MMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production

Treatment Sequence Matters: Anabolic and Antiresorptive Therapy for Osteoporosis

(2017) Felicia Cosman et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Genetic deletion of Sost or pharmacological inhibition of sclerostin prevent multiple myeloma-induced bone disease without affecting tumor growth

(2017) J Delgado-Calle et al.   LEUKEMIA

Commentary: Concurrent administration of PTH and antiresorptives: Additive effects or DXA cosmetics

(2016) Erik Fink Eriksen et al.   BONE

Letter to the editor in response to the commentary, "Concurrent administration of PTH and antiresorptives: Additive effects or DXA cosmetics

(2016) Benjamin Z. Leder et al.   BONE

Bidirectional Notch Signaling and Osteocyte-Derived Factors in the Bone Marrow Microenvironment Promote Tumor Cell Proliferation and Bone Destruction in Multiple Myeloma

(2016) J. Delgado-Calle et al.   CANCER RESEARCH

Effect of Abaloparatide vs Placebo on New Vertebral Fractures in Postmenopausal Women With Osteoporosis

(2016) Paul D. Miller et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin

(2016) Amy Y Sato et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Control of Bone Anabolism in Response to Mechanical Loading and PTH by Distinct Mechanisms Downstream of the PTH Receptor

(2016) Jesus Delgado-Calle et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Selective Inhibition of Membrane Type 1 Matrix Metalloproteinase Abrogates Progression of Experimental Inflammatory Arthritis: Synergy With Tumor Necrosis Factor Blockade

(2016) Kazuyo Kaneko et al.   Arthritis & Rheumatology

The Role of IL-17 and TH17 Cells in the Bone Catabolic Activity of PTH

(2016) Roberto Pacifici   Frontiers in Immunology

T cells, osteoblasts, and osteocytes: interacting lineages key for the bone anabolic and catabolic activities of parathyroid hormone

(2015) Roberto Pacifici   Annals of the New York Academy of Sciences

Biotechnological approach for systemic delivery of membrane Receptor Activator of NF-κB Ligand (RANKL) active domain into the circulation

(2015) Alfredo Cappariello et al.   BIOMATERIALS

Parathyroid hormone: anabolic and catabolic actions on the skeleton

(2015) Barbara C Silva et al.   CURRENT OPINION IN PHARMACOLOGY

Loss of MT1-MMP causes cell senescence and nuclear defects which can be reversed by retinoic acid

(2015) A. Gutierrez-Fernandez et al.   EMBO JOURNAL

Blockade of MMP14 Activity in Murine Breast Carcinomas: Implications for Macrophages, Vessels, and Radiotherapy

(2015) Eleanor I. Ager et al.   JNCI-Journal of the National Cancer Institute

Osteocytes mediate the anabolic actions of canonical Wnt/β-catenin signaling in bone

(2015) Xiaolin Tu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

FGF23 is elevated in multiple myeloma and increases heparanase expression by tumor cells

(2015) Attaya Suvannasankha et al.   Oncotarget

Blockade of MMP14 Activity in Murine Breast Carcinomas: Implications for Macrophages, Vessels, and Radiotherapy

(2015) Eleanor I. Ager et al.   JNCI-Journal of the National Cancer Institute

Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone

(2015) Jinhu Xiong et al.   PLoS One

Osteocyte-derived RANKL is a critical mediator of the increased bone resorption caused by dietary calcium deficiency

(2014) Jinhu Xiong et al.   BONE

The Rho-GEF Kalirin regulates bone mass and the function of osteoblasts and osteoclasts

(2014) Su Huang et al.   BONE

Parathyroid Hormone Receptor Signaling Induces Bone Resorption in the Adult Skeleton by Directly Regulating theRANKLGene in Osteocytes

(2014) Abdullah N. Ben-awadh et al.   ENDOCRINOLOGY

High Bone Mass in Mice Lacking Cx37 Because of Defective Osteoclast Differentiation

(2014) Rafael Pacheco-Costa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Atypical Femoral Fractures, Bisphosphonates, and Mechanical Stress

(2014) Per Aspenberg et al.   Current Osteoporosis Reports

Atypical Subtrochanteric and Diaphyseal Femoral Fractures: Second Report of a Task Force of the American Society for Bone and Mineral Research

(2013) Elizabeth Shane et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Effects of PTH on osteocyte function

(2012) Teresita Bellido et al.   BONE

Osteocyte control of osteoclastogenesis

(2012) Charles A. O'Brien et al.   BONE

Role of DNA methylation in the regulation of the RANKL-OPG system in human bone

(2012) Jesús Delgado-Calle et al.   Epigenetics

Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading

(2011) Xiaolin Tu et al.   BONE

DNA methylation contributes to the regulation of sclerostin expression in human osteocytes

(2011) Jesús Delgado-Calle et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Matrix-embedded cells control osteoclast formation

(2011) Jinhu Xiong et al.   NATURE MEDICINE

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

Biomimetic bone mechanotransduction modeling in neonatal rat femur organ cultures: structural verification of proof of concept

(2010) Marnie M. Saunders et al.   Biomechanics and Modeling in Mechanobiology

Shedding of RANKL by Tumor-Associated MT1-MMP Activates Src-Dependent Prostate Cancer Cell Migration

(2010) A. L. Sabbota et al.   CANCER RESEARCH

PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling

(2010) Yumie Rhee et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The amazing osteocyte

(2010) Lynda F Bonewald   JOURNAL OF BONE AND MINERAL RESEARCH

Proteolytic and non-proteolytic roles of membrane type-1 matrix metalloproteinase in malignancy

(2009) Alex Y. Strongin   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Control of RANKL gene expression

(2009) Charles A. O'Brien   BONE

Selective Inhibition of Matrix Metalloproteinase-14 Blocks Tumor Growth, Invasion, and Angiogenesis

(2009) Laetitia Devy et al.   CANCER RESEARCH

Control of Bone Mass and Remodeling by PTH Receptor Signaling in Osteocytes

(2008) Charles A. O'Brien et al.   PLoS One

Targeted Deletion of a Distant Transcriptional Enhancer of the Receptor Activator of Nuclear Factor-κB Ligand Gene Reduces Bone Remodeling and Increases Bone Mass

(2007) Carlo Galli et al.   ENDOCRINOLOGY