Use of Curcumin, a Natural Polyphenol for Targeting Molecular Pathways in Treating Age-Related Neurodegenerative Diseases

Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial

(2018) Gary W. Small et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Solid lipid curcumin particles provide greater anti-amyloid, anti-inflammatory and neuroprotective effects than curcumin in the 5xFAD mouse model of Alzheimer’s disease

(2018) Panchanan Maiti et al.   BMC NEUROSCIENCE

Curcuminoid Binds to Amyloid-β1-42 Oligomer and Fibril

(2018) Daijiro Yanagisawa et al.   JOURNAL OF ALZHEIMERS DISEASE

Curcumin-Mediated Neuroprotection Against Amyloid-β-Induced Mitochondrial Dysfunction Involves the Inhibition of GSK-3β

(2018) Han-Chang Huang et al.   JOURNAL OF ALZHEIMERS DISEASE

Curcumin Inhibits Tau Aggregation and Disintegrates Preformed Tau Filaments in vitro

(2017) Jitendra Subhash Rane et al.   JOURNAL OF ALZHEIMERS DISEASE

Solid Lipid Curcumin Particles Induce More DNA Fragmentation and Cell Death in Cultured Human Glioblastoma Cells than Does Natural Curcumin

(2017) Panchanan Maiti et al.   Oxidative Medicine and Cellular Longevity

Design, synthesis, and biological evaluation of novel EF24 and EF31 analogs as potential IκB kinase β inhibitors for the treatment of pancreatic cancer

(2017) Xuemeng Xie et al.   Drug Design Development and Therapy

A comparative study of dietary curcumin, nanocurcumin, and other classical amyloid-binding dyes for labeling and imaging of amyloid plaques in brain tissue of 5×-familial Alzheimer’s disease mice

(2016) Panchanan Maiti et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Oral bioavailability of curcumin: problems and advancements

(2016) Weidong Liu et al.   JOURNAL OF DRUG TARGETING

Curcumin causes DNA damage and affects associated protein expression in HeLa human cervical cancer cells

(2016) Hung-Sheng Shang et al.   ONCOLOGY REPORTS

Kinetics of inhibition of monoamine oxidase using curcumin and ellagic acid

(2016) ArchanaRamesh Juvekar et al.   Pharmacognosy Magazine

Curcumin modulates cell death and is protective in Huntington’s disease model

(2016) Anjalika Chongtham et al.   Scientific Reports

Curcumin Attenuates Beta-Amyloid-Induced Neuroinflammation via Activation of Peroxisome Proliferator-Activated Receptor-Gamma Function in a Rat Model of Alzheimer's Disease

(2016) Zun-Jing Liu et al.   Frontiers in Pharmacology

Examining the potential clinical value of curcumin in the prevention and diagnosis of Alzheimer’s disease

(2015) K. G. Goozee et al.   BRITISH JOURNAL OF NUTRITION

Metal complexes of curcumin – synthetic strategies, structures and medicinal applications

(2015) Simon Wanninger et al.   CHEMICAL SOCIETY REVIEWS

Clinical development of curcumin in neurodegenerative disease

(2015) Shuxin Hu et al.   Expert Review of Neurotherapeutics

Curcumin upregulates Nrf2 nuclear translocation and protects rat hepatic stellate cells against oxidative stress

(2015) ZHENXIONG LIU et al.   Molecular Medicine Reports

Curcumin, Inflammation, and Chronic Diseases: How Are They Linked?

(2015) Yan He et al.   MOLECULES

Curcumin and Apigenin - novel and promising therapeutics against chronic neuroinflammation in Alzheimer′s disease

(2015) Gerald Münch et al.   Neural Regeneration Research

Curcuminoids Extract, Hydrolyzed Collagen and Green Tea Extract Synergically Inhibit Inflammatory and Catabolic Mediator’s Synthesis by Normal Bovine and Osteoarthritic Human Chondrocytes in Monolayer

(2015) Fanny Comblain et al.   PLoS One

Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer’s disease

(2015) Xueli Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Curcumin analogues as selective fluorescence imaging probes for brown adipose tissue and monitoring browning

(2015) Xueli Zhang et al.   Scientific Reports

Clearance of amyloid β-protein and its role in the spreading of Alzheimer's disease pathology

(2015) Dietmar R. Thal   Frontiers in Aging Neuroscience

Clinical development of curcumin in neurodegenerative disease

(2015) Shuxin Hu et al.   Expert Review of Neurotherapeutics

Oxidative stress: a concept in redox biology and medicine

(2015) Helmut Sies   Redox Biology

Understanding the relationship between DNA methylation and histone lysine methylation

(2014) Nathan R. Rose et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

A bifunctional curcumin analogue for two-photon imaging and inhibiting crosslinking of amyloid beta in Alzheimer's disease

(2014) Xueli Zhang et al.   CHEMICAL COMMUNICATIONS

Effects of Curcumin (Curcuma longa) on Learning and Spatial Memory as Well as Cell Proliferation and Neuroblast Differentiation in Adult and Aged Mice by Upregulating Brain-Derived Neurotrophic Factor and CREB Signaling

(2014) Sung Min Nam et al.   JOURNAL OF MEDICINAL FOOD

Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population

(2014) Katherine HM Cox et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Targeting the β secretase BACE1 for Alzheimer's disease therapy

(2014) Riqiang Yan et al.   LANCET NEUROLOGY

The Chemistry of Curcumin: From Extraction to Therapeutic Agent

(2014) Kavirayani Priyadarsini   MOLECULES

Comparative absorption of curcumin formulations

(2014) Ralf Jäger et al.   Nutrition Journal

Curcumin mediates presenilin-1 activity to reduce β-amyloid production in a model of Alzheimer’s disease

(2014) Zhang Xiong et al.   Pharmacological Reports

CNB-001 a Novel Curcumin Derivative, Guards Dopamine Neurons in MPTP Model of Parkinson’s Disease

(2014) Richard L. Jayaraj et al.   Biomed Research International

Nanotechnology-Applied Curcumin for Different Diseases Therapy

(2014) Negar Ghalandarlaki et al.   Biomed Research International

Molecular Chaperone Dysfunction in Neurodegenerative Diseases and Effects of Curcumin

(2014) Panchanan Maiti et al.   Biomed Research International

Heat shock proteins in neurodegenerative disorders and aging

(2014) Rehana K. Leak   Journal of Cell Communication and Signaling

Curcumin and neurodegenerative diseases

(2013) Adriana Monroy et al.   BIOFACTORS

New analytical applications of gold nanoparticles as label in antibody based sensors

(2013) Kobra Omidfar et al.   BIOSENSORS & BIOELECTRONICS

Bioavailability of phytochemicals and its enhancement by drug delivery systems

(2013) Farrukh Aqil et al.   CANCER LETTERS

Structures in solid state and solution of dimethoxy curcuminoids: regioselective bromination and chlorination

(2013) Petra Galer et al.   Chemistry Central Journal

Curcumin-containing liposomes stabilized by thin layers of chitosan derivatives

(2013) Anna Karewicz et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Curcumin and its Derivatives: Their Application in Neuropharmacology and Neuroscience in the 21st Century

(2013) Wing-Hin Lee et al.   Current Neuropharmacology

Curcumin loaded solid lipid nanoparticles: An efficient formulation approach for cerebral ischemic reperfusion injury in rats

(2013) Vandita Kakkar et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Development and evaluation of a novel phytosome-loaded chitosan microsphere system for curcumin delivery

(2013) Jifen Zhang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Curcumin Ameliorates the Neurodegenerative Pathology in A53T α-synuclein Cell Model of Parkinson’s Disease Through the Downregulation of mTOR/p70S6K Signaling and the Recovery of Macroautophagy

(2013) Tian-Fang Jiang et al.   Journal of Neuroimmune Pharmacology

Curcumin Nanoparticles Attenuate Neurochemical and Neurobehavioral Deficits in Experimental Model of Huntington’s Disease

(2013) Rajat Sandhir et al.   NEUROMOLECULAR MEDICINE

Phosphorylation of Tau Protein as the Link between Oxidative Stress, Mitochondrial Dysfunction, and Connectivity Failure: Implications for Alzheimer’s Disease

(2013) Siddhartha Mondragón-Rodríguez et al.   Oxidative Medicine and Cellular Longevity

Therapeutic potential of curcumin in digestive diseases

(2013) Pietro Dulbecco   WORLD JOURNAL OF GASTROENTEROLOGY

Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials

(2012) Subash C. Gupta et al.   AAPS Journal

Curcumin Modulates α-Synuclein Aggregation and Toxicity

(2012) Pradeep K. Singh et al.   ACS Chemical Neuroscience

Anticoagulant activities of curcumin and its derivative

(2012) Dong-Chan Kim et al.   BMB Reports

Curcumin: A Potential Neuroprotective Agent in Parkinson's Disease

(2012) R. B. Mythri et al.   CURRENT PHARMACEUTICAL DESIGN

Curcumin Suppresses Soluble Tau Dimers and Corrects Molecular Chaperone, Synaptic, and Behavioral Deficits in Aged Human Tau Transgenic Mice

(2012) Qiu-Lan Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of curcumin on the determination of the critical micellar concentration by absorbance, fluorescence and fluorescence anisotropy techniques

(2012) Satyajit Mondal et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease

(2012) Miriam A Hickey et al.   Molecular Neurodegeneration

Synthesis of Novel Biodegradable Methoxy Poly(ethylene glycol)–Zein Micelles for Effective Delivery of Curcumin

(2012) Satheesh Podaralla et al.   MOLECULAR PHARMACEUTICS

Alzheimer’s Disease in the Retina: Imaging Retinal Aß Plaques for Early Diagnosis and Therapy Assessment

(2012) Yosef Koronyo et al.   Neurodegenerative Diseases

Diverse effects of a low dose supplement of lipidated curcumin in healthy middle aged people

(2012) Robert A DiSilvestro et al.   Nutrition Journal

Cyclodextrin-based nanosponges: effective nanocarrier for Tamoxifen delivery

(2012) Satyen Torne et al.   PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY

Curcumin Enhances Neurogenesis and Cognition in Aged Rats: Implications for Transcriptional Interactions Related to Growth and Synaptic Plasticity

(2012) Suzhen Dong et al.   PLoS One

Progress on stem cell research towards the treatment of Parkinson's disease

(2012) Stuart AJ Gibson et al.   Stem Cell Research & Therapy

Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study

(2012) John M Ringman et al.   Alzheimers Research & Therapy

Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Clifford R. Jack et al.   Alzheimers & Dementia

Effects of curcumin on the activities of the enzymes that hydrolyse adenine nucleotides in platelets from cigarette smoke-exposed rats

(2011) Jeandre Augusto dos Santos Jaques et al.   CELL BIOCHEMISTRY AND FUNCTION

Safety assessment of a solid lipid curcumin particle preparation: Acute and subchronic toxicity studies

(2011) Paresh Dadhaniya et al.   FOOD AND CHEMICAL TOXICOLOGY

Epigenetic changes induced by curcumin and other natural compounds

(2011) Simone Reuter et al.   Genes and Nutrition

Dendrosomal curcumin significantly suppresses cancer cell proliferation in vitro and in vivo

(2011) Esmaeil Babaei et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Investigations on the Interaction of Gold–Curcumin Nanoparticles with Human Peripheral Blood Lymphocytes

(2011) K. Sindhu et al.   Journal of Biomedical Nanotechnology

Regulated intramembrane proteolysis - lessons from amyloid precursor protein processing

(2011) Stefan F. Lichtenthaler et al.   JOURNAL OF NEUROCHEMISTRY

Factors responsible for neurofibrillary tangles and neuronal cell losses in tauopathy

(2011) Yasuhito Wakasaya et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Curcumin Protects Against Ischemia/Reperfusion Injury in Rat Skeletal Muscle

(2011) Gulden Avci et al.   JOURNAL OF SURGICAL RESEARCH

Binding of Curcumin to Senile Plaques and Cerebral Amyloid Angiopathy in the Aged Brain of Various Animals and to Neurofibrillary Tangles in Alzheimer's Brain

(2011) Mayu MUTSUGA et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Curcumin loaded chitin nanogels for skin cancer treatment via the transdermal route

(2011) Sabitha Mangalathillam et al.   Nanoscale

Multitargeting by curcumin as revealed by molecular interaction studies

(2011) Subash C. Gupta et al.   NATURAL PRODUCT REPORTS

Brain-Derived Neurotrophic Factor in Patients with Huntington's Disease

(2011) Chiara Zuccato et al.   PLoS One

Structure of modified ε-polylysine micelles and their application in improving cellular antioxidant activity of curcuminoids

(2011) Hailong Yu et al.   Food & Function

RETRACTED: Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptake

(2010) Vivek R. Yadav et al.   BIOCHEMICAL PHARMACOLOGY

Water-dispersible multifunctional hybrid nanogels for combined curcumin and photothermal therapy

(2010) Weitai Wu et al.   BIOMATERIALS

Inflammation in neurodegenerative diseases

(2010) Sandra Amor et al.   IMMUNOLOGY

Safety and Pharmacokinetics of a Solid Lipid Curcumin Particle Formulation in Osteosarcoma Patients and Healthy Volunteers

(2010) Vikram S. Gota et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Curcumin-loaded PLGA-PEG-PLGA triblock copolymeric micelles: Preparation, pharmacokinetics and distribution in vivo

(2010) Zhimei Song et al.   JOURNAL OF COLLOID AND INTERFACE SCIENCE

Fluorescence Enhancement of the Silver Nanoparticales – Curcumin - Cetyltrimethylammonium Bromide-nucleic Acids System and its Analytical Application

(2010) Haiping Zhou et al.   JOURNAL OF FLUORESCENCE

Differential vulnerability of neurons in Huntington’s disease: the role of cell type-specific features

(2010) Ina Han et al.   JOURNAL OF NEUROCHEMISTRY

Curcumin Labeling of Neuronal Fibrillar Tau Inclusions in Human Brain Samples

(2010) Nina Mohorko et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Effect of Combined Treatment With Curcumin and Candesartan on Ischemic Brain Damage in Mice

(2010) Azza S. Awad   Journal of Stroke & Cerebrovascular Diseases

Curcumin modulates leukocyte and platelet adhesion in murine sepsis.

(2010) Vidula Vachharajani et al.   MICROCIRCULATION

Prion-like transmission of protein aggregates in neurodegenerative diseases

(2010) Patrik Brundin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of amyloid plaques in retinas from Alzheimer's patients and noninvasive in vivo optical imaging of retinal plaques in a mouse model

(2010) Maya Koronyo-Hamaoui et al.   NEUROIMAGE

Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease

(2010) T. Ahmed et al.   NEUROSCIENCE

Oxidative stress in Alzheimer disease

(2010) Alejandro Gella et al.   Cell Adhesion & Migration

Curcumin and Cancer Cells: How Many Ways Can Curry Kill Tumor Cells Selectively?

(2009) Jayaraj Ravindran et al.   AAPS Journal

Nanogels as Pharmaceutical Carriers: Finite Networks of Infinite Capabilities

(2009) Alexander V. Kabanov et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The effect of curcumin (turmeric) onAlzheimer′s disease: An overview

(2009) Shrikant Mishra et al.   Annals of Indian Academy of Neurology

Role of mitochondrial dysfunction in the pathogenesis of Huntington's disease

(2009) Rodrigo A. Quintanilla et al.   BRAIN RESEARCH BULLETIN

Lung tumor promotion by curcumin

(2009) Stephanie T. Dance-Barnes et al.   CARCINOGENESIS

Identification and characterization of multiple curcumin synthases from the herbCurcuma longa

(2009) Yohei Katsuyama et al.   FEBS LETTERS

A pilot cross-over study to evaluate human oral bioavailability of BCM-95®CG (BiocurcumaxTM), a novel bioenhanced preparation of curcumin

(2009) B Antony et al.   INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES

The dark side of curcumin

(2009) Estefanía Burgos-Morón et al.   INTERNATIONAL JOURNAL OF CANCER

Curcuminoid Biosynthesis by Two Type III Polyketide Synthases in the HerbCurcuma longa

(2009) Yohei Katsuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Six-Month Randomized, Placebo-Controlled, Double-Blind, Pilot Clinical Trial of Curcumin in Patients With Alzheimer Disease

(2009) Larry Baum et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Design, Synthesis, and Testing of Difluoroboron-Derivatized Curcumins as Near-Infrared Probes for in Vivo Detection of Amyloid-β Deposits

(2009) Chongzhao Ran et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Effect of curcumin on the adhesion of platelets to brain microvascular endothelial cellsin vitro1

(2008) Li ZHANG et al.   ACTA PHARMACOLOGICA SINICA

Radical-free biology of oxidative stress

(2008) Dean P. Jones   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature

(2008) Preetha Anand et al.   BIOCHEMICAL PHARMACOLOGY

Pharmacokinetics of Curcumin Conjugate Metabolites in Healthy Human Subjects

(2008) S. K. Vareed et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Dendrimer-Based Contrast Agents for Molecular Imaging

(2008) Michelle Longmire et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

In Vivo Imaging Reveals Dissociation between Caspase Activation and Acute Neuronal Death in Tangle-Bearing Neurons

(2008) T. L. Spires-Jones et al.   JOURNAL OF NEUROSCIENCE

Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer's Disease

(2008) A. N. Begum et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

BDNF is essential to promote persistence of long-term memory storage

(2008) P. Bekinschtein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of monoamine oxidase-B by the polyphenolic compound, curcumin and its metabolite tetrahydrocurcumin, in a model of Parkinson’s disease induced by MPTP neurodegeneration in mice

(2008) A. Rajeswari et al.   INFLAMMOPHARMACOLOGY

Micelles of poly(ethylene oxide)‐b‐poly(ε‐caprolactone) as vehicles for the solubilization, stabilization, and controlled delivery of curcumin

(2007) Zengshuan Ma et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Gene–environment interactions modulating cognitive function and molecular correlates of synaptic plasticity in Huntington’s disease transgenic mice

(2007) Jess Nithianantharajah et al.   NEUROBIOLOGY OF DISEASE