Multiple Transmembrane Binding Sites forp-Trifluoromethyldiazirinyl-etomidate, a PhotoreactiveTorpedoNicotinic Acetylcholine Receptor Allosteric Inhibitor

Numerous Classes of General Anesthetics Inhibit Etomidate Binding to γ-Aminobutyric Acid Type A (GABAA) Receptors

(2010) Guo-Dong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p-Trifluoromethyldiazirinyl-etomidate: A Potent Photoreactive General Anesthetic Derivative of Etomidate That Is Selective for Ligand-Gated Cationic Ion Channels

(2010) S. Shaukat Husain et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nicotinic Acetylcholine Receptor Transmembrane Mutations Convert Ivermectin from a Positive to a Negative Allosteric Modulator

(2010) T. Collins et al.   MOLECULAR PHARMACOLOGY

Binding, activation and modulation of Cys-loop receptors

(2010) Paul S. Miller et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Insight in nAChR subtype selectivity from AChBP crystal structures

(2009) Prakash Rucktooa et al.   BIOCHEMICAL PHARMACOLOGY

Conformational Changes in the Nicotinic Acetylcholine Receptor during Gating and Desensitization

(2009) Innocent H. Yamodo et al.   BIOCHEMISTRY

Neurosteroids Allosterically Modulate Binding of the Anesthetic Etomidate to γ-Aminobutyric Acid Type A Receptors

(2009) Guo-Dong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Time-Resolved Photolabeling of the Nicotinic Acetylcholine Receptor by [3H]Azietomidate, an Open-State Inhibitor

(2009) D. C. Chiara et al.   MOLECULAR PHARMACOLOGY

Mammalian Nicotinic Acetylcholine Receptors: From Structure to Function

(2009) Edson X. Albuquerque et al.   PHYSIOLOGICAL REVIEWS

Probing the Structure of the Affinity-Purified and Lipid-ReconstitutedTorpedoNicotinic Acetylcholine Receptor†

(2008) Ayman K. Hamouda et al.   BIOCHEMISTRY

Structural answers and persistent questions about how nicotinic receptors work

(2008) Gregg et al.   Frontiers in Bioscience-Landmark

Identification of Binding Sites in the Nicotinic Acetylcholine Receptor for TDBzl-etomidate, a Photoreactive Positive Allosteric Effector

(2008) Selvanayagam Nirthanan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

(2008) Nicolas Bocquet et al.   NATURE

Potentiation of  7 nicotinic acetylcholine receptors via an allosteric transmembrane site

(2008) G. T. Young et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA