Nanoparticle-based approaches to immune tolerance for the treatment of autoimmune diseases

Peptide–MHC-based nanomedicines for autoimmunity function as T-cell receptor microclustering devices

(2017) Santiswarup Singha et al.   Nature Nanotechnology

Exosomes as Reconfigurable Therapeutic Systems

(2017) R. Steven Conlan et al.   TRENDS IN MOLECULAR MEDICINE

Expanding antigen-specific regulatory networks to treat autoimmunity

(2016) Xavier Clemente-Casares et al.   NATURE

Improving the efficacy and safety of biologic drugs with tolerogenic nanoparticles

(2016) Takashi K. Kishimoto et al.   Nature Nanotechnology

Biodegradable antigen-associated PLG nanoparticles tolerize Th2-mediated allergic airway inflammation pre- and postsensitization

(2016) Charles B. Smarr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tolerogenic nanoparticles inhibit T cell–mediated autoimmunity through SOCS2

(2016) Ada Yeste et al.   Science Signaling

First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases

(2016) A. Borroto et al.   Science Translational Medicine

Tolerogenic nanoparticles inhibit T cell–mediated autoimmunity through SOCS2

(2016) Ada Yeste et al.   Science Signaling

Exosomes as nanocarriers for immunotherapy of cancer and inflammatory diseases

(2015) Thanh-Huyen Tran et al.   CLINICAL IMMUNOLOGY

Nanoparticle-based autoimmune disease therapy

(2015) Pau Serra et al.   CLINICAL IMMUNOLOGY

Cutting Edge: Nanogel-Based Delivery of an Inhibitor of CaMK4 to CD4+T Cells Suppresses Experimental Autoimmune Encephalomyelitis and Lupus-like Disease in Mice

(2015) Kotaro Otomo et al.   JOURNAL OF IMMUNOLOGY

Harnessing nanoparticles for immune modulation

(2015) Daniel R. Getts et al.   TRENDS IN IMMUNOLOGY

Memory of tolerance and induction of regulatory T cells by erythrocyte-targeted antigens

(2015) Alizée J. Grimm et al.   Scientific Reports

Engineered binding to erythrocytes induces immunological tolerance to E. coli asparaginase

(2015) K. M. Lorentz et al.   Science Advances

A Biodegradable Nanoparticle Platform for the Induction of Antigen-Specific Immune Tolerance for Treatment of Autoimmune Disease

(2014) Zoe Hunter et al.   ACS Nano

Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance

(2014) Roberto A. Maldonado et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Therapeutic Inflammatory Monocyte Modulation Using Immune-Modifying Microparticles

(2014) D. R. Getts et al.   Science Translational Medicine

Red blood cells as innovative antigen carrier to induce specific immune tolerance

(2013) Magali Cremel et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Nanogel-based delivery of mycophenolic acid ameliorates systemic lupus erythematosus in mice

(2013) Michael Look et al.   JOURNAL OF CLINICAL INVESTIGATION

Exploiting Apoptosis for Therapeutic Tolerance Induction

(2013) D. R. Getts et al.   JOURNAL OF IMMUNOLOGY

Antigen-Specific Tolerance by Autologous Myelin Peptide-Coupled Cells: A Phase 1 Trial in Multiple Sclerosis

(2013) A. Lutterotti et al.   Science Translational Medicine

Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis

(2012) Daniel R Getts et al.   NATURE BIOTECHNOLOGY

Engineering antigens for in situ erythrocyte binding induces T-cell deletion

(2012) S. Kontos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis

(2012) A. Yeste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tolerance Induced by Apoptotic Antigen-Coupled Leukocytes Is Induced by PD-L1+ and IL-10-Producing Splenic Macrophages and Maintained by T Regulatory Cells

(2011) D. R. Getts et al.   JOURNAL OF IMMUNOLOGY

Antigenic strength controls the generation of antigen-specific IL-10-secreting T regulatory cells

(2010) Leona Gabryšová et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Reversal of Autoimmunity by Boosting Memory-like Autoregulatory T Cells

(2010) Sue Tsai et al.   IMMUNITY

Toxin-Coupled MHC Class I Tetramers Can Specifically Ablate Autoreactive CD8+ T Cells and Delay Diabetes in Nonobese Diabetic Mice

(2010) B. G. Vincent et al.   JOURNAL OF IMMUNOLOGY

Negative feedback control of the autoimmune response through antigen-induced differentiation of IL-10–secreting Th1 cells

(2009) Leona Gabryšová et al.   JOURNAL OF EXPERIMENTAL MEDICINE

ECDI-fixed allogeneic splenocytes induce donor-specific tolerance for long-term survival of islet transplants via two distinct mechanisms

(2008) X. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA