Roles of the bone marrow niche in hematopoiesis, leukemogenesis, and chemotherapy resistance in acute myeloid leukemia

The Possible Importance of β3 Integrins for Leukemogenesis and Chemoresistance in Acute Myeloid Leukemia

(2018) Silje Johansen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Phase I study of evofosfamide, an investigational hypoxia-activated prodrug, in patients with advanced leukemia

(2016) Talha Badar et al.   AMERICAN JOURNAL OF HEMATOLOGY

Advances in understanding the acute lymphoblastic leukemia bone marrow microenvironment: From biology to therapeutic targeting

(2016) Francesca Chiarini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Evolution of acute myelogenous leukemia stem cell properties after treatment and progression

(2016) T.-C. Ho et al.   BLOOD

AMD3100 and G-CSF disrupt the cross-talk between leukemia cells and the endosteal niche and enhance their sensitivity to chemotherapeutic drugs in biomimetic polystyrene scaffolds

(2016) Zhao-Hua Shen et al.   BLOOD CELLS MOLECULES AND DISEASES

Pexmetinib: A Novel Dual Inhibitor of Tie2 and p38 MAPK with Efficacy in Preclinical Models of Myelodysplastic Syndromes and Acute Myeloid Leukemia

(2016) L. Bachegowda et al.   CANCER RESEARCH

Harnessing the immune system in acute myeloid leukaemia

(2016) Rebecca Austin et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Osteoblast ablation burns out functional stem cells

(2015) M. Zhao et al.   BLOOD

Epigenetics and approaches to targeted epigenetic therapy in acute myeloid leukemia

(2015) B. J. Wouters et al.   BLOOD

CXCL12/CXCR4 axis in the pathogenesis of acute lymphoblastic leukemia (ALL): a possible therapeutic target

(2015) Aparecida de Lourdes Perim et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Loss of HIF-1α accelerates murine FLT-3ITD-induced myeloproliferative neoplasia

(2015) T Velasco-Hernandez et al.   LEUKEMIA

Endothelial cell derived angiocrine support of acute myeloid leukemia targeted by receptor tyrosine kinase inhibition

(2015) Leylah Drusbosky et al.   LEUKEMIA RESEARCH

Hypoxia regulates proliferation of acute myeloid leukemia and sensitivity against chemotherapy

(2015) Heidrun Drolle et al.   LEUKEMIA RESEARCH

Pre-Clinical Development of a Humanized Anti-CD47 Antibody with Anti-Cancer Therapeutic Potential

(2015) Jie Liu et al.   PLoS One

HIF-1  can act as a tumor suppressor gene in murine acute myeloid leukemia

(2014) T. Velasco-Hernandez et al.   BLOOD

Advances in understanding the leukaemia microenvironment

(2014) Yoko Tabe et al.   BRITISH JOURNAL OF HAEMATOLOGY

Redox Modulation of Adjacent Thiols in VLA-4 by AS101 Converts Myeloid Leukemia Cells from a Drug-Resistant to Drug-Sensitive State

(2014) A. Layani-Bazar et al.   CANCER RESEARCH

Regulation of hematopoietic and leukemic stem cells by the immune system

(2014) C Riether et al.   CELL DEATH AND DIFFERENTIATION

Acute Myelogenous Leukemia-Induced Sympathetic Neuropathy Promotes Malignancy in an Altered Hematopoietic Stem Cell Niche

(2014) Maher Hanoun et al.   Cell Stem Cell

A Phase I Trial of LY2510924, a CXCR4 Peptide Antagonist, in Patients with Advanced Cancer

(2014) M. D. Galsky et al.   CLINICAL CANCER RESEARCH

Activation of the vascular niche supports leukemic progression and resistance to chemotherapy

(2014) Michael G. Poulos et al.   EXPERIMENTAL HEMATOLOGY

Functional integration of acute myeloid leukemia into the vascular niche

(2014) C R Cogle et al.   LEUKEMIA

The Role of Hypoxia and Exploitation of the Hypoxic Environment in Hematologic Malignancies

(2014) Barbara Muz et al.   MOLECULAR CANCER RESEARCH

Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts

(2014) Aruna Kode et al.   NATURE

The role of the immunosuppressive microenvironment in acute myeloid leukemia development and treatment

(2014) Alessandro Isidori et al.   Expert Review of Hematology

Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy

(2013) B. Boyerinas et al.   BLOOD

Osteoblasts Protect AML Cells From SDF-1-Induced Apoptosis

(2013) Kimberly N. Kremer et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Dynamic Chemotherapy-Induced Upregulation of CXCR4 Expression: A Mechanism of Therapeutic Resistance in Pediatric AML

(2013) E. A. R. Sison et al.   MOLECULAR CANCER RESEARCH

The TPO/c-MPL Pathway in the Bone Marrow may Protect Leukemia Cells from Chemotherapy in AML Patients

(2013) Zeng Dong-Feng et al.   PATHOLOGY & ONCOLOGY RESEARCH

A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia

(2012) G. L. Uy et al.   BLOOD

Osteopontin is a prognostic factor for survival of acute myeloid leukemia patients

(2012) R. Liersch et al.   BLOOD

The HIF Signaling Pathway in Osteoblasts Directly Modulates Erythropoiesis through the Production of EPO

(2012) Erinn B. Rankin et al.   CELL

Angiopoietin1 contributes to the maintenance of cell quiescence in EVI1high leukemia cells

(2011) Emi Ichihara et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Wnt-inhibitory factor 1 dysregulation of the bone marrow niche exhausts hematopoietic stem cells

(2011) C. Schaniel et al.   BLOOD

Leukemia Stem Cells and Microenvironment: Biology and Therapeutic Targeting

(2011) Marina Y. Konopleva et al.   JOURNAL OF CLINICAL ONCOLOGY

Osteoblastic and Vascular Endothelial Niches, Their Control on Normal Hematopoietic Stem Cells, and Their Consequences on the Development of Leukemia

(2011) Bella S. Guerrouahen et al.   Stem Cells International

Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells

(2010) Y. Nakamura et al.   BLOOD

Targeting the angiopoietin (Ang)/Tie-2 pathway in the crosstalk between acute myeloid leukaemia and endothelial cells: studies of Tie-2 blocking antibodies, exogenous Ang-2 and inhibition of constitutive agonistic Ang-1 release

(2010) Håkon Reikvam et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia

(2010) Marc H. G. P. Raaijmakers et al.   NATURE

Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML

(2010) Yoriko Saito et al.   NATURE BIOTECHNOLOGY

Niche Regulation of Hematopoietic Stem Cells in the Endosteum

(2009) Fumio Arai et al.   Annals of the New York Academy of Sciences

Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML

(2009) J. A. Powell et al.   BLOOD

Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice

(2009) M. G. Kharas et al.   BLOOD

Functional differences between two Tie2 ligands, angiopoietin-1 and -2, in regulation of adult bone marrow hematopoietic stem cells

(2009) Yumiko Gomei et al.   EXPERIMENTAL HEMATOLOGY

CXCR4 expression and biologic activity in acute myeloid leukemia are dependent on oxygen partial pressure

(2008) M. Fiegl et al.   BLOOD

Targeting the leukemia microenvironment by CXCR4 inhibition overcomes resistance to kinase inhibitors and chemotherapy in AML

(2008) Z. Zeng et al.   BLOOD

Osteoblastic regulation of B lymphopoiesis is mediated by Gs -dependent signaling pathways

(2008) J. Y. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA