Manganese Superoxide Dismutase in Cancer Prevention

Cellular Redox Modulator, ortho Mn(III) meso-tetrakis(N-n-Hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP5+ in the Treatment of Brain Tumors

(2012) Stephen T. Keir et al.   Anti-Cancer Agents in Medicinal Chemistry

Prooxidant-Induced Glutathione Antioxidant Response in Vitro and in Vivo: A Comparative Study between Schisandrin B and Curcumin

(2012) Pou Kuan Leong et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Isocitrate dehydrogenase 1 is downregulated during early skin tumorigenesis which can be inhibited by overexpression of manganese superoxide dismutase

(2012) Delira Robbins et al.   CANCER SCIENCE

Phytochemical Activation of Nrf2 Protects Human Coronary Artery Endothelial Cells against an Oxidative Challenge

(2012) Elise L. Donovan et al.   Oxidative Medicine and Cellular Longevity

Curcumin targeting the thioredoxin system elevates oxidative stress in HeLa cells

(2012) Wenqing Cai et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Toxicology and pharmacology of selenium: emphasis on synthetic organoselenium compounds

(2011) Cristina W. Nogueira et al.   ARCHIVES OF TOXICOLOGY

Design, synthesis, and biological evaluation of curcumin analogues as multifunctional agents for the treatment of Alzheimer’s disease

(2011) Shang-Ying Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and evaluation of 1-(4-[18F]fluoroethyl)-7-(4′-methyl)curcumin with improved brain permeability for β-amyloid plaque imaging

(2011) Iljung Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases

(2011) Wei Xu et al.   CANCER CELL

Enhancing Mitochondrial Respiration Suppresses Tumor Promoter TPA-Induced PKM2 Expression and Cell Transformation in Skin Epidermal JB6 Cells

(2011) J. A. Wittwer et al.   Cancer Prevention Research

Manganese Superoxide Dismutase Is a p53-Regulated Gene That Switches Cancers between Early and Advanced Stages

(2011) S. K. Dhar et al.   CANCER RESEARCH

Dietary astaxanthin inhibits colitis and colitis-associated colon carcinogenesis in mice via modulation of the inflammatory cytokines

(2011) Yumiko Yasui et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Astaxanthin can alter CYP1A-dependent activities via two different mechanisms: Induction of protein expression and inhibition of NADPH P450 reductase dependent electron transfer

(2011) Marumi Ohno et al.   FOOD AND CHEMICAL TOXICOLOGY

Regulation of skin inflammation and angiogenesis by EC-SOD via HIF-1α and NF-κB pathways

(2011) Younghwa Kim et al.   FREE RADICAL BIOLOGY AND MEDICINE

Manganese superoxide dismutase and glutathione peroxidase as prognostic markers in patients with buccal mucosal squamous cell carcinomas

(2011) Ting-Ying Fu et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

D-4F, an apoA-I mimetic peptide, inhibits proliferation and tumorigenicity of epithelial ovarian cancer cells by upregulating the antioxidant enzyme MnSOD

(2011) Ekambaram Ganapathy et al.   INTERNATIONAL JOURNAL OF CANCER

Superoxide dismutase deficiency enhances superoxide levels in brain tissues during oxygenation and hypoxia-reoxygenation

(2011) Toru Sasaki et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The Association of Manganese Superoxide Dismutase Expression in Barrett's Esophageal Progression With MnTBAP and Curcumin Oil Therapy

(2011) Suzanne C. Schiffman et al.   JOURNAL OF SURGICAL RESEARCH

Expression of manganese superoxide dismutase in patients with breast cancer

(2011) Shih-Meng Tsai et al.   KAOHSIUNG JOURNAL OF MEDICAL SCIENCES

Alterations in the expression of genes related to NF-κB signaling in liver and kidney of CuZnSOD-deficient mice

(2011) Kamil Brzóska et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Genetic and Epigenetic Inactivation of Extracellular Superoxide Dismutase Promotes an Invasive Phenotype in Human Lung Cancer by Disrupting ECM Homeostasis

(2011) M. L. T. Teoh-Fitzgerald et al.   MOLECULAR CANCER RESEARCH

SOD Mimetics: A Novel Class of Androgen Receptor Inhibitors That Suppresses Castration-Resistant Growth of Prostate Cancer

(2011) R. Thomas et al.   MOLECULAR CANCER THERAPEUTICS

Superoxide dismutase 1 (SOD1) is a target for a small molecule identified in a screen for inhibitors of the growth of lung adenocarcinoma cell lines

(2011) R. Somwar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional up-regulation of SOD1 by CEBPD: A potential target for cisplatin resistant human urothelial carcinoma cells

(2010) Tzyh-Chyuan Hour et al.   BIOCHEMICAL PHARMACOLOGY

Bisdemethylcurcumin and structurally related hispolon analogues of curcumin exhibit enhanced prooxidant, anti-proliferative and anti-inflammatory activities in vitro

(2010) Jayaraj Ravindran et al.   BIOCHEMICAL PHARMACOLOGY

Superoxide dismutase 1 knockdown induces oxidative stress and DNA methylation loss in the prostate

(2010) Sachin S. Bhusari et al.   Epigenetics

Inhibition of acetylcholinesterase activities and some pro-oxidant induced lipid peroxidation in rat brain by two varieties of ginger (Zingiber officinale)

(2010) Ganiyu Oboh et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

A Phase I Study of Concurrent Chemotherapy (Paclitaxel and Carboplatin) and Thoracic Radiotherapy with Swallowed Manganese Superoxide Dismutase Plasmid Liposome Protection in Patients with Locally Advanced Stage III Non-Small-Cell Lung Cancer

(2010) Ahmad A. Tarhini et al.   HUMAN GENE THERAPY

Knockdown of SOD1 sensitizes the CD34+ CML cells to imatinib therapy

(2010) Li Liu et al.   MEDICAL ONCOLOGY

C-jun Inhibits Mammary Apoptosis In Vivo

(2010) Sanjay Katiyar et al.   MOLECULAR BIOLOGY OF THE CELL

The Chemopreventive Effects of Protandim: Modulation of p53 Mitochondrial Translocation and Apoptosis during Skin Carcinogenesis

(2010) Delira Robbins et al.   PLoS One

Mitochondrial Uncoupling Inhibits p53 Mitochondrial Translocation in TPA-Challenged Skin Epidermal JB6 Cells

(2010) Fei Wang et al.   PLoS One

Circulating Tumor M2 Pyruvate Kinase and Thymidine Kinase 1 Are Potential Predictors for Disease Recurrence in Renal Cell Carcinoma After Nephrectomy

(2010) Benjamin Nisman et al.   UROLOGY

Induction of apoptosis by [6]-gingerol associated with the modulation of p53 and involvement of mitochondrial signaling pathway in B[a]P-induced mouse skin tumorigenesis

(2009) Nidhi Nigam et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Overexpression of Extracellular Superoxide Dismutase Attenuates Heparanase Expression and Inhibits Breast Carcinoma Cell Growth and Invasion

(2009) M. L.T. Teoh et al.   CANCER RESEARCH

Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP5+, via suppression of oxidative stress in a mouse model of breast tumor

(2009) Zahid N. Rabbani et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protandim, a Fundamentally New Antioxidant Approach in Chemoprevention Using Mouse Two-Stage Skin Carcinogenesis as a Model

(2009) Jianfeng Liu et al.   PLoS One

Chemoprotective Effects of Curcuma aromatica on Esophageal Carcinogenesis

(2008) Yan Li et al.   ANNALS OF SURGICAL ONCOLOGY

Chemosensitisation by manganese superoxide dismutase inhibition is caspase-9 dependent and involves extracellular signal-regulated kinase 1/2

(2008) B H Y Yeung et al.   BRITISH JOURNAL OF CANCER

Identification of biomarkers for the antiangiogenic and antitumour activity of the superoxide dismutase 1 (SOD1) inhibitor tetrathiomolybdate (ATN-224)

(2008) F Doñate et al.   BRITISH JOURNAL OF CANCER

Nuclear factor-κB dependency of doxorubicin sensitivity in gastric cancer cells is determined by manganese superoxide dismutase expression

(2008) Sung Jin Cho et al.   CANCER SCIENCE

Antioxidant status and lipid peroxidation in the blood of breast cancer patients of different ages

(2008) Jelena Kasapović et al.   CELL BIOCHEMISTRY AND FUNCTION

Manganese superoxide dismutase gene dosage affects chromosomal instability and tumor onset in a mouse model of T cell lymphoma

(2008) Christopher I. van de Wetering et al.   FREE RADICAL BIOLOGY AND MEDICINE

Epigenetic silencing of SOD2 by histone modifications in human breast cancer cells

(2008) Michael J. Hitchler et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hesperetin exerts dose dependent chemopreventive effect against 1,2-dimethyl hydrazine induced rat colon carcinogenesis

(2008) Selvaraj Aranganathan et al.   INVESTIGATIONAL NEW DRUGS

Chemopreventive effect of lycopene alone or with melatonin against the genesis of oxidative stress and mammary tumors induced by 7,12 dimethyl(a)benzanthracene in sprague dawely female rats

(2008) Said S. Moselhy et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Activity and protein level of CuZnSOD and MnSOD in benign and malignant liver tumors

(2007) Michał Skrzycki et al.   CLINICAL BIOCHEMISTRY

Increased oxidative stress created by adenoviral MnSOD or CuZnSOD plus BCNU (1,3-bis(2-chloroethyl)-1-nitrosourea) inhibits breast cancer cell growth

(2007) Christine J. Weydert et al.   FREE RADICAL BIOLOGY AND MEDICINE