Big Lessons from Tiny Flies: Drosophila melanogaster as a Model to Explore Dysfunction of Dopaminergic and Serotonergic Neurotransmitter Systems

Dunce Phosphodiesterase Acts as a Checkpoint for Drosophila Long-Term Memory in a Pair of Serotonergic Neurons

(2018) Lisa Scheunemann et al.   NEURON

Satiation state-dependent dopaminergic control of foraging in Drosophila

(2018) Dan Landayan et al.   Scientific Reports

An unfolding story: Small molecules remedy misfolded monoamine transporters

(2017) Ameya Kasture et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Treating the Synapse in Major Psychiatric Disorders: The Role of Postsynaptic Density Network in Dopamine-Glutamate Interplay and Psychopharmacologic Drugs Molecular Actions

(2017) Carmine Tomasetti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pharmacochaperoning in aDrosophilamodel system rescues human dopamine transporter variants associated with infantile/juvenile parkinsonism

(2017) H. M. Mazhar Asjad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational state interactions provide clues to the pharmacochaperone potential of serotonin transporter partial substrates

(2017) Shreyas Bhat et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The N Terminus Specifies the Switch between Transport Modes of the Human Serotonin Transporter

(2017) Carina Kern et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Re-evaluation of learned information in Drosophila

(2017) Johannes Felsenberg et al.   NATURE

Serotonergic Modulation Enables Pathway-Specific Plasticity in a Developing Sensory Circuit in Drosophila

(2017) Takuya Kaneko et al.   NEURON

Branch-specific plasticity of a bifunctional dopamine circuit encodes protein hunger

(2017) Qili Liu et al.   SCIENCE

Serotonin modulates a depression-like state in Drosophila responsive to lithium treatment

(2017) Ariane-Saskia Ries et al.   Nature Communications

Dopamine Receptor DAMB Signals via Gq to Mediate Forgetting in Drosophila

(2017) Sophie Himmelreich et al.   Cell Reports

Drosophila Clock Is Required in Brain Pacemaker Neurons to Prevent Premature Locomotor Aging Independently of Its Circadian Function

(2017) Alexandra Vaccaro et al.   PLoS Genetics

Reciprocal synapses between mushroom body and dopamine neurons form a positive feedback loop required for learning

(2017) Isaac Cervantes-Sandoval et al.   eLife

A Genetic Screen for Sleep and Circadian Mutants Reveals Mechanisms Underlying Regulation of Sleep in Drosophila

(2017) Mark N. Wu et al.   SLEEP

Four Individually Identified Paired Dopamine Neurons Signal Reward in Larval Drosophila

(2016) Astrid Rohwedder et al.   CURRENT BIOLOGY

A new brain dopamine-deficientDrosophilaand its pharmacological and genetic rescue

(2016) K. Cichewicz et al.   GENES BRAIN AND BEHAVIOR

Pharmacological Chaperones of the Dopamine Transporter Rescue Dopamine Transporter Deficiency Syndrome Mutations in Heterologous Cells

(2016) Pieter Beerepoot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Rescue of a MisfoldedDrosophila melanogasterDopamine Transporter Mutant Associated with a Sleepless Phenotype by Pharmacological Chaperones

(2016) Ameya Kasture et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Operation of a homeostatic sleep switch

(2016) Diogo Pimentel et al.   NATURE

Dopaminergic Circuitry Underlying Mating Drive

(2016) Stephen X. Zhang et al.   NEURON

Dopaminergic neurons write and update memories with cell-type-specific rules

(2016) Yoshinori Aso et al.   eLife

Modulatory Action by the Serotonergic System: Behavior and Neurophysiology inDrosophila melanogaster

(2016) Zana R. Majeed et al.   NEURAL PLASTICITY

Utility of Induced Pluripotent Stem Cells for the Study and Treatment of Genetic Diseases: Focus on Childhood Neurological Disorders

(2016) Serena Barral et al.   Frontiers in Molecular Neuroscience

A Single Pair of Serotonergic Neurons Counteracts Serotonergic Inhibition of Ethanol Attraction in Drosophila

(2016) Li Xu et al.   PLoS One

Functional Interplay between Dopaminergic and Serotonergic Neuronal Systems during Development and Adulthood

(2015) Vera Niederkofler et al.   ACS Chemical Neuroscience

Sleep Facilitates Memory by Blocking Dopamine Neuron-Mediated Forgetting

(2015) Jacob A. Berry et al.   CELL

Morgan’s Legacy: Fruit Flies and the Functional Annotation of Conserved Genes

(2015) Hugo J. Bellen et al.   CELL

A Subset of Serotonergic Neurons Evokes Hunger in Adult Drosophila

(2015) Stephanie D. Albin et al.   CURRENT BIOLOGY

Sweet Taste and Nutrient Value Subdivide Rewarding Dopaminergic Neurons in Drosophila

(2015) Wolf Huetteroth et al.   CURRENT BIOLOGY

Identified Serotonin-Releasing Neurons Induce Behavioral Quiescence and Suppress Mating in Drosophila

(2015) A. Pooryasin et al.   JOURNAL OF NEUROSCIENCE

Amphetamines, new psychoactive drugs and the monoamine transporter cycle

(2015) Harald H. Sitte et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Control of Sleep by Dopaminergic Inputs to the Drosophila Mushroom Body

(2015) Divya Sitaraman et al.   Frontiers in Neural Circuits

A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster

(2015) Paula R Haynes et al.   eLife

Dopamine transporter deficiency syndrome: phenotypic spectrum from infancy to adulthood

(2014) Joanne Ng et al.   BRAIN

A Drosophila Genetic Resource of Mutants to Study Mechanisms Underlying Human Genetic Diseases

(2014) Shinya Yamamoto et al.   CELL

Cellular and Behavioral Functions of fruitless Isoforms in Drosophila Courtship

(2014) Anne C. von Philipsborn et al.   CURRENT BIOLOGY

Single Serotonergic Neurons that Modulate Aggression in Drosophila

(2014) Olga V. Alekseyenko et al.   CURRENT BIOLOGY

A Cytosolic Relay of Heat Shock Proteins HSP70-1A and HSP90β Monitors the Folding Trajectory of the Serotonin Transporter

(2014) Ali El-Kasaby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Axonal Targeting of the Serotonin Transporter in Cultured Rat Dorsal Raphe Neurons Is Specified by SEC24C-Dependent Export from the Endoplasmic Reticulum

(2014) T. R. Montgomery et al.   JOURNAL OF NEUROSCIENCE

Drosophila developmental biology methods

(2014) Norbert Perrimon   METHODS

Drosophila melanogaster as a genetic model system to study neurotransmitter transporters

(2014) Ciara A. Martin et al.   NEUROCHEMISTRY INTERNATIONAL

Distinct dopamine neurons mediate reward signals for short- and long-term memories

(2014) Nobuhiro Yamagata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Optimized CRISPR/Cas tools for efficient germline and somatic genome engineering in Drosophila

(2014) F. Port et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defining Midbrain Dopaminergic Neuron Diversity by Single-Cell Gene Expression Profiling

(2014) Jean-Francois Poulin et al.   Cell Reports

Functional characterization of dopamine transporter in vivo using Drosophila melanogaster behavioral assays

(2014) Taro Ueno et al.   Frontiers in Behavioral Neuroscience

Reinforcement signalling in Drosophila; dopamine does it all after all

(2013) Scott Waddell   CURRENT OPINION IN NEUROBIOLOGY

Switching the Clientele

(2013) Sonja Sucic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Drosophilaas a screening tool to study human neurodegenerative diseases

(2013) Sarah Lenz et al.   JOURNAL OF NEUROCHEMISTRY

Amphetamine-induced behavior requires CaMKII-dependent dopamine transporter phosphorylation

(2013) A B Pizzo et al.   MOLECULAR PSYCHIATRY

De novo mutation in the dopamine transporter gene associates dopamine dysfunction with autism spectrum disorder

(2013) P J Hamilton et al.   MOLECULAR PSYCHIATRY

Competing dopamine neurons drive oviposition choice for ethanol in Drosophila

(2013) R. Azanchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single dopaminergic neurons that modulate aggression in Drosophila

(2013) O. V. Alekseyenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Glutamate is an inhibitory neurotransmitter in the Drosophila olfactory system

(2013) W. W. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small molecule drug screening in Drosophila identifies the 5HT2A receptor as a feeding modulation target

(2013) Gabriel Gasque et al.   Scientific Reports

A Novel Role for Ecdysone in Drosophila Conditioned Behavior: Linking GPCR-Mediated Non-canonical Steroid Action to cAMP Signaling in the Adult Brain

(2013) Hiroshi Ishimoto et al.   PLoS Genetics

Two Dopaminergic Neurons Signal to the Dorsal Fan-Shaped Body to Promote Wakefulness in Drosophila

(2012) Qili Liu et al.   CURRENT BIOLOGY

Dispensable, Redundant, Complementary, and Cooperative Roles of Dopamine, Octopamine, and Serotonin in Drosophila melanogaster

(2012) A. Chen et al.   GENETICS

Glutamate-gated Chloride Channels

(2012) Adrian J. Wolstenholme   JOURNAL OF BIOLOGICAL CHEMISTRY

The membrane raft protein Flotillin-1 is essential in dopamine neurons for amphetamine-induced behavior in Drosophila

(2012) A B Pizzo et al.   MOLECULAR PSYCHIATRY

A subset of dopamine neurons signals reward for odour memory in Drosophila

(2012) Chang Liu et al.   NATURE

Dopamine neurons modulate pheromone responses in Drosophila courtship learning

(2012) Krystyna Keleman et al.   NATURE

Layered reward signalling through octopamine and dopamine in Drosophila

(2012) Christopher J. Burke et al.   NATURE

Patterns and rates of exonic de novo mutations in autism spectrum disorders

(2012) Benjamin M. Neale et al.   NATURE

Identification of a dopamine pathway that regulates sleep and arousal in Drosophila

(2012) Taro Ueno et al.   NATURE NEUROSCIENCE

Dopamine Is Required for Learning and Forgetting in Drosophila

(2012) Jacob A. Berry et al.   NEURON

Dopaminergic Modulation of Sucrose Acceptance Behavior in Drosophila

(2012) Sunanda Marella et al.   NEURON

Serotonin–glutamate and serotonin–dopamine reciprocal interactions as putative molecular targets for novel antipsychotic treatments: from receptor heterodimers to postsynaptic scaffolding and effector proteins

(2012) A. de Bartolomeis et al.   PSYCHOPHARMACOLOGY

Three Dopamine Pathways Induce Aversive Odor Memories with Different Stability

(2012) Yoshinori Aso et al.   PLoS Genetics

The Serotonin Transporter Is an Exclusive Client of the Coat Protein Complex II (COPII) Component SEC24C

(2011) Sonja Sucic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Serotonin Transporter Expression in Drosophila melanogaster

(2011) Thomas Giang et al.   JOURNAL OF NEUROGENETICS

The monoamine neurotransmitter disorders: an expanding range of neurological syndromes

(2011) Manju A Kurian et al.   LANCET NEUROLOGY

The Serotonin 5-HT7Dro Receptor Is Expressed in the Brain of Drosophila, and Is Essential for Normal Courtship and Mating

(2011) Jaime Becnel et al.   PLoS One

Schizophrenia susceptibility gene dysbindin regulates glutamatergic and dopaminergic functions via distinctive mechanisms in Drosophila

(2011) L. Shao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Serotonin-mushroom body circuit modulating the formation of anesthesia-resistant memory in Drosophila

(2011) P.-T. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vesicular and Plasma Membrane Transporters for Neurotransmitters

(2011) R. D. Blakely et al.   Cold Spring Harbor Perspectives in Biology

Role of Serotonin in Central Dopamine Dysfunction

(2010) Giuseppe Di Giovanni et al.   CNS Neuroscience & Therapeutics

Mutations in the Carboxyl-terminal SEC24 Binding Motif of the Serotonin Transporter Impair Folding of the Transporter

(2010) Ali El-Kasaby et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The N Terminus of Monoamine Transporters Is a Lever Required for the Action of Amphetamines

(2010) Sonja Sucic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serotonergic dystrophy induced by excess serotonin

(2010) Elizabeth A. Daubert et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Distinct Tonic and Phasic Anticipatory Activity in Lateral Habenula and Dopamine Neurons

(2010) Ethan S. Bromberg-Martin et al.   NEURON

Targeted Manipulation of Serotonergic Neurotransmission Affects the Escalation of Aggression in Adult Male Drosophila melanogaster

(2010) Olga V. Alekseyenko et al.   PLoS One

Behavioral consequences of dopamine deficiency in the Drosophila central nervous system

(2010) T. Riemensperger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Using in Vivo Electrochemistry To Study the Physiological Effects of Cocaine and Other Stimulants on the Drosophila melanogaster Dopamine Transporter

(2009) Monique A. Makos et al.   ACS Chemical Neuroscience

Detection of Endogenous Dopamine Changes inDrosophila melanogasterUsing Fast-Scan Cyclic Voltammetry

(2009) Trisha L. Vickrey et al.   ANALYTICAL CHEMISTRY

Writing Memories with Light-Addressable Reinforcement Circuitry

(2009) Adam Claridge-Chang et al.   CELL

A Neural Circuit Mechanism Integrating Motivational State with Memory Expression in Drosophila

(2009) Michael J. Krashes et al.   CELL

Identification of EMS-Induced Mutations in Drosophila melanogaster by Whole-Genome Sequencing

(2009) J. P. Blumenstiel et al.   GENETICS

Homozygous loss-of-function mutations in the gene encoding the dopamine transporter are associated with infantile parkinsonism-dystonia

(2009) Manju A. Kurian et al.   JOURNAL OF CLINICAL INVESTIGATION

Two types of dopamine neuron distinctly convey positive and negative motivational signals

(2009) Masayuki Matsumoto et al.   NATURE

Eight different types of dopaminergic neurons innervate the Drosophila mushroom body neuropil: anatomical and physiological heterogeneity

(2009) Zhengmei Mao   Frontiers in Neural Circuits

Increased Dopamine Level Enhances Male-Male Courtship in Drosophila

(2008) T. Liu et al.   JOURNAL OF NEUROSCIENCE

Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons

(2008) Danling Wang et al.   Molecular Neurodegeneration

Serotonin is necessary for place memory in Drosophila

(2008) D. Sitaraman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Glial Variant of the Vesicular Monoamine Transporter Is Required To Store Histamine in the Drosophila Visual System

(2008) Rafael Romero-Calderón et al.   PLoS Genetics

Loss of spastic paraplegia gene atlastin induces age-dependent death of dopaminergic neurons in Drosophila

(2006) Youngseok Lee et al.   NEUROBIOLOGY OF AGING