☆ 4.4 Article

Viral metagenomics, genetic and evolutionary characteristics of Crimean-Congo hemorrhagic fever orthonairovirus in humans, Kosovo

INFECTION GENETICS AND EVOLUTION (2018)

期刊

INFECTION GENETICS AND EVOLUTION

卷 65, 期 -, 页码 6-11

出版社

ELSEVIER

DOI: 10.1016/j.meegid.2018.07.010

关键词

CCHFV; Evolution; NGS; Jingmenvirus; Kosovo

类别

Infectious Diseases

资金

Ministry of Foreign Affairs [ZMV-16 2513AA0277]

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Protocol

Reagent

摘要

Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV) is a tick-borne virus which causes severe disease in humans with fatality cases up to 30%. We investigated the genetic and evolutionary characteristics of CCHFV in Kosovo, in particular in humans and found that different virus variants of genotype V circulate, with Turkey as a possible origin for the progenitor of southern European CCHF outbreaks. Phylogenetic analyses also revealed a single introduction event and in situ evolution of CCHFV in this country. The viral metagenomics revealed a more abundant virome in the fatal CCHF cases and the presence of a novel tick-borne segmented RNA virus belonging to the recently discovered Jingmenvirus group which raises questions about the potential pathogenic effect of this novel virus on human and animal health.

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