Review
Cell Biology
Nasim Kheshtchin, Jamshid Hadjati
Summary: Hypoxia, a common characteristic of solid tumors, contributes to different aspects of tumor progression and limits the efficacy of immunotherapies. Developing new immunotherapy strategies involving therapeutic targeting of HIF-1 molecules associated with hypoxia may enhance the clinical effectiveness of immunotherapy. Targeting hypoxia presents a potential opportunity to improve the clinical benefit of cancer immunotherapy.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Ka Lin Heck-Swain, Jiwen Li, Wei Ruan, Xiaoyi Yuan, Yanyu Wang, Michael Koeppen, Holger K. Eltzschig
Summary: The myeloid-expressed HIF1A plays a functional role in providing cardioprotection during ischemia and reperfusion injury by inducing the neuronal guidance molecule netrin-1 in neutrophils.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Thuy-Hang Nguyen, Stephanie Conotte, Alexandra Belayew, Anne-Emilie Decleves, Alexandre Legrand, Alexandra Tassin
Summary: Muscular dystrophies are genetic degenerative muscle disorders characterized by muscle wasting, often accompanied by respiratory impairments and hypoxemia. Hypoxic stress activates compensatory mechanisms, with HIF-1α playing a key role. Alterations in HIF-1α in muscle may impact the pathophysiology of muscular dystrophies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Liyun Yong, Shasha Tang, Haixin Yu, Hongyi Zhang, Yi Zhang, Yuan Wan, Fengfeng Cai
Summary: Breast cancer is the most common cancer in women, and drug resistance is a persistent clinical challenge. Hypoxia-inducible Factor-1 Alpha (HIF-1α) plays a crucial role in regulating cellular response to hypoxia and is closely associated with multidrug resistance in breast cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Xiao-Yi Chen, Qian-Long Wang, Wei-Xue Huang, Long-Wei Li, Lan-Cong Liu, Yi Yang, You-Jiao Wu, Shan-Shan Song, Hao Ma, Hua Zhou, Pei Luo
Summary: This study aimed to analyze and evaluate the dynamic changes in HIF-1 alpha concentration in serum exosomes during bacterial peritonitis. A new colorimetric method to quantitate these changes was established. The results showed that the serum exosomal HIF-1 alpha levels increased in the early stage of bacterial peritonitis, reached a peak at 24-48 hours, and then gradually decreased. Intervention treatment reduced the abdominal infection extent, HIF-1 alpha concentration in serum exosomes, and the serum pro-inflammatory factors levels. These findings suggest that serum exosomal HIF-1 alpha can be used as a biomarker for predicting and monitoring the pathological process of bacterial peritonitis.
Review
Cell Biology
Mykyta Malkov, Chee Teik Lee, Cormac T. Taylor
Summary: Hypoxia and inflammation frequently co-occur in inflammatory diseases, with pro-inflammatory cytokines such as TNF-alpha and IL-1 beta directly impacting HIF signaling pathways. Multi-level crosstalk between inflammatory and hypoxic signaling pathways plays a crucial role in shaping the degree of inflammation at hypoxic sites.
Article
Environmental Sciences
Meriam N. N. Rezk, Gerges M. Beshreda, Dalia Abdelrahman Meshref, Walaa Yehia Abdelzaher, Gaber El-Saber Batiha, Amin A. Hafiz, Duaa Althumairy, Nada H. Aljarba, Nermeen N. Welson
Summary: This study aimed to investigate the role of hypoxiainducible factor-1 alpha (HIF-1 alpha) in the diagnosis, prediction, and follow-up of Dormex-intoxicated patients. The results showed that HIF-1 alpha can effectively predict and follow up patients within 24 hours after admission. Additionally, blood-related indicators were also significantly abnormal in patients with Dormex intoxication.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Physiology
Mariela Beatriz Nolly, Lorena Alejandra Vargas, Maria Veronica Correa, Juan Manuel Lofeudo, Andres Oscar Pinilla, Jorge Omar Velez Rueda, Martin E. Guerrero-Gimenez, Erik Richard Swenson, Maria Teresa Damiani, Bernardo Victor Alvarez
Summary: The study found that after myocardial infarction, the interaction between CAIX and NBC1 to prevent acidic damage in hypoxic tissue may be a promising therapeutic target.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2021)
Article
Chemistry, Physical
Zheng Wang, Xuewen Mu, Qian Yang, Jiajia Luo, Yanjun Zhao
Summary: This study utilizes hypoxia-responsive polymer micelles combined with an NQO1 inhibitor (dicoumarol) to enhance the sensitivity of ovarian cancer cells to the anticancer drug sorafenib under low oxygen conditions. Both drugs are encapsulated in nanoscale micelles and the degradation of HIF-1α is increased to improve apoptosis induced by the drug.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Kenta Kaihara, Shuji Nakagawa, Yuji Arai, Hiroaki Inoue, Shinji Tsuchida, Yuta Fujii, Yoichiro Kamada, Tsunao Kishida, Osam Mazda, Kenji Takahashi
Summary: The study found that hypoxia can suppress the development of rheumatoid arthritis by controlling HIF-1 alpha expression, delaying joint swelling and reducing joint destruction. Deferoxamine-mediated activation of HIF-1 alpha can counteract the inhibitory effect of sustained hypoxia on pro-inflammatory cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yu-Kun Jie, Jian-Jun Jiang, Hong-Ling Ma, Chang -Hong Cheng, Guang-Xin Liu, Si-Gang Fan, Juan Feng, Zhi-Xun Guo
Summary: In this study, a novel PHD2 gene, SpPHD2, was cloned and identified in the mud crab Scylla paramamosain. The mRNA expression of SpPHD2 was widely distributed across all examined tissues, and the protein was mainly localized in the cytoplasm. Silencing SpPHD2 in vivo upregulated SpHIF-1 alpha and downstream genes, while overexpression of SpPHD2 in vitro dose-dependently reduced SpHIF-1 alpha transcriptional activity, indicating the crucial role of SpPHD2 in regulating SpHIF-1 alpha.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
(2023)
Review
Oncology
Bich Phuong Bui, Phuong Linh Nguyen, Kyeong Lee, Jungsook Cho
Summary: This review discusses the crucial role of hypoxia-inducible factor-1 (HIF-1) in tumor biology, particularly in hypoxic environments. Despite numerous identified HIF-1 inhibitors as potential therapeutic agents for various cancers, none of them have been successfully translated into clinically available cancer treatments. The review summarizes the roles of the HIF-1 pathway in tumor proliferation, angiogenesis, metastasis, drug resistance, and cancer-related pain. Additionally, it highlights the current status of HIF-1 inhibitors in clinical trials and their future perspectives. HIF-1 inhibitors may be promising combinational therapeutic interventions to improve the efficacy of current cancer treatments and reduce drug resistance and cancer-related pain.
Article
Biochemistry & Molecular Biology
Marina Sakai, Nobuaki Takahashi, Hiroaki Ikeda, Yutaka Furutani, Shoko Higuchi, Takehiro Suzuki, Naoshi Dohmae, Sayaka Kobayashi, Hiroshi Harada, Soichi Kojima, Tomokazu Matsuura, Akira Hattori, Hideaki Kakeya
Summary: HIF-1 is a promising drug target for cancer chemotherapy, with KUSC-5037 identified as an effective inhibitor under hypoxic conditions. KUSC-5037 suppresses HIF-1 signaling and reduces the expression of HIF-1 target genes, showing potential as a lead molecule for cancer treatment.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Immunology
Gabriela Burczyk, Iwona Cichon, Elzbieta Kolaczkowska
Summary: 4-octyl itaconate (4-OI) diminishes the formation of neutrophil extracellular traps (NETs) in mice, regardless of their health status or metabolic challenges. The inhibition is mediated by downregulating Hif-1 alpha and inducing HO-1.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Elena V. Mitroshina, Maria O. Savyuk, Evgeni Ponimaskin, Maria V. Vedunova
Summary: Hypoxia is a common pathological condition induced by various events, with the body's adaptation to it being crucial for health and disease. HIFs, a family of transcription factors, play a key role in cellular responses to hypoxia and are increasingly viewed as potential targets for treating a range of hypoxia-associated diseases. The role of HIFs in adaptation to hypoxia is universal across tissue types, including the CNS, where they are involved in regulating neurogenesis, nerve cell differentiation, and neuronal apoptosis, potentially offering new therapeutic opportunities.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)