Ganetespib limits ciliation and cystogenesis in autosomal-dominant polycystic kidney disease (ADPKD)

Genome-wide screen identifies novel machineries required for both ciliogenesis and cell cycle arrest upon serum starvation

(2016) Ji Hyun Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The importance of total kidney volume in evaluating progression of polycystic kidney disease

(2016) Jared J. Grantham et al.   Nature Reviews Nephrology

2-Deoxy-D-Glucose Ameliorates PKD Progression

(2015) M. Chiaravalli et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes

(2015) Gabrielle Wheway et al.   NATURE CELL BIOLOGY

The hallmarks of cancer: relevance to the pathogenesis of polycystic kidney disease

(2015) Tamina Seeger-Nukpezah et al.   Nature Reviews Nephrology

Vascular complications in autosomal dominant polycystic kidney disease

(2015) Ronald D. Perrone et al.   Nature Reviews Nephrology

Nek2 activation of Kif24 ensures cilium disassembly during the cell cycle

(2015) Sehyun Kim et al.   Nature Communications

Opposing Effects of Inhibitors of Aurora-A and EGFR in Autosomal-Dominant Polycystic Kidney Disease

(2015) Anna S. Nikonova et al.   Frontiers in Oncology

HSP90 Inhibition Suppresses Lipopolysaccharide-Induced Lung Inflammation In Vivo

(2015) Andrew Lilja et al.   PLoS One

Pharmacological management of polycystic kidney disease

(2014) Rudolf P Wüthrich et al.   EXPERT OPINION ON PHARMACOTHERAPY

The Tumor Suppressor pVHL Down-regulates Never-in-Mitosis A-related Kinase 8 via Hypoxia-inducible Factors to Maintain Cilia in Human Renal Cancer Cells

(2014) Xiao-Fei Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blood Pressure in Early Autosomal Dominant Polycystic Kidney Disease

(2014) Robert W. Schrier et al.   NEW ENGLAND JOURNAL OF MEDICINE

Angiotensin Blockade in Late Autosomal Dominant Polycystic Kidney Disease

(2014) Vicente E. Torres et al.   NEW ENGLAND JOURNAL OF MEDICINE

Inhibiting Heat Shock Protein 90 (HSP90) Limits the Formation of Liver Cysts Induced by Conditional Deletion of Pkd1 in Mice

(2014) Zachary B. Smithline et al.   PLoS One

Nedd9 restrains renal cystogenesis in Pkd1-/- mice

(2014) A. S. Nikonova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitin-proteasome system controls ciliogenesis at the initial step of axoneme extension

(2014) Kousuke Kasahara et al.   Nature Communications

Polycystin Signaling Is Required for Directed Endothelial Cell Migration and Lymphatic Development

(2014) Patricia Outeda et al.   Cell Reports

Cost-Effectiveness of Tolvaptan in Autosomal Dominant Polycystic Kidney Disease

(2013) Kevin F. Erickson et al.   ANNALS OF INTERNAL MEDICINE

VDAC3 and Mps1 negatively regulate ciliogenesis

(2013) Shubhra Majumder et al.   CELL CYCLE

A Multicenter Phase II Study of Ganetespib Monotherapy in Patients with Genotypically Defined Advanced Non-Small Cell Lung Cancer

(2013) M. A. Socinski et al.   CLINICAL CANCER RESEARCH

Loss of cilia suppresses cyst growth in genetic models of autosomal dominant polycystic kidney disease

(2013) Ming Ma et al.   NATURE GENETICS

Defective glucose metabolism in polycystic kidney disease identifies a new therapeutic strategy

(2013) Isaline Rowe et al.   NATURE MEDICINE

Inhibiting the HSP90 chaperone slows cyst growth in a mouse model of autosomal dominant polycystic kidney disease

(2013) T. Seeger-Nukpezah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

The role of the cilium in normal and abnormal cell cycles: emphasis on renal cystic pathologies

(2012) Junmin Pan et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Aurora A kinase (AURKA) in normal and pathological cell division

(2012) Anna S. Nikonova et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

The extracellular matrix and ciliary signaling

(2012) Tamina Seeger-Nukpezah et al.   CURRENT OPINION IN CELL BIOLOGY

Trichoplein and Aurora A block aberrant primary cilia assembly in proliferating cells

(2012) Akihito Inoko et al.   JOURNAL OF CELL BIOLOGY

Plk2 regulates centriole duplication through phosphorylation-mediated degradation of Fbxw7 (human Cdc4)

(2012) Onur Cizmecioglu et al.   JOURNAL OF CELL SCIENCE

Systematic Identification of the HSP90 Regulated Proteome

(2012) Zhixiang Wu et al.   MOLECULAR & CELLULAR PROTEOMICS

Calmodulin activation of Aurora-A kinase (AURKA) is required during ciliary disassembly and in mitosis

(2012) Olga V. Plotnikova et al.   MOLECULAR BIOLOGY OF THE CELL

Tolvaptan in Patients with Autosomal Dominant Polycystic Kidney Disease

(2012) Vicente E. Torres et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Nek8 protein kinase, mutated in the human cystic kidney disease nephronophthisis, is both activated and degraded during ciliogenesis

(2011) Detina Zalli et al.   HUMAN MOLECULAR GENETICS

Aurora A kinase activity influences calcium signaling in kidney cells

(2011) Olga V. Plotnikova et al.   JOURNAL OF CELL BIOLOGY

Mechanism-Based Therapeutics for Autosomal Dominant Polycystic Kidney Disease: Recent Progress and Future Prospects

(2011) Ming-Yang Chang et al.   NEPHRON CLINICAL PRACTICE

An Interaction Network Predicted from Public Data as a Discovery Tool: Application to the Hsp90 Molecular Chaperone Machine

(2011) Pablo C. Echeverría et al.   PLoS One

Activating AMP-activated protein kinase (AMPK) slows renal cystogenesis

(2011) V. Takiar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A systems-biology approach to understanding the ciliopathy disorders

(2011) Ji Eun Lee et al.   Genome Medicine

The HALT Polycystic Kidney Disease Trials: Design and Implementation

(2010) A. B. Chapman et al.   Clinical Journal of the American Society of Nephrology

Sirolimus and Kidney Growth in Autosomal Dominant Polycystic Kidney Disease

(2010) Andreas L. Serra et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rapid calcium-dependent activation of Aurora-A kinase

(2010) Olga V. Plotnikova et al.   Nature Communications

ERK1/2-Dependent Vascular Endothelial Growth Factor Signaling Sustains Cyst Growth in Polycystin-2 Defective Mice

(2009) Carlo Spirli et al.   GASTROENTEROLOGY

Mammalian target of rapamycin regulates vascular endothelial growth factor-dependent liver cyst growth in polycystin-2-defective mice

(2009) Carlo Spirli et al.   HEPATOLOGY

Autosomal dominant polycystic kidney disease: the last 3 years

(2009) Vicente E. Torres et al.   KIDNEY INTERNATIONAL

Polycystic Kidney Disease

(2008) Peter C. Harris et al.   Annual Review of Medicine

Src Inhibition Ameliorates Polycystic Kidney Disease

(2008) W. E. Sweeney et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Monitoring kidney and renal cyst volumes applying MR approaches on a rapamycin treated mouse model of ADPKD

(2008) Wilfried Reichardt et al.   MAGNETIC RESONANCE MATERIALS IN PHYSICS BIOLOGY AND MEDICINE

STRING 8--a global view on proteins and their functional interactions in 630 organisms

(2008) L. J. Jensen et al.   NUCLEIC ACIDS RESEARCH