Article
Endocrinology & Metabolism
Seunghyun Lee, Namki Hong, Kyoung Jin Kim, Chung Hyun Park, Jooyeon Lee, Yumie Rhee
Summary: This retrospective cohort study found that treatment with teriparatide (TPTD) in premenopausal women with pregnancy- and lactation-associated osteoporosis (PLO) can effectively maintain bone mineral density (BMD) without the need for sequential antiresorptive therapy (ART).
CALCIFIED TISSUE INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Sabashini K. Ramchand, Natalie L. David, Hang Lee, Michael Bruce, Mary L. Bouxsein, Benjamin Z. Leder, Joy N. Tsai
Summary: In postmenopausal women at high risk of fracture, combination therapy with denosumab and high- or standard-dose teriparatide significantly improves bone density, microstructure, and estimated strength, with greater gains observed in the high-dose group.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Takaaki Ishida, Shuzo Yoshida, Youhei Fujiki, Kenichiro Hata, Takuya Kotani, Tohru Takeuchi
Summary: The study demonstrates that denosumab is effective in increasing bone mineral density in patients with glucocorticoid-induced osteoporosis refractory to previous treatment. Additionally, denosumab shows potential in reducing bone turnover markers.
ARCHIVES OF OSTEOPOROSIS
(2021)
Article
Endocrinology & Metabolism
Sabashini K. Ramchand, Natalie L. David, Hang Lee, Richard Eastell, Joy N. Tsai, Benjamin Z. Leder
Summary: Combination therapy of teriparatide and denosumab can significantly increase bone mineral density, while discontinuation of denosumab may lead to bone loss and increased fracture risk. A single dose of zoledronic acid effectively maintains the BMD improvements achieved with the combination therapy for at least 27 months. Spine BMD was largely preserved during this period as well.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Multidisciplinary Sciences
Jae-Young Kim, Hyo-Won Jang, Jung-In Kim, In-Ho Cha
Summary: This study revealed that administering intermittent parathyroid hormone (iPTH) before and after tooth extraction can affect healing outcomes, with post-extraction iPTH administration showing better bone healing in the extraction socket compared to pre-extraction administration.
SCIENTIFIC REPORTS
(2021)
Article
Physiology
Marwa Bouamra, Hassane Zouhal, Sebastien Ratel, Issam Makhlouf, Ikram Bezrati, Mokhtar Chtara, David G. Behm, Urs Granacher, Anis Chaouachi
Summary: The prevalence of obesity in the pediatric population is a major public health issue. Physical activity, especially exercise, is crucial in the fight against childhood obesity. This study compares the effects of different exercise methods on body composition and physical fitness in obese youth and finds that duration-matched concurrent training promotes significant improvements in fat, weight loss, and cardiorespiratory fitness.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Veterinary Sciences
Lauren Crawford, Shollie Falkenberg, Ellie Jordan Putz, Steven Olsen, Paola M. Boggiatto
Summary: Brucella abortus is a zoonotic pathogen that can cause abortions and stillbirths in cattle. Cell mediated immunity plays a crucial role in protection against this pathogen. In this study, PBMCs from vaccinated and non-vaccinated cattle were analyzed. Results showed that simultaneous administration of RB51 and a viral modified live vaccine did not interfere with immune responses, suggesting that potential vaccine combinations should be evaluated for biological effects.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Leandro Kansuke Oharomari, Mitsushi J. Ikemoto, Dong Joo Hwang, Hikaru Koizumi, Hideaki Soya
Summary: Maintaining a healthy lifestyle with regular exercise and a nutritious diet is crucial for physical and mental well-being. The interaction between exercise training and dietary nutrients to promote health promotion is still not well understood, with further research needed on potential additive or synergistic effects. Astaxanthin (ASX), a bioactive compound found in seafood, is being studied for its potential benefits when combined with exercise regimes, highlighting the importance of integrative studies in the field of health and sports nutrition science.
Article
Multidisciplinary Sciences
Dean Follmann, Meagan P. O'Brien, Jonathan Fintzi, Michael P. Fay, David Montefiori, Allyson Mateja, Gary A. Herman, Andrea T. Hooper, Kenneth C. Turner, Kuo- Chen Chan, Eduardo Forleo-Neto, Flonza Isa, Lindsey R. Baden, Hana M. El Sahly, Holly Janes, Nicole Doria-Rose, Jacqueline Miller, Honghong Zhou, Weiping Dang, David Benkeser, Youyi Fong, Peter B. Gilbert, Mary Marovich, Myron S. Cohen
Summary: This study demonstrates the correlation between neutralizing antibody titers and the efficacy of monoclonal antibodies and vaccines in providing protection against COVID-19. It shows that a certain level of neutralizing antibody titer is associated with high protective efficacy (92-97%). These findings suggest that neutralizing antibody titers can serve as surrogate endpoints for authorizing new monoclonal antibodies.
NATURE COMMUNICATIONS
(2023)
Article
Agriculture, Dairy & Animal Science
A. R. Bayat, J. Vilkki, A. Razzaghi, H. Leskinen, H. Kettunen, R. Khurana, T. Brand, S. Ahvenjarvi
Summary: This study evaluated the effects of high-oil rapeseed cake and natural additives on enteric methane emissions in dairy cows. The results showed that replacing rapeseed meal with rapeseed cake reduced CH4 emissions, while the addition of natural additives did not have a significant effect on CH4 emissions.
JOURNAL OF DAIRY SCIENCE
(2022)
Review
Medicine, Research & Experimental
Ya Li, Tonghua Liu, Lingling Qin, Lili Wu
Summary: This study aimed to investigate the effects of probiotics on eight factors in overweight or obese children. Meta-analysis of four publications showed that probiotics significantly decreased levels of HDL-C, LDL-C, adiponectin, leptin, and TNF-α compared to placebo. However, there was no significant difference in BMI, TC, and TG between the two groups.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Agriculture, Dairy & Animal Science
Nathalia T. S. Grigoletto, Lucas G. Ghizzi, Larissa S. Gheller, Mauro S. da S. Dias, Alanne T. Nunes, Tassia B. P. Silva, Guilherme G. da Silva, Luiz F. Costa e Silva, Daniel N. Lobato, Francisco P. Renno
Summary: This study evaluated the effects of feed additives on dairy cows during the hot season, with results showing that adding Milk Sacc+ improved milk yield and solids yield, while adding monensin increased milk urea nitrogen content. Physiological parameters were not affected by the treatments.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Agriculture, Dairy & Animal Science
Francesca Cubeddu, Gerolamo Masala, Giovanni Sotgiu, Alessandra Mollica, Sylvia Versace, Giovanni Mario Careddu
Summary: This study evaluated the cardiorespiratory effects and analgesic properties of maropitant and methadone combined with desflurane in dogs undergoing ovariectomy. The results showed that maropitant produced analgesia and reduced the requirement of desflurane, while maintaining cardiovascular and respiratory parameters at a satisfactory level.
Article
Multidisciplinary Sciences
Katsuhito Nagai, Yoshikazu Ryuno, Yoshihito Iwanami, Sachiko Omotani, Shuhei Fukuno, Yasutoshi Hatsuda, Hiroki Konishi, Michiaki Myotoku
Summary: The study found that the pharmacokinetic profiles of sodium valproate and levetiracetam were not significantly affected by altering the dosing time of the prescribed semi-solid enteral formula. However, the plasma concentration of carbamazepine decreased with extended dosing time. Staggered administration of carbamazepine and semi-solid enteral nutrient prevented their interaction.
Article
Oncology
Teresa Bernardo, Carina Behrends, Diana Klein, Anna Kuntze, Beate Timmermann, Claere von Neubeck
Summary: High-precision radiotherapy with proton beams combined with doxorubicin for aggressive soft tissue sarcoma (STS) has high local recurrence rates. Optimized treatment protocols considering STS heterogeneity are needed. Preclinical STS models showed dose-dependent radiation response with reduced survival, proliferation, viability, and motility. Doxorubicin showed highest efficiency when combined with radiation, especially before or after radiation. Further investigations are needed for alternative drug therapies combined with proton irradiation.
FRONTIERS IN ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Brian C. Lentle, Claudie Berger, Jacques P. Brown, Linda Probyn, Lisa Langsetmo, Ian Hammond, Jeff Hu, William D. Leslie, Jerilynn C. Prior, David A. Hanley, Jonathan D. Adachi, Robert G. Josse, Angela M. Cheung, Stephanie M. Kaiser, Tanveer Towheed, Christopher S. Kovacs, Andy Kin On Wong, David Goltzman
Summary: This study compared two different morphometric evaluation methods in identifying vertebral fractures and found that morphologic fractures were more common than morphometric deformities, closely aligning with the expected epidemiology of vertebral fractures.
CANADIAN ASSOCIATION OF RADIOLOGISTS JOURNAL-JOURNAL DE L ASSOCIATION CANADIENNE DES RADIOLOGISTES
(2021)
Article
Endocrinology & Metabolism
D. L. Kendler, J. D. Adachi, J. P. Brown, A. G. Juby, C. S. Kovacs, C. Duperrouzel, R. K. McTavish, C. Cameron, L. Slatkovska, N. Burke
Summary: The scorecard evaluated the burden and management of osteoporosis in Canada, revealing inequities in patients' access to diagnosis, treatment, and care programs across provinces. Interventions are needed to address these disparities and close the treatment gap.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Delphine Farlay, Sebastien Rizzo, Louis-Georges Ste-Marie, Laetitia Michou, Suzanne N. Morin, Shijing Qiu, Pascale Chavassieux, Roland D. Chapurlat, Sudhaker D. Rao, Jacques P. Brown, Georges Boivin
Summary: Bisphosphonates are commonly used drugs for treating osteoporosis, but long-term use may increase the risk of atypical femur fracture. Research found that patients with AFF had higher bone mineralization levels compared to non-AFF patients, potentially due to the accumulation of bisphosphonates in bone mineral affecting the osteocyte cytoskeleton.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Orthopedics
Jonathan D. Adachi, Jacques P. Brown, Emil Schemitsch, Jean-Eric Tarride, Vivien Brown, Alan D. Bell, Maureen Reiner, Millicent Packalen, Ponda Motsepe-Ditshego, Natasha Burke, Lubomira Slatkovska
Summary: The study found that Canadian patients aged over 65 who experienced a fragility fracture at any site are at imminent risk of experiencing subsequent fracture within the next 2 years and should be proactively assessed and treated.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Endocrinology & Metabolism
J. -E. Tarride, J. D. Adachi, J. P. Brown, E. Schemitsch, L. Slatkovska, N. Burke
Summary: The study revealed that in Ontario, the first-year direct healthcare costs of fragility fractures were three times higher for patients with fractures compared to those without fractures. Over 60% of the direct costs were attributed to hospitalization and continuing care, highlighting the significant economic burden fractures pose on the healthcare system.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Claudia Beaudoin, Sonia Jean, Lynne Moore, Philippe Gamache, Louis Bessette, Louis-Georges Ste-Marie, Jacques P. Brown
Summary: This study derived and validated predictive models using healthcare administrative data to accurately identify individuals at high risk of osteoporotic fracture. The models included predictors such as age, sex, diabetes, and were found to have good predictive performance, especially for predicting hip/femur fractures. Further validation in external cohorts is recommended for future surveillance of osteoporosis.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Jacques P. Brown, Klaus Engelke, Tony M. Keaveny, Arkadi Chines, Roland Chapurlat, A. Joseph Foldes, Xavier Nogues, Roberto Civitelli, Tobias De Villiers, Fabio Massari, Cristiano A. F. Zerbini, Zhenxun Wang, Mary K. Oates, Christopher Recknor, Cesar Libanati
Summary: The study demonstrated that romosozumab significantly improved bone mass and bone strength at the lumbar spine compared to alendronate, indicating a superior treatment effect of romosozumab for postmenopausal women with osteoporosis at high risk.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Emil Schemitsch, Jonathan D. Adachi, Jacques P. Brown, Jean-Eric Tarride, Natasha Burke, Thiago Oliveira, Lubomira Slatkovska
Summary: In this large retrospective cohort study, one in four patients experienced a subsequent hip fracture after any initial fracture, with the most common being hip fractures, occurring on average within 1.5 years. These findings emphasize the importance of early post-fracture interventions to reduce the risk of imminent hip fractures and the associated high costs.
OSTEOPOROSIS INTERNATIONAL
(2022)
Editorial Material
Endocrinology & Metabolism
J. C. Prior, E. H. G. Oei, J. P. Brown, L. Oei, F. Koromani, Brian C. Lentle
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Delphine Farlay, Sebastien Rizzo, David W. Dempster, Shuang Huang, Arkadi Chines, Jacques P. Brown, Georges Boivin
Summary: In postmenopausal women with osteoporosis, denosumab therapy for 10 years significantly increased bone mineralization, with more pronounced changes within the first 5 years. The study showed that denosumab treatment for 5 years led to a transition of mineral to more mature crystals and lower microhardness, indicating a persistence of low bone remodeling state at 5 and 10 years.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Ron Goeree, Natasha Burke, Manon Jobin, Jacques P. Brown, Donna Lawrence, Bjorn Stollenwerk, Damon Willems, Ben Johnson
Summary: This study shows that romosozumab followed by alendronate is a cost-effective treatment option for postmenopausal women with osteoporosis at high risk for fracture in Canada. It is associated with reduced costs and greater benefit compared to alendronate and risedronate alone.
ARCHIVES OF OSTEOPOROSIS
(2022)
Article
Endocrinology & Metabolism
T. Oliveira, D. L. Kendler, P. Schneider, A. G. Juby, R. J. Wani, M. Packalen, S. Avcil, S. Li, C. Waters-Banker, E. Graves, S. McMullen, J. Brown
Summary: The study found that the rate of low-energy fractures slightly decreased in the first few months of the COVID-19 pandemic, while the rates of surgeries and surgical outcomes remained stable.
ARCHIVES OF OSTEOPOROSIS
(2022)
Article
Endocrinology & Metabolism
T. Oliveira, J. Brown, A. G. Juby, P. Schneider, R. J. Wani, M. Packalen, S. Avcil, S. Li, M. Farris, E. Graves, S. McMullen, D. L. Kendler
Summary: This study aimed to describe the care patterns for osteoporosis during the COVID-19 pandemic in Alberta, Canada, compared to the preceding three years. The study found a decline in healthcare resource utilization, physician visits, diagnostic and laboratory tests, and treatment initiations for osteoporosis during the pandemic. Despite an increase in telehealth visits, oral bisphosphonate treatment initiations remained lower than pre-pandemic levels.
ARCHIVES OF OSTEOPOROSIS
(2022)
Article
Medical Laboratory Technology
Jacques P. Brown, Andrew Don-Wauchope, Pierre Douville, Caroline Albert, Samuel D. Vasikaran
Summary: Bone turnover markers provide a dynamic assessment of bone remodeling, but are not useful in diagnosing osteoporosis or predicting bone loss and fractures. However, they have proven to be valuable in elucidating the pharmacodynamics and effectiveness of osteoporosis medications in clinical trials.
CLINICAL BIOCHEMISTRY
(2022)
Review
Endocrinology & Metabolism
Jacques P. Brown
Summary: Osteoporosis is a chronic condition that cannot be cured, with a major gap in primary prevention of fractures. Case finding strategies and pharmacological interventions are available to provide lifelong fracture protection, with the benefits of osteoporosis therapies far outweighing the rare risks.
ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.