Review
Pharmacology & Pharmacy
Mahmoud Mostafa, Adel Al Fatease, Raid G. Alany, Hamdy Abdelkader
Summary: Chronic ocular diseases have a significant impact on vision and the potential to cause blindness. Developing sophisticated, long-acting drug delivery systems is crucial for treating these conditions. This review explores non-invasive drug delivery nanocarriers that can control chronic eye disorders, although most are still in preclinical or clinical stages.
Article
Biochemistry & Molecular Biology
Debora Santonocito, Maria Vivero-Lopez, Maria Rosaria Lauro, Cristina Torrisi, Francesco Castelli, Maria Grazia Sarpietro, Carmelo Puglia
Summary: This study nanoencapsulated MGN into nanostructured lipid carriers (NLC) to improve its ocular bioavailability and preserve its antioxidant activity. The results showed that MGN-NLC had good technological parameters and higher antioxidant activity in ocular delivery, without causing irritation to ocular tissues.
Review
Pharmacology & Pharmacy
Sofia M. Saraiva, Lucia Martin-Banderas, Matilde Duran-Lobato
Summary: The interest in using cannabinoids for medical applications, especially in treating eye conditions, has been growing. However, due to the unfavorable properties of cannabinoids and barriers for local administration in the eye, drug delivery systems are needed. This review focuses on identifying eye diseases that could be treated with cannabinoids, reviewing formulation properties, evaluating cannabinoid-based formulations for ocular administration, and exploring potential alternative formulations for eye administration.
Review
Polymer Science
Andreea E. Bodoki, Bogdan-C. Iacob, Elena Dinte, Oliviu Vostinaru, Ovidiu Samoila, Ede Bodoki
Summary: The human eye presents challenges for drug administration due to anatomical and physiological barriers, but molecular imprinting technology shows promise in addressing these issues, especially in ocular therapy. Molecularly imprinted polymers have the potential to improve drug delivery systems for treating eye diseases.
Review
Pharmacology & Pharmacy
Xiaojun Wang, Fuxiao Luan, Hua Yue, Cui Song, Shuang Wang, Jing Feng, Xiao Zhang, Wei Yang, Yuxin Li, Wei Wei, Yong Tao
Summary: Due to the complexity of ocular diseases and the natural ocular barriers, drug therapy for these diseases has limitations. With the development of biotechnology, smart materials have been widely tested to treat ocular diseases. This review analyzes recent developments in smart materials and discusses future directions for clinical translation.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Multidisciplinary Sciences
Sean Swetledge, Renee Carter, Rhett Stout, Carlos E. Astete, Jangwook P. Jung, Cristina M. Sabliov
Summary: Polymeric nanoparticles loaded with lutein showed higher stability at low temperature with minimal lutein release and no significant morphological changes, but had decreased stability and increased lutein release at room temperature and high temperature. Additionally, these lutein-loaded nanoparticles demonstrated higher resistance to photodegradation compared to free lutein when exposed to ultraviolet light.
SCIENTIFIC REPORTS
(2021)
Review
Pharmacology & Pharmacy
Saumyakanti Giri, Hemant Badwaik, Tapan Kumar Giri
Summary: This article discusses the impact of ocular barriers on the treatment of eye diseases and how nano lipid carriers effectively overcome these barriers and increase drug bioavailability.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Review
Cell Biology
Nguyen Thi Thanh Nhan, Daniel E. Maidana, Kaori H. Yamada
Summary: Cell-penetrating peptides (CPPs) can facilitate the cellular uptake of drugs in the eye, particularly for retinal diseases. They have the potential to reduce the frequency of injections by delivering long-acting drugs to the posterior pole of the eye. Recent studies have shown that CPPs can effectively deliver FDA-approved drugs to the targeted area in animal models. This review summarizes the advances in CPPs, peptide-based drugs, and their use in ocular drug delivery.
Review
Pharmacology & Pharmacy
Christopher D. Conrady, Steven Yeh
Summary: Uveitis is a group of inflammatory disorders of the eye that require medical and surgical management, with challenges in drug delivery due to absorption barriers. New drugs and drug delivery platforms are being developed to reduce intraocular inflammation and its complications.
Review
Pharmacology & Pharmacy
Bastien Leclercq, Dan Mejlachowicz, Francine Behar-Cohen
Summary: The eye is composed of tissues and cavities that are regulated to maintain their optical properties and functions. Specialized junctions between cells control the passage of drugs, while specific transporters regulate the movement of water, ions, and macromolecules. Ocular barriers limit the bioavailability of gene therapy products, but also allow for local treatment with minimal systemic side-effects. Understanding these barriers is essential for the development of efficient gene delivery systems.
Article
Chemistry, Multidisciplinary
Jing-jie Wang, Xin-xin Liu, Chen-chen Zhu, Tian-zuo Wang, Si-yu Wang, Yan Liu, Xin-yang Pan, Min-hua Liu, Ding Chen, Ling-li Li, Zhi-min Zhou, Kai-hui Nan
Summary: Researchers developed an affinity hydrogel for diquafosol tetrasodium (DQS) to achieve sustained release. The hydrogel demonstrated sustained release, low corneal permeation, and extended ocular retention, which are desirable attributes for ocular surface drug delivery. The superior therapeutic effects of the hydrogel over other vehicles were demonstrated in a mouse dry eye model.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Pharmacology & Pharmacy
Nooshin Tasharrofi, Mohammad Nourozi, Abdolrazagh Marzban
Summary: The eye is a highly specialized organ, and delivering drugs to it is challenging. The development of novel drug delivery systems, like nanoparticles, offers potential solutions. This review focuses on liposomes as effective carriers and their impact on ocular drug delivery.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Nanoscience & Nanotechnology
W. Cui, Y. Wang, C. Luo, J. Xu, K. Wang, H. Han, K. Yao
Summary: Nanoceria, a nanozyme with unique auto-regenerative antioxidant capacity, shows potential in managing oxidative stress-related ocular diseases and delivering drugs to ocular tissues. This review discusses recent advances and the importance of surface modification in enhancing the safety and targeting properties of nanoceria.
MATERIALS TODAY NANO
(2022)
Article
Chemistry, Multidisciplinary
Mingyue Cui, Mengjia Zheng, Christian Wiraja, Sharon Wan Ting Chew, Arti Mishra, Venkatesh Mayandi, Rajamani Lakshminarayanan, Chenjie Xu
Summary: The study introduced cryomicroneedles (cryoMN) for the ocular delivery of predatory Bdellovibrio bacteriovorus (B. bacteriovorus) bacteria, demonstrating their effectiveness in treating ocular bacterial infections and opening new avenues for the treatment of ocular surface disorders.
Article
Pharmacology & Pharmacy
Xiang Chen, Jicheng Wu, Xueqi Lin, Xingdi Wu, Xuewen Yu, Ben Wang, Wen Xu
Summary: This study constructed cationic liposome eye drops to improve the ocular bioavailability of eye drops in dry eye treatment. The cationic liposomes prolonged the ocular retention time, increased the drug concentration in the ocular surface, and reduced inflammation factors.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Food Science & Technology
Madhavi Gupta, Sanjay Dey, Daphisha Marbaniang, Paulami Pal, Subhabrata Ray, Bhaskar Mazumder
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2020)
Article
Chemistry, Physical
Arpita Bhattacharjee, Pranab J. Das, Sanjay Dey, Amit Kumar Nayak, Probin Kr. Roy, Srijita Chakrabarti, Daphisha Marbaniang, Sanjoy Kumar Das, Subhabrata Ray, Pronobesh Chattopadhyay, Bhaskar Mazumder
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2020)
Article
Pharmacology & Pharmacy
Prakash Rajak, Lila Kanta Nath, Bhaskar Mazumder
Summary: The pH-sensitive Lyotropic liquid crystals (LLC) can flip their structure according to different pH environments, facilitating colon-targeted release of 5-FU. The formulation containing 40% MO and 60% OA showed the best drug release performance in the colon and rectum pH conditions, with slow and extended release over longer periods of time.
JOURNAL OF PHARMACEUTICAL INNOVATION
(2021)
Review
Biology
Kumud Joshi, Danswrang Goyary, Bhaskar Mazumder, Pronobesh Chattopadhyay, Reshmi Chakraborty, Y. D. Bhutia, Sanjeev Karmakar, Sanjai Kumar Dwivedi
JOURNAL OF THERMAL BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Srijita Chakrabarti, Bhaskar Mazumder, Jadab Rajkonwar, Manash Pratim Pathak, Pompy Patowary, Pronobesh Chattopadhyay
Summary: Hydrogels are considered an important delivery system for wound treatment, with the study showing that bFGF-collagen-AgSD incorporated hydrogel formulation can accelerate burn healing and promote fibroblast cell proliferation. The developed hydrogel significantly accelerated wound closure by increasing re-epithelialization and granulation tissue formation, indicating its potential as a promising delivery system against second degree burns.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Biomedical
Vipin Kumar Sharma, Prince Prashant Sharma, Bhaskar Mazumder, Aseem Bhatnagar, Vetriselvan Subramaniyan, Shivkanya Fuloria, Neeraj Kumar Fuloria
Summary: This study developed mucoadhesive microspheres using Isabgol husk mucilage as a polymeric backbone for sustained release of gliclazide. The microspheres showed prolonged retention in the gastrointestinal tract of rabbits for up to 24 hours, indicating their potential rationality in controlling hyperglycemia in diabetes.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2021)
Article
Chemistry, Medicinal
Kumud Joshi, Bhaskar Mazumder, Pronobesh Chattopadhyay, Danswrang Goyary, Madhubanti Das, Sanjai Kumar Dwivedi
Summary: The study developed a hydrogel formulation for frostbite healing using Manuka honey and hyaluronic acid, showing significant antimicrobial and antithrombotic properties. It promotes wound contraction and complete healing, potentially acting through the VEGF-NRF-2 pathway.
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
(2021)
Article
Nursing
Nongmaithem Randhoni Chanu, Kunal Bhattacharya, Daphisha Marbaniang, Paulami Pal, Subhabrata Ray, Bhaskar Mazumder
Summary: The study aimed to formulate and study the characteristics of a gelation-based melatonin sponge crosslinked with fructose for wound healing application. The results showed that the formulated sponge had good mechanical properties, water uptake, and water retention capacities. Animal experiments demonstrated that wounds covered by the gelatin loaded with a melatonin sponge healed quickly.
JOURNAL OF VASCULAR NURSING
(2022)
Retraction
Pharmacology & Pharmacy
Nilutpal Sharma Bora, Bhaskar Mazumder, Santa Mandal, Pompy Patowary, Danswrang Goyary, Pronobesh Chattopadhyay, Sanjai Kumar Dwivedi
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Chemistry, Medicinal
Daphisha Marbaniang, Anup Kumar Das, Paulami Pal, Niva Rani Gogoi, Ananta Saikia, Subhabrata Ray, Bhaskar Mazumder
Summary: Boswellic acids are pentacyclic triterpenes derived from Boswellia serrata trees, known as Indian Frankincense, and traditionally used as an anti-inflammatory agent. They have various pharmacological potentials like anti-inflammatory, anti-cancer, anti-microbial, anti-arthritic, immunomodulatory activity, neuroprotective activity, and are effective against ileitis, ulcerative colitis, hypolipidemic, hypertension and hepatotoxicity. However, their poor oral bioavailability and high lipophilicity have led to the development of novel delivery systems to improve their pharmacokinetic profile.
NATURAL PRODUCTS JOURNAL
(2023)
Review
Integrative & Complementary Medicine
Ratna Jyoti Das, Kalyani Pathak, Smita Bordoloi, Riya Saikia, Saif Aboud Alqahtani, Jon Saharia, Mary Devi, Bhaskar Mazumder
Summary: This article summarizes the ethnopharmacology, pharmacological properties, and phytochemistry of Clerodendrum colebrookianum Walp. The research suggests that this plant has the potential to treat hypertension, diabetes, and other chronic diseases.
CURRENT TRADITIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Sayani Bhattacharyya, Preethi Sudheer, Kuntal Das, Subhabrata Ray
Summary: The study developed a liposomal formulation of aztreonam for inhalation therapy in treating pneumonia, showing promising in vitro antimicrobial and cell uptake efficacy. The optimized formulation had small particle size, satisfactory drug entrapment, potential antibacterial activity, safety on epithelial cells, and a marked increase in cellular uptake of aztreonam. The findings suggest that the optimized liposomal aztreonam could be a promising approach for delivering the drug through inhalation.
ADVANCED PHARMACEUTICAL BULLETIN
(2021)
Article
Pharmacology & Pharmacy
Vipin Kumar, Bhaskar Mazumder, Prince Prashant Sharma, Yusra Ahmed
Summary: The study found that the hypoglycemic effect and bioavailability of gliclazide loaded in Isabgol husk microparticles were better than pure gliclazide, suggesting the potential of microparticulate formulation as a novel anti-diabetic drug delivery system.
JOURNAL OF PHARMACEUTICAL INVESTIGATION
(2021)
