Presenilins as Drug Targets for Alzheimer’s Disease—Recent Insights from Cell Biology and Electrophysiology as Novel Opportunities in Drug Development

Control of Neuronal Ryanodine Receptor-Mediated Calcium Signaling by Calsenilin

(2018) Michael A. Grillo et al.   MOLECULAR NEUROBIOLOGY

Distinct Mechanisms Underlying Resveratrol-Mediated Protection from Types of Cellular Stress in C6 Glioma Cells

(2017) John Means et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Acceleration of amyloidogenesis and memory impairment by estrogen deficiency through NF-κB dependent beta-secretase activation in presenilin 2 mutant mice

(2016) Chul Ju Hwang et al.   BRAIN BEHAVIOR AND IMMUNITY

Single administration of a novel γ-secretase modulator ameliorates cognitive dysfunction in aged C57BL/6J mice

(2016) Tatsuya Hayama et al.   BRAIN RESEARCH

The Zebrafish Equivalent of Alzheimer’s Disease-Associated PRESENILIN Isoform PS2V Regulates Inflammatory and Other Responses to Hypoxic Stress

(2016) Esmaeil Ebrahimie et al.   JOURNAL OF ALZHEIMERS DISEASE

Presenilin 1 promotes trypsin-induced neuroprotection via the PAR2/ERK signaling pathway. Effects of presenilin 1 FAD mutations

(2016) Angeliki M. Nikolakopoulou et al.   NEUROBIOLOGY OF AGING

Mutation analyses and association studies to assess the role of the presenilin-associated rhomboid-like gene in Parkinson's disease

(2016) Richard Wüst et al.   NEUROBIOLOGY OF AGING

The dynamic mechanism of presenilin-1 function: Sensitive gate dynamics and loop unplugging control protein access

(2016) Arun Kumar Somavarapu et al.   NEUROBIOLOGY OF DISEASE

The expression of presenilin 1 enhances carcinogenesis and metastasis in gastric cancer

(2016) Ping Li et al.   Oncotarget

Metformin increases APP expression and processing via oxidative stress, mitochondrial dysfunction and NF-κB activation: Use of insulin to attenuate metformin's effect

(2015) Pasquale Picone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Effect of PSEN1 mutations on MAPT methylation in early-onset Alzheimer’s disease

(2015) Kirsten Coupland et al.   Current Alzheimer Research

A Frameshift Mutation in PEN-2 Causes Familial Comedones Syndrome

(2015) Wipa Panmontha et al.   DERMATOLOGY

A ubiquitin-binding CUE domain in presenilin-1 enables interaction with K63-linked polyubiquitin chains

(2015) Stephen P. Duggan et al.   FEBS LETTERS

A  -Secretase Independent Role for Presenilin in Calcium Homeostasis Impacts Mitochondrial Function and Morphology in Caenorhabditis elegans

(2015) S. Sarasija et al.   GENETICS

Dual pathways mediate β-amyloid stimulated glutathione release from astrocytes

(2015) Bing Ye et al.   GLIA

Alzheimer's disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of γ-secretase activity

(2015) Seyyed Hani Moussavi Nik et al.   HUMAN MOLECULAR GENETICS

Presenilin Transmembrane Domain 8 Conserved AXXXAXXXG Motifs Are Required for the Activity of the γ-Secretase Complex

(2015) Claudia Marinangeli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Three novel presenilin 1 mutations marking the wide spectrum of age at onset and clinical patterns in familial Alzheimer’s disease

(2015) Sigrun Roeber et al.   JOURNAL OF NEURAL TRANSMISSION

Pathophysiology of hidradenitis suppurativa: An update

(2015) Errol Prens et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Hippo Pathway Gene Mutations in Malignant Mesothelioma: Revealed by RNA and Targeted Exon Sequencing

(2015) Akihiko Miyanaga et al.   Journal of Thoracic Oncology

Alterations in mitochondrial number and function in Alzheimer’s disease fibroblasts

(2015) Nora E. Gray et al.   METABOLIC BRAIN DISEASE

Decrease in catalytic capacity of γ-secretase can facilitate pathogenesis in sporadic and Familial Alzheimer's disease

(2015) Željko M. Svedružić et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Reduction of increased calcineurin activity rescues impaired homeostatic synaptic plasticity in presenilin 1 M146V mutant

(2015) Seonil Kim et al.   NEUROBIOLOGY OF AGING

Oxidative stress caused by ozone exposure induces β-amyloid 1–42 overproduction and mitochondrial accumulation by activating the amyloidogenic pathway

(2015) L.F. Hernández-Zimbrón et al.   NEUROSCIENCE

Presenilin 1 Maintains Lysosomal Ca2+ Homeostasis via TRPML1 by Regulating vATPase-Mediated Lysosome Acidification

(2015) Ju-Hyun Lee et al.   Cell Reports

An ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba Dictyostelium discoideum

(2014) M. H. R. Ludtmann et al.   JOURNAL OF CELL SCIENCE

Loss of Spatial Memory, Learning, and Motor Function During Normal Aging Is Accompanied by Changes in Brain Presenilin 1 and 2 Expression Levels

(2014) Simon Kaja et al.   MOLECULAR NEUROBIOLOGY

Correction: Intracellular Calcium Deficits in Drosophila Cholinergic Neurons Expressing Wild Type or FAD-Mutant Presenilin

(2014) Kinga Michno et al.   PLoS One

Cardiomyocyte ryanodine receptor degradation by chaperone-mediated autophagy

(2013) Zully Pedrozo et al.   CARDIOVASCULAR RESEARCH

Presenilins regulate the cellular activity of ryanodine receptors differentially through isotype-specific N-terminal cysteines

(2013) Andrew J. Payne et al.   EXPERIMENTAL NEUROLOGY

Interactome Analyses of Mature γ-Secretase Complexes Reveal Distinct Molecular Environments of Presenilin (PS) Paralogs and Preferential Binding of Signal Peptide Peptidase to PS2

(2013) Amy Hye Won Jeon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Presenilins Regulate Neurotrypsin Gene Expression and Neurotrypsin-dependent Agrin Cleavage via Cyclic AMP Response Element-binding Protein (CREB) Modulation

(2013) Angels Almenar-Queralt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

γ-Secretase Modulator (GSM) Photoaffinity Probes Reveal Distinct Allosteric Binding Sites on Presenilin

(2013) Nikolay Pozdnyakov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Beta amyloid peptide plaques fail to alter evoked neuronal calcium signals in APP/PS1 Alzheimer's disease mice

(2013) Clark A. Briggs et al.   NEUROBIOLOGY OF AGING

Presenilin Promotes Dietary Copper Uptake

(2013) Adam Southon et al.   PLoS One

Presenilins regulate calcium homeostasis and presynaptic function via ryanodine receptors in hippocampal neurons

(2013) B. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Presenilin-null cells have altered two-pore calcium channel expression and lysosomal calcium: Implications for lysosomal function

(2012) Kara M Neely Kayala et al.   BRAIN RESEARCH

Retention in Endoplasmic Reticulum 1 (RER1) Modulates Amyloid-β (Aβ) Production by Altering Trafficking of γ-Secretase and Amyloid Precursor Protein (APP)

(2012) Hyo-Jin Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Role for Presenilins in Autophagy Revisited: Normal Acidification of Lysosomes in Cells Lacking PSEN1 and PSEN2

(2012) X. Zhang et al.   JOURNAL OF NEUROSCIENCE

Modulation of γ-Secretase Activity by Multiple Enzyme-Substrate Interactions: Implications in Pathogenesis of Alzheimer's Disease

(2012) Željko M. Svedružić et al.   PLoS One

Changes in the Expression of the Alzheimers Disease-Associated Presenilin Gene in Drosophila Heart Leads to Cardiac Dysfunction

(2011) A. Li et al.   Current Alzheimer Research

Amyloid-β Annular Protofibrils Evade Fibrillar Fate in Alzheimer Disease Brain

(2011) Cristian A. Lasagna-Reeves et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Presenilin Is Necessary for Efficient Proteolysis through the Autophagy-Lysosome System in a  -Secretase-Independent Manner

(2011) K. M. Neely et al.   JOURNAL OF NEUROSCIENCE

Antioxidant proteins TSA and PAG interact synergistically with Presenilin to modulate Notch signaling in Drosophila

(2011) Michael F. Wangler et al.   Protein & Cell

Dictyostelium possesses highly diverged presenilin/ -secretase that regulates growth and cell-fate specification and can accurately process human APP: a system for functional studies of the presenilin/ -secretase complex

(2010) V. C. McMains et al.   Disease Models & Mechanisms

APH1 Polar Transmembrane Residues Regulate the Assembly and Activity of Presenilin Complexes

(2009) Raphaëlle Pardossi-Piquard et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Amyloid Monomers Are Neuroprotective

(2009) M. L. Giuffrida et al.   JOURNAL OF NEUROSCIENCE

Presenilins are essential for regulating neurotransmitter release

(2009) Chen Zhang et al.   NATURE