期刊
FOOD RESEARCH INTERNATIONAL
卷 109, 期 -, 页码 358-367出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.foodres.2018.04.046
关键词
L-NAME; Arginase; Acetylcholinesterase; Adenosine deaminase; Nitric oxide; Tiger nut; Quercetin
资金
- 2015 TWAS/CNPQ sandwich postgraduate fellowship
- Conselho National de Desenvolvimento Cientifico e Tecnologico (CNPq) FR [3240286543]
- Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS)
- Fundacao Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Academy of Sciences for the Developing World (TWAS)
Tiger nut tubers have been reportedly used for the treatment of erectile dysfunction (ED) in folk medicine without scientific basis. Hence, this study evaluated the effect of tiger nut on erectile dysfunction by assessing biochemical parameters relevant to ED in male rats by nitric oxide synthase (NOS) inhibitor, Nco-nitro-L-arginine methyl ester hydrochloride (L-NAME) treatment. Rats were divided into five groups (n = 10) each: Control group; L-NAME plus basal diet; L-NAME plus Sildenafil citrate; diet supplemented processed tiger nut(20%) plus L-NAME;diet supplemented raw tiger nut (20%) plus L-NAME. L-NAME pre-treatment (40 mg/kg/day) lasted for 14 days. Arginase, acetycholinesterase (AChE) and adenosine deaminase (ADA) activities as well as nitric oxide levels (NO) in serum, brain and penile tissue were measured. L-NAME increased the activity of arginase, AChE and ADA and reduced NO levels. However, dietary supplementation with tiger nut caused a reduction on the activities of the above enzymes and up regulated nitric oxide levels when compared to the control group. The effect of tiger nut supplemented diet may be said to prevent alterations of the activities of the enzymes relevant in erectile function. Quercetin was revealed to be the most active component of tiger nut tuber by HPLC finger printing.
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