Programmed Cell Death in the Pathogenesis of Influenza

Proteomics to study macrophage response to viral infection

(2018) Tuula A. Nyman et al.   Journal of Proteomics

Influenza A Virus Infection Triggers Pyroptosis and Apoptosis of Respiratory Epithelial Cells through the Type I Interferon Signaling Pathway in a Mutually Exclusive Manner

(2018) SangJoon Lee et al.   JOURNAL OF VIROLOGY

Molecular mechanism of influenza A NS1-mediated TRIM25 recognition and inhibition

(2018) Marios G. Koliopoulos et al.   Nature Communications

Signal transduction analysis of the NLRP3-inflammasome pathway after cellular damage and its paracrine regulation

(2017) Denise Veltman et al.   JOURNAL OF THEORETICAL BIOLOGY

An Inflammatory Perspective on Necroptosis

(2017) Conor J. Kearney et al.   MOLECULAR CELL

Recognition of Viral RNA by Pattern Recognition Receptors in the Induction of Innate Immunity and Excessive Inflammation During Respiratory Viral Infections

(2017) Masaaki Okamoto et al.   VIRAL IMMUNOLOGY

Pandemic H1N1 influenza A viruses suppress immunogenic RIPK3-driven dendritic cell death

(2017) Boris M. Hartmann et al.   Nature Communications

RIPK3 interacts with MAVS to regulate type I IFN-mediated immunity to Influenza A virus infection

(2017) Jeffrey Downey et al.   PLoS Pathogens

Influenza A Virus PA Antagonizes Interferon-β by Interacting with Interferon Regulatory Factor 3

(2017) Chenyang Yi et al.   Frontiers in Immunology

The H7N9 influenza A virus infection results in lethal inflammation in the mammalian host via the NLRP3-caspase-1 inflammasome

(2017) Rongrong Ren et al.   Scientific Reports

Roles of Caspases in Necrotic Cell Death

(2016) Junying Yuan et al.   CELL

DAI Senses Influenza A Virus Genomic RNA and Activates RIPK3-Dependent Cell Death

(2016) Roshan J. Thapa et al.   Cell Host & Microbe

RIPK3 Activates Parallel Pathways of MLKL-Driven Necroptosis and FADD-Mediated Apoptosis to Protect against Influenza A Virus

(2016) Shoko Nogusa et al.   Cell Host & Microbe

Influenza virus RNA polymerase: insights into the mechanisms of viral RNA synthesis

(2016) Aartjan J. W. te Velthuis et al.   NATURE REVIEWS MICROBIOLOGY

The IL-1 cytokine family and its role in inflammation and fibrosis in the lung

(2016) L. A. Borthwick   Seminars in Immunopathology

A Fluorescent Reporter Mouse for Inflammasome Assembly Demonstrates an Important Role for Cell-Bound and Free ASC Specks during In Vivo Infection

(2016) Te-Chen Tzeng et al.   Cell Reports

Exosomes

(2015) Heinrich J. Huber et al.   CURRENT OPINION IN LIPIDOLOGY

TRAIL+ monocytes and monocyte-related cells cause lung damage and thereby increase susceptibility to influenza-Streptococcus pneumoniae coinfection

(2015) G. T. Ellis et al.   EMBO REPORTS

The diverse role of RIP kinases in necroptosis and inflammation

(2015) John Silke et al.   NATURE IMMUNOLOGY

Phagocytosis of apoptotic cells in homeostasis

(2015) Sanja Arandjelovic et al.   NATURE IMMUNOLOGY

Influenza virus activation of the interferon system

(2015) Marian J. Killip et al.   VIRUS RESEARCH

Multi-spectral fluorescent reporter influenza viruses (Color-flu) as powerful tools for in vivo studies

(2015) Satoshi Fukuyama et al.   Nature Communications

Inhibition of the OAS/RNase L pathway by viruses

(2015) Melissa Drappier et al.   Current Opinion in Virology

CD8 T Cells Utilize TRAIL to Control Influenza Virus Infection

(2014) E. L. Brincks et al.   JOURNAL OF IMMUNOLOGY

Harnessing system models of cell death signalling for cytotoxic chemotherapy: towards personalised medicine approaches?

(2014) Heinrich J. Huber et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Emerging novel and antimicrobial-resistant respiratory tract infections: new drug development and therapeutic options

(2014) Alimuddin Zumla et al.   LANCET INFECTIOUS DISEASES

Pandemic Preparedness and Response — Lessons from the H1N1 Influenza of 2009

(2014) Harvey V. Fineberg   NEW ENGLAND JOURNAL OF MEDICINE

Molecular mechanisms enhancing the proteome of influenza A viruses: An overview of recently discovered proteins

(2014) A.V. Vasin et al.   VIRUS RESEARCH

Influenza A virus protein PB1-F2 translocates into mitochondria via Tom40 channels and impairs innate immunity

(2014) Takuma Yoshizumi et al.   Nature Communications

Alveolar Macrophages Are Essential for Protection from Respiratory Failure and Associated Morbidity following Influenza Virus Infection

(2014) Christoph Schneider et al.   PLoS Pathogens

MicroRNA-containing microvesicles regulating inflammation in association with atherosclerotic disease

(2013) Maarten Hulsmans et al.   CARDIOVASCULAR RESEARCH

Type-I Interferon is Critical for FasL Expression on Lung Cells to Determine the Severity of Influenza

(2013) Daisuke Fujikura et al.   PLoS One

Macrophage-expressed IFN-β Contributes to Apoptotic Alveolar Epithelial Cell Injury in Severe Influenza Virus Pneumonia

(2013) Katrin Högner et al.   PLoS Pathogens

Influenza Virus Protein PB1-F2 Inhibits the Induction of Type I Interferon by Binding to MAVS and Decreasing Mitochondrial Membrane Potential

(2012) Zsuzsanna T. Varga et al.   JOURNAL OF VIROLOGY

Neurovirulence of H5N1 Infection in Ferrets Is Mediated by Multifocal Replication in Distinct Permissive Neuronal Cell Regions

(2012) Jennifer R. Plourde et al.   PLoS One

Excessive Neutrophils and Neutrophil Extracellular Traps Contribute to Acute Lung Injury of Influenza Pneumonitis

(2011) Teluguakula Narasaraju et al.   AMERICAN JOURNAL OF PATHOLOGY

Measuring and Modeling Apoptosis in Single Cells

(2011) Sabrina L. Spencer et al.   CELL

Programmed necrosis: backup to and competitor with apoptosis in the immune system

(2011) Jiahuai Han et al.   NATURE IMMUNOLOGY

Transcriptomic Analysis of Host Immune and Cell Death Responses Associated with the Influenza A Virus PB1-F2 Protein

(2011) Ronan Le Goffic et al.   PLoS Pathogens

Influenza Virus Evolution, Host Adaptation, and Pandemic Formation

(2010) Jeffery K. Taubenberger et al.   Cell Host & Microbe

Influenza A Virus Protein PB1-F2 Exacerbates IFN-  Expression of Human Respiratory Epithelial Cells

(2010) R. Le Goffic et al.   JOURNAL OF IMMUNOLOGY

Postmortem findings in eight cases of influenza A/H1N1

(2010) Daniel G Rosen et al.   MODERN PATHOLOGY

Immunological and Inflammatory Functions of the Interleukin-1 Family

(2009) Charles A. Dinarello   Annual Review of Immunology

Inflammasome recognition of influenza virus is essential for adaptive immune responses

(2009) Takeshi Ichinohe et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Highly pathogenic H5N1 influenza virus can enter the central nervous system and induce neuroinflammation and neurodegeneration

(2009) H. Jang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lung epithelial apoptosis in influenza virus pneumonia: the role of macrophage-expressed TNF-related apoptosis-inducing ligand

(2008) Susanne Herold et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The biology of influenza viruses

(2008) Nicole M. Bouvier et al.   VACCINE