Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranes

Gating modifier toxin interactions with ion channels and lipid bilayers: Is the trimolecular complex real?

(2017) Akello J. Agwa et al.   NEUROPHARMACOLOGY

Lengths of the C-Terminus and Interconnecting Loops Impact Stability of Spider-Derived Gating Modifier Toxins

(2017) et al.   Toxins

Membrane-binding properties of gating modifier and pore-blocking toxins: Membrane interaction is not a prerequisite for modification of channel gating

(2016) Evelyne Deplazes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Development of a μO-Conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Sodium Channel NaV1.8

(2016) Jennifer R. Deuis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction of Tarantula Venom Peptide ProTx-II with Lipid Membranes Is a Prerequisite for Its Inhibition of Human Voltage-gated Sodium Channel NaV1.7

(2016) Sónia Troeira Henriques et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action

(2016) Yuan Gao et al.   NATURE

Selective spider toxins reveal a role for the Nav1.1 channel in mechanical pain

(2016) Jeremiah D. Osteen et al.   NATURE

Molecular Interactions between Tarantula Toxins and Low-Voltage-Activated Calcium Channels

(2016) Autoosa Salari et al.   Scientific Reports

Molecular basis of the interaction between gating modifier spider toxins and the voltage sensor of voltage-gated ion channels

(2016) Carus H. Y. Lau et al.   Scientific Reports

Engineering Potent and Selective Analogues of GpTx-1, a Tarantula Venom Peptide Antagonist of the NaV1.7 Sodium Channel

(2015) Justin K. Murray et al.   JOURNAL OF MEDICINAL CHEMISTRY

From Foe to Friend: Using Animal Toxins to Investigate Ion Channel Function

(2015) Jeet Kalia et al.   JOURNAL OF MOLECULAR BIOLOGY

A gamut of undiscovered electrophysiological effects produced by Tityus serrulatus toxin 1 on NaV-type isoforms

(2015) Steve Peigneur et al.   NEUROPHARMACOLOGY

Mapping the interaction site for the tarantula toxin hainantoxin-IV (β-TRTX-Hn2a) in the voltage sensor module of domain II of voltage-gated sodium channels

(2015) Tianfu Cai et al.   PEPTIDES

No Gain, No Pain: NaV1.7 as an Analgesic Target

(2014) Glenn F. King et al.   ACS Chemical Neuroscience

A Tarantula-Venom Peptide Antagonizes the TRPA1 Nociceptor Ion Channel by Binding to the S1–S4 Gating Domain

(2014) Junhong Gui et al.   CURRENT BIOLOGY

Analysis of the Structural and Molecular Basis of Voltage-sensitive Sodium Channel Inhibition by the Spider Toxin Huwentoxin-IV (μ-TRTX-Hh2a)

(2013) Natali A. Minassian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spider-Venom Peptides: Structure, Pharmacology, and Potential for Control of Insect Pests

(2012) Glenn F. King et al.   Annual Review of Entomology

Phosphatidylethanolamine Binding Is a Conserved Feature of Cyclotide-Membrane Interactions

(2012) Sónia Troeira Henriques et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A positively charged surface patch is important for hainantoxin-IV binding to voltage-gated sodium channels

(2012) Yu Liu et al.   JOURNAL OF PEPTIDE SCIENCE

Decoding the Membrane Activity of the Cyclotide Kalata B1

(2011) Sónia Troeira Henriques et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sodium Channels in Normal and Pathological Pain

(2010) Sulayman D. Dib-Hajj et al.   Annual Review of Neuroscience

Structure and Orientation of a Voltage-Sensor Toxin in Lipid Membranes

(2010) Hyun Ho Jung et al.   BIOPHYSICAL JOURNAL

Lipid map of the mammalian cell

(2010) G. van Meer et al.   JOURNAL OF CELL SCIENCE

SYMPOSIUM REVIEW: Lipid microdomains and the regulation of ion channel function

(2010) Caroline Dart   JOURNAL OF PHYSIOLOGY-LONDON

Targeting voltage sensors in sodium channels with spider toxins

(2010) Frank Bosmans et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Toxicity of Prion Protein Fragment PrP(106−126) is Not Mediated by Membrane Permeabilization as Shown by a M112W Substitution

(2009) Sónia Troeira Henriques et al.   BIOCHEMISTRY

Interactions between lipids and voltage sensor paddles detected with tarantula toxins

(2009) Mirela Milescu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lipids and membrane protein structures

(2008) C HUNTE et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Tarantula Huwentoxin-IV Inhibits Neuronal Sodium Channels by Binding to Receptor Site 4 and Trapping the Domain II Voltage Sensor in the Closed Configuration

(2008) Yucheng Xiao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ProTx-II, a Selective Inhibitor of NaV1.7 Sodium Channels, Blocks Action Potential Propagation in Nociceptors

(2008) W. A. Schmalhofer et al.   MOLECULAR PHARMACOLOGY

Deconstructing voltage sensor function and pharmacology in sodium channels

(2008) Frank Bosmans et al.   NATURE

Synthesis and characterization of huwentoxin-IV, a neurotoxin inhibiting central neuronal sodium channels

(2007) Yucheng Xiao et al.   TOXICON