ERp57 is protective against mutant SOD1-induced cellular pathology in amyotrophic lateral sclerosis

Genetics of Amyotrophic Lateral Sclerosis

(2017) Mehdi Ghasemi et al.   Cold Spring Harbor Perspectives in Medicine

Biological Spectrum of Amyotrophic Lateral Sclerosis Prions

(2017) Magdalini Polymenidou et al.   Cold Spring Harbor Perspectives in Medicine

Disulfide cross-linked multimers of TDP-43 and spinal motoneuron loss in a TDP-43A315T ALS/FTD mouse model

(2017) Leslie Bargsted et al.   Scientific Reports

Protein folding alterations in amyotrophic lateral sclerosis

(2016) Sonam Parakh et al.   BRAIN RESEARCH

Proteostasis impairment in ALS

(2016) Céline Ruegsegger et al.   BRAIN RESEARCH

ALS‐linked protein disulfide isomerase variants cause motor dysfunction

(2016) Ute Woehlbier et al.   EMBO JOURNAL

Mitochondria and endoplasmic reticulum crosstalk in amyotrophic lateral sclerosis

(2016) Giovanni Manfredi et al.   NEUROBIOLOGY OF DISEASE

Rab1-dependent ER–Golgi transport dysfunction is a common pathogenic mechanism in SOD1, TDP-43 and FUS-associated ALS

(2015) Kai Y. Soo et al.   ACTA NEUROPATHOLOGICA

Endoplasmic reticulum stress and proteasomal system in amyotrophic lateral sclerosis

(2015) Betul Karademir et al.   FREE RADICAL BIOLOGY AND MEDICINE

Protein disulfide–isomerase, a folding catalyst and a redox-regulated chaperone

(2015) Lei Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Structures and functions of protein disulfide isomerase family members involved in proteostasis in the endoplasmic reticulum

(2015) Masaki Okumura et al.   FREE RADICAL BIOLOGY AND MEDICINE

Identification of rare protein disulfide isomerase gene variants in amyotrophic lateral sclerosis patients

(2015) Paloma Gonzalez-Perez et al.   GENE

The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein

(2015) Mauricio Torres et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The expanding syndrome of amyotrophic lateral sclerosis: a clinical and molecular odyssey

(2015) Martin R Turner et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Amyotrophic lateral sclerosis: mechanisms and therapeutics in the epigenomic era

(2015) Ximena Paez-Colasante et al.   Nature Reviews Neurology

TDP-43 Proteinopathy and ALS: Insights into Disease Mechanisms and Therapeutic Targets

(2015) Emma L. Scotter et al.   Neurotherapeutics

Distinct partitioning of ALS associated TDP-43, FUS and SOD1 mutants into cellular inclusions

(2015) Natalie E. Farrawell et al.   Scientific Reports

Functional Role of the Disulfide Isomerase ERp57 in Axonal Regeneration

(2015) Valentina Castillo et al.   PLoS One

Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress

(2014) Yong-Jie Zhang et al.   ACTA NEUROPATHOLOGICA

Partial inhibition of Cdk1 in G2phase overrides the SAC and decouples mitotic events

(2014) Rachael A McCloy et al.   CELL CYCLE

Disturbance of endoplasmic reticulum proteostasis in neurodegenerative diseases

(2014) Claudio Hetz et al.   NATURE REVIEWS NEUROSCIENCE

Association studies indicate that protein disulfide isomerase is a risk factor in amyotrophic lateral sclerosis

(2013) Chun Tak Kwok et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ero1-α and PDIs constitute a hierarchical electron transfer network of endoplasmic reticulum oxidoreductases

(2013) Kazutaka Araki et al.   JOURNAL OF CELL BIOLOGY

Mutant SOD1 inhibits ER-Golgi transport in amyotrophic lateral sclerosis

(2013) Julie D. Atkin et al.   JOURNAL OF NEUROCHEMISTRY

Potential Effect of S-Nitrosylated Protein Disulfide Isomerase on Mutant SOD1 Aggregation and Neuronal Cell Death in Amyotrophic Lateral Sclerosis

(2013) Gye Sun Jeon et al.   MOLECULAR NEUROBIOLOGY

Genetics of amyotrophic lateral sclerosis: an update

(2013) Sheng Chen et al.   Molecular Neurodegeneration

ALS-Associated TDP-43 Induces Endoplasmic Reticulum Stress, Which Drives Cytoplasmic TDP-43 Accumulation and Stress Granule Formation

(2013) Adam K. Walker et al.   PLoS One

Chronic Excitotoxin-Induced Axon Degeneration in a Compartmented Neuronal Culture Model

(2012) Katherine A Hosie et al.   ASN Neuro

The unfolded protein response in models of human mutant G93A amyotrophic lateral sclerosis

(2012) T. Prell et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase

(2012) Manal A. Farg et al.   NEUROBIOLOGY OF AGING

Bim Links ER Stress and Apoptosis in Cells Expressing Mutant SOD1 Associated with Amyotrophic Lateral Sclerosis

(2012) Kai Y. Soo et al.   PLoS One

Protein disulfide isomerase-immunopositive inclusions in patients with amyotrophic lateral sclerosis

(2011) Yasuyuki Honjo et al.   Amyotrophic Lateral Sclerosis

Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking

(2011) Todd J Cohen et al.   EMBO JOURNAL

Amyotrophic Lateral Sclerosis Multiprotein Biomarkers in Peripheral Blood Mononuclear Cells

(2011) Giovanni Nardo et al.   PLoS One

ER Stress and Its Functional Link to Mitochondria: Role in Cell Survival and Death

(2011) J. D. Malhotra et al.   Cold Spring Harbor Perspectives in Biology

A structural overview of the PDI family of proteins

(2010) Guennadi Kozlov et al.   FEBS Journal

A PDI Family Network Acts Distinctly and Coordinately with ERp29 To Facilitate Polyomavirus Infection

(2010) C. P. Walczak et al.   JOURNAL OF VIROLOGY

Functional Relationship between Protein Disulfide Isomerase Family Members during the Oxidative Folding of Human Secretory Proteins

(2010) Lori A. Rutkevich et al.   MOLECULAR BIOLOGY OF THE CELL

Protein disulphide isomerase protects against protein aggregation and is S-nitrosylated in amyotrophic lateral sclerosis

(2009) Adam K. Walker et al.   BRAIN

TDP-43 Is Intrinsically Aggregation-prone, and Amyotrophic Lateral Sclerosis-linked Mutations Accelerate Aggregation and Increase Toxicity

(2009) Brian S. Johnson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein disulphide isomerase family members show distinct substrate specificity: P5 is targeted to BiP client proteins

(2009) C. E. Jessop et al.   JOURNAL OF CELL SCIENCE

A role for motoneuron subtype–selective ER stress in disease manifestations of FALS mice

(2009) Smita Saxena et al.   NATURE NEUROSCIENCE

TDP-43 is consistently co-localized with ubiquitinated inclusions in sporadic and Guam amyotrophic lateral sclerosis but not in familial amyotrophic lateral sclerosis with and without SOD1 mutations

(2009) Satomi Maekawa et al.   NEUROPATHOLOGY

The Ubiquitin-Proteasome Reporter GFPu Does Not Accumulate in Neurons of the R6/2 Transgenic Mouse Model of Huntington's Disease

(2009) John S. Bett et al.   PLoS One

The Amyotrophic Lateral Sclerosis 8 Protein VAPB Is Cleaved, Secreted, and Acts as a Ligand for Eph Receptors

(2008) Hiroshi Tsuda et al.   CELL

The endoplasmic reticulum-Golgi pathway is a target for translocation and aggregation of mutant superoxide dismutase linked to ALS

(2008) Makoto Urushitani et al.   FASEB JOURNAL

ALS-linked mutant SOD1 induces ER stress- and ASK1-dependent motor neuron death by targeting Derlin-1

(2008) H. Nishitoh et al.   GENES & DEVELOPMENT

Recruitment of mitochondria into apoptotic signaling correlates with the presence of inclusions formed by amyotrophic lateral sclerosis-associated SOD1 mutations

(2008) Kai Y. Soo et al.   JOURNAL OF NEUROCHEMISTRY

Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis

(2008) Julie D. Atkin et al.   NEUROBIOLOGY OF DISEASE