Asp 58 modulates lens αA-crystallin oligomer formation and chaperone function

Isomerization of Asp residues plays an important role in αA-crystallin dissociation

(2016) Takumi Takata et al.   FEBS Journal

Search for conserved amino acid residues of the α-crystallin proteins of vertebrates

(2016) Nikita G. Shiliaev et al.   Journal of Bioinformatics and Computational Biology

Alpha B- and βA3-crystallins containing d-Aspartic acids exist in a monomeric state

(2015) Hiroaki Sakaue et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Rapid Survey of Four Asp Isomers in Disease-Related Proteins by LC-MS combined with Commercial Enzymes

(2014) Hiroki Maeda et al.   ANALYTICAL CHEMISTRY

A Rapid, Comprehensive Liquid Chromatography-Mass Spectrometry (LC-MS)-based Survey of the Asp Isomers in Crystallins from Human Cataract Lenses

(2012) Norihiko Fujii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cataract-Causing Defect of a Mutant γ-Crystallin Proceeds through an Aggregation Pathway Which Bypasses Recognition by the α-Crystallin Chaperone

(2012) Kate L. Moreau et al.   PLoS One

Global estimates of visual impairment: 2010

(2011) Donatella Pascolini et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

The Common Modification in αA-Crystallin in the Lens, N101D, Is Associated with Increased Opacity in a Mouse Model

(2011) Ratna Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Partially Folded Aggregation Intermediates of Human γD-, γC-, and γS-Crystallin Are Recognized and Bound by Human αB-Crystallin Chaperone

(2010) Ligia Acosta-Sampson et al.   JOURNAL OF MOLECULAR BIOLOGY

Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function

(2010) Arthur Laganowsky et al.   PROTEIN SCIENCE

Truncated Human βB1-Crystallin Shows Altered Structural Properties and Interaction with Human βA3-Crystallin

(2009) K. Srivastava et al.   BIOCHEMISTRY

The eye lens chaperone  -crystallin forms defined globular assemblies

(2009) J. Peschek et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic analysis of the oxidation of cysteine residues in human age-related nuclear cataract lenses

(2008) Peter G. Hains et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Differential rate constants of racemization of aspartyl and asparaginyl residues in human alpha A-crystallin mutants

(2008) Tooru Nakamura et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Deamidation destabilizes and triggers aggregation of a lens protein, βA3-crystallin

(2008) Takumi Takata et al.   PROTEIN SCIENCE

Zn2+Enhances the Molecular Chaperone Function and Stability of α-Crystallin†

(2007) Ashis Biswas et al.   BIOCHEMISTRY