Article
Chemistry, Organic
Killari Satyam, Jakkula Ramarao, Surisetti Suresh
Summary: The NHC-catalyzed intramolecular benzoin condensation-oxidation allows for the expedient synthesis of diverse cyclic 1,2-diketones incorporated in dibenzo-fused seven-membered heterocycles in good to excellent yields under ambient conditions. The transformation appears to proceed through the benzoin intermediate followed by aerobic oxidation.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2021)
Article
Chemistry, Physical
Ricardo J. Alves, Laize Zaramello, Elvis N. Nishida, Frank H. Quina, Bruno S. Souza
Summary: In this study, we investigated the transient formation of N-heterocyclic carbenes (NHCs) in zwitterionic imidazolium sulfonate surfactants in a water environment. The formation of NHCs was accelerated above the critical micelle concentration, due to increased local concentration of hydroxide or deuteroxide ions. The rate of NHC formation could be controlled by the anions of added salts, which also affected the selectivity of anion binding to the micelle surface. The NHCs generated at the micelle surface promoted the selective oxidation of 4-nitrobenzaldehyde, demonstrating the importance of micellar microenvironment in controlling reactivity and selectivity in aqueous media.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Multidisciplinary
Nils Boysen, Anish Philip, Detlef Rogalla, Maarit Karppinen, Anjana Devi
Summary: Cu and Ag precursors that are volatile, reactive, and thermally stable are currently of high interest for their application in atomic-layer deposition (ALD) of thin metal films. In pursuit of new precursors for coinage metals, namely Cu and Ag, a series of new N-heterocyclic carbene (NHC)-based Cu-I and Ag-I complexes were synthesized. Modifications in the substitution pattern of diketonate-based anionic backbones led to five monomeric Cu complexes and four closely related Ag complexes with the general formula [M((NHC)-N-tBu)(R)] (M=Cu, Ag; (NHC)-N-tBu=1,3-di-tert-butyl-imidazolin-2-ylidene; R=diketonate). Thermal analysis indicated that most of the Cu complexes are thermally stable and volatile compared to the more fragile Ag analogs. One of the promising Cu precursors was evaluated for the ALD of nanoparticulate Cu metal deposits by using hydroquinone as the reducing agent at appreciably low deposition temperatures (145-160 degrees C). This study highlights the considerable impact of the employed ligand sphere on the structural and thermal properties of metal complexes that are relevant for vapor-phase processing of thin films.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Applied
Lakshmikanta Maity, Sahadev Barik, Raju Biswas, Ramalingam Natarajan, Joydev Dinda
Summary: In this study, the synthesis, structures, luminescent properties, and electrochemistry of gold(III)-N-heterocyclic carbene (NHC) complexes with 2,2'-bipyridine (bpy) or 1,10'-phenanthroline (phen) were investigated. The presence of NHC significantly enhanced the emission properties of the complexes.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Parasitology
Minghui Zhao, Xin Ran, Yu Bai, Zu Ma, Jian Gao, Dan Xing, Chunxiao Li, Xiaoxia Guo, Xianyi Jian, Wei Liu, Yun Liao, Kan Chen, Hengduan Zhang, Tongyan Zhao
Summary: This study investigated the genetic diversity and differentiation of Ae. aegypti and Ae. albopictus in Hainan Island and the Leizhou Peninsula, China. The results showed that Ae. albopictus had higher genetic diversity than Ae. aegypti. These findings are important for controlling arboviral diseases transmitted by mosquitoes and may support the elimination of Ae. aegypti in China.
PARASITES & VECTORS
(2023)
Article
Chemistry, Multidisciplinary
Yunquan Man, Xiaojun Zeng, Bo Xu
Summary: We have developed an efficient N-heterocyclic carbene (NHC)-catalyzed thioesterification of aldehydes using N-thiosuccinimides as the thiolation reagent. This method allows easy access to highly functionalized thioesters and demonstrates good chemical yields and functional group tolerance.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Organic
Li Cheng, Wenrong Wang, Yuqian Sun, Tuanjie Li, Chenxia Yu, Changsheng Yao
Summary: An efficient synthesis of 2-oxo-2-arylethyl aryl formates was achieved through N-heterocyclic carbene (NHC)/Ag(I) co-catalyzed reaction of aryl aldehydes with (bromoethynyl)benzenes. This method offers a broad substrate scope, easy access to starting materials, and operational simplicity, providing an alternative route to alpha-acyloxycarbonyl derivatives.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Elvan Ustun, Neslihan Sahin, Cem Celik, Ugur Tutar, Namik Ozdemir, Nevin Gurbuz, Ismail Ozdemir
Summary: Microorganisms form biofilms that provide sheltered areas for host cell response in fields such as medicine, food, and pharmaceuticals, causing troubles. Inhibition of biofilm formation through hindering of quorum sensing could be a method for new generation antibiotics production. This study synthesized and characterized new benzimidazole type NHC precursors and evaluated their antimicrobial and biofilm formation inhibition activities. The complex molecules showed higher activity compared to the benzimidazole derivative ligands.
DALTON TRANSACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Ashmita Singh, A. K. Narula
Summary: A facile method for the amidation of aldehydes by a cascade approach has been developed using NHC as the catalyst and NHS as the mediator. The method utilizes TBHP as the oxidant. Various substituted aldehydes reacted smoothly with NHS to form active esters, which were easily converted into amides. The drug moclobemide was successfully synthesized using this methodology to demonstrate its practical utility.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Sebastien G. Guillet, Ishfaq Ibni Hashim, Marek Belis, Kristof Van Hecke, Catherine S. J. Cazin, Steven. P. Nolan
Summary: A simple synthetic method for synthesizing various [Rh(acac)(CO)(NHC)] complexes is presented. In situ infrared monitoring provides valuable information on the reaction mechanism, including the identification of a crucial intermediate. Understanding the reaction mechanism has led to the discovery of novel pathways to commonly used congeners.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Gianmarco Pisano, Catherine S. J. Cazin
Summary: A user-friendly and highly efficient mechanochemical strategy for the synthesis of well-defined, catalytically relevant N-heterocyclic carbene-metal complexes is reported. The protocol yields good to excellent results and minimizes solvent usage by only using environmentally benign solvents in the purification step.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Chemistry, Physical
Semra Dasgin, Yetkin Gok, Duygu Barut Celepci, Parham Taslimi, Merve Izmirli, Aydin Aktas, Ilhami Gulcin
Summary: New benzimidazole-functionalized Pd-based complexes bearing N-propylphthalimide group were synthesized and showed inhibitory effects on various enzymes, with similar inhibition profiles.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Physical
Sughra Gulzar, Umme Ammara, Zeeshan Abid, Munazza Shahid, Raja Shahid Ashraf, Nadeem Baig, Abdel-Nasser Kawde, Gaurav A. Bhatia, Anvarhusein A. Isab, Muhammad Altaf
Summary: In this study, five new gold(I)-NHC complexes with thione ligands were synthesized and their structures were elucidated. Three of the complexes were subjected to single-crystal X-ray diffraction studies, revealing a close to linear coordination geometry of gold(I) atoms. In vitro experiments demonstrated that these synthesized complexes exhibited inhibitory effects against colon, lung, and breast cancer cells. Electrochemical reactions were performed to investigate the possible mechanism of interaction between the complexes and biomolecules.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Organic
Wei Zhao, Jing Liu, Xiangkui He, Hao Jiang, Liangqiu Lu, Wenjing Xiao
Summary: A NHC-catalyzed oxidative esterification reaction for synthesizing axially chiral aldehydes with mild conditions, excellent yields and enantioselectivity, broad substrate scope, and good functional group tolerance has been developed. It provides new possibilities for the synthesis of axially chiral aldehydes and their derivatives.
CHINESE JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Shuo Liu, Hongyun Chen, Xiaoyun Wu, Haixin Ding, Shengxian Xu, Yaqian Wu, Yibo Wang, Feng Zhao
Summary: The synthesis, characterization, and photophysical properties of a series of four-coordinate N-heterocyclic carbene (NHC) copper(I) complexes are reported. The photophysical properties of these complexes can be adjusted by modifying the substituent groups on the ligand, resulting in a tunable emission wavelength range and high photoluminescence efficiency.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Agriculture, Multidisciplinary
Blessing C. Umeh, Silas W. Avicor, Enock Dankyi, Rosina Kyerematen
Summary: Although evidence of the limiting role of pollination in cocoa production is increasing, there is also growing concern about the potential harm of insecticides to pollinators. However, there is limited effort to examine farmer knowledge and practices on pollination and insecticide use aimed at promoting cocoa pollination. This study assessed farmers' knowledge and practices on pollination and insecticide usage in four cocoa-growing communities in Ghana and found that educating smallholder farmers on pollination and judicious insecticide use is crucial in improving long-term cocoa yields.
INTERNATIONAL JOURNAL OF AGRICULTURAL SUSTAINABILITY
(2022)
Article
Chemistry, Organic
Umie F. M. Haziz, Rosenani A. Haque, Takumi Konno, Yoshinari Nobuto, Mohd R. Razali
Summary: This study reports the synthesis of seven new mononuclear gold(I)-N-heterocyclic carbene complexes. The successful formation of these complexes was confirmed by various analysis methods. Complex 3 exhibited weak blue emission under UV light, and the luminescence became more intense at low temperature.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Chemistry, Physical
Nurul Azmi, Shun-Ze Zhan, Mohd R. Razali
Summary: In this study, two dinuclear terbium complexes with anthracene and pyrroloanthracene derivatives were synthesized and their properties were characterized by crystal structure determination and spectroscopic analysis.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Inorganic & Nuclear
Nuraddeen Abdurrahman, Ahmad Mudzakir, Huda Hisham Alkatib, Sreenivasan Sasidharan, Mohd. R. Razali
Summary: Through self-assembly, trinuclear carbene complexes with potential anticancer activity were prepared and their structures were investigated.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2022)
Article
Entomology
Sara Abdelrahman Abuelmaali, Jamsari Amirul Firdaus Jamaluddin, Mushal Allam, Hind Mohamed Abushama, Dia Eldin Elnaiem, Kheder Noaman, Silas Wintuma Avicor, Intan Haslina Ishak, Mustafa Fadzil Farid Wajidi, Zairi Jaal, Nur Faeza Abu Kassim
Summary: This study investigated the genetic differences between two subspecies of Aedes aegypti mosquitoes in Sudan. The findings showed insignificant genetic variance between the subspecies and shared components in the gene/marker used in the study. This information is important for improving control strategies against the Aedes aegypti vector in the area.
Article
Agriculture, Multidisciplinary
Yahaya Bukari, Silas W. Avicor, Godfred Awudzi, Michael K. Ainooson, Eric K. Asare, Ishmael Amoako-Attah
Summary: This study evaluated the antifungal and insecticidal properties of soybean extract on Marasmiellus scandens, Erythricium salmonicolor, and termite. The extract showed inhibitory activity on mycelial growth of the fungal pathogens, with higher inhibition observed for the cocoa pathogens. However, its activity on the termite was low. These findings are important for exploring plant-based control methods against white thread blight and pink diseases of cocoa.
COGENT FOOD & AGRICULTURE
(2022)
Article
Agronomy
Wisdom Edem Anyomi, Michael Teye Barnor, Agyemang Danquah, Kwadwo Ofori, Francis Kwame Padi, Silas Wintuma Avicor, Iago Hale, Eric Yirenkyi Danquah
Summary: Due to the rapid genetic erosion of shea trees, urgent conservation efforts are needed. In situ germplasm conservation has been established to monitor and preserve the trees. Technologies have been developed to graft shea germplasms, allowing for the establishment of germplasm banks. This study evaluated the fruit and nut traits of tagged shea trees in their natural habitats.
Article
Agriculture, Multidisciplinary
Akua Safo, Silas Wintuma Avicor, Philip Kweku Baidoo, Patrick Addo-Fordjour, Michael Kojo Ainooson, Michael Osae, Sylvia Esther Gyan, Jerry Asalma Nboyine
Summary: This study investigated the knowledge, practices, and impact of the fall armyworm (FAW) on maize farms in a major municipality in Ghana. The majority of farmers used insecticides, but there was no significant relationship between application frequency and resulting effects. The use of personal protective equipment (PPE) was low, and the FAW outbreak caused negative effects on farmers' relationships and economic losses.
COGENT FOOD & AGRICULTURE
(2023)
Article
Forestry
Silas Wintuma Avicor, Jerome Agbesi Dogbatse, Wisdom Edem Anyomi, Samuel Tetteh Lowor, Eric Kumi Asare
Summary: This study reports on shea tree mortality in Northern Ghana due to pest infestation. The results show that 34% of shea trees in Maluwe and 2% in Gindabo were infested. The infested trees had the highest nitrogen and potassium levels in Maluwe, while co-infested and un-infested trees had the highest phosphorus and magnesium levels, respectively. However, un-infested trees had the highest nutrient levels in Gindabo.
TREES FORESTS AND PEOPLE
(2023)
Article
Environmental Studies
G. K. Awudzi, E. F. Appiah, S. W. Avicor, S. K. Ahadzi
Summary: Cola nitida, an important cash crop in West Africa, is attacked by various insect pests, including the kola seed weevil, Balanogastris kolae, and some Sophrorhinus pests. The impact of fruit fly species, particularly Bactrocera invadens and Ceratitis colae that exclusively feed on the crop, is not well studied. This study assesses the incidence, population dynamics, and damage caused by insect pests on kola in Ghana's middle belt, aiming to inform pest management decisions. The most significant pests identified include the kola seed weevils, Sophrorhinus spp, Bactrocera invadens, Ceratitis colae, and other Ceratitis spp. Understanding the dynamics of these pests could contribute to the development of an integrated pest management strategy.
FORESTS TREES AND LIVELIHOODS
(2023)
Correction
Entomology
Jennifer Oppong, Silas Wintuma Avicor, Philip Kweku Baidoo, Patrick Addo-Fordjour
INTERNATIONAL JOURNAL OF TROPICAL INSECT SCIENCE
(2023)
Article
Entomology
Jennifer Oppong, Silas Wintuma Avicor, Philip Kweku Baidoo, Patrick Addo-Fordjour
Summary: This study assessed the mosquito community structure and the factors influencing them in two anthropogenically-modified landscapes in Ghana. The results showed that landscape modification and environmental factors have a significant impact on mosquito community structure, highlighting the need for strategies to eliminate man-made mosquito breeding sites.
INTERNATIONAL JOURNAL OF TROPICAL INSECT SCIENCE
(2023)
Article
Agriculture, Multidisciplinary
Samuel Abukari Bawa, Enoch Selorm Ofori, Michael Osae, Silas Wintuma Avicor, Ebenezer Oduro Owusu
Summary: This study evaluated the efficacy of two commonly used commercial insecticide products on the Sitophilus zeamais populations in the Central region of Ghana and found that the insecticides were ineffective at their recommended label concentrations. Alternative effective management methods or products with different active ingredients are needed.
JOURNAL OF AGRICULTURE AND FOOD RESEARCH
(2022)
Article
Agriculture, Multidisciplinary
Silas Wintuma Avicor, Richard Adu-Acheampong, Godfred Kweku Awudzi
Summary: Cocoa is an important source of foreign exchange and income in Ghana. In 2018, a larval outbreak occurred on cocoa pods in Ghana, which was believed to be caused by a secondary pest outbreak. This study conducted a survey and laboratory studies to identify the pest, assess its susceptibility to an insecticide, and evaluate field management strategies. The outbreak was primarily caused by larvae of Anomis leona, which caused extensive damage to cocoa pods. Bifenthrin, a commonly used insecticide, was found to be toxic to the larvae and effective in managing the outbreak.
PERTANIKA JOURNAL OF TROPICAL AGRICULTURAL SCIENCE
(2022)
Article
Entomology
Nur Hanani Ridzuan, Salina Abdul Farouk, Sarah Abdul Razak, Silas Wintuma Avicor, Nooriati Taib, Siti Nasuha Hamzah
Summary: Urban green spaces can enhance biodiversity and insect conservation through habitat protection and environmental modifications, with different plant types affecting the richness of insect species.
INTERNATIONAL JOURNAL OF TROPICAL INSECT SCIENCE
(2022)
Article
Chemistry, Medicinal
Shuang Mei, Su Jiang, Yuting Wang, Han Jing, Peng Yang, Miao-Miao Niu, Jindong Li, Kai Yuan, Yan Zhang
Summary: This study identifies a dual-targeting peptide, AP-1, that effectively inhibits variants of concern (VOCs) of SARS-CoV-2 without impairing host cell viability. The findings suggest that AP-1 could be a promising broad-spectrum agent for treating emerging VOCs of SARS-CoV-2.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Hyeonjun Lee, Ju Yeon Lee, Hyunsoo Jang, Hye Young Cho, Minhee Kang, Sang Hyun Bae, Suin Kim, Eunji Kim, Jaebong Jang, Jin Young Kim, Young Ho Jeon
Summary: By using liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance experiments, we identified new chemical moieties that bind to the target sites of the protein of interest, allowing for reversible binding and protein degradation. This method has the potential to expand the application of PROTAC technology.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Yingying Li, Xiyou Du, Xinru Kong, Yuelin Fang, Zhijing He, Dongzhu Liu, Hang Wu, Jianbo Ji, Xiaoye Yang, Lei Ye, Guangxi Zhai
Summary: This study proposes a novel nanoplatform based on the autophagy cascade to overcome the obstacles in chemo-immunotherapy. The platform combines chemotherapy and starvation therapy to initiate pro-death autophagy and enhance antigen presentation, while also remodeling the immunosuppressive tumor microenvironment. Furthermore, the study discovers a new therapeutic direction for the respiration inhibitor 3-bromopyruvic acid (3BP) in cancer treatment. Overall, this study offers an opportunity to improve antitumor efficacy and boost immune responses.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Bingsi Wang, Mingxu Ma, Yusen Dai, Pengfei Yu, Liang Ye, Wenyan Wang, Chunjie Sha, Huijie Yang, Yingjie Yang, Yunjing Zhu, Lin Dong, Shujuan Wei, Linlin Wang, Jingwei Tian, Hongbo Wang
Summary: Breast cancer is a common malignant tumor in women, and drug resistance remains a clinical challenge. In this study, a novel compound, G-5b, was developed with potent antagonistic and degradation activities comparable to the current drug fulvestrant. G-5b also showed improved stability and solubility. Mechanistically, G-5b engages the proteasome pathway to degrade ER, inhibiting the ER signaling pathway and inducing apoptosis and cell cycle arrest. In animal models, G-5b exhibited superior pharmacokinetics and pharmacodynamics properties. Overall, G-5b is a promising long-acting SERD worthy of further investigation and optimization.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Karoline B. Waitman, Larissa C. de Almeida, Marina C. Primi, Jorge A. E. G. Carlos, Claudia Ruiz, Thales Kronenberger, Stefan Laufer, Marcia Ines Goettert, Antti Poso, Sandra V. Vassiliades, Vinicius A. M. de Souza, Monica F. Z. J. Toledo, Neuza M. A. Hassimotto, Michael D. Cameron, Thomas D. Bannister, Leticia Costa-Lotufo, Joa o A. Machado-Neto, Mauricio T. Tavares, Roberto Parise-Filho
Summary: A series of hybrid inhibitors combining pharmacophores of known kinase inhibitors and benzohydroxamate HDAC inhibitors were synthesized and evaluated for their anticancer activity and pharmacokinetic properties. Compounds 4d-f exhibited promising cytotoxicity against hematological cells and moderate activity against solid tumor models. Compound 4d showed potent inhibition of multiple kinase targets and had stable interactions with HDAC and members of the JAK family. These compounds showed selective cytotoxicity with minimal effects on non-tumorigenic cells and favorable pharmacokinetic profiles.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Michal Sulik, Diana Fontinha, Dietmar Steverding, Szymon Sobczak, Michal Antoszczak, Miguel Prudencio, Adam Huczynski
Summary: This study describes the synthesis of the first-in-class ivermectin derivatives obtained through derivatization of the C13 position, along with the unexpected rearrangement of the macrolide ring. These derivatives show potential for antiparasitic activity and are important for the development of new antiparasitic agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Jun Liu, Qiu-Xian Chen, Wen-Fu Wu, Dong Wang, Si -Yu Zhao, Jia-Hao Li, Yi-Qun Chang, Shao-Gao Zeng, Jia-Yi Hu, Yu-Jie Li, Jia-Xin Du, Shu-Meng Jiao, Hai-Chuan Xiao, Qiang Zhang, Jun Xu, Jian-Fu Zhao, Hai -Bo Zhou, Yong-Heng Wang, Jian Zou, Ping-Hua Sun
Summary: A new anti-infective drug strategy has been discovered to attenuate virulence and modulate inflammation caused by drug-resistant Pseudomonas aeruginosa infections. Compound 5f inhibits biofilm formation, macrophage migration, and inflammatory response induced by P. aeruginosa, showing potential as a novel candidate against drug-resistant infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Liuzeng Chen, Ke Wang, Lingyun Wang, Wei Wang, Lifan Wang, Jia Li, Xiaohan Liu, Mengya Wang, Banfeng Ruan
Summary: In this study, a series of novel anti-inflammatory compounds were designed and synthesized based on the natural product pterostilbene skeleton. Among them, compound 8 showed the highest activity and exhibited its effects through inhibition of pro-inflammatory cytokines by blocking the NF-KB/MAPK signaling pathway. Compound 8 also demonstrated a good relieving effect on acute colitis in mice and showed good safety in acute toxicity experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Si-Min Liang, Gui-Bin Liang, Hui-Ling Wang, Hong Jiang, Xian-Li Ma, Jian-Hua Wei, Ri-Zhen Huang, Ye Zhang
Summary: A series of novel multi-target antitumor agents were designed, synthesized, and evaluated. Some compounds exhibited significant antitumor activity and one compound showed excellent efficacy, limited toxicity, and low resistance. Further mechanism studies revealed that the compound exerted antitumor effects through multiple pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)