Article
Biochemistry & Molecular Biology
Sunyeong Jang, Hyungju Seo, Hojin Kim, Hyoyoung Kim, Jongsung Ahn, Hyunjeong Cho, Sunghie Hong, Seunghwa Lee, Taewoong Na
Summary: A method for the rapid and quantitative analysis of 30 veterinary drugs in feed samples was developed and validated. The method showed good linearity and recovery rates, and can be used for screening residual multiclass veterinary drugs in feed samples.
Article
Biochemical Research Methods
Garnet McRae, Donald M. Leek, Juris Meija, Bryn Shurmer, Steven J. Lehotay, Joachim Polzer, Jeremy E. Melanson, Zoltan Mester
Summary: A freeze-dried bovine muscle-certified reference material (CRM), called BOTS-1, containing residues of commonly used veterinary drugs, was produced and certified. Liquid chromatography tandem mass spectrometry (LC-MS/MS) methods were used for value assignment, along with isotope dilution and standard addition approaches. Data from multiple organizations were used for value assignment. Results were obtained through an international inter-laboratory comparison. Primary standards were characterized using quantitative NMR (1H-qNMR). The certified mass fractions of the veterinary drug residues were reported with expanded uncertainties.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Veterinary Sciences
Zehra Hajrulai-Musliu, Risto Uzunov, Stefan Jovanov, Dea Musliu, Elizabeta Dimitrieska-Stojkovikj, Biljana Stojanovska-Dimzoska, Aleksandra Angeleska, Velimir Stojkovski, James Jacob Sasanya
Summary: A sensitive and reliable quantitative LC-MS/MS method has been developed and validated for simultaneous determination of a wide range of veterinary drug and pesticide residues and mycotoxins in bovine urine. The method fulfills the requirements under Regulation 2021/808/EC and can be used for routine analysis of bovine urine samples.
BMC VETERINARY RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Amanda Barros, Caue S. Novo, Vivian Feddern, Arlei Coldebella, Gerson N. Scheuermann
Summary: This study surveyed 45 meat industries in Brazil capable of exporting, collecting and analyzing 2580 chicken meat samples, with results showing that all residue concentrations were below the maximum limits established by legislation. This demonstrates the capability of the Brazilian chicken meat industries in compliance with foreign market regulations.
APPLIED SCIENCES-BASEL
(2021)
Article
Chemistry, Multidisciplinary
Abdullah Al Tamim, Saeed Alzahrani, Sarah Al-Subaie, Mohammed A. Almutairi, Ahmed Al Jaber, Abdullah M. Alowaifeer
Summary: This study presented a simple method for the accurate determination of beta-lactams, quinolones, sulphonamides, and tetracyclines in animal origin food, showing excellent linearity, good recovery rates, and low quantification limits, which can be effectively applied in food residue analysis.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Abdullah Al Tamim, Saeed Alzahrani, Sarah Al-Subaie, Mohammed A. Almutairi, Ahmed Al Jaber, Abdullah M. Alowaifeer
Summary: In this study, a simple method for the accurate determination of several veterinary drug residues in fish, poultry, and red meat was described. The method involved a straightforward extraction process without using extraction cartridges. Extensive validation demonstrated the method's excellent linearity, recovery, and repeatability. The quantification limits of drug residues were well below the maximum residue limits set by regulatory authorities. The method was successfully applied to the routine analysis of actual samples.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Applied
Dan-Bi Kim, Nho-Eul Song, Tae Gyu Nam, Young Sung Jung, Miyoung Yoo
Summary: The study validated a method for detecting 26 antibiotics in honey and found that chlorotetracycline and tetracycline had the highest residues. The upper residue levels of tetracycline class exceeded acceptable daily intake by several times. In particular, chlorotetracycline accounted for a large proportion of the hazard index.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2021)
Article
Chemistry, Applied
Joost L. D. Nelis, Amanda L. Dawson, Utpal Bose, Alisha Anderson, Michelle L. Colgrave, James A. Broadbent
Summary: Accidental milk cross-contamination is a common cause for food recalls, but current methods for quantifying trace-level allergens are not suitable for routine analysis. Here, a rapid LC-MS method was developed to quantify milk allergens, using specific peptides and allergen epitopes. The method showed good sensitivity, recovery rates, and a wide linear range, making it useful for routine determination of trace-contamination and adulteration of dairy products.
Article
Environmental Sciences
Isra Toptanci, Mustafa Kiralan, Mohamed Fawzy Ramadan
Summary: In this study, pesticide residues in 493 fruit and vegetable samples from markets in Turkey were detected using a highly efficient extraction method. The results showed that nearly half of the samples were contaminated, with 30% of them containing pesticide residues above maximum residue limits. Chlorpyrifos was the most commonly detected pesticide, affecting a variety of different crops.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Anna Roszkowska, Natalia Treder, Alina Plenis, Natalia Miekus, Ilona Oledzka, Piotr Kowalski, Tomasz Baczek
Summary: This study compared and optimized two microextraction strategies for the extraction of four immunosuppressants in biofluids. The results showed that one strategy exhibited better performance for the extraction of a novel immunosuppressive drug.
SUSTAINABLE CHEMISTRY AND PHARMACY
(2021)
Article
Agriculture, Multidisciplinary
Myriam Bustamante-Rangel, Maria Milagros Delgado-Zamarreno, Encarnacion Rodriguez-Gonzalo
Summary: A simple and sensitive method has been developed for the analysis of anthelmintic drugs in milk, involving extraction using QuEChERS method and separation and determination by LC-MS/MS. This method provides high sensitivity for the determination of anthelmintics in milk samples and can be successfully used for routine analysis.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Food Science & Technology
Nader Zad, Lisa A. Tell, Remya Ampadi Ramachandran, Xuan Xu, Jim E. Riviere, Ronald Baynes, Zhoumeng Lin, Fiona Maunsell, Jennifer Davis, Majid Jaberi-Douraki
Summary: Establishing maximum-residue limits (MRLs) for veterinary medicine helps protect the human food supply. This study demonstrates that unestablished MRLs can be reliably predicted for under-represented food commodity groups using machine learning (ML).
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Chemistry, Analytical
Sally Tarek Mahmoud, Marwa A. Moffid, Rawda M. Sayed, Eman A. Mostafa
Summary: A sensitive and selective UPLC-MS/MS method was developed for the simultaneous determination of four drugs used in SARS-CoV-2 in rat plasma. The study also found potential food-drug and drug-drug interactions between grapefruit juice and the selected drugs.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Analytical
Nur Cebi, Ozun Gorel Manav, Elmas Oktem Olgun
Summary: This research developed an analytical methodology to efficiently monitor 77 pesticides in hazelnut samples, validated the method's effectiveness, and successfully applied it to real hazelnut samples. Various pesticide residues were detected in commercial hazelnuts, but the quantities were significantly lower than the maximum residue limits published by the European Union.
MICROCHEMICAL JOURNAL
(2021)
Article
Food Science & Technology
Buket Er Demirhan, Burak Demirhan
Summary: The study analyzed 85 cereal-based baby foods with or without milk for mycotoxins, TAMB, and Enterobacteriaceae contamination. At least one mycotoxin was found in 69.41% of the samples, with STE and HT-2 being the most frequently detected. AFM1 was not detected in any baby foods with milk. TAMB and Enterobacteriaceae were isolated from 30.59% and 10.59% of the samples, respectively. The mycotoxin levels in the analyzed samples were compliant with the Turkish Food Codex.
Article
Food Science & Technology
Justin G. Bendall, Robert A. Crawford, Jaap M. Evers, Betty W. Smythe, Thomas Bessaire, Pascal Mottier, Claudia Mujahid, Gordana Aleksic, Robert Hutchinson
INTERNATIONAL DAIRY JOURNAL
(2019)
Article
Food Science & Technology
Thomas Bessaire, Irene Perrin, Adrienne Tarres, Aude Bebius, Frederique Reding, Viviane Theurillat
Article
Biochemical Research Methods
Aurelien Desmarchelier, Jonas Hamel, Thierry Delatour
JOURNAL OF CHROMATOGRAPHY A
(2020)
Article
Food Science & Technology
Thomas Bessaire, Claudia Mujahid, Pascal Mottier, Aurelien Desmarchelier
Article
Chemistry, Applied
Thierry Delatour, Jose F. Huertas-Perez, Mathieu Dubois, Xanthippe Theurillat, Aurelien Desmarchelier, Marion Ernest, Richard H. Stadler
Article
Agriculture, Multidisciplinary
Bjorn Eriksen, Aurelien Desmarchelier, Nancy Frank, Richard H. Stadler, Thierry Delatour
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2020)
Article
Food Science & Technology
Claudia Mujahid, Marie-Claude Savoy, Quentin Basle, Pei Mun Woo, Edith Chin Yean Ee, Pascal Mottier, Thomas Bessaire
Article
Chemistry, Analytical
Aurelien Desmarchelier, Thomas Bessaire, Marie-Claude Savoy, Adrienne Tarres, Claudia Mujahid, Andrea Beck, Pascal Mottier, Thierry Delatour
Summary: The study validated a method for screening 154 veterinary drug residues in various food categories using liquid chromatography-tandem mass spectrometry. The method demonstrated high probabilities of detection at the target concentration and low probabilities in blank samples, meeting the acceptance criteria. The method was approved as AOAC Official First Action2020.04 by the Expert Review Panel.
JOURNAL OF AOAC INTERNATIONAL
(2021)
Article
Chemistry, Applied
Karma C. Fussell, Maricel Marin-Kuan, Emma Debon, Bastien Gentili, Delphine Morin-Rivron, Laure Poquet, Patrick Serrant, Flavia Badoud, Thomas Bessaire, Nicolas Christinat, Marion Ernest, Alexandre Felix, Helia Latado, Gina Montoya Parra, Gabriele Scholz, Thomas Stroheker, Benoit Schilter
Summary: The study found that there are differences in activity levels when using different methods in effect-based assays of food products, indicating that the current food testing data may not be suitable for consumer advice or food decision-making yet.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2021)
Article
Chemistry, Applied
Thomas Bessaire, Thomas Stroheker, Bjorn Eriksen, Claudia Mujahid, Yves-Alexis Hammel, Jesus Varela, Thierry Delatour, Alexandre Panchaud, Pascal Mottier, Richard H. Stadler
Summary: Residues of banned fumigant ethylene oxide (EO) were found in carob bean gum above the maximum residue limit in ice cream, leading to withdrawal or recall of products in multiple European countries. A reliable method was developed to detect EO and its marker compound 2-chloroethanol (2-CE) in ice cream, with new findings indicating 2-CE as the predominant analyte in contaminated samples, highlighting its significance in risk assessment of EO in food.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2021)
Article
Chemistry, Applied
Aurelien Desmarchelier, Aude Bebius, Frederique Reding, Ashley Griffin, Marta Ahijado Fernandez, Jason Beasley, Emilie Clauzier, Thierry Delatour
Summary: This article discusses the issue of misquantification in acrylamide analysis and presents four different methods to illustrate the problem. The author introduces a modified extraction and chromatographic method, which has been validated in various samples and shown excellent performance.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2022)
Article
Chemistry, Applied
Benoit M. Carreres, Thomas Bessaire, Aurelien Desmarchelier, Pascal Mottier, Thierry Delatour
Summary: LC-HRMS is an advanced analytical technique for multi-residue analysis of chemical contaminants in food, but its data processing is challenging due to the lack of critical calculation features and adapted reporting tools. To address this issue, a four-step LC-HRMS workflow is proposed to speed up data processing and maximize the time spent on data interpretation. The workflow involves specific software settings and a newly coded R-script to generate comprehensive report files in seconds. The reporting tool also provides options for data formatting, filtering, and color-coding to provide a clear picture of compound detection and quality control criteria.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2022)
Article
Chemistry, Applied
Thomas Bessaire, Bjorn Eriksen, Stephanie Laborie, Claudia Mujahid, Pascal Mottier, Thierry Delatour, Alexandre Panchaud, Richard H. Stadler, Thomas Stroheker
Summary: This study extends the application of a GC-MS method from analyzing ethylene oxide (EO) in ice cream to a wider range of food items. The results show that 2-chloroethanol (2-CE) is the predominant analyte detected in processed ingredients suspected to have been previously treated with EO. Different laboratories using different analytical strategies for EO determination in food show similar concentration ranges but varying reproducibility. The study suggests the need for an official analysis method for different food matrices to avoid result discrepancies.
FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT
(2023)
Article
Chemistry, Analytical
Aurelien Desmarchelier, Marie-Claude Savoy, Thierry Delatour, Pascal Mottier
Summary: This study explored the feasibility of monitoring approximately 400 veterinary drug residues in various foodstuffs using a single method. The researchers successfully developed a generic QuEChERS-based approach for sample preparation and utilized liquid chromatography-high resolution mass spectrometry (LC-HRMS) for detection. The LC-HRMS method was found to be suitable for screening a wide range of parent compounds and marker residues in raw materials, processed ingredients, and commercialized items. The researchers validated the screening approach in 70 samples, achieving low false positive and false negative rates. Additionally, the quantitative method demonstrated acceptable performance in terms of recovery and precision for a significant number of compounds.
MICROCHEMICAL JOURNAL
(2022)