期刊
FOOD RESEARCH INTERNATIONAL
卷 105, 期 -, 页码 159-168出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.foodres.2017.11.004
关键词
Moringa oleifera; Colon cancer; Azoxymethane; Polyphenols; Dietary fiber; Fecal enzymes
资金
- Consejo Nacional de Ciencia y Tecnologia (CONACYT-Mexico) [278375, 384201]
- Fondo de Proyectos Especiales de Rectoria (FOPER) from Universidad Autonoma de Queretaro [231214]
Moringa (Moringa oleifera) is a plant that has generated great interest in recent years because of its attributed medicinal properties. The aim of this study was to characterize the bioactive compounds of moringa leaves (MO) and evaluate their effect on a colorectal carcinogenesis model. Twenty-four male CD-1 mice were divided into 4 groups: Group 1 fed with basal diet (negative control/NC); Group 2 received AOM/DSS (positive control); Groups 3 and 4 were fed with basal diet supplemented with moringa leaves (2.5% w/w and 5% w/w, respectively) for 12 weeks. Moringa leaves exhibited a high content of dietary fiber (similar to 18.75%) and insoluble dietary fiber (2.29%). There were identified 9 phenolic compounds whereas the chlorogenic and p-coumaric acid showed the higher contents (44.23-63.34 mu g/g and 180.45-707.42 mu g/g, respectively). Moringa leaves decreased the activity of harmful fecal enzymes (beta-glucosidase, beta-glucuronidase, tryptophanase and urease up to 40%, 43%, 103% and 266%, respectively) as well tumors incidence in male CD1-mice (similar to 50% with 5% w/v of moringa dose). These findings suggest that the bioactive compounds of moringa such as total dietary fiber and phenolic compounds may have chemopreventive capacity. This is the first study of the suppressive effect of moringa leaves in an in vivo model of AOM/DSS-induced colorectal carcinogenesis.
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