期刊
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
卷 21, 期 23, 页码 7072-7075出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmcl.2011.09.090
关键词
c-Jun; JNK; Kinase inhibitor; Phenoxypyridine
The design and synthesis of a novel series of c-jun N-terminal kinase (JNK3) inhibitors is described. The development and optimization of the 2-phenoxypyridine series was carried out from an earlier pyrimidine series of JNK1 inhibitors. Through the optimization of the scaffold 2, several potent compounds with good in vivo profiles were discovered. (C) 2011 Elsevier Ltd. All rights reserved.
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