Article
Multidisciplinary Sciences
Seonghee Jeon, Heewon Kang, Inhyung Cho, Sung-Il Cho
Summary: The alcohol flushing response is common among East Asians and may serve as an indicator of the health risks associated with alcohol intake. Current flushers are more likely to develop depression with a small dose of alcohol compared to never flushers.
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Biomedical
Ji-Yan Qiao, Wen Li, Run-Yao Zeng, Yun-Jian Yu, Qi-Wen Chen, Xin-Hua Liu, Si-Xue Cheng, Xian-Zheng Zhang
Summary: Alcohol intoxication causes serious diseases, but current treatments are limited. An oral intestinal-coating coacervate antidote was developed, containing acetic acid bacteria and sodium alginate, which can convert alcohol into nontoxic products. In vivo study shows that this bacteria-based antidote significantly reduces blood alcohol concentration and alleviates alcoholic liver injury in mice. It can be considered as a promising candidate antidote for alcohol-induced acute liver injury.
Review
Oncology
Zili Zhai, Takeshi Yamauchi, Sarah Shangraw, Vincent Hou, Akiko Matsumoto, Mayumi Fujita
Summary: Acetaldehyde (AcAH), a carcinogenic byproduct of ethanol metabolism, has been linked to the development of malignancies in the upper gastrointestinal tract as well as cutaneous melanoma. This review examines the sources of ethanol and AcAH in the skin, their metabolic pathways, and the role of dysfunctional ethanol and AcAH metabolizing enzymes in melanoma development and progression. Data analysis also shows reduced activity of alcohol and AcAH metabolizing enzymes in melanoma tissues.
Review
Oncology
Takeshi Yamauchi, Sarah Shangraw, Zili Zhai, Dinoop Ravindran Menon, Nisha Batta, Robert P. Dellavalle, Mayumi Fujita
Summary: Studying social-environmental risk factors associated with melanoma is crucial for improving public health initiatives and patient outreach and education methods.
Article
Pharmacology & Pharmacy
Alistair C. Leitch, Ibrahim Ibrahim, Tarek M. Abdelghany, Alex Charlton, Clair Roper, Dan Vidler, Jeremy M. Palmer, Colin Wilson, David E. Jones, Peter G. Blain, Matthew C. Wright
Summary: This study found human exposure to M8OI, which undergoes monooxygenation by cytochromes P450 followed by oxidation by alcohol and acetaldehyde dehydrogenase to a carboxylic acid, partially excreted via bile in human liver.
Article
Medicine, General & Internal
Bhautesh Dinesh Jani, Ross McQueenie, Barbara I. Nicholl, Ryan Field, Peter Hanlon, Katie I. Gallacher, Frances S. Mair, Jim Lewsey
Summary: The study found that drinking red wine, consuming alcohol with food, and spreading alcohol intake over 3-4 days were associated with lower risk of mortality and vascular events among regular alcohol drinkers. Drinking spirits and beer/cider was associated with higher mortality risk.
Article
Nutrition & Dietetics
Aitor Hernandez-Hernandez, David Oliver, Miguel Angel Martinez-Gonzalez, Miguel Ruiz-Canela, Sonia Eguaras, Estefania Toledo, Pedro Antonio de la Rosa, Maira Bes-Rastrollo, Alfredo Gea
Summary: Alcohol drinking patterns, especially adherence to the Mediterranean alcohol-drinking pattern, can affect the risk of hypertension. Low adherence to the Mediterranean alcohol-drinking pattern is associated with a higher incidence of hypertension, while high adherence is associated with a lower incidence.
Article
Biochemistry & Molecular Biology
Evgeniy Protasov, Michael Martinov, Elena Sinauridze, Victor Vitvitsky, Fazoil Ataullakhanov
Summary: A mathematical model was constructed to analyze the energy metabolism in erythrocyte-bioreactors containing alcohol dehydrogenase and acetaldehyde dehydrogenase. These erythrocytes can convert ethanol to acetate and potentially be used for alcohol intoxication treatment. The analysis revealed that the rate of ethanol consumption by the erythrocyte-bioreactors increases until a specific threshold level of enzyme activity is reached. Beyond this threshold, the model switches to an oscillation mode, leading to the accumulation of glycolytic intermediates and the destruction of erythrocyte-bioreactors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Seung Hee Jung, Yun Ha Lee, Eun Kyu Lee, Soo-Dong Park, Jae-Jung Shim, Jung-Lyoul Lee, Hye Hyun Yoo
Summary: This study found that HY_IPA combined with Mesembryanthemum crystallinum, Pueraria lobata flower, and Artemisia indica can alleviate hangovers. HY_IPA promotes the decomposition of alcohol and acetaldehyde, reducing hangover symptoms, and increases the enzyme activity related to alcohol metabolism.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Chong Sha, Qiang Wang, Hongcheng Wang, Yilan Duan, Chongmao Xu, Lian Wu, Kesen Ma, Weilan Shao, Yu Jiang
Summary: This study identified that Fe-AAdh and Fe-Adh2 are the main enzymes responsible for ethanol production in Tne, while Zn-Adh plays a major role in ethanol consumption. These findings could potentially facilitate the development of a novel hyperthermophilic strain for cellulosic ethanol production.
Article
Cell Biology
Hongchao Guo, Xuan Yu, Yu Liu, David T. Paik, Johanne Marie Justesen, Mark Chandy, James W. S. Jahng, Tiejun Zhang, Weijun Wu, Freeborn Rwere, Shane Rui Zhao, Suman Pokhrel, Rabindra V. Shivnaraine, Souhrid Mukherjee, Daniel J. Simon, Amit Manhas, Angela Zhang, Che-Hong Chen, Manuel A. Rivas, Eric R. Gross, Daria Mochly-Rosen, Joseph C. Wu
Summary: The common ALDH2*2 variant affects around 8% of the global population and is associated with a severe loss of ALDH2 enzymatic activity and an increased risk of CAD. Empagliflozin, an SGLT2 inhibitor, has been shown to improve EC dysfunction caused by ALDH2*2, suggesting a potential preventive measure against CAD.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Heng-Zhi Zhang, Bo Shao, Qi-Yu Wang, Yi-Han Wang, Ze-Zhong Cao, Lu-Lu Chen, Jin-Yu Sun, Mu-Feng Gu
Summary: This study aimed to investigate the dose-response association between alcohol consumption and atrial fibrillation (AF) risk. The findings showed that moderate alcohol intake significantly increased the risk of AF in males but not in females. The cubic spline regression analysis indicated a significant positive association between daily alcohol intake and AF risk. Therefore, alcohol consumption should be restricted to reduce the risk of AF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Guangqing Du, Youduo Wu, Wei Kang, Yongping Xu, Shuying Li, Chuang Xue
Summary: In this study, the strain Clostridium acetobutylicum ATCC 55025 and its mutant HKKO were engineered to improve butanol production. Knocking out the acetoacetate decarboxylase gene adc decreased acetone production and increased the butanol/ABE ratio. Overexpression of the acetaldehyde/alcohol dehydrogenase gene adhE2 further increased butanol production.
PROCESS BIOCHEMISTRY
(2022)
Article
Public, Environmental & Occupational Health
Jinhee Hur, Stephanie A. Smith-Warner, Eric B. Rimm, Walter C. Willett, Kana Wu, Yin Cao, Edward Giovannucci
Summary: The study found that high alcohol consumption in early adulthood may be associated with a higher risk of developing colorectal cancer, especially for never or light smokers.
EUROPEAN JOURNAL OF EPIDEMIOLOGY
(2021)
Article
Oncology
Jasmine D. Peake, Chiaki Noguchi, Baicheng Lin, Amber Theriault, Margaret O'Connor, Shivani Sheth, Koji Tanaka, Hiroshi Nakagawa, Eishi Noguchi
Summary: The study reveals that acetaldehyde causes DNA damage and impedes replication fork progression, leading to genomic instability in esophageal epithelial cells. FANCD2, which triggers apoptosis upon acetaldehyde exposure and prevents genomic instability in esophageal SCCs, plays a critical role in the replication abnormalities induced by acetaldehyde.
MOLECULAR ONCOLOGY
(2021)
Article
Nutrition & Dietetics
Keren Papier, Maria G. Kakkoura, Yu Guo, Anika Knuppel, Pei Pei, Tammy Y. N. Tong, Canqing Yu, Aurora Perez-Cornago, Wing Ching Chang, Junshi Chen, Jun Lv, Liming Li, Zhengming Chen, Huaidong Du, Timothy J. Key
Summary: There are significant differences in dietary intakes between participants in the China Kadoorie Biobank (CKB) and the UK Biobank (UKB), and these differences are associated with socio-economic status and body mass index (BMI). These differences may lead to different interpretations of diet-disease associations.
EUROPEAN JOURNAL OF NUTRITION
(2023)
Article
Peripheral Vascular Disease
Xuanming Hong, Ke Miao, Weihua Cao, Jun Lv, Canqing Yu, Tao Huang, Dianjianyi Sun, Chunxiao Liao, Yuanjie Pang, Zengchang Pang, Min Yu, Hua Wang, Xianping Wu, Yu Liu, Wenjing Gao, Liming Li
Summary: This study identified CpG sites associated with systolic and diastolic blood pressure and examined the temporal relationship between DNA methylation and blood pressure. The findings suggest the significance of DNA methylation in the development of hypertension.
Article
Peripheral Vascular Disease
Robert Clarke, Neil Wright, Robin Walters, Wei Gan, Yu Guo, Iona Y. Millwood, Ling Yang, Yiping Chen, Sarah Lewington, Jun Lv, Canqing Yu, Daniel Avery, Kuang Lin, Kang Wang, Richard Peto, Rory Collins, Liming Li, Derrick A. Bennett, Sarah Parish, Zhengming Chen
Summary: This study found a positive association between systolic blood pressure and major cardiovascular disease outcomes, with a higher risk observed in younger individuals. The findings support the initiation of blood pressure-lowering treatment at a younger age to maximize cardiovascular disease prevention.
Article
Nutrition & Dietetics
Xuanming Hong, Zhiyu Wu, Weihua Cao, Jun Lv, Canqing Yu, Tao Huang, Dianjianyi Sun, Chunxiao Liao, Yuanjie Pang, Zengchang Pang, Liming Cong, Hua Wang, Xianping Wu, Yu Liu, Wenjing Gao, Liming Li
Summary: This study found that both genetic and environmental factors play essential roles in obesity and cardiometabolic disease traits. However, as age increases, the influence of genetic factors decreases and the importance of environmental factors increases.
Article
Medicine, General & Internal
Songchun Yang, Dong Sun, Zhijia Sun, Canqing Yu, Yu Guo, Jiahui Si, Dianjianyi Sun, Yuanjie Pang, Pei Pei, Ling Yang, Iona Y. Millwood, Robin G. Walters, Yiping Chen, Huaidong Du, Zengchang Pang, Dan Schmidt, Rebecca Stevens, Robert Clarke, Junshi Chen, Zhengming Chen, Jun Lv, Liming Li
Summary: This study aimed to evaluate the potential of polygenic risk scores (PRSs) for predicting coronary artery disease (CAD) in the Chinese population. The results showed that PRS had a stronger predictive ability for hard CAD compared to soft CAD. Therefore, this method may not be suitable for improving CAD risk prediction in the general Chinese population.
CHINESE MEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Lu Chen, Yiqian Zhang, Canqing Yu, Yu Guo, Dianjianyi Sun, Yuanjie Pang, Pei Pei, Ling Yang, Iona Y. Millwood, Robin G. Walters, Yiping Chen, Huaidong Du, Yongmei Liu, Sushila Burgess, Rebecca Stevens, Junshi Chen, Zhengming Chen, Liming Li, Jun Lv
Summary: This study aimed to assess the associations between biological age acceleration based on Klemera and Doubal's method and long-term risk of all-cause mortality. The results showed that participants who developed major coronary events or intracerebral hemorrhage/subarachnoid hemorrhage during follow-up exhibited accelerated aging at baseline compared to other groups. KDM-AA was positively associated with long-term risk of all-cause mortality and improved mortality prediction compared to models based solely on sociodemographic and lifestyle factors.
Article
Medicine, General & Internal
Xin Huang, Jiachen Li, Weihua Cao, Jun Lyu, Yu Guo, Pei Pei, Qingmei Xia, Huaidong Du, Yiping Chen, Yang Ling, Rene Kerosi, Rebecca Stevens, Xujun Yang, Junshi Chen, Canqing Yu, Zhengming Chen, Liming Li, China Kadoorie Biobank
Summary: High-frequency fruit consumption is associated with a lower risk of COPD in Chinese adults, especially among non-smokers and individuals with normal body weight. Therefore, increasing fruit consumption should be considered in the prevention and management of COPD, along with smoking cessation and weight control.
CHINESE MEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Yuanjie Pang, Jun Lv, Christiana Kartsonaki, Canqing Yu, Yu Guo, Yiping Chen, Ling Yang, Iona Y. Millwood, Robin G. Walters, Silu Lv, Sushila Burgess, Sam Sansome, Junshi Chen, Zhengming Chen, Liming Li
Summary: The study found that healthy lifestyle factors are associated with a lower risk of severe liver disease (SLD) regardless of genetic risk. In addition, lifestyle modification can also improve the prognosis of SLD in individuals with a low genetic risk.
CHINESE MEDICAL JOURNAL
(2023)
Article
Gastroenterology & Hepatology
Sailimai Man, Yuhan Deng, Yuan Ma, Jingzhu Fu, Heling Bao, Canqing Yu, Jun Lv, Hui Liu, Bo Wang, Liming Li
Summary: The prevalence of liver steatosis and fibrosis is relatively high in the general population and high-risk populations in China. This study provides evidence for shaping future strategies for screening and risk stratification of liver steatosis and fibrosis in the general population.
Article
Oncology
Xiaoxia Wei, Dianjianyi Sun, Jiaxin Gao, Jing Zhang, Meng Zhu, Canqing Yu, Zhimin Ma, Yating Fu, Chen Ji, Pei Pei, Ling Yang, Iona Y. Millwood, Robin G. Walters, Yiping Chen, Huaidong Du, Guangfu Jin, Zhengming Chen, Zhibin Hu, Liming Li, Hongbing Shen, Jun Lv, Hongxia Ma
Summary: The study developed a polygenic risk score (PRS) to identify individuals at higher risk of lung cancer among never-smoking Asian women. The utility and effectiveness of the PRS were evaluated in a Chinese prospective cohort, demonstrating improved risk stratification and prediction accuracy for incident lung cancer. The PRS shows potential for identifying high-risk individuals and early screening.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Cardiac & Cardiovascular Systems
Mohsen Mazidi, Neil Wright, Pang Yao, Christiana Kartsonaki, Iona Y. Millwood, Hannah Fry, Saredo Said, Alfred Pozarickij, Pei Pei, Yiping Chen, Daniel Avery, Huaidong Du, Dan Valle Schmidt, Ling Yang, Jun Lv, Canqing Yu, Junshi Chen, Michael Hill, Michael Holmes, Joanna M. M. Howson, Richard Peto, Rory Collins, Derrick A. Bennett, Robin G. Walters, Liming Li, Robert Clarke, Zhengming Chen
Summary: Integrated analyses of proteomic and genetic data in Chinese and European adults revealed potential associations between FURIN and multiple other proteins and IHD, providing evidence for them as novel drug targets.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Endocrinology & Metabolism
Xinyu Wang, Zhiyu Wu, Jun Lv, Canqing Yu, Dianjianyi Sun, Pei Pei, Ling Yang, Iona Y. Millwood, Robin Walters, Yiping Chen, Huaidong Du, Mingqiang Yuan, Dan Schmidt, Maxim Barnard, Junshi Chen, Zhengming Chen, Liming Li, Yuanjie Pang
Summary: The current study provides genetic evidence on the associations between life-course adiposity and severe liver disease (SLD).
Article
Clinical Neurology
Xuanming Hong, Ke Miao, Weihua Cao, Jun Lv, Canqing Yu, Tao Huang, Dianjianyi Sun, Chunxiao Liao, Yuanjie Pang, Runhua Hu, Zengchang Pang, Min Yu, Hua Wang, Xianping Wu, Yu Liu, Wenjing Gao, Liming Li
Summary: This study identified and validated PD-related CpGs in a Chinese twin population and suggested that PD may be the cause of changes in DNAm over time.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Yuhan Deng, Yuan Ma, Jingzhu Fu, Xiaona Wang, Canqing Yu, Jun Lv, Sailimai Man, Bo Wang, Liming Li
Summary: This study aimed to develop a practical prediction model for identifying individuals at risk of carotid plaque among those with fatty liver disease. By combining machine learning and logistic regression, the model showed good predictive performance and had significant implications for early identification and risk assessment of carotid plaque in individuals with fatty liver disease.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)