Roquin—a multifunctional regulator of immune homeostasis

MicroRNA signatures differentiate Crohn’s disease from ulcerative colitis

(2015) Jeremy S Schaefer et al.   BMC IMMUNOLOGY

Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms

(2015) Takashi Mino et al.   CELL

Stable inhibitory activity of regulatory T cells requires the transcription factor Helios

(2015) H.-J. Kim et al.   SCIENCE

Roquin binds microRNA-146a and Argonaute2 to regulate microRNA homeostasis

(2015) Monika Srivastava et al.   Nature Communications

RC3H1 post-transcriptionally regulates A20 mRNA and modulates the activity of the IKK/NF-κB pathway

(2015) Yasuhiro Murakawa et al.   Nature Communications

MicroRNA-146a regulates ICOS–ICOSL signalling to limit accumulation of T follicular helper cells and germinal centres

(2015) Alvin Pratama et al.   Nature Communications

Regnase-1 and Roquin regulate inflammatory mRNAs

(2015) Takashi Mino et al.   Oncotarget

Over-expression of Roquin aggravates T cell mediated hepatitis in transgenic mice using T cell specific promoter

(2014) Young Rae Ji et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A role for IL-10 in the transcriptional regulation of Roquin-1

(2014) Jeremy S. Schaefer et al.   GENE

Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote TH17 differentiation

(2014) Katharina M Jeltsch et al.   NATURE IMMUNOLOGY

Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation

(2014) Andreas Schlundt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The ROQ domain of Roquin recognizes mRNA constitutive-decay element and double-stranded RNA

(2014) Dazhi Tan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Roquin-2 Promotes Ubiquitin-Mediated Degradation of ASK1 to Regulate Stress Responses

(2014) T. Maruyama et al.   Science Signaling

Hematopoietic not systemic impairment of Roquin expression accounts for intestinal inflammation in Roquin-deficient mice

(2014) Dina Montufar-Solis et al.   Scientific Reports

RING-type E3 ligases: Master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination

(2013) Meredith B. Metzger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Malt1-Induced Cleavage of Regnase-1 in CD4+ Helper T Cells Regulates Immune Activation

(2013) Takuya Uehata et al.   CELL

Roquin Promotes Constitutive mRNA Decay via a Conserved Class of Stem-Loop Recognition Motifs

(2013) Kathrin Leppek et al.   CELL

Roquin Paralogs 1 and 2 Redundantly Repress the Icos and Ox40 Costimulator mRNAs and Control Follicular Helper T Cell Differentiation

(2013) Katharina U. Vogel et al.   IMMUNITY

Roquin-2 Shares Functions with Its Paralog Roquin-1 in the Repression of mRNAs Controlling T Follicular Helper Cells and Systemic Inflammation

(2013) Alvin Pratama et al.   IMMUNITY

Small Intestine Inflammation in Roquin-Mutant and Roquin-Deficient Mice

(2013) Jeremy S. Schaefer et al.   PLoS One

ROQUIN/RC3H1 Alterations Are Not Found in Angioimmunoblastic T-Cell Lymphoma

(2013) Tiphanie Auguste et al.   PLoS One

Heterozygosity for Roquinsan leads to angioimmunoblastic T-cell lymphoma-like tumors in mice

(2012) J. I. Ellyard et al.   BLOOD

Enforced Expression of Roquin Protein in T Cells Exacerbates the Incidence and Severity of Experimental Arthritis

(2012) Young Rae Ji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Regulatory Role for IL-10 Receptor Signaling in Development and B Cell Help of T Follicular Helper Cells in Mice

(2012) G. Cai et al.   JOURNAL OF IMMUNOLOGY

MicroRNAs in inflammatory bowel disease - pathogenesis, diagnostics and therapeutics

(2012) Mehmet Coskun   WORLD JOURNAL OF GASTROENTEROLOGY

The role of Roquin overexpression in the modulation of signaling during in vitro and ex vivo T-cell activation

(2011) Hei Jung Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Altered miR-146a expression in Sjögren's syndrome and its functional role in innate immunity

(2011) Kaleb M. Pauley et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Loss of Roquin induces early death and immune deregulation but not autoimmunity

(2011) Arianna Bertossi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Selective Upregulation of microRNA Expression in Peripheral Blood Leukocytes in IL-10-/- Mice Precedes Expression in the Colon

(2011) J. S. Schaefer et al.   JOURNAL OF IMMUNOLOGY

The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs

(2010) Vicki Athanasopoulos et al.   FEBS Journal

Identification of microRNAs associated with ileal and colonic Crohnʼs disease†

(2010) Feng Wu et al.   INFLAMMATORY BOWEL DISEASES

Peripheral blood MicroRNAs distinguish active ulcerative colitis and Crohnʼs disease

(2010) Feng Wu et al.   INFLAMMATORY BOWEL DISEASES

Inducible costimulator (ICOS) is a marker for highly suppressive antigen-specific T cells sharing features of TH17/TH1 and regulatory T cells

(2010) Marc Vocanson et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

miR-21: an oncomir on strike in prostate cancer

(2010) Marco Folini et al.   Molecular Cancer

Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression

(2010) Elke Glasmacher et al.   NATURE IMMUNOLOGY

Roquin Differentiates the Specialized Functions of Duplicated T Cell Costimulatory Receptor Genes Cd28 and Icos

(2009) Michelle A. Linterman et al.   IMMUNITY

ICOS expression by effector T cells influences the ability of regulatory T cells to inhibit anti-chromatin B cell responses in recipient mice

(2009) Brian D. Hondowicz et al.   JOURNAL OF AUTOIMMUNITY

ICOS promotes IL-17 synthesis in colonic intraepithelial lymphocytes in IL-10−/− mice

(2009) Jeremy S. Schaefer et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Expression of microRNA-146 in rheumatoid arthritis synovial tissue

(2008) Tomoyuki Nakasa et al.   ARTHRITIS AND RHEUMATISM

The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development

(2008) Francesca Bernassola et al.   CANCER CELL

MicroRNAs Are Differentially Expressed in Ulcerative Colitis and Alter Expression of Macrophage Inflammatory Peptide-2α

(2008) Feng Wu et al.   GASTROENTEROLOGY

Biomarkers in osteoarthritis

(2008) Frances MK Williams et al.   ARTHRITIS RESEARCH & THERAPY