Free Heme and Amyloid-β: A Fatal Liaison in Alzheimer’s Disease

Is there correlation between Aβ-heme peroxidase activity and the peptide aggregation state? A literature review combined with hypothesis

(2017) Reza Khodarahmi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Thioflavin T as an amyloid dye: fibril quantification, optimal concentration and effect on aggregation

(2017) Christine Xue et al.   Royal Society Open Science

What is the concentration of hydrogen peroxide in blood and plasma?

(2016) Henry Jay Forman et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Heme interacts with histidine- and tyrosine-based protein motifs and inhibits enzymatic activity of chloramphenicol acetyltransferase from Escherichia coli

(2016) Hans Henning Brewitz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Atrophy, hypometabolism and clinical trajectories in patients with amyloid-negative Alzheimer’s disease

(2016) Gaël Chételat et al.   BRAIN

Relationship between chronic disturbance of 2,3-diphosphoglycerate metabolism in erythrocytes and Alzheimer disease

(2016) Elena A. Kosenko et al.   CNS & Neurological Disorders-Drug Targets

Interactions between heme and tau-derived R1 peptides: binding and oxidative reactivity

(2016) V. Pirota et al.   DALTON TRANSACTIONS

Structure of amyloid oligomers and their mechanisms of toxicities: Targeting amyloid oligomers using novel therapeutic approaches

(2016) Parveen Salahuddin et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Inhibition of the heme-induced hemolysis of red blood cells by the chlorite-based drug WF10

(2016) J. Flemmig et al.   FREE RADICAL RESEARCH

Alzheimer disease is in part a thrombohemorrhagic disorder

(2016) A. H. Schmaier   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The activities of amyloids from a structural perspective

(2016) Roland Riek et al.   NATURE

Atomic-resolution structure of a disease-relevant Aβ(1–42) amyloid fibril

(2016) Marielle Aulikki Wälti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson’s disease and Alzheimer’s disease

(2016) Tianfang Jiang et al.   PROGRESS IN NEUROBIOLOGY

Tau and Aβ imaging, CSF measures, and cognition in Alzheimer’s disease

(2016) Matthew R. Brier et al.   Science Translational Medicine

The Three-Dimensional Structures of Amyloids

(2016) Roland Riek   Cold Spring Harbor Perspectives in Biology

Molecular Structure of Aggregated Amyloid-β: Insights from Solid-State Nuclear Magnetic Resonance

(2016) Robert Tycko   Cold Spring Harbor Perspectives in Medicine

Amyloid Beta-Mediated Hypomethylation of Heme Oxygenase 1 Correlates with Cognitive Impairment in Alzheimer’s Disease

(2016) Hye Youn Sung et al.   PLoS One

Alzheimer’s Disease: A Heme–Aβ Perspective

(2015) Chandradeep Ghosh et al.   ACCOUNTS OF CHEMICAL RESEARCH

Neuroprotective action of resveratrol

(2015) Stéphane Bastianetto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Lactoperoxidase as a potential drug target

(2015) Jörg Flemmig et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Impact of myeloperoxidase-derived oxidants on the product profile of human 5-lipoxygenase

(2015) Josefin Zschaler et al.   FREE RADICAL BIOLOGY AND MEDICINE

Amyloid-β Peptide Aβ3pE-42 Induces Lipid Peroxidation, Membrane Permeabilization, and Calcium Influx in Neurons

(2015) Adam P. Gunn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exploring the Alzheimer amyloid-β peptide conformational ensemble: A review of molecular dynamics approaches

(2015) Linh Tran et al.   PEPTIDES

Neurotherapeutic effects of novel HO-1 inhibitorsin vitroand in a transgenic mouse model of Alzheimer's disease

(2015) Ajay Gupta et al.   JOURNAL OF NEUROCHEMISTRY

Erythrocyte Membrane Stability to Hydrogen Peroxide is Decreased in Alzheimer Disease

(2014) Marilena Gilca et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Characterization of the enhanced peroxidatic activity of amyloid β peptide–hemin complexes towards neurotransmitters

(2014) Bettina Neumann et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Key roles of Arg5, Tyr10 and His residues in Aβ–heme peroxidase: Relevance to Alzheimer’s disease

(2014) Naihao Lu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hemin as a generic and potent protein misfolding inhibitor

(2014) Yanqin Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Key Roles for Tyrosine 10 in Aβ–Heme Complexes and Its Relevance to Oxidative Stress

(2014) Naihao Lu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Local interactions influence the fibrillation kinetics, structure and dynamics of Aβ(1–40) but leave the general fibril structure unchanged

(2014) Juliane Adler et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Oxidative stress in Alzheimer’s disease

(2014) Zhichun Chen et al.   Neuroscience Bulletin

Interaction between Amyloid-β Peptide and Heme Probed by Electrochemistry and Atomic Force Microscopy

(2013) Yanli Zhou et al.   ACS Chemical Neuroscience

Heme Binding Induces Dimerization and Nitration of Truncated β-Amyloid Peptide Aβ16 Under Oxidative Stress

(2013) Grégory Thiabaud et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aβ Interacts with Both the Iron Center and the Porphyrin Ring of Heme: Mechanism of Heme’s Action on Aβ Aggregation and Disaggregation

(2013) Can Yuan et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Review article What causes alzheimer’s disease?

(2013) Richard A. Armstrong   FOLIA NEUROPATHOLOGICA

Fe(III)–Heme Complexes with the Amyloid Beta Peptide of Alzheimer’s Disease: QM/MM Investigations of Binding and Redox Properties of Heme Bound to the His Residues of Aβ(1–42)

(2013) Samira Azimi et al.   Journal of Chemical Theory and Computation

Heme prevents amyloid beta peptide aggregation through hydrophobic interaction based on molecular dynamics simulation

(2013) Li Na Zhao et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

The development of cerebral amyloid angiopathy in cerebral vessels. A review with illustrations based upon own investigated post mortem cases

(2013) Tadeusz Andrzej Mendel et al.   POLISH JOURNAL OF PATHOLOGY

Rapid cell death is preceded by amyloid plaque-mediated oxidative stress

(2013) H. Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A central role for dityrosine crosslinking of Amyloid-β in Alzheimer’s disease

(2013) Youssra K Al-Hilaly et al.   Acta Neuropathologica Communications

Proteomic Changes in Cerebrospinal Fluid of Presymptomatic and Affected Persons Carrying Familial Alzheimer Disease Mutations

(2012) John M. Ringman   ARCHIVES OF NEUROLOGY

Amyloid β Levels in Human Red Blood Cells

(2012) Takehiro Kiko et al.   PLoS One

Amyloid β Induces Adhesion of Erythrocytes to Endothelial Cells and Affects Endothelial Viability and Functionality

(2011) Kiyotaka NAKAGAWA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Animal models in the drug discovery pipeline for Alzheimer's disease

(2011) Debby Van Dam et al.   BRITISH JOURNAL OF PHARMACOLOGY

Amyloid β-induced erythrocytic damage and its attenuation by carotenoids

(2011) Kiyotaka Nakagawa et al.   FEBS LETTERS

The mechanism for heme to prevent Aβ1–40 aggregation and its cytotoxicity

(2011) Qingui Bao et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Amyloid beta–heme peroxidase promoted protein nitrotyrosination: relevance to widespread protein nitration in Alzheimer’s disease

(2011) Can Yuan et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Alzheimer’s disease is characterized by more low-density erythrocytes with increased volume and enhanced β-amyloid x-40 content

(2011) P. Järemo et al.   JOURNAL OF INTERNAL MEDICINE

Monitoring blood flow alterations in the Tg2576 mouse model of Alzheimer's disease by in vivo magnetic resonance angiography at 17.6T

(2011) F. Kara et al.   NEUROIMAGE

Human myeloperoxidase in innate and acquired immunity

(2010) Juergen Arnhold et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Inhibitors of Catalase-Amyloid Interactions Protect Cells from β-Amyloid-Induced Oxidative Stress and Toxicity

(2010) Lila K. Habib et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction of hypochlorous acid and myeloperoxidase with phosphatidylserine in the presence of ammonium ions

(2010) Joerg Flemmig et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Detection of vascular alterations by in vivo magnetic resonance angiography and histology in APP/PS1 mouse model of Alzheimer’s disease

(2010) Nadine El Tannir El Tayara et al.   MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE

Thioflavine T interaction with synthetic Alzheimer's disease β-amyloid peptides: Detection of amyloid aggregation in solution

(2010) Harry Levine   PROTEIN SCIENCE

Human and rodent amyloid-β peptides differentially bind heme: Relevance to the human susceptibility to Alzheimer’s disease

(2009) Hani Atamna et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Amino acids variations in Amyloid-β peptides, mitochondrial dysfunction, and new therapies for Alzheimer’s disease

(2009) Hani Atamna   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Neurodegeneration and peroxidases

(2007) Johannes Everse et al.   NEUROBIOLOGY OF AGING