Photoaffinity labeling in target- and binding-site identification

Alzheimer's Disease and the Amyloid-β Peptide

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

Multivalent Photoaffinity Probe for Labeling Small Molecule Binding Proteins

(2014) Gang Li et al.   BIOCONJUGATE CHEMISTRY

Synthesis and evaluation of effective photoaffinity probe molecule of furospinosulin-1, a hypoxia-selective growth inhibitor

(2014) Naoyuki Kotoku et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Comparison of the Reactivity of Carbohydrate Photoaffinity Probes with Different Photoreactive Groups

(2014) Kaori Sakurai et al.   CHEMBIOCHEM

Chemoproteomic Profiling of Lysine Acetyltransferases Highlights an Expanded Landscape of Catalytic Acetylation

(2014) David C. Montgomery et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mapping the Protein Interaction Landscape for Fully Functionalized Small-Molecule Probes in Human Cells

(2014) Tohru Kambe et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Identification of Malate Dehydrogenase 2 as a Target Protein of the HIF-1 Inhibitor LW6 using Chemical Probes

(2013) Kyeong Lee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Photoaffinity Labeling of Small-Molecule-Binding Proteins by DNA-Templated Chemistry

(2013) Gang Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Design and synthesis of tag-free photoprobes for the identification of the molecular target for CCG-1423, a novel inhibitor of the Rho/MKL1/SRF signaling pathway

(2013) Jessica L Bell et al.   Beilstein Journal of Organic Chemistry

Characterization of the receptor binding residues of kisspeptins by positional scanning using peptide photoaffinity probes

(2013) Ryosuke Misu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fluorophores and Their Applications as Molecular Probes in Living Cells

(2013) Junjia Liu et al.   CURRENT ORGANIC CHEMISTRY

γ-Secretase Modulator (GSM) Photoaffinity Probes Reveal Distinct Allosteric Binding Sites on Presenilin

(2013) Nikolay Pozdnyakov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Specificity of Intersubunit General Anesthetic-binding Sites in the Transmembrane Domain of the Human α1β3γ2 γ-Aminobutyric Acid Type A (GABAA) Receptor

(2013) David C. Chiara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Propofol Binding Sites in a Nicotinic Acetylcholine Receptor with a Photoreactive Propofol Analog

(2013) Selwyn S. Jayakar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Photoaffinity Labeling of Nicotinic Receptors: Diversity of Drug Binding Sites!

(2013) Ayman K Hamouda et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Identification of a Mitochondrial Target of Thiazolidinedione Insulin Sensitizers (mTOT)—Relationship to Newly Identified Mitochondrial Pyruvate Carrier Proteins

(2013) Jerry R. Colca et al.   PLoS One

Thiazolidinediones are acute, specific inhibitors of the mitochondrial pyruvate carrier

(2013) A. S. Divakaruni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Target validation using in-cell small molecule clickable imaging probes

(2013) Brahma Ghosh et al.   MedChemComm

Affinity-based target identification for bioactive small molecules

(2013) Makoto Kawatani et al.   MedChemComm

Presenilins and  -Secretase: Structure, Function, and Role in Alzheimer Disease

(2013) B. De Strooper et al.   Cold Spring Harbor Perspectives in Medicine

Tandem photoaffinity labeling–bioorthogonal conjugation in medicinal chemistry

(2012) David J. Lapinsky   BIOORGANIC & MEDICINAL CHEMISTRY

A Pan Photoaffinity Probe for Detecting Active Forms of Matrix Metalloproteinases

(2012) Catherine Nury et al.   CHEMBIOCHEM

A Peptide Photoaffinity Probe Specific for the Active Conformation of the Abl Tyrosine Kinase

(2012) Yang Deng et al.   CHEMBIOCHEM

Isotope-coded, fluorous photoaffinity labeling reagents

(2012) Zhiquan Song et al.   CHEMICAL COMMUNICATIONS

Molecular Pathways: VCAM-1 as a Potential Therapeutic Target in Metastasis

(2012) Q. Chen et al.   CLINICAL CANCER RESEARCH

Alterations in the ribosomal machinery in cancer and hematologic disorders

(2012) Niraj Shenoy et al.   Journal of Hematology & Oncology

Cell-Based Proteome Profiling of Potential Dasatinib Targets by Use of Affinity-Based Probes

(2012) Haibin Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemical Genetics–Based Target Identification in Drug Discovery

(2011) Feng Cong et al.   Annual Review of Pharmacology and Toxicology

Photoaffinity labeling of Ras converting enzyme using peptide substrates that incorporate benzoylphenylalanine (Bpa) residues: Improved labeling and structural implications

(2011) Kelly Kyro et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Diazirine based photoaffinity labeling

(2011) Luba Dubinsky et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design and synthesis of novel photoaffinity probes for study of the target proteins of oleanolic acid

(2011) Liying Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A novel vascular disrupting agent plinabulin triggers JNK-mediated apoptosis and inhibits angiogenesis in multiple myeloma cells

(2011) A. V. Singh et al.   BLOOD

Aliphatic Diazirines as Photoaffinity Probes for Proteins: Recent Developments

(2011) Joydip Das   CHEMICAL REVIEWS

Multiple Transmembrane Binding Sites forp-Trifluoromethyldiazirinyl-etomidate, a PhotoreactiveTorpedoNicotinic Acetylcholine Receptor Allosteric Inhibitor

(2011) Ayman K. Hamouda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Direct Protein Targets of Small Molecules

(2010) Brett Lomenick et al.   ACS Chemical Biology

Anti-microtubule ‘plinabulin’ chemical probe KPU-244-B3 labeled both α- and β-tubulin

(2010) Yuri Yamazaki et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Principles of early drug discovery

(2010) JP Hughes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Thiazolidinediones/PPARγ agonists and fatty acid synthase inhibitors as an experimental combination therapy for prostate cancer

(2010) Mansour   INTERNATIONAL JOURNAL OF ONCOLOGY

Identification of a Substrate-binding Site in a Peroxisomal β-Oxidation Enzyme by Photoaffinity Labeling with a Novel Palmitoyl Derivative

(2010) Yoshinori Kashiwayama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chemical Probes Identify a Role for Histone Deacetylase 3 in Friedreich's Ataxia Gene Silencing

(2009) Chunping Xu et al.   CHEMISTRY & BIOLOGY

Target profiling of small molecules by chemical proteomics

(2009) Uwe Rix et al.   Nature Chemical Biology

Proteomic methods for drug target discovery

(2008) Lekha Sleno et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Recent Progress in Diazirine-Based Photoaffinity Labeling

(2008) Makoto Hashimoto et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice

(2008) E. A. Thomas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA