Alpha-synuclein inhibits Snx3–retromer-mediated retrograde recycling of iron transporters in S. cerevisiae and C. elegans models of Parkinson’s disease

VPS35, the Retromer Complex and Parkinson’s Disease

(2017) Erin T. Williams et al.   Journal of Parkinsons Disease

Structural Mechanism for Cargo Recognition by the Retromer Complex

(2016) María Lucas et al.   CELL

Alpha-synuclein modulates retinal iron homeostasis by facilitating the uptake of transferrin-bound iron: Implications for visual manifestations of Parkinson's disease

(2016) Shounak Baksi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Parkinson Disease-linked Vps35 R524W Mutation Impairs the Endosomal Association of Retromer and Induces α-Synuclein Aggregation

(2016) Jordan Follett et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of Iron Transporters and Pathological Hallmarks of Parkinson’s and Alzheimer’s Diseases in the Brain of Young, Adult, and Aged Rats

(2016) Li-Na Lu et al.   MOLECULAR NEUROBIOLOGY

Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice

(2016) Pavle Matak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity

(2016) Susana A. Gonçalves et al.   PLoS Genetics

Parkinson's Disease Iron Deposition Caused by Nitric Oxide-Induced Loss of  -Amyloid Precursor Protein

(2015) S. Ayton et al.   JOURNAL OF NEUROSCIENCE

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Spatiotemporal dynamics of membrane remodeling and fusion proteins during endocytic transport

(2015) Henning Arlt et al.   MOLECULAR BIOLOGY OF THE CELL

Retromer in Alzheimer disease, Parkinson disease and other neurological disorders

(2015) Scott A. Small et al.   NATURE REVIEWS NEUROSCIENCE

Parkinson’s Disease Genes VPS35 and EIF4G1 Interact Genetically and Converge on α-Synuclein

(2015) Nripesh Dhungel et al.   NEURON

Single-nucleotide polymorphisms and haplotypes of non-coding area in the CP gene are correlated with Parkinson’s disease

(2015) Na Zhao et al.   Neuroscience Bulletin

sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin

(2014) R. C. McCarthy et al.   EMBO REPORTS

Ceruloplasmin and β-amyloid precursor protein confer neuroprotection in traumatic brain injury and lower neuronal iron

(2014) Scott Ayton et al.   FREE RADICAL BIOLOGY AND MEDICINE

G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome

(2013) Suzanne Lesage et al.   ANNALS OF NEUROLOGY

Snx3 Regulates Recycling of the Transferrin Receptor and Iron Assimilation

(2013) Caiyong Chen et al.   Cell Metabolism

α-Synuclein Oligomers with Broken Helical Conformation Form Lipoprotein Nanoparticles

(2013) Jobin Varkey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sortilin and SorLA Display Distinct Roles in Processing and Trafficking of Amyloid Precursor Protein

(2013) C. Gustafsen et al.   JOURNAL OF NEUROSCIENCE

A novel  -synuclein missense mutation in Parkinson disease

(2013) C. Proukakis et al.   NEUROLOGY

A mechanism for retromer endosomal coat complex assembly with cargo

(2013) M. S. Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease

(2012) Scott Ayton et al.   ANNALS OF NEUROLOGY

Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicity

(2012) Marija Usenovic et al.   HUMAN MOLECULAR GENETICS

Functional Analysis of VPS41-Mediated Neuroprotection in Caenorhabditis elegans and Mammalian Models of Parkinson's Disease

(2012) A. J. Harrington et al.   JOURNAL OF NEUROSCIENCE

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

(2012) Peng Lei et al.   NATURE MEDICINE

100 years of Lewy pathology

(2012) Michel Goedert et al.   Nature Reviews Neurology

Identification of VPS35 mutations replicated in French families with Parkinson disease

(2012) S. Lesage et al.   NEUROLOGY

A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease

(2011) Alexander Zimprich et al.   AMERICAN JOURNAL OF HUMAN GENETICS

VPS35 Mutations in Parkinson Disease

(2011) Carles Vilariño-Güell et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Ceruloplasmin Oxidation, a Feature of Parkinson's Disease CSF, Inhibits Ferroxidase Activity and Promotes Cellular Iron Retention

(2011) S. Olivieri et al.   JOURNAL OF NEUROSCIENCE

A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion

(2011) Martin Harterink et al.   NATURE CELL BIOLOGY

Sorting nexins provide diversity for retromer-dependent trafficking events

(2011) Peter J. Cullen et al.   NATURE CELL BIOLOGY

Defects in Very Long Chain Fatty Acid Synthesis Enhance Alpha-Synuclein Toxicity in a Yeast Model of Parkinson's Disease

(2011) Yong Joo Lee et al.   PLoS One

Decreased serum ceruloplasmin levels characteristically aggravate nigral iron deposition in Parkinson’s disease

(2010) Lirong Jin et al.   BRAIN

Chemical enhancement of torsinA function in cell and animal models of torsion dystonia

(2010) S. Cao et al.   Disease Models & Mechanisms

Membrane Curvature Induction and Tubulation Are Common Features of Synucleins and Apolipoproteins

(2010) Jobin Varkey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Retromer-mediated direct sorting is required for proper endosomal recycling of the mammalian iron transporter DMT1

(2010) M. Tabuchi et al.   JOURNAL OF CELL SCIENCE

Increased Iron in the Substantia Nigra Compacta of the MPTP-Lesioned Hemiparkinsonian African Green Monkey: Evidence from Proton Microprobe Elemental Microanalysis

(2010) J. A. Temlett et al.   JOURNAL OF NEUROCHEMISTRY

Parkin regulates metal transport via proteasomal degradation of the 1B isoforms of divalent metal transporter 1

(2010) Jerome A. Roth et al.   JOURNAL OF NEUROCHEMISTRY

Diabetes-Associated SorCS1 Regulates Alzheimer's Amyloid-  Metabolism: Evidence for Involvement of SorL1 and the Retromer Complex

(2010) R. F. Lane et al.   JOURNAL OF NEUROSCIENCE

Enhanced neuronal RNAi in C. elegans using SID-1

(2010) Andrea Calixto et al.   NATURE METHODS

Core glycan in the yeast multicopper ferroxidase, Fet3p: A case study of N-linked glycosylation, protein maturation, and stability

(2010) Lynn Ziegler et al.   PROTEIN SCIENCE

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Quantifying Western blots: Pitfalls of densitometry

(2009) Max Gassmann et al.   ELECTROPHORESIS

Opposing Activities of the Snx3-Retromer Complex and ESCRT Proteins Mediate Regulated Cargo Sorting at a Common Endosome

(2008) Todd I. Strochlic et al.   MOLECULAR BIOLOGY OF THE CELL

GATA transcription factors directly regulate the Parkinson's disease-linked gene  -synuclein

(2008) C. R. Scherzer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypothesis-based RNAi screening identifies neuroprotective genes in a Parkinson's disease model

(2008) S. Hamamichi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease

(2008) J. Salazar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity

(2008) Liyan Qiao et al.   Molecular Brain