SIRT1 antagonizes liver fibrosis by blocking hepatic stellate cell activation in mice

The origin of fibrogenic myofibroblasts in fibrotic liver

(2017) Tatiana Kisseleva   HEPATOLOGY

The histone methyltransferase Suv39h2 contributes to nonalcoholic steatohepatitis in mice

(2017) Zhiwen Fan et al.   HEPATOLOGY

Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease

(2017) Karim Gariani et al.   JOURNAL OF HEPATOLOGY

Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression

(2017) Teresa Ramirez et al.   JOURNAL OF HEPATOLOGY

PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis

(2017) Partha Mukhopadhyay et al.   JOURNAL OF HEPATOLOGY

The histone H3K9 methyltransferase SUV39H links SIRT1 repression to myocardial infarction

(2017) Guang Yang et al.   Nature Communications

HDAC4 mediates IFN-γ induced disruption of energy expenditure-related gene expression by repressing SIRT1 transcription in skeletal muscle cells

(2016) Mingming Fang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Myocardin-related transcription factor A (MRTF-A) plays an essential role in hepatic stellate cell activation by epigenetically modulating TGF-β signaling

(2016) Wenfang Tian et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Resveratrol ameliorates fibrosis and inflammation in a mouse model of nonalcoholic steatohepatitis

(2016) Takaomi Kessoku et al.   Scientific Reports

MKL1 is an epigenetic modulator of TGF-β induced fibrogenesis

(2015) Zhiwen Fan et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Emerging role of silent information regulator 1 (SIRT1) in hepatocellular carcinoma: a potential therapeutic target

(2015) Yuting Wu et al.   TUMOR BIOLOGY

The Protective Effect of Resveratrol on Concanavalin-A-Induced Acute Hepatic Injury in Mice

(2015) Yingqun Zhou et al.   Gastroenterology Research and Practice

Transforming Growth Factor-β–Independent Role of Connective Tissue Growth Factor in the Development of Liver Fibrosis

(2014) Keiko Sakai et al.   AMERICAN JOURNAL OF PATHOLOGY

Sirtuin 1 ablation in endothelial cells is associated with impaired angiogenesis and diastolic dysfunction

(2014) Julien Maizel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Origin of myofibroblasts in the fibrotic liver in mice

(2014) K. Iwaisako et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proinflammatory Stimuli Engage Brahma Related Gene 1 and Brahma in Endothelial Injury

(2013) Fei Fang et al.   CIRCULATION RESEARCH

Transforming Growth Factor–β Signaling in Hepatocytes Promotes Hepatic Fibrosis and Carcinogenesis in Mice With Hepatocyte-Specific Deletion of TAK1

(2013) Ling Yang et al.   GASTROENTEROLOGY

Deletion of SIRT1 From Hepatocytes in Mice Disrupts Lipin-1 Signaling and Aggravates Alcoholic Fatty Liver

(2013) Huquan Yin et al.   GASTROENTEROLOGY

PIASy mediates hypoxia-induced SIRT1 transcriptional repression and epithelial-to-mesenchymal transition in ovarian cancer cells

(2013) L. Sun et al.   JOURNAL OF CELL SCIENCE

Cell-specific PPARγ deficiency establishes anti-inflammatory and anti-fibrogenic properties for this nuclear receptor in non-parenchymal liver cells

(2013) Eva Morán-Salvador et al.   JOURNAL OF HEPATOLOGY

A SUMOylation-Dependent Pathway Regulates SIRT1 Transcription and Lung Cancer Metastasis

(2013) Lina Sun et al.   JNCI-Journal of the National Cancer Institute

Fate tracing reveals hepatic stellate cells as dominant contributors to liver fibrosis independent of its aetiology

(2013) Ingmar Mederacke et al.   Nature Communications

SIRT1 Suppresses the Epithelial-to-Mesenchymal Transition in Cancer Metastasis and Organ Fibrosis

(2013) Petra Simic et al.   Cell Reports

Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ

(2012) Li Qiang et al.   CELL

Brahma-related gene 1 bridges epigenetic regulation of proinflammatory cytokine production to steatohepatitis in mice

(2012) Wenfang Tian et al.   HEPATOLOGY

Quantitative Acetylome Analysis Reveals the Roles of SIRT1 in Regulating Diverse Substrates and Cellular Pathways

(2012) Yue Chen et al.   MOLECULAR & CELLULAR PROTEOMICS

Hepatic Deletion of SIRT1 Decreases Hepatocyte Nuclear Factor 1 /Farnesoid X Receptor Signaling and Induces Formation of Cholesterol Gallstones in Mice

(2012) A. Purushotham et al.   MOLECULAR AND CELLULAR BIOLOGY

Myocardin-Related Transcription Factor A Mediates OxLDL-Induced Endothelial Injury

(2011) Fei Fang et al.   CIRCULATION RESEARCH

Interferon gamma (IFN-γ) disrupts energy expenditure and metabolic homeostasis by suppressing SIRT1 transcription

(2011) Ping Li et al.   NUCLEIC ACIDS RESEARCH

SIRT1 links CIITA deacetylation to MHC II activation

(2011) Xiaoyan Wu et al.   NUCLEIC ACIDS RESEARCH

Endothelial to Mesenchymal Transition via Transforming Growth Factor-β1/Smad Activation Is Associated with Portal Venous Stenosis in Idiopathic Portal Hypertension

(2009) Azusa Kitao et al.   AMERICAN JOURNAL OF PATHOLOGY

MeCP2 Controls an Epigenetic Pathway That Promotes Myofibroblast Transdifferentiation and Fibrosis

(2009) Jelena Mann et al.   GASTROENTEROLOGY

Targeting liver fibrosis: Strategies for development and validation of antifibrotic therapies

(2009) Yury Popov et al.   HEPATOLOGY

PPARγ enhances IFNγ-mediated transcription and rescues the TGFβ antagonism by stimulating CIITA in vascular smooth muscle cells

(2009) Xiaocen Kong et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

(2008) Xiang-Jiao Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY