) A. D. McClelland et al.   CLINICAL SCIENCE

Origin of myofibroblasts and cellular events triggering fibrosis

(2015) Matthias Mack et al.   KIDNEY INTERNATIONAL

Secreted fibroblast-derived miR-34a induces tubular cell apoptosis in fibrotic kidney

(2014) Yang Zhou et al.   JOURNAL OF CELL SCIENCE

Anti–microRNA-21 oligonucleotides prevent Alport nephropathy progression by stimulating metabolic pathways

(2014) Ivan G. Gomez et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-21 in Glomerular Injury

(2014) J. Y. Lai et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

miR-21–Containing Microvesicles from Injured Tubular Epithelial Cells Promote Tubular Phenotype Transition by Targeting PTEN Protein

(2013) Yang Zhou et al.   AMERICAN JOURNAL OF PATHOLOGY

Myofibroblast and extracellular matrix origins in proliferative vitreoretinopathy

(2013) Richard M. Feist et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

The regulation and function of micrornas in kidney diseases

(2013) Qingqing Wei et al.   IUBMB LIFE

The Autoregulatory Feedback Loop of MicroRNA-21/Programmed Cell Death Protein 4/Activation Protein-1 (MiR-21/PDCD4/AP-1) as a Driving Force for Hepatic Fibrosis Development

(2013) Zhengping Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rheb/mTORC1 Signaling Promotes Kidney Fibroblast Activation and Fibrosis

(2013) L. Jiang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A microRNA-30e/mitochondrial uncoupling protein 2 axis mediates TGF-β1-induced tubular epithelial cell extracellular matrix production and kidney fibrosis

(2013) Lei Jiang et al.   KIDNEY INTERNATIONAL

Role of miR-17 Family in the Negative Feedback Loop of Bone Morphogenetic Protein Signaling in Neuron

(2013) Qi Sun et al.   PLoS One

Myofibroblasts: Biochemical and Proteomic Approaches to Fibrosis

(2013) Eiko Honda et al.   TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE

MicroRNA-21 in the pathogenesis of acute kidney injury

(2013) Ya-Feng Li et al.   Protein & Cell

MicroRNAs in Kidney Fibrosis and Diabetic Nephropathy: Roles on EMT and EndMT

(2013) Swayam Prakash Srivastava et al.   Biomed Research International

MicroRNA-21 Promotes Fibrosis of the Kidney by Silencing Metabolic Pathways

(2012) B. N. Chau et al.   Science Translational Medicine

MicroRNA Circuits in Transforming Growth Factor-β Actions and Diabetic Nephropathy

(2012) Mitsuo Kato et al.   SEMINARS IN NEPHROLOGY

The extracellular matrix: an active or passive player in fibrosis?

(2011) Thomas N. Wight et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Pathogenesis of Liver Fibrosis

(2011) Virginia Hernandez-Gea et al.   Annual Review of Pathology-Mechanisms of Disease

Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart

(2011) Clint L. Miller et al.   BASIC RESEARCH IN CARDIOLOGY

Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice

(2011) Nariaki Asada et al.   JOURNAL OF CLINICAL INVESTIGATION

Smad3-Mediated Upregulation of miR-21 Promotes Renal Fibrosis

(2011) X. Zhong et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

MicroRNA-21 targets peroxisome proliferators-activated receptor-  in an autoregulatory loop to modulate flow-induced endothelial inflammation

(2011) J. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Modulation of K-Ras-Dependent Lung Tumorigenesis by MicroRNA-21

(2010) Mark E. Hatley et al.   CANCER CELL

AP-1 — The Jun proteins: Oncogenes or tumor suppressors in disguise?

(2010) Eitan Shaulian   CELLULAR SIGNALLING

Enhanced Fibroblast–Myocyte Interactions in Response to Cardiac Injury

(2010) Carolina Vasquez et al.   CIRCULATION RESEARCH

Fibroblast Expression of an I B Dominant-Negative Transgene Attenuates Renal Fibrosis

(2010) T. Inoue et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Upregulation of miR-21 by Ras in vivo and its role in tumor growth

(2010) D Frezzetti et al.   ONCOGENE

Identification of a microRNA signature of renal ischemia reperfusion injury

(2010) J. G. Godwin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fate Tracing Reveals the Pericyte and Not Epithelial Origin of Myofibroblasts in Kidney Fibrosis

(2009) Benjamin D. Humphreys et al.   AMERICAN JOURNAL OF PATHOLOGY

MicroRNA profiling of clear cell renal cell cancer identifies a robust signature to define renal malignancy

(2009) Monika Jung et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Translational regulation mechanisms of AP-1 proteins

(2009) Paul Willi Vesely et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

The nuclear receptors SF1 and LRH1 are expressed in endometrial cancer cells and regulate steroidogenic gene transcription by cooperating with AP-1 factors

(2008) Charlotte Dubé et al.   CANCER LETTERS

miR-21 Gene Expression Triggered by AP-1 Is Sustained through a Double-Negative Feedback Mechanism

(2008) Shuji Fujita et al.   JOURNAL OF MOLECULAR BIOLOGY

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

(2008) Thomas Thum et al.   NATURE