Article
Biochemistry & Molecular Biology
Jiayao Qu, Jia Li, Yaming Zhang, Rongzhang He, Xiangting Liu, Ke Gong, Lili Duan, Weihao Luo, Zheng Hu, Gengsheng Wang, Chenglai Xia, Dixian Luo
Summary: Elevated expression of AKR1B10 in breast cancer tissues was associated with lymph node metastasis, tumor size, Ki67 expression, and p53 expression, while inversely correlated with overall and disease-free survival rates. AKR1B10 promotes proliferation, migration, and invasion of breast cancer cells via the PI3K/AKT/NF-kappa B signaling pathway, indicating its potential as a prognostic indicator and therapeutic target in breast cancer.
CELL AND BIOSCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Fangfang Gao, Xiaoqian Mu, Huijuan Wu, Lijuan Chen, Jie Liu, Yanqiu Zhao
Summary: Calreticulin (CALR) is aberrantly expressed in lung cancer, and its overexpression promotes proliferation of lung cancer cells, possibly through activation of the NF-kappa B signaling pathway.
Article
Oncology
Yen-Yun Wang, Amos C. Hung, Steven Lo, Shyng-Shiou F. Yuan
Summary: Obesity is a major modifiable risk factor for breast cancer, with adipocytokines like visfatin and resistin playing important roles in tumor-stromal interactions and breast cancer development. Therapeutic strategies targeting these adipocytokines hold promise for novel breast cancer therapies.
Article
Biochemistry & Molecular Biology
Sang Eun Ha, Seong Min Kim, Preethi Vetrivel, Hun Hwan Kim, Pritam Bhagwan Bhosale, Jeong Doo Heo, Ho Jeong Lee, Gon Sup Kim
Summary: SCU as a potential agent for HCC therapy inhibits cell proliferation and metastasis in HepG2 cells through upregulation of PTEN and inhibition of the PI3K/Akt/NF-kappa B signaling pathway. It is a natural based agent that shows promise in improving therapeutic outcomes for HCC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Huajie Mao, Ya Zhao, Li Lei, Yanxia Hu, Hangrui Zhu, Runzhi Wang, Dongsheng Ni, Jianing Liu, Lei Xu, Hua Xia, Zaikuan Zhang, Meng Ma, Zheng Pan, Qin Zhou, Yajun Xie
Summary: SELS is highly expressed in clear cell renal cell carcinoma (ccRCC) and associated with multiple pathological features. SELS overexpression promotes cell proliferation and inhibits apoptosis, while silence of SELS has the opposite effect. Mechanistically, SELS activates AKT/GSK3 beta/NF-kappa B signaling pathway to enhance cell proliferation and inhibit apoptosis, and stabilizes c-Myc by preventing ubiquitin-proteasome-mediated degradation. Furthermore, SELS inhibits ccRCC cell migration likely through repressing epithelial-mesenchymal transition (EMT).
Article
Immunology
Guoliang Chen, Guiting Pu, Liqun Wang, Yanping Li, Tingli Liu, Hong Li, Shaohua Zhang, Xuelin Wang, Xiaolei Liu, Xuenong Luo
Summary: C. pisiformis-derived novel-miR1 was released into rabbit serum via exosomes and suppressed the expression of TLR2, inhibiting the immune response and facilitating parasite infection.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Laura Sole, Teresa Lobo-Jarne, Daniel Alvarez-Villanueva, Josune Alonso-Maranon, Yolanda Guillen, Marta Guix, Irene Sangrador, Catalina Rozalen, Anna Vert, Antonio Barbachano, Joan Lop, Marta Salido, Beatriz Bellosillo, Raquel Garcia-Romero, Marta Garrido, Jessica Gonzalez, Maria Martinez-Iniesta, Erika Lopez-Arribillaga, Ramon Salazar, Clara Montagut, Ferran Torres, Mar Iglesias, Toni Celia-Terrassa, Alberto Munoz, Alberto Villanueva, Anna Bigas, Lluis Espinosa
Summary: This study reveals that sub-lethal dose of chemotherapy induces a quiescence-like phenotype and a YAP-dependent fetal-like intestinal stem cell state in wild-type p53 colorectal cancers, which is associated with higher metastatic activity and poor prognosis in patients.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Mao Li, Markus W. Schweiger, Daniel J. Ryan, Ichiro Nakano, Litia A. Carvalho, Bakhos A. Tannous
Summary: The study found that in breast cancer metastasis, OR5B21 showed increased transcript abundance in distant metastatic sites, and its knockdown significantly reduced invasion and migration of cancer cells. OR5B21 expression was associated with epithelial to mesenchymal transition through the STAT3/NF-kappa B/CEBPb signaling axis.
Review
Pharmacology & Pharmacy
Munther Alomari
Summary: TRIM21 is involved in innate immunity, systemic lupus erythematosus, Sjogren's syndrome, and cancer proliferation. It is shown to affect major cancer-promoting proteins and signaling pathways in the presence of various carcinogenesis effectors. TRIM21 may enhance cancer proliferation or induce the degradation of cancer-triggering proteins, highlighting its potential as a novel cancer therapeutic target.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Begum Dariya, Santosh Kumar Behera, Gowru Srivani, Batoul Farran, Afroz Alam, Ganji Purnachandra Nagaraju
Summary: NF-kappa B is a major regulator of the biological characteristics of tumor cells, and antioxidants or protease inhibitors may suppress colorectal cancer. Computational studies suggest NF-kappa B could be a potential target for anti-cancer drugs.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Medicine, Research & Experimental
Thais Gomes de Carvalho, Pablo Lara, Carla Jorquera-Cordero, Cicero Flavio Soares Araga, Artur de Santana Oliveira, Vinicius Barreto Garcia, Shirley Vitoria de Paiva Souza, Timo Schomann, Luiz Alberto Lira Soares, Paulo Marcos da Matta Guedes, Raimundo Fernandes de Araujo Junior
Summary: This study demonstrates that EVs derived from M1 antitumor macrophages can serve as nanocarriers for drug delivery, enhancing the immunomodulatory and antitumor activity of the drugs through modulation of pathways associated with cell proliferation, migration, survival, and drug resistance. The results show that M1EV2 and M1EV3 alone or particularly M1EV4 can effectively suppress tumor progression and prevent metastasis. In vitro experiments also reveal that M1EVs promote cell death, inhibit epithelial-mesenchymal transition, and reduce drug resistance.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Shenglan Liu, Liangmei He, Junhong Wu, Xinqiang Wu, Lu Xie, Wei Dai, Lingxia Chen, Fuhua Xie, Zhiping Liu
Summary: DHX9 plays a crucial role in promoting proliferation and metastasis in colorectal cancer, making it a potential therapeutic target for prevention and treatment of CRC.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Qun Wang, Yun Huang, Min Jia, Dong Lu, Hong-Wei Zhang, Dan Huang, San-Hong Liu, Chao Lv
Summary: SPS-1, an active fraction from safflower polysaccharide, demonstrated strong antitumor effects in a mouse model of colorectal cancer by regulating the immune pathway and changing macrophage phenotype. It inhibited tumor growth, suppressed cell proliferation, induced apoptosis in CRC cells, and could potentially be used as a therapeutic option for CRC prevention and treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Matthew Martin, Mengyao Sun, Aishat Motolani, Tao Lu
Summary: This article provides an overview of colorectal cancer (CRC) and its stages, types of biomarkers, signaling pathways related to CRC, and the significant role of NF-kappa B in CRC. The authors suggest that more ideal NF-kappa B inhibitors may be developed with the discovery of novel regulators of the pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Huan Zhang, Huanji Xu, Chenliang Zhang, Qiulin Tang, Feng Bi
Summary: The study shows that Ursodeoxycholic acid (UDCA) can suppress YAP signaling by activating TGR5, inhibiting tumor growth in colorectal cancer (CRC) and regulating the cAMP/PKA signaling pathway to inhibit RhoA activity. This provides a new understanding of the importance of maintaining normal intestinal bile acid metabolism in cancer patients, offering a new approach for potential therapeutic intervention in CRC.
CELL DEATH DISCOVERY
(2021)
Article
Chemistry, Multidisciplinary
Lixia Wang, Jikun Li, Junfeng Xiang, Jie Cui, Yalin Tang
Summary: Nuclear magnetic resonance (NMR) spectroscopy has provided powerful tools for studying dynamic processes. Chemical exchange saturation transfer (CEST) is suitable for systems with slow exchange rates and shows potential in detecting metastable substances and understanding dynamic mechanisms. This study used QUEZS and QUEST methods to investigate the kinetics of slow chemical exchange in N,N-dimethylacetylamide (DMA). The results demonstrated the reliability of CEST-based techniques in providing accurate kinetic data under different temperatures.
CHINESE CHEMICAL LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Liang Yu, Can Cao, Xu Li, Mili Zhang, Qisheng Gu, Hugh Gao, Jesse J. Balic, Duogang Xu, Lei Zhang, Le Ying, Dakang Xu, Yuqin Yang, Di Wu, Baokun He, Brendan J. Jenkins, Youdong Liu, Jikun Li
Summary: The miR-200 family plays a crucial role in maintaining the epithelial phenotype in gastric cancer, but its suppression in late-stage gastric tumors leads to EMT and affects prognosis.
Article
Oncology
Mili Zhang, Can Cao, Xu Li, Qisheng Gu, Yixin Xu, Ziyan Zhu, Duogang Xu, Shanshan Wei, Haonan Chen, Yuqin Yang, Hugh Gao, Liang Yu, Jikun Li
Summary: This study identified the EMT signaling pathway as a representative pathway for predicting the survival of MSI-H gastric cancer (GC) patients. A novel five-gene signature (CALU, PCOLCE2, PLOD2, SGCD, and THBS2) was established from the EMT signaling gene set for disease outcome prediction. The five genes were found to be abundantly expressed in cancer-associated fibroblasts, and patients with different risk groups based on the five-gene signature showed distinct patterns of tumor immune microenvironment.
Article
Chemistry, Multidisciplinary
Pei Zhang, Xinchen Kang, Liming Tao, Lirong Zheng, Junfeng Xiang, Ran Duan, Jikun Li, Peng Chen, Xueqing Xing, Guang Mo, Zhonghua Wu, Buxing Han
Summary: This study discovered a stable radical solution that allows for rapid synthesis of various MOFs with different metal nodes and ligands at room temperature without external energy. MOFs with conjugated ligands achieved instantaneous architecture formation with a 100% yield. The mechanism was thoroughly investigated using multiple techniques.
Article
Chemistry, Multidisciplinary
De-Hui Tuo, Shuxuan Tang, Pengfei Jin, Jikun Li, Xinping Wang, Chuang Zhang, Yu-Fei Ao, Qi-Qiang Wang, De-Xian Wang
Summary: This article presents the synthesis, crystal structures, and physical properties of novel benzene triimide (BTI) radical anions, focusing on the relationship between molecular structure, spin-spin intermolecular interactions, and physical properties in the crystalline state. The radical species exhibited diverse intermolecular stackings in the crystalline state, resulting in different spin-spin interactions and various physical properties. The structure-property relationship was studied in terms of magnetism and conductivity, showing that the radical pi-pimers and pi-stacks with effective charge transport exhibited paramagnetic property and conductivity at room temperature.
Article
Nanoscience & Nanotechnology
Tianjiao Liu, Chaoyuan Deng, Di Meng, Yufan Zhang, Ran Duan, Hongwei Ji, Hua Sheng, Jikun Li, Chuncheng Chen, Jincai Zhao, Wenjing Song
Summary: In this study, it is discovered that the amino and carboxylic functionalities in visible-light-harvesting metal-organic frameworks can form nickel ions, which exhibit different activities in cross-coupling reactions of aryl halides and nucleophiles. This work provides a new approach to construct and regulate metal centers by manipulating the coordination environments of MOFs.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Ji-Kun Li, Xing-Yu Chen, Wen-Long Zhao, Yun-Long Guo, Yi Zhang, Xin-Chang Wang, Andrew C. -H. Sue, Xiao-Yu Cao, Meng Li, Chuan-Feng Chen, Xiao-Ye Wang
Summary: In this study, a new design strategy is proposed to achieve chiral nanographenes with high fluorescence quantum yields by helical pi-extension of strongly luminescent chromophores. The synthesized chiral nanographene, with perylene as the core and two dibenzo[6]helicene fragments as the wings, exhibits a record high fluorescence quantum yield of 93% among reported chiral nanographenes and excellent circularly polarized luminescence brightness of 32 M-1 cm(-1).
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Tongtong Jia, Di Meng, Ran Duan, Hongwei Ji, Hua Sheng, Chuncheng Chen, Jikun Li, Wenjing Song, Jincai Zhao
Summary: Prospects in light-driven water activation have led to rapid progress in hydrogenation reactions. In this study, a Ni2+-N-4 site built on carbon nitride was used for catalyzing the semihydrogenation of alkynes with water providing protons, powered by visible-light irradiation. Importantly, this photocatalytic approach enabled the production of diverse deuterated alkenes in D2O with excellent deuterium incorporation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Materials Science, Multidisciplinary
Xing-Yu Chen, Ji-Kun Li, Wen-Long Zhao, Cheng-Zhuo Du, Meng Li, Chuan-Feng Chen, Xiao-Ye Wang
Summary: By using aza[7]helicene as the chiral donor and triazine as the acceptor, a new type of circularly polarized luminescence material has been developed. The influence of the dihedral angle between the donor and acceptor moieties on the dissymmetry factors has been revealed for the first time, offering a novel strategy to enhance dissymmetry factors through engineering the dihedral angles in donor-acceptor type chiral materials.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Materials Science, Multidisciplinary
Cheng-Zhuo Du, Yang Lv, Hengyi Dai, Xiangchen Hong, Jianping Zhou, Ji-Kun Li, Rong-Rong Gao, Dongdong Zhang, Lian Duan, Xiao-Ye Wang
Summary: A new family of indole-fused multi-resonance thermally activated delayed fluorescence materials have been developed, which exhibit narrowband blue emission with a small full width at half maximum of 22-23 nm. High maximum external quantum efficiencies of up to 16.8% have been achieved in organic light-emitting diodes. Furthermore, it is unveiled that peripheral substitutions can not only promote device efficiency but also help to maintain narrowband emission under high dopant concentrations.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Chemistry, Multidisciplinary
Yucui Zhao, Tingting Lu, Yanwei Song, Yanqin Wen, Zheng Deng, Jiahui Fan, Minghui Zhao, Ruyi Zhao, Yuntao Luo, Jianzhu Xie, Binjie Hu, Haoran Sun, Yiwei Wang, Sijia He, Yanping Gong, Jin Cheng, Xinjian Liu, Liang Yu, Jikun Li, Chuanyuan Li, Yongyong Shi, Qian Huang
Summary: Cancer cells enter a radiation-tolerant persister state by poly- and de-polyploidization to survive radiotherapy and repopulate the tumor, suggesting a new therapeutic concept to improve outcome of patients receiving radiotherapy.
Article
Chemistry, Multidisciplinary
Ji-Kun Li, Ming-Yu Zhang, Le Zeng, Ling Huang, Xiao-Ye Wang
Summary: In this study, the first NIR-absorbing B,N-heteroarene-based sensitizer (BNS) with multi-resonance thermally activated delayed fluorescence (MR-TADF) is developed to achieve efficient NIR-to-blue TTA-UC. The small energy gap between the singlet and triplet excited states (0.14 eV) of BNS suppresses the energy loss during ISC, and its long-delayed fluorescence lifetime (115 μs) contributes to efficient triplet energy transfer. As a result, the largest anti-Stokes shift (1.03 eV) among all heavy-atom-free NIR-activatable TTA-UC systems is obtained with a high TTA-UC quantum yield of 2.9% (upper limit 50%).
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Fangfang Peng, Junfeng Xiang, Huisheng Qin, Bingfeng Chen, Ran Duan, Wenling Zhao, Shiqiang Liu, Tianbin Wu, Wenli Yuan, Qian Li, Jikun Li, Xinchen Kang, Buxing Han
Summary: This study reports a highly selective electro-oxidation method for the synthesis of benzylic alcohols from benzylic C-H in an ionic liquid-based solution. Under specific conditions, the selectivity of the reaction can reach 95.7%. Mechanistic investigation reveals the crucial roles of proton-coupled electron transfer and low-barrier hydrogen bonds in the reaction.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Shijia Yang, Wenxing Liu, Jing Guo, Zhusheng Yang, Zhi Qiao, Chenguang Zhang, Jikun Li, Jian Xu, Ning Zhao
Summary: The recycling of thermosetting polymers, which cannot be reprocessed due to their covalently cross-linked structures, can be achieved through the implantation of dynamic covalent bonds. This study demonstrates the direct and catalyst-free ester metathesis of N-acyloxyphthalimide (NAPI) and its use in the creation of covalent adaptable networks (CANs). The NAPI metathesis reaction shows interesting kinetics, proceeds via a free radical chain mechanism, and allows for fast associative exchange at low dissociation.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Multidisciplinary Sciences
Shichao Xu, Haifeng Wu, Siyuan Liu, Peidong Du, Hui Wang, Haijun Yang, Wenjie Xu, Shuangming Chen, Li Song, Jikun Li, Xinghua Shi, Zhen-Gang Wang
Summary: In this study, a supramolecular mimetic enzyme with catechol oxidase-like copper-cluster active sites was synthesized. This catalyst exhibits catalytic functions similar to those of copper cluster-dependent oxidases, and its performance surpasses previously reported artificial complexes.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)