Article
Biochemistry & Molecular Biology
Cinzia Benincasa, Chiara La Torre, Alessia Fazio, Enzo Perri, Maria Cristina Caroleo, Pierluigi Plastina, Erika Cione
Summary: Recent study identified the presence of tyrosyl oleate, a subclass of lipophenols, in olive oil with anti-inflammatory, antioxidant, and tissue regenerating properties.
Tyrosyl oleate was quantitatively determined and its effects on skin cells were investigated, showing improved cell viability and antioxidant activity.
Interestingly, tyrosyl oleate concentration was found to be higher in lower quality oils, likely due to processing and rancidity, suggesting a correlation between concentration and oil quality.
Review
Chemistry, Multidisciplinary
Chenyang Zhang, Xin Wang, Jiangfeng Du, Zhanjun Gu, Yuliang Zhao
Summary: ROS play a vital role in physiological and pathological processes, and research on regulating ROS for disease treatments has gained wide attention. Advances in nanotechnology have led to the development of numerous nanomaterials with the ability to regulate ROS, aiming to find new and effective ROS-related nanotherapeutic modalities. Despite significant progress in ROS-based nanomedicines, there is a need to address fundamental principles for designing ROS-associated nanomedicines to minimize gaps in biomedical applications. This review summarizes current progress in ROS-associated nanomedicines in disease treatments and presents key principles for their design. Future perspectives in the development of ROS-associated nanomedicines are also discussed.
Review
Chemistry, Inorganic & Nuclear
Nahyun Kwon, Dayeh Kim, K. M. K. Swamy, Juyoung Yoon
Summary: Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play crucial roles in human life, but overproduction can lead to cell damage and diseases. Researchers have developed fluorescent and luminescent probes based on metal-coordinated systems to detect and image these active species, providing valuable tools for studying their roles in signaling and pathology.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Biotechnology & Applied Microbiology
Jiaxue Liu, Boyan Jia, Zhibo Li, Wenliang Li
Summary: Applying reactive polymer materials sensitive to biological stimuli has attracted extensive research interest. The application of reactive oxygen species (ROS)-responsive polymers as drug-delivery systems in organisms has received much attention due to the special physiological effects of ROS on tumors or inflammation. The research progress of ROS-responsive polymers and their application in recent years were summarized and analyzed in this paper. From the perspective of nanoparticle drug delivery systems, multi-responsive delivery systems, and ROS-responsive hydrogels, the future development trends in this field were discussed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Silvia Piccirillo, Simona Magi, Alessandra Preziuso, Tiziano Serfilippi, Giorgia Cerqueni, Monia Orciani, Salvatore Amoroso, Vincenzo Lariccia
Summary: ROS have dual roles, acting as signaling molecules shaping physiological cell functions and as detrimental end products of unbalanced redox reactions. The brain is particularly vulnerable to ROS-mediated toxicity, which may influence the onset and progression of neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Vania Costa, Marlene Costa, Romeu Antonio Videira, Paula Branquinho Andrade, Fatima Paiva-Martins
Summary: It has been found that oleacein, the main polyphenolic compound in olive oil, and its metabolites have anti-inflammatory potential. They can reduce the production of pro-inflammatory substances by macrophages. Oleacein can also inhibit the activity of enzymes associated with inflammation, but other metabolites do not have significant inhibitory effects. These results indicate the anti-inflammatory activity of olive oil polyphenols.
Review
Chemistry, Analytical
Zhishun Jie, Jia Liu, Mingcong Shu, Ye Ying, Haifeng Yang
Summary: Reactive oxygen species (ROS) play a crucial role in regulating various physiological functions in living organisms, with superoxide anion being an important type of ROS closely related to many inflammatory diseases. In recent years, more detection techniques for superoxide anion have been developed as understanding of its role deepens in the field of biomedicine.
Article
Biochemistry & Molecular Biology
Byulhana Kim, Young Kim, Yoonho Lee, Joomin Oh, Youngmee Jung, Won-Gun Koh, Justin J. Chung
Summary: Chronic wounds are difficult to repair due to continuous inflammatory response, which inhibits the normal wound healing mechanism. An antioxidant hydrogel has been developed to scavenge reactive oxygen species (ROS) and promote chronic wound healing.
MACROMOLECULAR BIOSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Martina Bartolomei, Carlotta Bollati, Maria Bellumori, Lorenzo Cecchi, Ivan Cruz-Chamorro, Guillermo Santos-Sanchez, Giulia Ranaldi, Simonetta Ferruzza, Yula Sambuy, Anna Arnoldi, Nadia Mulinacci, Carmen Lammi
Summary: This study provides a comprehensive characterization of the antioxidant properties of phenolic extract (BUO) obtained from extra virgin olive oil, cultivated in Tuscany, Italy. The findings show that BUO extract can reduce harmful substances produced in cells after oxidative stress and demonstrate selective trans-epithelial transport of some phenolic components in differentiated Caco-2 cells, a mature enterocyte model.
Article
Medicine, General & Internal
Ignatios Ikonomidis, Konstantinos Katogiannis, Christina Chania, Nikolaos Iakovis, Maria Tsoumani, Andriana Christodoulou, Evangelia Brinia, George Pavlidis, John Thymis, Damianos Tsilivarakis, Aikaterini Kountouri, Emmanouil Korakas, Vaia Lambadiari, Filippos Triposkiadis, Leandros Skaltsounis, Ioulia Tseti, Efstathios K. K. Iliodromitis, Ioanna Andreadou
Summary: In this study, it was found that hydroxytyrosol-enriched olive oil has beneficial effects on arterial and cardiac diastolic function in patients with chronic coronary artery syndrome (CCAS), likely by reducing oxidative and inflammatory burden.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Nutrition & Dietetics
Annalisa Noce, Giulia Marrone, Silvia Urciuoli, Francesca Di Daniele, Manuela Di Lauro, Anna Pietroboni Zaitseva, Nicola Di Daniele, Annalisa Romani
Summary: The Mediterranean diet with extra virgin olive oil appears beneficial for patients with chronic kidney disease, improving renal function, reducing oxidative stress and inflammation, enhancing body composition, with more significant and long-lasting effects observed in those consuming high MPC EVOO content.
Review
Chemistry, Multidisciplinary
Gabriel T. Huynh, Vidhishri Kesarwani, Julia A. Walker, Jessica E. Frith, Laurence Meagher, Simon R. Corrie
Summary: The combination of nanomaterials and fluorescent detection offers new opportunities for monitoring oxygen and ROS in biological systems, improving optical properties and interactions with cells and media, and providing ratiometric sensing robust to environmental drift.
FRONTIERS IN CHEMISTRY
(2021)
Article
Chemistry, Physical
Patryk Szymaszek, Patrycja Sroda, Malgorzata Tyszka-Czochara, Anna Chachaj-Brekiesz, Tomasz Swiergosz, Joanna Ortyl
Summary: Here we report the synthesis of a novel fluorescent probe P182 for quantitative measurement of H2O2. This fluorometric probe displays a fluorescence turn-on response in the presence of H2O2. It offers good performances in terms of sensitivity and response time, and shows non-toxic activity for in vivo studies. This study provides research on molecular fluorescence probe for the detection of H2O2.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Engineering, Environmental
Mi Tian, Guangcan Chen, Jingchen Xu, Yao Lin, Zeng Yi, Xiangyu Chen, Xudong Li, Song Chen
Summary: Chronic periodontitis, a common oral disease, is aggravated by excessive levels of reactive oxygen species (ROS), which leads to tissue destruction. Tea polyphenol-derived nanoparticles can effectively scavenge ROS, reduce inflammation, and inhibit bone loss in chronic periodontitis through reprogramming macrophages. These nanoparticles have the potential to be a promising therapy for periodontitis.
CHEMICAL ENGINEERING JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Aikaterini Berdiaki, Monica Neagu, Ioanna Spyridaki, Andrey Kuskov, Serge Perez, Dragana Nikitovic
Summary: Hyaluronan (HA) is a natural compound that is found on the cell surface and tissue extracellular matrix. It is synthesized by enzymes and degraded by other substances. HA has different effects on the body depending on its molecular weight, with high molecular weight HA being anti-inflammatory and low molecular weight HA being pro-inflammatory. Reactive oxygen species (ROS) can degrade HA and affect vascular integrity, while HA can also play a role in wound healing. Understanding the interactions between ROS and HA is an important research topic.
Article
Agriculture, Multidisciplinary
Maria Garcia-Burgos, Jorge Moreno-Fernandez, Javier Diaz-Castro, Maria Jose Alferez, Inmaculada Lopez-Aliaga
Summary: Fermented goat's milk consumption enhances immune function during iron deficiency recovery by modifying immune system indicators through the improvement of iron homeostasis.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Review
Biochemistry & Molecular Biology
Juan M. Toledano, Jorge Moreno-Fernandez, Maria Puche-Juarez, Julio J. Ochoa, Javier Diaz-Castro
Summary: Since the emergence of COVID-19, finding preventive and therapeutic options has become a priority. The approval of vaccines is crucial, but there is still a need to study alternative methods to support the immune system. Adequate nutrition and vitamin intake can improve immune response and prevent infection.
Article
Biochemistry & Molecular Biology
Jorge Moreno-Fernandez, Julio J. Ochoa, Catalina De Paco Matallana, Africa Cano, Estefania Martin-Alvarez, Javier Sanchez-Romero, Juan M. Toledano, Maria Puche-Juarez, Sonia Prados, Susana Ruiz-Duran, Lucia Diaz-Meca, Maria Paz Carrillo, Javier Diaz-Castro
Summary: COVID-19 infection during pregnancy can lead to decreased serum antioxidant capacity in mothers and alterations in placental iron metabolism. Further research is required to understand the pathogenic mechanisms and outcomes in maternal and infant health.
Review
Oncology
Beatriz Puente-Cobacho, Alfonso Varela-Lopez, Jose L. Quiles, Laura Vera-Ramirez
Summary: Decades of research have revealed the complexity of tumour cellular and molecular biology, with some progress made in treating primary tumours. However, less progress has been made in developing therapies against metastasis, which is the main cause of cancer-related deaths. Recent studies have shown that epigenetic and microenvironmental factors play a key role in tumour progression. Free radicals act as second messengers and modulate tumour cell signalling, leading to either cell survival or cell death depending on the context. Redox signalling is involved in controlling disseminated tumour cell fate and metastasis.
CANCER AND METASTASIS REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Ana Belen Diaz-Ruano, Nuria Martinez-Alarcon, Macarena Peran, Karim Benabdellah, Maria de los angeles Garcia-Martinez, Ovidiu Preda, Cesar Ramirez-Tortosa, Andrea Gonzalez-Hernandez, Juan Antonio Marchal, Manuel Picon-Ruiz
Summary: The risk of cancer increases with age, but the development of estrogen-receptor-positive (ER+) cancer types in women is more related to menopausal status than age. Obesity-induced inflammation, a general risk factor for cancer, shows differences in its association with ER+ cancer risk in pre- and postmenopausal women. This study demonstrates the different biological functions of estradiol (E2) and estrone (E1) in ER+ gynecologic cancers, highlighting the potential role of E1 and HSD17B E1-synthesizing enzymes in the development and progression of these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biology
Carmen Rodriguez-Garcia, Francisco Gutierrez-Santiago
Summary: Colorectal cancer (CRC) is a common cancer with modifiable risk factors including diet, alcohol consumption, and smoking. Natural dietary components have shown chemopreventive activity in CRC through modulation of cellular processes. Post-translational modifications (PTMs) of proteins associated with CRC have gained interest as inappropriate modification is linked to carcinogenesis. This review collects and analyzes the main PTMs associated with CRC, explores the relationship between different proteins susceptible to inappropriate PTMs, and reviews the literature on the role of plant-based dietary compounds in modulating CRC-associated PTMs. The review suggests that plant-based dietary components can correct inappropriate PTMs and promote apoptosis in tumor cells.
Review
Biochemistry & Molecular Biology
Jose M. Romero-Marquez, Tamara Y. Forbes-Hernandez, Maria D. Navarro-Hortal, Rosa Quirantes-Pine, Giuseppe Grosso, Francesca Giampieri, Vivian Lipari, Cristina Sanchez-Gonzalez, Maurizio Battino, Jose L. Quiles
Summary: Alzheimer's Disease (AD) is a major cause of global dementia cases, affecting around 50 million people worldwide. The leaves of olive trees contain bioactive compounds such as oleuropein (OLE) and hydroxytyrosol (HT), which have shown medicinal properties in fighting AD. Olive leaf (OL), OLE, and HT can reduce amyloid-beta and neurofibrillary tangles formation, and OL has exhibited high cholinergic inhibitory activity. These compounds may also decrease neuroinflammation and oxidative stress, potentially promoting autophagy and restoring loss of proteostasis in AD models. Therefore, olive phytochemicals hold promise as an adjuvant in AD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Lorenzo Rivas-Garcia, Alfonso Lopez-Varela, Jose L. Quiles, Maria Montes-Bayon, Pilar Aranda, Juan Llopis, Cristina Sanchez-Gonzalez
Summary: The present study aimed to evaluate the effect of co-treatment with copper (Cu) and bis(maltolato)oxovanadium(IV) (BMOV) on reducing the toxicity of BMOV. The results showed that co-incubation with both metals effectively reduced the toxicity of BMOV and enhanced its potential therapeutic applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Jorge Moreno-Fernandez, Maria Puche-Juarez, Juan M. Toledano, Ignacio Chirosa, Luis J. Chirosa, Mario Pulido-Moran, Naroa Kajarabille, Isabel M. Guisado, Rafael Guisado, Javier Diaz-Castro, Julio J. Ochoa
Summary: This study aimed to evaluate the potential positive effects of ubiquinol supplementation on muscle aggression, physical performance, and fatigue perception in non-elite athletes after high intensity circuit weight training. The results showed that ubiquinol supplementation improved muscle performance, reduced muscle damage markers, and had a protective effect on muscle fibers.
Review
Biochemistry & Molecular Biology
Juan M. Toledano, Maria Puche-Juarez, Jorge Moreno-Fernandez, Julio J. Ochoa, Javier Diaz-Castro
Summary: Since the COVID-19 pandemic is ongoing, exploring strategies to support the immune system during infection is necessary. An adequate diet can improve immune responses, and minerals, which have immune-modulatory and antioxidant activities, might be useful in fighting this illness. Although more research is needed, evidence from studies on respiratory diseases suggests the rationality of investigating the use of minerals during this pandemic.
Article
Biochemistry & Molecular Biology
Jose M. Romero-Marquez, Maria D. Navarro-Hortal, Francisco J. Orantes, Adelaida Esteban-Munoz, Cristina M. Perez-Oleaga, Maurizio Battino, Cristina Sanchez-Gonzalez, Lorenzo Rivas-Garcia, Francesca Giampieri, Jose L. Quiles, Tamara Y. Forbes-Hernandez
Summary: This study aims to characterize monofloral avocado honey (AH) and evaluate its phenolic profile and antioxidant capacity. The results show that AH exhibits high antioxidant capacity in vitro and in vivo, which is relevant for the prevention of Alzheimer's disease.
Review
Medicine, General & Internal
Maria Puche-Juarez, Juan M. Toledano, Julio J. Ochoa, Javier Diaz-Castro, Jorge Moreno-Fernandez
Summary: Background: Obesity and being overweight have become severe global health issues. Maternal dietary habits and other factors during pregnancy can have a significant impact on the prevention of obesity in children. A review of recent human studies aims to determine modifiable factors that influence adiposity and prevent specific disorders later in life. Conclusion: A healthy diet and lifestyle starting from pregnancy and throughout childhood, particularly in the first two years, can prevent the emergence of noncommunicable diseases and metabolic syndrome-related pathologies.
Article
Chemistry, Applied
Danila Cianciosi, Yasmany Armas Diaz, Jose M. Alvarez-Suarez, Xiumin Chen, Di Zhang, Nohora Milena Martinez L. Lopez, Mercedes Briones Urbano, Jose L. Quiles, Adolfo Amici, Maurizio Battino, Francesca Giampieri
Summary: This study investigated the chemosensitizing effects of Manuka honey against 5-Fluorouracil in colonspheres enriched with cancer stem cells (CSCs). The results showed that combining Manuka honey with 5-Fluorouracil decreased the gene expression of ABC sub-family G member 2 and thymidylate synthase, which are associated with drug resistance and DNA synthesis respectively. Manuka honey also regulated the Wnt/β-catenin, Hedgehog and Notch pathways, reducing the self-renewal ability of CSCs. This preliminary study opens new possibilities for the combination of natural compounds and pharmaceuticals to enhance efficacy or reduce adverse effects.
Review
Integrative & Complementary Medicine
L. Jurado-Fasoli, A. Mesas-Fernandez, C. Rodriguez-Garcia
Summary: The study investigates the effects of lycopene supplementation on cancer therapy outcomes and circulating lycopene concentration in patients. The results show that lycopene supplementation does not modify cancer hallmarks but increases circulating lycopene concentration in patients under cancer therapy, which could have a positive impact on potential clinical and molecular outcomes in cancer patients.
JOURNAL OF HERBAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jose M. Romero-Marquez, Maria D. Navarro-Hortal, Tamara Y. Forbes-Hernandez, Alfonso Varela-Lopez, Juan G. Puentes, Raquel Del Pino-Garcia, Cristina Sanchez-Gonzalez, Inaki Elio, Maurizio Battino, Roberto Garcia, Sebastian Sanchez, Jose L. Quiles
Summary: In this study, olive leaves from different geographical origins were analyzed for their phytochemical profile, antioxidant capacity, neuroprotective activity, and anti-inflammatory effects. The results showed that olive leaves from Spain and Italy had the highest antioxidant and neuroprotective activities, while those from Greece had the lowest. The content of oleoside methyl ester and p-hydroxybenzoic acid in the Spanish and Italian samples, respectively, were strongly associated with these biological activities.
Article
Food Science & Technology
Yonghong Ye, Songyan Zheng, Yuanxing Wang
Summary: In this study, the changes of aroma components in Gannan navel orange during growth were systematically studied using HS-SPME-GC-MS. Key aroma components and markers were identified. These findings contribute to a better understanding of the dynamic variation of aroma compounds during navel orange growth and have potential for industrial applications.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Jia Xu, Yayuan Zhang, Mengke Zhang, Xinlin Wei, Yiming Zhou
Summary: This study evaluated the effects of glucosamine selenium on summer-autumn tea, showing that it can enhance nutritional quality, improve sensory characteristics, and increase plant adaptation to environmental changes and abiotic stresses.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Yuanming Chu, Zhaoyang Ding, Jing Xie
Summary: This study investigated the use of ice glazing containing D-sodium erythorbate (DSE) and vacuum packaging to maintain the quality of large yellow croaker during frozen storage. The results showed that vacuum packaging effectively inhibited ice crystal growth and minimized water loss, while the combination of vacuum packaging and 0.3% DSE-infused ice glazing maintained freshness indicators at low levels throughout the 300-day storage period. This combination was considered the most effective in preserving the quality of the fish.
FOOD RESEARCH INTERNATIONAL
(2024)
Review
Food Science & Technology
Md. Ashikur Rahman, Shirin Akter, Md. Ashrafudoulla, Md. Anamul Hasan Chowdhury, A. G. M. Sofi Uddin Mahamud, Si Hong Park, Sang-Do Ha
Summary: This comprehensive review aims to provide insights into the mechanisms and key factors influencing biofilm formation by A. hydrophila in the food industry. It explores the molecular processes involved in various stages of biofilm formation and investigates the impact of intrinsic factors and environmental conditions on biofilm architecture and resilience. The article also highlights the potential of bibliometric analysis in conceptualizing the research landscape and identifying knowledge gaps in A. hydrophila biofilm research.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Chujing Wang, Wenni Tian, Zengliu Song, Qun Wang, Yong Cao, Jie Xiao
Summary: Solid lipid ratio in emulsions has significant effects on colloidal stability, mucus permeability, and bioavailability in vivo. Higher solid lipid ratio improves intestinal stability but reduces mucus permeability.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Dacai Zhong, Liping Kang, Juan Liu, Xiang Li, Li Zhou, Luqi Huang, Zidong Qiu
Summary: In this study, a novel online extraction electrospray ionization mass spectrometry method was developed to comprehensively characterize complex foods. Meanwhile, a characteristic marker screening method and chemometrics modeling were used for the accurate authentication of highly-similar foods. This research has significant implications for ensuring food quality and safety.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Qiannan Zhao, Jinyi Yang, Jiahui Li, Lei Zhang, Xiaohai Yan, Tianli Yue, Yahong Yuan
Summary: This study investigated the transport and hypoglycemic effects of phenolics in mulberry leaves using an in vitro digestion model. The results showed that digested phenolics had higher absorbability and could inhibit glucose digestion and absorption. Phenolics also regulated glucose metabolism. Luteoforol and p-coumaric acid were found to be the primary phenolics strongly correlated with the hypoglycemic ability of mulberry leaves.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Yanyun Cao, Qingling Wang, Jinou Lin, Yin-Yi Ding, Jianzhong Han
Summary: This study investigated the effects of gallic acid (GA) and epigallocatechin gallate (EGCG) at different ratios on the gel properties of calcium induced-whey protein emulsion gel. It was found that GA and EGCG could promote gel formation, increase gel strength, and delay the release of emulsified oil droplets.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Monique Martins Strieder, Vitor Lacerda Sanches, Mauricio Ariel Rostagno
Summary: This study proposed an integrated and automated procedure for extracting, separating, and quantifying bioactive compounds from coffee co-products. By optimizing the extraction, separation, and analysis method, real-time analysis was achieved. The results suggest that coupling different techniques can efficiently extract, separate, and analyze phenolic compounds, providing an integrated method to produce high-added value ingredients for various applications.
FOOD RESEARCH INTERNATIONAL
(2024)
Article
Food Science & Technology
Kyu Sang Sim, Hyoyoung Kim, Suel Hye Hur, Tae Woong Na, Ji Hye Lee, Ho Jin Kim
Summary: Geographical origin plays a crucial role in determining the quality and safety of agricultural products. In this study, ICP analysis was used to determine the inorganic elemental content of onions and identify their geographical origin. Chemometric methods were applied to analyze the ICP results, and the accuracy of distinguishing between Korean and Chinese onions was found to be excellent. The findings suggest that this method can be beneficial for identifying agricultural products.
FOOD RESEARCH INTERNATIONAL
(2024)
