Article
Engineering, Biomedical
Xueyu Jiang, Fanwei Zeng, Xuefeng Yang, Chao Jian, Lina Zhang, Aixi Yu, Ang Lu
Summary: In this study, a smart nano drug delivery system targeting MMPs was successfully constructed using collagen peptides scaffolds with MMPs recognition sequences. The system effectively inhibited the activity of MMPs and achieved targeted drug release in tumor tissues.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Li Ching Wong, Jia Huey Poh, Wan Ting Tan, Boon-Keat Khor, Vikneswaran Murugaiyah, Cheu Peng Leh, Choon Fu Goh
Summary: This study aims to develop a hydrogel for dermal drug delivery using cellulose extracted from oil palm empty fruit bunches, and evaluate the effects of alkali solvent compositions on hydrogel formation. The hydrogels formed with 7%w/v NaOH and 4%w/v urea showed excellent biodegradability, low cytotoxicity, and high drug permeation into the skin.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Applied
Xiaoping Zhao, Qin Wang, Ning Wang, Ge Zhu, Jingzhi Ma, Ning Lin
Summary: Cellulose nanocrystals (CNCs) show great potential in cancer treatment due to their biocompatibility and the ability to modify them with proteins and fluorescent molecules. Immobilizing CNCs with GAPDH and FITC creates the compound FCNC-G, which inhibits cancer cell proliferation and affects mitochondrial function. Loading FCNC-G with doxorubicin (DOX) further enhances its therapeutic potential.
CARBOHYDRATE POLYMERS
(2024)
Review
Pharmacology & Pharmacy
Xiangjie Di, Xiao Liang, Chao Shen, Yuwen Pei, Bin Wu, Zhiyao He
Summary: This review surveys carbohydrate-based or carbohydrate-modified drug delivery systems and their applications in disease therapy. Polymeric carbohydrates have advantages of nontoxicity, biocompatibility, and biodegradability, making them an ideal choice for drug targeting, sustained drug release, immune antigens, and adjuvants.
Review
Pharmacology & Pharmacy
Jeongrae Kim, Yongwhan Choi, Dong-Hwee Kim, Hong Yeol Yoon, Kwangmeyung Kim
Summary: This review summarizes recent advances in the use of injectable hydrogels for combination immunotherapy in treating tumors. Injectable hydrogels, with their biocompatibility, degradability, and controllable properties, can effectively encapsulate various immunotherapeutic agents and elicit antitumor immune responses. The review also discusses the application of injectable hydrogels in chemoimmunotherapy, photoimmunotherapy, and radioimmunotherapy.
Article
Chemistry, Applied
Hyung Sun Yoon, Kyungjik Yang, Young Min Kim, Keonwook Nam, Young Hoon Roh
Summary: The research developed a dual droplet-based, freeform 3D printing method for pseudoplastic alginate biomaterial inks using Bingham plastic cellulose nanocrystals (CNCs) as support nanomaterials, offering enhanced printability with improved shape fidelity and structural stability.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Mehrab Pourmadadi, Erfan Rahmani, Amin Shamsabadipour, Amirmasoud Samadi, Javad Esmaeili, Rabia Arshad, Abbas Rahdar, Fariborz Tavangarian, Sadanand Pandey
Summary: Cellulose derivatives have gained significant attention in the field of biomedical applications due to their biocompatibility and favorable physical and mechanical features. This study discusses the potential of carboxymethyl cellulose (CMC) in biomedical applications, and reviews different methods for producing CMC hydrogels. Literature review shows that CMC exhibits strong anti-bacterial and anti-tumor properties, and has widespread applications in tissue engineering, wound dressing, and drug delivery.
PROCESS BIOCHEMISTRY
(2023)
Article
Engineering, Biomedical
Theresa M. Lutz, Ceren Kimna, Angela Casini, Oliver Lieleg
Summary: The slime mold Physarum polycelphalum has been chosen as the unicellular organism of the year 2021, highlighting the overlooked diversity of life forms in nature. This article provides an overview of naturally occurring slimy substances with adhesive properties, categorizing them based on their chemical motifs. It also highlights recent developments in material design and functionalization using these biological compounds for novel applications in medicine.
MATERIALS TODAY BIO
(2022)
Article
Biophysics
Yin Xiao, Yuhong Gu, Li Qin, Lin Chen, Xiaoliang Chen, Weiheng Cui, Fuling Li, Ni Xiang, Xiaoai He
Summary: Injectable thermosensitive hydrogel is an attractive drug delivery system that has become increasingly important in cancer therapy due to its ability to provide high local drug concentration, sustained release, minimal invasiveness, and low systemic toxicities. This review highlights its extensive application in local cancer therapy, including chemotherapy, photothermal therapy, photodynamic therapy, gene therapy, chemo-photothermal combined therapy, and chemo-/immuno- combined therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Chemistry, Multidisciplinary
Vijay Sagar Madamsetty, Shima Tavakol, Saeid Moghassemi, Arezoo Dadashzadeh, John D. Schneible, Iman Fatemi, Abdolsamad Shirvani, Ali Zarrabi, Fereshteh Azedi, Ali Dehshahri, Abbas Aghaei Afshar, Kian Aghaabbasi, Abbas Pardakhty, Reza Mohammadinejad, Prashant Kesharwani
Summary: Breast cancer is a highly deadly neoplastic disease with limited efficacy in existing treatment methods, prompting a search for new remedies. Nanotechnology has shown promise in the field, particularly with chitosan as a potential carrier for anticancer drugs. Further research is ongoing to explore the therapeutic and diagnostic applications of chitosan in breast cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Chemistry, Multidisciplinary
Suliman Khan, Majid Sharifi, Jason P. Gleghorn, Mohammad Mahdi Nejadi Babadaei, Samir Haj Bloukh, Zehra Edis, Mohammadreza Amin, Qian Bai, Timo L. M. ten Hagen, Mojtaba Falahati, William C. Cho
Summary: This paper discusses the importance of artificially engineering protein interactions with nanoparticles in biological systems and the effects of various factors on the protein corona properties, laying the foundation for further research on drug delivery and cancer nanotherapy.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Maryam Shafique, Muhammad Sohail, Muhammad Usman Minhas, Touba Khaliq, Mubeen Kousar, Shahzeb Khan, Zahid Hussain, Arshad Mahmood, Mudassir Abbasi, Heather C. Aziz, Syed Ahmed Shah
Summary: This study developed a novel wound dressing based on hydrogel membranes loaded with cefepime nanoparticles, which showed promising potential for accelerating wound healing process. The in vitro analysis indicated that the developed membrane has ideal water vapor transmission rate and oxygen permeability, along with sustained drug release and high zone of inhibition against various bacteria.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Review
Biochemistry & Molecular Biology
Ping He, Lei Dai, Jiasheng Wei, Xulong Zhu, Jianhui Li, Zhirong Chen, Yonghao Ni
Summary: This article comprehensively summarizes the recent research progress on nanocellulose hydrogels as drug carriers. The study evaluates the influence of nanocellulose on hydrogel properties and drug release behaviors, and highlights the application of nanocellulose hydrogel-based drug carriers in specific routes of administration. It provides a critical review and outlook in the field, aiming to inspire future work on the practical applications of nanocellulose hydrogels in designing controlled drug delivery systems.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Biochemistry & Molecular Biology
Ayaz Mahmood, Dev Patel, Brandon Hickson, John DesRochers, Xiao Hu
Summary: Hydrogels from biopolymers have various characteristics and find wide applications in biomedicine, contributing to patient treatments and outcomes. Different types of biopolymer hydrogels can be synthesized for specific purposes, such as cell delivery and drug delivery, in the field of biomedicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Ling-Jie Huang, Wen-Jau Lee, Yi-Chun Chen
Summary: Hydrogel composites made from cellulose and other gel materials were studied in this research. The addition of waterborne polyurethane (WPU) helped improve the structure and reusability of cellulose hydrogel, reducing weight loss caused by water absorption and dehydration. The best weight ratio for creating cellulose/WPU composite aerogel with the highest water swelling capacity and heat resistance was found to be 90/10.
Article
Chemistry, Multidisciplinary
Zeeshan Ali, Jiuhai Wang, Xianbo Mou, Yongjun Tang, Taotao Li, Wenbiao Liang, Muhammad Ali A. Shah, Rasheed Ahmad, Zhiyang Li, Nongyue He
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
(2017)
Review
Chemistry, Multidisciplinary
Mubashir Hussain, Rasheed Ahmad, Yuan Liu, Bin Liu, Mu He, Nongyue He
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
(2017)
Article
Geriatrics & Gerontology
Man Zhang, Jianqian Chao, Dan Li, Jiayi Gu, Wenji Chen, Hui Xu, Mubashir Hussain, Wenjuan Wu, Lin Deng, Tingting He, Ruizhi Zhang
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2018)
Article
Chemistry, Multidisciplinary
Mubashir Hussain, Zhen Chen, Mu Lv, Jingyi Xu, Xiaohan Dong, Jingzhou Zhao, Song Li, Yan Deng, Nongyue He, Zhiyang Li, Bin Liu
CHINESE CHEMICAL LETTERS
(2020)
Article
Chemistry, Multidisciplinary
Mubashir Hussain, Mu Lv, Xiaohan Dong, Han Shen, Wei Wang, Song Li, Zhu Chen, Lian Jin, Nongyue He, Zhiyang Li, Bin Liu
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
(2020)
Article
Chemistry, Multidisciplinary
Mubashir Hussain, Xiaolong Liu, Jun Zou, Jian Yang, Zeeshan Ali, Hamood Ur Rehman, Nongyue He, Jianguo Dai, Yongjun Tang
Summary: The study proposes a method for rapid detection of microparticles using laser light scattering and support vector machines. The method shows high classification accuracy and can detect microparticles at low concentrations.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Analytical
Mubashir Hussain, Xiaolong Liu, Shuming Tang, Jun Zou, Zhifei Wang, Zeeshan Ali, Nongyue He, Yongjun Tang
Summary: The proposed approach involves the development of a novel lab-on-a-chip device for the rapid detection of P. aeruginosa using immunomagnetic separation, optical scattering, and machine learning. The method can specifically and quantitatively detect P. aeruginosa within 10 minutes, with the total assay time being 25 minutes. The device was shown to classify the pathogen accurately with a high classification performance using support vector machines (SVM) among other classifiers.
ANALYTICA CHIMICA ACTA
(2022)
Review
Chemistry, Analytical
Mubashir Hussain, Jun Zou, He Zhang, Ru Zhang, Zhu Chen, Yongjun Tang
Summary: Early detection of foodborne pathogens is critical for food quality control and medical response improvement. Traditional detection methods are time-consuming, expensive, and cumbersome. Therefore, the integration of spectroscopy techniques with artificial intelligence and advanced materials has become a popular research direction. This paper provides an overview of the progress and application of spectroscopy techniques, including surface-enhanced Raman spectroscopy, surface plasmon resonance, fluorescence spectroscopy, multiangle laser light scattering, and imaging analysis, for the rapid detection of foodborne pathogens. The paper also discusses the potential applications of artificial intelligence, microfluidics, smartphone-based techniques, and advanced materials in this field.
Review
Biology
Mubashir Hussain, Zeeshan Ali, Bin Liu, Jianguo Dai, Xiaolong Liu, Junchen Zhu, Yongjun Tang
Summary: Dengue virus infections are increasing worldwide, posing a serious threat to children. The development of effective diagnostic systems is crucial for the progress of diagnostic tools.
Proceedings Paper
Computer Science, Software Engineering
Mubashir Hussain, Jingzhou Zhao, Ali Hassan, Hamood Ur Rahman, Amer S. Kashif, Yongjun Tang
Summary: Public health data show that breast cancer is a significant global health issue among women, with DIET system offering a non-invasive screening approach that utilizes mechanical vibrations and SIFT algorithm for accurate tumor detection compared to marker-based systems.
2021 IEEE INTERNATIONAL CONFERENCE ON INFORMATION COMMUNICATION AND SOFTWARE ENGINEERING (ICICSE 2021)
(2021)
Article
Computer Science, Information Systems
Mubashir Hussain, Songsheng Zhu, Ping Yang, Yukun An, Zhiyang Li, Irshad Ali, Bin Liu, Han Shen, Nongyue He
Meeting Abstract
Geriatrics & Gerontology
M. Zhang, J. Q. Chao, J. Y. Gu, W. J. Chen, H. Xu, M. Hussain, W. J. Wu, H. H. Chen, Z. C. Wu, L. Deng, T. T. He, R. Z. Zhang
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2017)
