Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote TH17 differentiation

Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis

(2014) Conor Mc Guire et al.   Journal of Neuroinflammation

Structural basis for RNA recognition in roquin-mediated post-transcriptional gene regulation

(2014) Andreas Schlundt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The ROQ domain of Roquin recognizes mRNA constitutive-decay element and double-stranded RNA

(2014) Dazhi Tan et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Malt1-Induced Cleavage of Regnase-1 in CD4+ Helper T Cells Regulates Immune Activation

(2013) Takuya Uehata et al.   CELL

Roquin Promotes Constitutive mRNA Decay via a Conserved Class of Stem-Loop Recognition Motifs

(2013) Kathrin Leppek et al.   CELL

Interferon Regulatory Factor 4 Sustains CD8+ T Cell Expansion and Effector Differentiation

(2013) Shuyu Yao et al.   IMMUNITY

Roquin Paralogs 1 and 2 Redundantly Repress the Icos and Ox40 Costimulator mRNAs and Control Follicular Helper T Cell Differentiation

(2013) Katharina U. Vogel et al.   IMMUNITY

Post-transcriptional regulatory networks in immunity

(2013) Pavel Ivanov et al.   IMMUNOLOGICAL REVIEWS

Targeted disruption of MCPIP1/Zc3h12a results in fatal inflammatory disease

(2013) Ruidong Miao et al.   IMMUNOLOGY AND CELL BIOLOGY

T Cell-Derived IL-17 Mediates Epithelial Changes in the Airway and Drives Pulmonary Neutrophilia

(2013) L. K. Fogli et al.   JOURNAL OF IMMUNOLOGY

Paracaspase MALT1 Deficiency Protects Mice from Autoimmune-Mediated Demyelination

(2013) C. Mc Guire et al.   JOURNAL OF IMMUNOLOGY

The transcription factor IRF4 is essential for TCR affinity–mediated metabolic programming and clonal expansion of T cells

(2013) Kevin Man et al.   NATURE IMMUNOLOGY

MCPIP1 Deficiency in Mice Results in Severe Anemia Related to Autoimmune Mechanisms

(2013) Zhou Zhou et al.   PLoS One

Pharmacologic Inhibition of MALT1 Protease by Phenothiazines as a Therapeutic Approach for the Treatment of Aggressive ABC-DLBCL

(2012) Daniel Nagel et al.   CANCER CELL

Interferon-γ Excess Leads to Pathogenic Accumulation of Follicular Helper T Cells and Germinal Centers

(2012) Sau K. Lee et al.   IMMUNITY

IκBNS Protein Mediates Regulatory T Cell Development via Induction of the Foxp3 Transcription Factor

(2012) Marc Schuster et al.   IMMUNITY

The NF-κB regulator MALT1 determines the encephalitogenic potential of Th17 cells

(2012) Anne Brüstle et al.   JOURNAL OF CLINICAL INVESTIGATION

Structural Determinants of MALT1 Protease Activity

(2012) Christian Wiesmann et al.   JOURNAL OF MOLECULAR BIOLOGY

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

(2011) Eric V. Dang et al.   CELL

T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1

(2011) Jens Staal et al.   EMBO JOURNAL

c-Rel promotes type 1 and type 17 immune responses during Leishmania major infection

(2011) Katharina Reinhard et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Loss of Roquin induces early death and immune deregulation but not autoimmunity

(2011) Arianna Bertossi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Th17 immune response is controlled by the Rel–RORγ–RORγT transcriptional axis

(2011) Qingguo Ruan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The NF- B Transcription Factor c-Rel Is Required for Th17 Effector Cell Development in Experimental Autoimmune Encephalomyelitis

(2011) G. Chen et al.   JOURNAL OF IMMUNOLOGY

MCPIP1 Ribonuclease Antagonizes Dicer and Terminates MicroRNA Biogenesis through Precursor MicroRNA Degradation

(2011) Hiroshi I. Suzuki et al.   MOLECULAR CELL

The IκB kinase complex regulates the stability of cytokine-encoding mRNA induced by TLR–IL-1R by controlling degradation of regnase-1

(2011) Hidenori Iwasaki et al.   NATURE IMMUNOLOGY

Malt1-dependent RelB cleavage promotes canonical NF- B activation in lymphocytes and lymphoma cell lines

(2011) S. Hailfinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective C-Rel Activation via Malt1 Controls Anti-Fungal TH-17 Immunity by Dectin-1 and Dectin-2

(2011) Sonja I. Gringhuis et al.   PLoS Pathogens

MCP-induced protein 1 deubiquitinates TRAF proteins and negatively regulates JNK and NF-κB signaling

(2010) Jian Liang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IκBζ regulates TH17 development by cooperating with ROR nuclear receptors

(2010) Kazuo Okamoto et al.   NATURE

Roquin binds inducible costimulator mRNA and effectors of mRNA decay to induce microRNA-independent post-transcriptional repression

(2010) Elke Glasmacher et al.   NATURE IMMUNOLOGY

A20 Negatively Regulates T Cell Receptor Signaling to NF- B by Cleaving Malt1 Ubiquitin Chains

(2009) M. Duwel et al.   JOURNAL OF IMMUNOLOGY

Zc3h12a is an RNase essential for controlling immune responses by regulating mRNA decay

(2009) Kazufumi Matsushita et al.   NATURE

Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens

(2008) Maciej Lech et al.   JOURNAL OF EXPERIMENTAL MEDICINE

T cell antigen receptor stimulation induces MALT1 paracaspase–mediated cleavage of the NF-κB inhibitor A20

(2008) Beatrice Coornaert et al.   NATURE IMMUNOLOGY

The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells

(2008) Aurelie T Bauquet et al.   NATURE IMMUNOLOGY

The proteolytic activity of the paracaspase MALT1 is key in T cell activation

(2008) Fabien Rebeaud et al.   NATURE IMMUNOLOGY

Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA processing

(2008) K Mark Ansel et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells

(2008) T. Korn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA