期刊
ONCOGENE
卷 31, 期 23, 页码 2836-2848出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2011.456
关键词
ANKRD11; centrosome aberrations; gain of function; invasion; mutant p53
资金
- Cancer Council of South Australia and San Remo
- NHMRC Program grant
- Cancer Council NSW
- Cure Cancer Foundation Australia
- Cancer Council SA
Mutations of p53 in cancer can result in a gain of function associated with tumour progression and metastasis. We show that inducible expression of several p53 'hotspot' mutants promote a range of centrosome abnormalities, including centrosome amplification, increased centrosome size and loss of cohesion, which lead to mitotic defects and multinucleation. These mutant p53-expressing cells also show a change in morphology and enhanced invasive capabilities. Consequently, we sought for a means to specifically target the function of mutant p53 in cancer cells. This study has identified ANKRD11 as a key regulator of the oncogenic potential of mutant p53. Loss of ANKRD11 expression with p53 mutation defines breast cancer patients with poor prognosis. ANKRD11 alleviates the mitotic defects driven by mutant p53 and suppresses mutant p53-mediated mesenchymal-like transformation and invasion. Mechanistically, we show that ANKRD11 restores a native conformation to the mutant p53 protein and causes dissociation of the mutant p53-p63 complex. This represents the first evidence of an endogenous protein with the capacity to suppress the oncogenic properties of mutant p53. Oncogene (2012) 31, 2836-2848; doi:10.1038/onc.2011.456; published online 10 October 2011
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