Astroglial major histocompatibility complex class I following immune activation leads to behavioral and neuropathological changes

Oxidative stress-driven parvalbumin interneuron impairment as a common mechanism in models of schizophrenia

(2017) P Steullet et al.   MOLECULAR PSYCHIATRY

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Major histocompatibility complex class I molecules protect motor neurons from astrocyte-induced toxicity in amyotrophic lateral sclerosis

(2016) SungWon Song et al.   NATURE MEDICINE

Insensitivity of astrocytes to interleukin 10 signaling following peripheral immune challenge results in prolonged microglial activation in the aged brain

(2016) Diana M. Norden et al.   NEUROBIOLOGY OF AGING

Energy deficit in parvalbumin neurons leads to circuit dysfunction, impaired sensory gating and social disability

(2016) Melis Inan et al.   NEUROBIOLOGY OF DISEASE

Phosphoproteomics of the Dopamine Pathway Enables Discovery of Rap1 Activation as a Reward Signal In Vivo

(2016) Taku Nagai et al.   NEURON

MHC-I and PirB Upregulation in the Central and Peripheral Nervous System following Sciatic Nerve Injury

(2016) André Luis Bombeiro et al.   PLoS One

Major Histocompatibility Complex class I proteins are critical for maintaining neuronal structural complexity in the aging brain

(2016) Maciej J. Lazarczyk et al.   Scientific Reports

Elimination of microglia improves cognitive function following cranial irradiation

(2016) Munjal M. Acharya et al.   Scientific Reports

Depressive symptoms as a side effect of Interferon-α therapy induced by induction of indoleamine 2,3-dioxygenase 1

(2016) Yuki Murakami et al.   Scientific Reports

Early Postnatal Lipopolysaccharide Exposure Leads to Enhanced Neurogenesis and Impaired Communicative Functions in Rats

(2016) Yi Pang et al.   PLoS One

A distinct brain pathway links viral RNA exposure to sickness behavior

(2016) Xinxia Zhu et al.   Scientific Reports

Indoleamine 2,3-dioxygenase-dependent neurotoxic kynurenine metabolism mediates inflammation-induced deficit in recognition memory

(2015) Jillian M. Heisler et al.   BRAIN BEHAVIOR AND IMMUNITY

Viral sensing at the blood-brain barrier: New roles for innate immunity at the CNS vasculature

(2015) BP Daniels et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Prenatal Nicotine Exposure Impairs the Proliferation of Neuronal Progenitors, Leading to Fewer Glutamatergic Neurons in the Medial Prefrontal Cortex

(2015) Yuki Aoyama et al.   NEUROPSYCHOPHARMACOLOGY

CD99 regulates neural differentiation of Ewing sarcoma cells through miR-34a-Notch-mediated control of NF-κB signaling

(2015) S Ventura et al.   ONCOGENE

Knocking on Closed Doors: Host Interferons Dynamically Regulate Blood-Brain Barrier Function during Viral Infections of the Central Nervous System

(2015) Brian P. Daniels et al.   PLoS Pathogens

Neuroinflammation in Parkinson’s disease and its potential as therapeutic target

(2015) Qinqin Wang et al.   Translational Neurodegeneration

Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease

(2014) Min Shi et al.   ACTA NEUROPATHOLOGICA

The pro-inflammatory cytokine interferon-gamma is an important driver of neuropathology and behavioural sequelae in experimental pneumococcal meningitis

(2014) L.K. Too et al.   BRAIN BEHAVIOR AND IMMUNITY

Matrix metalloproteinase-3 is a possible mediator of neurodevelopmental impairment due to polyI:C-induced innate immune activation of astrocytes

(2014) Shinnosuke Yamada et al.   BRAIN BEHAVIOR AND IMMUNITY

Neurodegeneration by Activation of the Microglial Complement-Phagosome Pathway

(2014) L.-G. Bodea et al.   JOURNAL OF NEUROSCIENCE

Enhancement of Blood-Brain Barrier Permeability and Reduction of Tight Junction Protein Expression Are Modulated by Chemokines/Cytokines Induced by Rabies Virus Infection

(2014) Q. Chai et al.   JOURNAL OF VIROLOGY

Synapse elimination and learning rules co-regulated by MHC class I H2-Db

(2014) Hanmi Lee et al.   NATURE

Brain Interleukin-1β and the Intrinsic Receptor Antagonist Control Peripheral Toll-Like Receptor 3-Mediated Suppression of Spontaneous Activity in Rats

(2014) Masanori Yamato et al.   PLoS One

Functional Deficiency of MHC Class I Enhances LTP and Abolishes LTD in the Nucleus Accumbens of Mice

(2014) Mitsuhiro Edamura et al.   PLoS One

Minocycline improves recognition memory and attenuates microglial activation in Gunn rat: A possible hyperbilirubinemia-induced animal model of schizophrenia

(2014) Kristian Liaury et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration

(2014) Carolina Cebrián et al.   Nature Communications

The spatio-temporal expression of MHC class I molecules during human hippocampal formation development

(2013) Aifeng Zhang et al.   BRAIN RESEARCH

Astroglial IFITM3 mediates neuronal impairments following neonatal immune challenge in mice

(2013) Daisuke Ibi et al.   GLIA

MHCI Requires MEF2 Transcription Factors to Negatively Regulate Synapse Density during Development and in Disease

(2013) B. M. Elmer et al.   JOURNAL OF NEUROSCIENCE

MHC class I immune proteins are critical for hippocampus-dependent memory and gate NMDAR-dependent hippocampal long-term depression

(2013) P. A. Nelson et al.   LEARNING & MEMORY

Systemic Immune Activation Leads to Neuroinflammation and Sickness Behavior in Mice

(2013) Steven Biesmans et al.   MEDIATORS OF INFLAMMATION

Postsynaptic FMRP bidirectionally regulates excitatory synapses as a function of developmental age and MEF2 activity

(2013) Tong Zang et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Neuroprotection from Stroke in the Absence of MHCI or PirB

(2012) Jaimie D. Adelson et al.   NEURON

TNF-α Affects Human Cortical Neural Progenitor Cell Differentiation through the Autocrine Secretion of Leukemia Inhibitory Factor

(2012) Xiqian Lan et al.   PLoS One

Major histocompatibility complex class I proteins in brain development and plasticity

(2012) Bradford M. Elmer et al.   TRENDS IN NEUROSCIENCES

Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential

(2011) Mark L. Hanke et al.   CLINICAL SCIENCE

Neocortical excitation/inhibition balance in information processing and social dysfunction

(2011) Ofer Yizhar et al.   NATURE

MHCI negatively regulates synapse density during the establishment of cortical connections

(2011) Marian W Glynn et al.   NATURE NEUROSCIENCE

A Potential Role for Shed Soluble Major Histocompatibility Class I Molecules as Modulators of Neurite Outgrowth

(2011) Lorraine R. Washburn et al.   PLoS One

Neuroinflammation in schizophrenia especially focused on the role of microglia

(2011) Akira Monji et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Chronic restraint stress impairs neurogenesis and hippocampus-dependent fear memory in mice: possible involvement of a brain-specific transcription factor Npas4

(2010) Jaesuk Yun et al.   JOURNAL OF NEUROCHEMISTRY

Differential expression of interferon-γ receptor on human glial cells in vivo and in vitro

(2010) Sadayuki Hashioka et al.   JOURNAL OF NEUROIMMUNOLOGY

Japanese Encephalitis Virus Utilizes the Canonical Pathway To Activate NF- B but It Utilizes the Type I Interferon Pathway To Induce Major Histocompatibility Complex Class I Expression in Mouse Embryonic Fibroblasts

(2010) S. Abraham et al.   JOURNAL OF VIROLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

MHC class I modulates NMDA receptor function and AMPA receptor trafficking

(2010) L. Fourgeaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combined effect of neonatal immune activation and mutant DISC1 on phenotypic changes in adulthood

(2009) Daisuke Ibi et al.   BEHAVIOURAL BRAIN RESEARCH

Molecular Mechanisms of IFN-γ to Up-Regulate MHC Class I Antigen Processing and Presentation

(2009) Fang Zhou   INTERNATIONAL REVIEWS OF IMMUNOLOGY

The HLA genomic loci map: expression, interaction, diversity and disease

(2009) Takashi Shiina et al.   JOURNAL OF HUMAN GENETICS

Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals

(2009) H. Wake et al.   JOURNAL OF NEUROSCIENCE

Primary support cultures of hippocampal and substantia nigra neurons

(2009) Thomas Fath et al.   Nature Protocols

MHC Class I: An Unexpected Role in Neuronal Plasticity

(2009) Carla J. Shatz   NEURON

Neonatal polyI:C treatment in mice results in schizophrenia-like behavioral and neurochemical abnormalities in adulthood

(2009) Daisuke Ibi et al.   NEUROSCIENCE RESEARCH

Acute in vivo exposure to interferon-  enables resident brain dendritic cells to become effective antigen presenting cells

(2009) A. Gottfried-Blackmore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of MHC Class I Assembly and Peptide Binding

(2008) David R. Peaper et al.   Annual Review of Cell and Developmental Biology

Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia

(2008) Christopher J Henry et al.   Journal of Neuroinflammation

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE