Article
Nutrition & Dietetics
Yuning Pang, Xiang Xu, Xiaojun Xiang, Yongnan Li, Zengqi Zhao, Jiamin Li, Shengnan Gao, Qiangde Liu, Kangsen Mai, Qinghui Ai
Summary: The study revealed that the impact of high-fat diet or oleic acid on liver fat deposition mechanism may be related to the role of AICAR and activation of O-GlcNAcylation, thereby affecting the AMPK/ACC pathway to regulate lipid synthesis, emphasizing the importance of ACC in lipid homeostasis.
Article
Biotechnology & Applied Microbiology
Andrea L. Livieri, Facundo Colaccini, Martin A. Hernandez, Gabriela Gago, Hector M. Alvarez, Hugo Gramajo, Eduardo Rodriguez
Summary: In actinomycetes, acyl-CoA carboxylases (ACCs) are biotin-dependent enzymes with diverse structures and functions. Rhodococcus jostii RHA1 was found to have multiple putative ACC domains and subunits. Mutant strains with specific genes disrupted showed the importance of these genes in lipid biosynthesis and growth.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sijia Chen, Weidong Ye, Kendall D. Clements, Ziye Zan, Weishan Zhao, Hong Zou, Guitang Wang, Shangong Wu
Summary: In this study, it was found that Bacillus licheniformis FA6 can alter the gut microbiota composition of zebrafish and increase lipid accumulation. Moreover, it was shown that B. licheniformis FA6 promotes acetate production, leading to increased acetyl-CoA levels and lipid synthesis in the liver. Additionally, B. licheniformis FA6 downregulates genes involved in fatty acid beta-oxidation, thereby reducing fatty acid oxidation in the liver.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Camille J. Devereux, Jacqueline Bayliss, Stacey N. Keenan, Magdalene K. Montgomery, Matthew J. Watt
Summary: The dysregulation of hepatic lipid metabolism is a characteristic feature of nonalcoholic fatty liver disease. In this study, dual inhibition of the de novo lipogenesis enzyme, ACC, and the hepatic deletion of the fatty acid transporter, CD36, was found to be ineffective for the treatment of NAFLD in mice.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Agriculture, Multidisciplinary
Buli Su, Peixuan Lai, Fan Yang, Anzhang Li, Ming-Rong Deng, Honghui Zhu
Summary: This study developed a novel method to increase the supply of acetyl-CoA in Saccharomyces cerevisiae and improve the production of downstream products. By optimizing metabolic pathways and conducting genetic engineering, the production of mevalonic acid was successfully increased, and further improvement was achieved by dynamically downregulating gene expression. The final strain produced a high yield of lycopene.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Shaista Nosheen, Tahira Naz, Junhuan Yang, Syed Ammar Hussain, Abu Bakr Ahmad Fazili, Yusuf Nazir, Shaoqi Li, Hassan Mohamed, Wu Yang, Kiren Mustafa, Yuanda Song
Summary: Our study revealed that the Snf-beta gene is crucial in regulating lipid accumulation in M. circinelloides WJ11. By manipulating the Snf-beta gene, we can alter lipid content in the strain. Furthermore, changes in GLA content were observed in Snf-beta knockout and overexpressing strains.
MICROBIAL CELL FACTORIES
(2021)
Article
Biochemistry & Molecular Biology
Siraprapa Siritutsoontorn, Witchuda Sukjoi, Steven W. Polyak, Chareeporn Akekawatchai, Sarawut Jitrapakdee
Summary: HLCS plays a crucial role in breast cancer growth and migration by promoting the biotinylation of carboxylases. Depletion of biotin or reduced expression of HLCS inhibits cell proliferation and migration, leading to apoptosis in breast cancer cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Oncology
Yu Wang, Weixing Yu, Sha Li, Dingyuan Guo, Jie He, Yugang Wang
Summary: Acetyl-CoA carboxylases (ACCs) are enzymes that play important roles in fatty acid synthesis and oxidation. ACC1 and ACC2 are two members of ACCs in mammals, with ACC1 being involved in various diseases such as cancer, diabetes, and obesity. ACC1 also has the ability to influence protein post-translational modifications. Therefore, studying ACC1 can provide insights into disease treatment and the development of specific inhibitors.
FRONTIERS IN ONCOLOGY
(2022)
Article
Entomology
Xiaojin Pei, Tiantian Bai, Yuan Luo, Zhanfeng Zhang, Sheng Li, Yongliang Fan, Tong-Xian Liu
Summary: This study characterizes the role of the BgACC gene in lipid and sugar metabolism in Blattella germanica. Knockdown of BgACC affects insect development and survival, as well as the expression of insulin-like peptide genes. It further demonstrates the interplay between lipid and sugar metabolism.
Article
Biochemistry & Molecular Biology
Takaya Saito, Paul Whatmore, John F. Taylor, Jorge M. O. Fernandes, Anne-Catrin Adam, Douglas R. Tocher, Marit Espe, Kaja H. Skjaerven
Summary: Micronutrients play important roles in growth and metabolism, with studies indicating that increased levels of certain B-vitamins and microminerals are needed when using plant-based diets. Micronutrient supplementation affects hepatic gene expression and DNA methylation levels, showing an important role in lipid metabolism through epigenetic control of gene expression.
Article
Geriatrics & Gerontology
Amy Zheng, Seong Eun Kwak, Jesper B. Birk, Edward B. Arias, Dominic Thorley, Jorgen F. P. Wojtaszewski, Gregory D. Cartee
Summary: This study investigated the impact of caloric restriction (CR) on AMP-activated protein kinase (AMPK) and its substrates in skeletal muscle of older animals. The results revealed that CR significantly increased the phosphorylation of AMPK and several AMPK substrates, suggesting a potential role of AMPK in the antiaging effects of CR.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Yong Yu, Qingzhu Nie, Ziyi Wang, Yu Di, Xiaolong Chen, Kaiming Ren
Summary: Metabolic adaptation in tumors is heavily influenced by fatty acid synthesis, with acetyl-CoA carboxylase 1 playing a crucial role. This enzyme is involved in the production of fatty acids and has potential therapeutic implications for metabolic diseases and anti-tumor therapy.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hiroyuki Takagi, Tatsuya Ikehara, Kumi Hashimoto, Keiichi Tanimoto, Atsuyuki Shimazaki, Yuto Kashiwagi, Shingo Sakamoto, Hideo Yukioka
Summary: ACC2 inhibition reduces diacylglycerol and ceramide accumulation in skeletal muscle, improving insulin resistance in normal and diabetic rats. The metabolic improvements and delayed diabetes progression were strongly correlated with reductions in bioactive lipids.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Weijing He, Qingguo Li, Xinxiang Li
Summary: Acetyl-CoA is an important molecule that participates in multiple intracellular metabolic reactions and affects protein post-translational modification, playing a key role in cell metabolism and epigenetic inheritance. In cancer, extensive lipid metabolism and histone acetylation are required for cancer cell growth and expression of cancer-promoting genes. Acetyl-CoA, as a raw material for lipid synthesis and histone acetylation, has a major impact on lipid metabolism and histone acetylation in cancer. Moreover, acetyl-CoA connects lipid metabolism with histone acetylation, forming a complex regulatory mechanism that influences cancer growth, proliferation, and metastasis.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Orthopedics
Huanhuan Liu, Luke Witzigreuter, Roshini Sathiaseelan, Martin-Paul Agbaga, Richard S. Brush, Michael B. Stout, Shouan Zhu
Summary: Obesity promotes the development of osteoarthritis by increasing lipid deposition in cartilage. This study provides evidence that inhibiting de novo lipogenesis may be a potential treatment for obesity-associated osteoarthritis.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Fisheries
Yi-Fan Tao, Jun Qiang, Guo-Jun Yin, Pao Xu, Qiong Shi, Jing-Wen Bao
FISH & SHELLFISH IMMUNOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Rui Jia, Yao Li, Liping Cao, Jinliang Du, Tao Zheng, Hao Qian, Zhengyan Gu, Galina Jeney, Pao Xu, Guojun Yin
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2019)
Article
Fisheries
Rui Jia, Jinliang Du, Liping Cao, Yao Li, Opigo Johnson, Zhengyan Gu, Galina Jeney, Pao Xu, Guojun Yin
FISH & SHELLFISH IMMUNOLOGY
(2019)
Article
Fisheries
Rui Jia, Zhengyan Gu, Qin He, Jinliang Du, Liping Cao, Galina Jeney, Pao Xu, Guojun Yin
FISH & SHELLFISH IMMUNOLOGY
(2019)
Article
Fisheries
Yi-Fan Tao, Jun Qiang, Jie He, Hao-Jun Zhu, Jing-Wen Bao, Pao Xu
Summary: Fatty liver commonly occurs in intensively farmed tilapia, leading to impairments in hepatic lipid metabolism and disruptions to protein and carbohydrate metabolism. In this study, high-fat diet fed tilapia accumulated more fat in the liver compared to normal-fat diet fed tilapia, with differential accumulation of 36 metabolites between the two groups. These metabolic disorders may be related to the lower growth rate observed in high-fat diet fed tilapia.
AQUACULTURE RESEARCH
(2021)
Article
Environmental Sciences
Zhengyan Gu, Rui Jia, Qin He, Liping Cao, Jinliang Du, Wenrong Feng, Galina Jeney, Pao Xu, Guojun Yin
Summary: The research demonstrated that BPA exposure disrupted lipid metabolism, induced oxidative stress, ERS, apoptosis, autophagy, and inflammatory response in the liver of common carp.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Fisheries
Yi-Fan Tao, Jun Qiang, Missinhoun Dagoudo, Hao-Jun Zhu, Jing-Wen Bao, Jun-Lei Ma, Ming-Xiao Li, Pao Xu
Summary: The study compared transcriptomic and physiological changes in gill tissues of hybrid yellow catfish under hypoxic and control conditions. Exposure to hypoxic conditions increased anaerobic metabolism and decreased antioxidant and immune capacity in gill tissues.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yifan Tao, Yifan Pan, Qingchun Wang, Siqi Lu, Yan Li, Wenting Liu, Tao Zheng, Bei Wang, Jun Qiang, Pao Xu
Summary: Aquaculture feed containing olive oil (OO) instead of fish oil (FO) can cause oxidative stress and impair gonad development in fish. This study investigated the effect of dietary OO-induced oxidative stress on ovarian development and found that supplementation with vitamin E (VE) could mitigate the negative effects. OO reduced growth rate, inhibited antioxidant enzymes, delayed ovarian development, decreased sex hormone levels, and affected lipid metabolism in fish. However, supplementation with VE improved antioxidant capacity, alleviated inflammation and abnormal lipid metabolism, possibly through regulating the nrf2-nf-kb signaling pathway.
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.