Article
Nutrition & Dietetics
Penny M. Kremer, Daniel J. Torres, Ann C. Hashimoto, Marla J. Berry
Summary: Selenium is an essential micronutrient that plays a crucial role in antioxidant defense and supporting various biological functions. Mice with genetic deficiencies related to selenium display sexual dimorphic neurological deficits, with females showing signs of hyper-adiposity, a metabolic phenotype that can be reversed by restricting selenium intake at specific periods.
FRONTIERS IN NUTRITION
(2021)
Article
Biotechnology & Applied Microbiology
Meyli Claudia Escobar-Ramirez, Gabriela Mariana Rodriguez-Serrano, Eduardo Zuniga-Leon, Mario Adolfo Garcia-Montes, Emmanuel Perez-Escalante, Luis Guillermo Gonzalez-Olivares
Summary: Lactic acid bacteria (LAB) exhibit resistance to sodium selenite concentrations above 100 mg/L. This study confirmed the presence of selenocysteine in Enterococcus faecium ABMC-05. The microorganism was cultured in a medium with a minimum inhibitory concentration of 184 mg/L sodium selenite, and the absorption of selenium and its conversion into selenocysteine were determined using ICP-OES and RP-HPLC, respectively. PCR analysis revealed the presence of the cysK gene and the absence of the selD and selA genes. The results demonstrate that this microorganism produces selenocysteine through a pathway independent of SelA and SelD, unlike other LAB.
FERMENTATION-BASEL
(2023)
Article
Nutrition & Dietetics
Kaitlin Day, Lucia A. Seale, Ross M. Graham, Barbara R. Cardoso
Summary: Observational studies suggest that selenium may be involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), with the possibility of lower selenium levels in the liver of NAFLD patients due to increased consumption. Variations in gene expression may be associated with the progressive risk of NAFLD, with differences in gene expression levels in certain selenoprotein pathways between NAFLD patients and healthy individuals.
FRONTIERS IN NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Waldemar B. Minich
Summary: Selenium is an essential trace element that plays a significant role in human health. It is involved in the synthesis of selenoproteins, which have diverse functions such as antioxidant activity and participation in thyroid hormone synthesis. Optimizing selenium intake is crucial for preventing diseases associated with selenium deficiency or excess.
BIOCHEMISTRY-MOSCOW
(2022)
Article
Chemistry, Multidisciplinary
Junyan Ma, Yaoyu Xu, Wen Zhao, Beibei Wang, Chunhuan Zhang, Zhenxing Zhang
Summary: Researchers have developed a Tag-Sec fluorescent probe that can detect both thioredoxin reductase and selenocysteine with high sensitivity and selectivity, along with broad pH tolerance and good water solubility. This concept may serve as a useful guide for designing probes for detecting Sec-containing proteins in clinical diagnosis.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Review
Chemistry, Medicinal
Kainat Ahmed, Ghayoor Abbas Chotana, Amir Faisal, Rahman Shah Zaib Saleem
Summary: This article summarizes the synthetic methodologies of selenium-containing peptides and provides a brief description of their chemistry and biological activities. These methodologies enable the access to various natural and unnatural selenium-containing peptides that have been used in a range of applications, from modulating protein characteristics to structure-activity relationship studies for applications in nutraceuticals and drug development.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2023)
Review
Endocrinology & Metabolism
Giulia Lanzolla, Michele Marino, Claudio Marcocci
Summary: Selenium has been proposed as a therapy for Graves' hyperthyroidism and Graves' Orbitopathy, with studies showing potential benefits in patients with mild eye disease. Although the effectiveness of selenium in severe cases of Graves' Orbitopathy remains uncertain, its use is generally believed to be beneficial in clinical practice for patients with mild eye disease.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Claire Hogan, Anthony V. Perkins
Summary: Selenium is an essential trace element for human health, and deficiency can lead to various diseases. Selenium is incorporated into selenoproteins, which play important roles in antioxidant defense, signaling, hormone production, DNA synthesis, and protein response. This review highlights the importance of selenium for a healthy pregnancy and the role of placental selenoproteins in early life development.
Article
Biochemistry & Molecular Biology
Luz Marina Sanchez-Mendoza, Carlos Perez-Sanchez, Sandra Rodriguez-Lopez, Chary Lopez-Pedrera, Miguel Calvo-Rubio, Rafael de Cabo, Maria I. Buron, Jose A. Gonzalez-Reyes, Jose M. Villalba
Summary: The study investigates the effect of sex on metabolic adaptations induced by overexpression of CYB5R3 and the modulation of key markers related to mitochondrial function in skeletal muscle. It was found that CYB5R3 overexpression leads to enhanced mitochondrial biogenesis and function, as well as increased mitochondrial abundance in skeletal muscle. These beneficial actions are predominantly observed in females, with differences in NADH levels and the abundance of cytochrome c and DRP-1. The results also show ultrastructural changes in transgenic females, including an increase in the number and size of mitochondria.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Plant Sciences
Tao Liu, Xiaoting Liu, Rangrang Zhou, Hong Chen, Huaigang Zhang, Bo Zhang
Summary: Selenium is shown to have a significant impact on gene expression in oats, particularly in key genes related to selenate metabolism. The study identified 27 unigenes associated with selenate metabolism, with key genes exhibiting dramatic upregulation under selenate treatment. The research provides insights into the mechanisms underlying selenium uptake and metabolism in oats under high-selenium conditions.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Multidisciplinary Sciences
Emily C. Moore, Patrick J. Ciccotto, Erin N. Peterson, Melissa S. Lamm, R. Craig Albertson, Reade B. Roberts
Summary: For many vertebrates, a single genetic locus initiates a cascade of developmental sex differences, resulting in adults with two phenotypically distinct sexes. However, species with polygenic sex determination have multiple interacting sex determination alleles, allowing for more than two genotypic sexes. In the cichlid fish Metriaclima mbenjii, polygenic sex determination produces modular variation in morphological and behavioral traits, and the evolution or introgression of a newly acquired sex determiner creates additional axes of phenotypic variation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Biology
Nicolas Perrin
Summary: Studies on two families of amphibians, Ranidae and Hylidae, show that sex-antagonistic (SA) genes do not play a significant role in the evolutionary dynamics of their sex chromosomes. Instead, neutral processes and deleterious mutations are found to be more central in driving the evolution of sex chromosomes in these groups.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Petra A. Tsuji, Didac Santesmasses, Byeong J. Lee, Vadim N. Gladyshev, Dolph L. Hatfield
Summary: Selenium is an essential element in the diet and has many health benefits, such as preventing heart disease and cancer, supporting male reproduction, and boosting the immune system. It plays important roles in the molecular biology of organisms and its incorporation into proteins is a unique feature. Research has focused on selenium's role in cancer prevention and its potential involvement in various diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Joseph A. Pinto, Jhajaira M. Araujo, Henry L. Gomez
Summary: The composition of the tumor microenvironment is influenced by the interaction between tumoral and host factors, with sex differences mainly regulated by sex hormones affecting tumor-host interaction and immune system sexual dimorphism. Sex-specific differences exist in cancer susceptibility, treatment response, and the importance of sex as a biomarker in cancer therapy has recently gained attention due to varying results in immunotherapy treatment.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Plant Sciences
Zhenjun Li, Yongsheng Tian, Bo Wang, Rihe Peng, Jing Xu, Xiaoyan Fu, Hongjuan Han, Lijuan Wang, Wenhui Zhang, Yongdong Deng, Yu Wang, Zehao Gong, Jianjie Gao, Quanhong Yao
Summary: This study successfully redirected selenium flow in rice by overexpressing the genes encoding selenocysteine lyase and selenocysteine methyltransferase. Transgenic plants showed lower sensitivity to selenium stress and increased tolerance to selenate and selenite, as well as improved selenium elimination capabilities. These findings suggest that genetically modified plants have the potential to restore selenium-contaminated environments.
JOURNAL OF PLANT PHYSIOLOGY
(2022)
Article
Nutrition & Dietetics
Lucia A. Seale, Vedbar S. Khadka, Mark Menor, Guoxiang Xie, Ligia M. Watanabe, Alexandru Sasuclark, Kyrillos Guirguis, Herena Y. Ha, Ann C. Hashimoto, Karolina Peplowska, Maarit Tiirikainen, Wei Jia, Marla J. Berry, Youping Deng
Article
Biochemistry & Molecular Biology
Lucia A. Seale, Ashley N. Ogawa-Wong, Ligia M. Watanabe, Vedbar S. Khadka, Mark Menor, Daniel J. Torres, Bradley A. Carlson, Dolph L. Hatfield, Marla J. Berry
Summary: Selenoproteins are proteins containing the selenium-containing amino acid selenocysteine and play important roles in various tissues. Mouse models with targeted deletion of Trsp in brown adipocytes showed increased triglyceride accumulation in BAT and mild hypothyroidism in males, with no significant changes in adaptive thermogenesis markers under acute cold exposure. The loss of Trsp affected specific gene transcripts in BAT, suggesting a role in thyroid hormone dysfunction in brown adipocytes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ligia M. Watanabe, Ann C. Hashimoto, Daniel J. Torres, Marla J. Berry, Lucia A. Seale
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2020)
Article
Cell Biology
Ligia M. Watanabe, Ann C. Hashimoto, Daniel J. Torres, Naghum Alfulaij, Rafael Peres, Razvan Sultana, Alika K. Maunakea, Marla J. Berry, Lucia A. Seale
Summary: This study investigated the effects of statins on hepatic and muscular selenoprotein expression, oxidative stress, and creatine metabolism, revealing a sex-dependent role of selenium in statin responses.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Review
Nutrition & Dietetics
Ligia M. Watanabe, Anderson M. Navarro, Lucia A. Seale
Summary: Obesity is a major health concern in developing countries like Brazil, where approximately one quarter of the population is obese. The combination of obesity, selenium deficiency, and statin treatment poses significant challenges to public health in Brazil.
Review
Biochemistry & Molecular Biology
Briana K. Shimada, Naghum Alfulaij, Lucia A. Seale
Summary: Selenium is an essential trace element crucial for cardiovascular health through its incorporation into selenoproteins, which are key to maintaining proper cardiovascular function. Deficiency in selenium can lead to various cardiovascular diseases, and selenium may potentially serve as a complementary therapy for prevention or treatment of cardiovascular disease by interacting with microRNAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Daniel J. Torres, Matthew W. Pitts, Lucia A. Seale, Ann C. Hashimoto, Katlyn J. An, Ashley N. Hanato, Katherine W. Hui, Stella Maris A. Remigio, Bradley A. Carlson, Dolph L. Hatfield, Marla J. Berry
Summary: Selenium plays a crucial role in hypothalamic physiology by supporting leptin signaling and maintaining proper redox balance. Knockout mice of the selenocysteine tRNA gene showed less weight gain on a high-fat diet, with female mice retaining hypothalamic sensitivity to leptin while males were unaffected, indicating a sexually dimorphic influence of selenium on neurobiology and energy homeostasis. These findings provide new insights into the impact of selenoproteins on a specific population of hypothalamic neurons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Lucia A. Seale, Christy L. Gilman, Ann Marie Zavacki, P. Reed Larsen, Mayu Inokuchi, Jason P. Breves, Andre P. Seale
Summary: The study indicates that thyroid hormones play a crucial role in the adaptation of Mozambique tilapia to freshwater environments by interacting with branchial deiodinases to modulate their activities. External osmotic conditions do not directly affect the gene expression of branchial deiodinases, while systemic signals may stimulate thyroid hormone metabolism.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Kaitlin Day, Lucia A. Seale, Ross M. Graham, Barbara R. Cardoso
Summary: Observational studies suggest that selenium may be involved in the pathogenesis of non-alcoholic fatty liver disease (NAFLD), with the possibility of lower selenium levels in the liver of NAFLD patients due to increased consumption. Variations in gene expression may be associated with the progressive risk of NAFLD, with differences in gene expression levels in certain selenoprotein pathways between NAFLD patients and healthy individuals.
FRONTIERS IN NUTRITION
(2021)
Editorial Material
Nutrition & Dietetics
Barbara R. Cardoso, Cristiane Cominetti, Lucia A. Seale
FRONTIERS IN NUTRITION
(2022)
Review
Public, Environmental & Occupational Health
Ligia M. Watanabe, Lucia A. Seale
Summary: Cardiometabolic disorders are a major health concern in the United States, particularly among indigenous populations like Native Hawaiian and Other Pacific Islanders. High-intensity statin therapy can prevent cardiovascular disease, but it also comes with side effects. Different ethnic groups may experience variations in statin side effects due to sociodemographic, behavioral, and/or biological factors.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Briana K. Shimada, Ligia M. Watanabe, Sydonie Swanson, Pamela Toh, Lucia A. Seale
Summary: Selenium plays a role in energy metabolism, particularly in brown and beige adipocytes. The selenoprotein DIO2 is crucial for activating adaptive thermogenesis, and other selenoproteins may also be involved. This review discusses the involvement of selenium metabolism and selenoproteins in the mechanisms of adaptive thermogenesis in brown and beige adipocytes, highlighting the gaps in knowledge.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
Briana Shimada, Sydonie Swanson, Pamela Toh, Daniel Torres, Lucia Seale
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Neurosciences
Pamela Toh, Lucia A. Seale, Marla J. Berry, Daniel J. Torres
Summary: Abnormal activation of the stress-response system in early life can cause long-term neurological changes. High levels of glucocorticoids can promote oxidative damage in the brain. Selenium, an essential trace element, can mitigate this damage by synthesizing antioxidant selenoproteins. This study demonstrates that early life exposure to excess glucocorticoid levels can alter selenoprotein levels in the developing brain.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Katlyn J. An, Ashley N. Hanato, Katherine W. Hui, Matthew W. Pitts, Lucia A. Seale, Jessica L. Nicholson, Pamela Toh, Jun Kyoung Kim, Marla J. Berry, Daniel J. Torres
Summary: The use of glucocorticoid medications can cause metabolic side effects such as overeating, weight gain, and insulin resistance. The hypothalamus, a regulator of feeding behavior and energy expenditure, is responsive to glucocorticoids and may play a role in metabolic defects. Selenium has been found to counter the effects of glucocorticoids and is important for hypothalamic function. This study aimed to investigate if selenium could protect hypothalamic cells from dysfunction caused by glucocorticoid exposure.
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
