Hepatic PPARα function is controlled by polyubiquitination and proteasome-mediated degradation through the coordinated actions of PAQR3 and HUWE1

Mule Regulates the Intestinal Stem Cell Niche via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation

(2016) Carmen Dominguez-Brauer et al.   Cell Stem Cell

PAQR3 controls autophagy by integrating AMPK signaling to enhance ATG14L-associated PI3K activity

(2016) D.-Q. Xu et al.   EMBO JOURNAL

Liver PPARα is crucial for whole-body fatty acid homeostasis and is protective against NAFLD

(2016) Alexandra Montagner et al.   GUT

PPARs in obesity-induced T2DM, dyslipidaemia and NAFLD

(2016) Barbara Gross et al.   Nature Reviews Endocrinology

A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins

(2016) Min-Kyung Sung et al.   eLife

Ubiquitin Ligase NEDD4 Regulates PPARγ Stability and Adipocyte Differentiation in 3T3-L1 Cells

(2016) Jing Jing Li et al.   Scientific Reports

The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination

(2015) Jessica E. Rodríguez et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Regulation of mitochondrial morphology and function by stearoylation of TFR1

(2015) Deniz Senyilmaz et al.   NATURE

PAQR3 modulates cholesterol homeostasis by anchoring Scap/SREBP complex to the Golgi apparatus

(2015) Daqian Xu et al.   Nature Communications

The E3 ubiquitin ligase TRIM23 regulates adipocyte differentiation via stabilization of the adipogenic activator PPARγ

(2015) Masashi Watanabe et al.   eLife

Dichotomous role of pancreatic HUWE1/MULE/ARF-BP1 in modulating beta cell apoptosis in mice under physiological and genotoxic conditions

(2014) Linyuan Wang et al.   DIABETOLOGIA

Suppression of PPARγ through MKRN1-mediated ubiquitination and degradation prevents adipocyte differentiation

(2013) J-H Kim et al.   CELL DEATH AND DIFFERENTIATION

An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice

(2013) William L. Holland et al.   Cell Metabolism

PAQR3 Has Modulatory Roles in Obesity, Energy Metabolism, and Leptin Signaling

(2013) Lingdi Wang et al.   ENDOCRINOLOGY

PAQR3 Plays a Suppressive Role in the Tumorigenesis of Colorectal Cancers

(2012) X. Wang et al.   CARCINOGENESIS

PAQR3 Modulates Insulin Signaling by Shunting Phosphoinositide 3-Kinase p110  to the Golgi Apparatus

(2012) X. Wang et al.   DIABETES

PPARs: Fatty acid sensors controlling metabolism

(2012) Lars la Cour Poulsen et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

PPARγ is an E3 ligase that induces the degradation of NFκB/p65

(2012) Yongzhong Hou et al.   Nature Communications

The story so far: post-translational regulation of peroxisome proliferator-activated receptors by ubiquitination and SUMOylation

(2011) Kristine M. Wadosky et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Functional Cooperation of RKTG with p53 in Tumorigenesis and Epithelial-Mesenchymal Transition

(2011) Y. Jiang et al.   CANCER RESEARCH

Inactivation ofarf-bp1Induces p53 Activation and Diabetic Phenotypes in Mice

(2011) Ning Kon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RKTG inhibits angiogenesis by suppressing MAPK-mediated autocrine VEGF signaling and is downregulated in clear-cell renal cell carcinoma

(2010) Y Zhang et al.   ONCOGENE

Characterization of the topology and functional domains of RKTG

(2008) Xiaolin Luo et al.   BIOCHEMICAL JOURNAL

The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development

(2008) Francesca Bernassola et al.   CANCER CELL

Suppressive function of RKTG on chemical carcinogen-induced skin carcinogenesis in mouse

(2008) X. Xie et al.   CARCINOGENESIS

The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein

(2008) Xudong Zhao et al.   NATURE CELL BIOLOGY

Regulation of Peroxisome Proliferator–Activated Receptor-α by MDM2

(2008) Lakshmi Gopinathan et al.   TOXICOLOGICAL SCIENCES