CD47 is a novel potent immunotherapy target in human malignancies: current studies and future promises

Toxicity profiles of immunotherapy

(2018) S. Cousin et al.   PHARMACOLOGY & THERAPEUTICS

Cancer immunotherapy targeting the CD47/SIRPα axis

(2017) Kipp Weiskopf   EUROPEAN JOURNAL OF CANCER

The CD47-SIRPα signaling axis as an innate immune checkpoint in cancer

(2017) Hanke L. Matlung et al.   IMMUNOLOGICAL REVIEWS

Tumor-associated macrophages: implications in cancer immunotherapy

(2017) Amy J Petty et al.   Immunotherapy

PD-L1 expression as a predictive biomarker in advanced non-small-cell lung cancer: updated survival data

(2017) Pedro N Aguiar et al.   Immunotherapy

Programmed Death-Ligand 1 Immunohistochemistry Testing: A Review of Analytical Assays and Clinical Implementation in Non–Small-Cell Lung Cancer

(2017) Reinhard Büttner et al.   JOURNAL OF CLINICAL ONCOLOGY

Selective Blockade of the Ubiquitous Checkpoint Receptor CD47 Is Enabled by Dual-Targeting Bispecific Antibodies

(2017) Elie Dheilly et al.   MOLECULAR THERAPY

Localized CD47 blockade enhances immunotherapy for murine melanoma

(2017) Jessica R. Ingram et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disrupting the CD47-SIRPα anti-phagocytic axis by a humanized anti-CD47 antibody is an efficacious treatment for malignant pediatric brain tumors

(2017) Sharareh Gholamin et al.   Science Translational Medicine

Significance of CD47 expression in gastric cancer

(2017) Tomoya Sudo et al.   Oncology Letters

Anti-leukemic activity and tolerability of anti-human CD47 monoclonal antibodies

(2017) E C Pietsch et al.   Blood Cancer Journal

Effectiveness and safety of PD-1/PD-L1 inhibitors in the treatment of solid tumors: a systematic review and meta-analysis

(2017) Xiaohui Wang et al.   Oncotarget

Anti-CD47 antibodies induce phagocytosis of live, malignant B cells by macrophages via the Fc domain, resulting in cell death by phagoptosis

(2017) Lucy E. Métayer et al.   Oncotarget

CD47 promotes ovarian cancer progression by inhibiting macrophage phagocytosis

(2017) Ran Liu et al.   Oncotarget

CD20-selective inhibition of CD47-SIRPα “don't eat me” signaling with a bispecific antibody-derivative enhances the anticancer activity of daratumumab, alemtuzumab and obinutuzumab

(2017) Peter E. van Bommel et al.   OncoImmunology

How do red blood cells know when to die?

(2017) Clemente Fernandez Arias et al.   Royal Society Open Science

CD47 surface stability is sensitive to actin disruption prior to inclusion within the band 3 macrocomplex

(2017) Kathryn E. Mordue et al.   Scientific Reports

Targeting myeloid cells in the tumor sustaining microenvironment

(2017) Jonathan Schupp et al.   CELLULAR IMMUNOLOGY

TSP1–CD47 signaling is upregulated in clinical pulmonary hypertension and contributes to pulmonary arterial vasculopathy and dysfunction

(2016) Natasha M. Rogers et al.   CARDIOVASCULAR RESEARCH

TTI-621 (SIRPαFc): A CD47-Blocking Innate Immune Checkpoint Inhibitor with Broad Antitumor Activity and Minimal Erythrocyte Binding

(2016) Penka S. Petrova et al.   CLINICAL CANCER RESEARCH

PD-1/PD-L1 blockade in cancer treatment: perspectives and issues

(2016) Junzo Hamanishi et al.   International Journal of Clinical Oncology

CD47-blocking immunotherapies stimulate macrophage-mediated destruction of small-cell lung cancer

(2016) Kipp Weiskopf et al.   JOURNAL OF CLINICAL INVESTIGATION

Relationship between tumor-associated macrophage subsets and CD47 expression in squamous cell carcinoma of the head and neck in the tumor microenvironment

(2016) Koichi Sakakura et al.   LABORATORY INVESTIGATION

Durable antitumor responses to CD47 blockade require adaptive immune stimulation

(2016) Jonathan T. Sockolosky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MYC regulates the antitumor immune response through CD47 and PD-L1

(2016) S. C. Casey et al.   SCIENCE

A function-blocking CD47 antibody suppresses stem cell and EGF signaling in triple-negative breast cancer

(2016) Sukhbir Kaur et al.   Oncotarget

Anti-CD47 Treatment Stimulates Phagocytosis of Glioblastoma by M1 and M2 Polarized Macrophages and Promotes M1 Polarized Macrophages In Vivo

(2016) Michael Zhang et al.   PLoS One

Antibody mediated therapy targeting CD47 inhibits tumor progression of hepatocellular carcinoma

(2015) Zhenyu Xiao et al.   CANCER LETTERS

Immune checkpoint blockade opens an avenue of cancer immunotherapy with a potent clinical efficacy

(2015) Keishi Adachi et al.   CANCER SCIENCE

CD47 protein expression in acute myeloid leukemia: A tissue microarray-based analysis

(2015) Serena Galli et al.   LEUKEMIA RESEARCH

A bispecific antibody targeting CD47 and CD20 selectively binds and eliminates dual antigen expressing lymphoma cells

(2015) Emily C Piccione et al.   mAbs

CD47 blockade triggers T cell–mediated destruction of immunogenic tumors

(2015) Xiaojuan Liu et al.   NATURE MEDICINE

Macrophages eat cancer cells using their own calreticulin as a guide: Roles of TLR and Btk

(2015) Mingye Feng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD47 is an adverse prognostic factor and a therapeutic target in gastric cancer

(2015) Kazumichi Yoshida et al.   Cancer Medicine

Pre-Clinical Development of a Humanized Anti-CD47 Antibody with Anti-Cancer Therapeutic Potential

(2015) Jie Liu et al.   PLoS One

Bispecific antibody platforms for cancer immunotherapy

(2014) Roeland Lameris et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Signal-regulatory proteinαfrom the NOD mouse binds human CD47 with an exceptionally high affinity - implications for engraftment of human cells

(2014) Lai Shan Kwong et al.   IMMUNOLOGY

Therapeutic use of anti-CTLA-4 antibodies

(2014) C. U. Blank et al.   INTERNATIONAL IMMUNOLOGY

The CD47-SIRP  signalling system: its physiological roles and therapeutic application

(2014) Y. Murata et al.   JOURNAL OF BIOCHEMISTRY

CD47 Signaling Regulates the Immunosuppressive Activity of VEGF in T Cells

(2014) Sukhbir Kaur et al.   JOURNAL OF IMMUNOLOGY

Development and function of human innate immune cells in a humanized mouse model

(2014) Anthony Rongvaux et al.   NATURE BIOTECHNOLOGY

Ratio of Intratumoral Macrophage Phenotypes Is a Prognostic Factor in Epithelioid Malignant Pleural Mesothelioma

(2014) Robin Cornelissen et al.   PLoS One

The Interaction Between Signal Regulatory Protein Alpha (SIRPα) and CD47: Structure, Function, and Therapeutic Target

(2013) A. Neil Barclay et al.   Annual Review of Immunology

CD47 and Osteopontin Expression in Diffuse Large B-cell Lymphoma With Nodal and Intravascular Involvement

(2013) Jason S. Starr et al.   Clinical Lymphoma Myeloma & Leukemia

Engineered SIRP  Variants as Immunotherapeutic Adjuvants to Anticancer Antibodies

(2013) K. Weiskopf et al.   SCIENCE

CD47 update: a multifaceted actor in the tumour microenvironment of potential therapeutic interest

(2012) E Sick et al.   BRITISH JOURNAL OF PHARMACOLOGY

The CD47–SIRPα pathway in cancer immune evasion and potential therapeutic implications

(2012) Mark P Chao et al.   CURRENT OPINION IN IMMUNOLOGY

In Vitro Generation of Monocyte-Derived Macrophages under Serum-Free Conditions Improves Their Tumor Promoting Functions

(2012) Flora Rey-Giraud et al.   PLoS One

Transgenic expression of human signal regulatory protein alpha in Rag2−/−γc−/−mice improves engraftment of human hematopoietic cells in humanized mice

(2011) Till Strowig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-CD47 Antibody Synergizes with Rituximab to Promote Phagocytosis and Eradicate Non-Hodgkin Lymphoma

(2010) Mark P. Chao et al.   CELL

Thrombospondin-1 Inhibits VEGF Receptor-2 Signaling by Disrupting Its Association with CD47

(2010) Sukhbir Kaur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis

(2009) Siddhartha Jaiswal et al.   CELL

Association of CD47 with Natural Killer Cell-Mediated Cytotoxicity of Head-and-Neck Squamous Cell Carcinoma Lines

(2008) Min Jung Kim et al.   TUMOR BIOLOGY