Article
Biology
Danilo Menicucci, Claudia Lunghi, Andrea Zaccaro, Maria Concetta Morrone, Angelo Gemignani
Summary: Sleep plays a role in stabilizing the homeostatic plasticity of visual ocular dominance induced by short-term monocular deprivation in adult humans. The enhanced response of the deprived eye after sleep is correlated with changes in sleep slow oscillations and spindle power in the occipital visual cortex.
Review
Neurosciences
Jacques Taillard, Claude Gronfier, Stephanie Bioulac, Pierre Philip, Patricia Sagaspe
Summary: In the context of geriatric research, a growing body of evidence suggests that normal age-related changes in sleep are linked to adverse health outcomes, particularly cognitive decline in older adults. Sleep alterations such as timing, maintenance, and reduced sigma activity are more pronounced after 60 years, with gender differences also becoming more apparent. Despite declines in sleep quality, daytime wakefulness and sleepiness do not change significantly with age for older adults. Moreover, older adults show less cognitive impairment under sleep deprivation conditions compared to younger adults, indicating a lower vulnerability to extended wakefulness with age.
Article
Clinical Neurology
Manivannan Subramaniyan, Chao Wang, Srinivas Laxminarayan, Francisco G. Vital-Lopez, John D. Hughes, Tracy J. Doty, Jaques Reifman
Summary: Sleep loss can impair cognition, but individuals have different vulnerability to it. This study analyzed electroencephalographic markers of sleep-loss vulnerability and found that individuals who are vulnerable to sleep loss exhibit higher slow-wave activity power and rise rate, as well as lower sleep spindle frequency, suggesting a persistently higher sleep pressure.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Ian G. Campbell, Zoey Y. Zhang, Kevin J. Grimm
Summary: Limiting spindle activity through sleep restriction can explain some of the negative cognitive effects of sleep loss in adolescents. This study evaluates how sleep restriction affects various aspects of sleep spindles and tests whether these effects change throughout adolescence. The study also investigates the relationship between sleep restriction effects and daytime sleepiness, vigilance, and cognition.
Article
Clinical Neurology
T. Vanneau, M. Quiquempoix, M. -C Erkel, C. Drogou, A. Trignol, F. Sauvet, D. Leger, D. Gomez-merino, M. Chennaoui
Summary: This study found that muscle injury increases total sleep time during the dark period in rats, specifically in non-rapid eye movement (NREM) sleep. The increase in sleep time is associated with higher sleep stability and may be related to decreased protein levels of IGF-1 in the brain and BMAL1 in the muscle after injury.
Review
Nutrition & Dietetics
Elena Gangitano, Matthew Baxter, Maria Voronkov, Andrea Lenzi, Lucio Gnessi, David Ray
Summary: Sleep disturbances are a new risk factor for metabolic diseases, which are a growing concern globally. The importance of sleep for metabolic health is increasingly recognized, not only in terms of duration but also quality. This review examines the evidence on the influence of macronutrients on sleep, particularly focusing on the mechanisms involved. Both preclinical studies on circadian and homeostatic processes and clinical studies in humans are reviewed. Understanding how macronutrients regulate circadian clocks and sleep homeostasis is crucial given the importance of sleep for overall health.
FRONTIERS IN NUTRITION
(2023)
Article
Clinical Neurology
Karim Fifel, Tom Deboer
Summary: Sleep states and disturbances significantly affect neuronal activity within the striatum. Sleep deprivation induces heterogeneous alterations in neuronal activity across striatal subregions, lasting for up to 48 hours.
Review
Biochemistry & Molecular Biology
Mohammed E. Choudhury, Kazuya Miyanishi, Haruna Takeda, Junya Tanaka
Summary: Aging leads to a reduction in brain microglial cells, disrupting the circadian rhythmicity of brain tissue, and microglial cells also play a role in sleep homeostasis and response to sleep loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Chelsea M. Reynolds, Michelle A. Short, Michal Kahn, Cele Richardson, Melanie Heath, Hannah Whittall, Leon Lack, Michael Gradisar
Summary: The physiological processes governing sleep regulation undergo maturational changes during adolescent development. This longitudinal study aimed to investigate whether changes in evening sleep propensity can be observed during early adolescence. The results indicated a stable evening sleep propensity in boys during early adolescence, without significant differences across four waves of assessment. Future research should include larger samples of both girls and boys across a broader age range in the teenage years.
Review
Pharmacology & Pharmacy
M. Panagiotou, S. Michel, J. H. Meijer, T. Deboer
Summary: Aging is a multifactorial process involving damage accumulation and decline in maintenance and repair mechanisms. The aging brain undergoes morphological and functional alterations affecting sleep and circadian clock, with differences between human and rodent models. Physical exercise is highlighted as a beneficial lifestyle intervention for healthy aging and longevity, ameliorating aging characteristics related to sleep and circadian rhythms.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Jeanne F. Duffy, Wei Wang, Joseph M. Ronda, Charles A. Czeisler
Summary: Aging is associated with changes in sleep, and improving sleep can have important consequences for the health and quality of life of older adults. Melatonin, especially at higher doses, may be a viable option for sleep aid in older adults, as it can increase sleep efficiency during both the day and night.
JOURNAL OF PINEAL RESEARCH
(2022)
Article
Clinical Neurology
Eunjin Lee Tracy, Jun Zhang, Kristine Wilckens, Robert T. Krafty, Brant P. Hasler, Martica H. Hall, Daniel J. Buysse
Summary: This study investigated the differences in homeostatic sleep drive and circadian rhythmicity between older adults with insomnia (OAI) and older good sleepers (GS). The results showed that OAI and GS did not differ in their response to sleep deprivation in delta EEG or repeated sleep latency tests. There were also no differences in circadian phase or amplitude of melatonin or core body temperature rhythms, but OAI had significantly elevated core body temperature mesor. These findings suggest that effective treatments for insomnia in older adults may focus on maintaining stable sleep and circadian regulatory mechanisms, rather than repairing defective sleep and circadian regulation.
Article
Neurosciences
Basma Radwan, Alvaro Yanez Touzet, Soaad Hammami, Dipesh Chaudhury
Summary: Stress and sleep are tightly regulated through the interaction of homeostatic and circadian processes. Chronic stress can lead to deficient sleep homeostasis, but the understanding of how chronic stress affects sleep regulation and the differences in adaptation to stress on sleep remains limited.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Neurosciences
W. Xu, F. De Carvalho, A. K. Clarke, A. Jackson
Summary: Through long-term wireless recording, researchers characterized dynamic cerebro-thalamo-cerebellar interactions during natural sleep in monkeys. The observations suggest a contribution of the cerebellum to neocortical sleep spindles, potentially involving communication via cerebello-thalamo-neocortical pathways. The study highlights the complexity of neural activity in the sleeping cerebellum and its interaction with other brain regions during sleep.
PROGRESS IN NEUROBIOLOGY
(2021)
Review
Neurosciences
Srishti Banerjee, Sandipan Ray
Summary: Aging leads to deterioration of daily rhythms and disruption in sleep-wake cycles. Mutations in core clock genes contribute to premature aging and sleep irregularities. Targeting the molecular clock or dosing time-oriented medications may provide novel therapeutic strategies for aging attenuation and sleep disorders.
PROGRESS IN NEUROBIOLOGY
(2022)
Letter
Critical Care Medicine
Andree-Ann Baril, Ricardo S. Osorio, Julie Carrier, Marta Kaminska, Nadia Gosselin
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2019)
Article
Developmental Biology
Emilie Tetreault, Annie Bernier, Celia Matte-Gagne, Julie Carrier
DEVELOPMENTAL PSYCHOBIOLOGY
(2019)
Article
Clinical Neurology
Thomas Lehoux, Julie Carrier, Roger Godbout
JOURNAL OF SLEEP RESEARCH
(2019)
Article
Geriatrics & Gerontology
Veronique Latreille, Malo Gaubert, Jonathan Dube, Jean-Marc Lina, Jean-Francois Gagnon, Julie Carrier
NEUROBIOLOGY OF AGING
(2019)
Article
Neurosciences
Catherine Vien, Arnaud Bore, Arnaud Boutin, Basile Pinsard, Julie Carrier, Julien Doyon, Stuart Fogel
Article
Clinical Neurology
Pierre-Alexandre Bourgouin, Shady Rahayel, Malo Gaubert, Ronald B. Postuma, Jacques Montplaisir, Julie Carrier, Oury Monchi, Amelie Pelletier, Jean-Francois Gagnon
PARKINSONISM & RELATED DISORDERS
(2019)
Article
Multidisciplinary Sciences
Ella Gabitov, Arnaud Boutin, Basile Pinsard, Nitzan Censor, Stuart M. Fogel, Genevieve Albouy, Bradley R. King, Julie Carrier, Leonardo G. Cohen, Avi Karni, Julien Doyon
Article
Clinical Neurology
Shady Rahayel, Malo Gaubert, Ronald B. Postuma, Jacques Montplaisir, Julie Carrier, Oury Monchi, David Remillard-Pelchat, Pierre-Alexandre Bourgouin, Michel Panisset, Sylvain Chouinard, Sven Joubert, Jean-Francois Gagnon
Article
Neurosciences
Menno P. Veldman, Nina Dolfen, Mareike A. Gann, Julie Carrier, Bradley R. King, Genevieve Albouy
Summary: Research has shown that the effects of somatosensory targeted memory reactivation (TMR) on motor memory consolidation are still unclear. The study found that applying somatosensory TMR during sleep and wakefulness can lead to changes in brain oscillatory activity, but these changes do not impact motor performance.
Article
Biology
Maude Bouchard, Jean-Marc Lina, Pierre-Olivier Gaudreault, Alexandre Lafreniere, Jonathan Dube, Nadia Gosselin, Julie Carrier
Summary: Two types of slow waves, slow switchers and fast switchers, were found to coexist in humans. Older individuals showed lower temporal dissipation of sleep pressure and decreased flexibility in EEG connectivity at the microscale of the oscillations.
Review
Neurosciences
Julie Legault, Cynthia Thompson, Marie-Eve Martineau-Dussault, Claire Andre, Andree-Ann Baril, Guillermo Martinez Villar, Julie Carrier, Nadia Gosselin
Summary: Around 40% of dementia risk is attributable to modifiable factors such as physical inactivity, hypertension, diabetes, and obesity, with sleep disorders like obstructive sleep apnea also being considered. However, there is still no consensus on whether OSA increases the risk of dementia or not. The heterogeneity in previous studies may be related to individual characteristics that modulate the association between OSA and cognitive decline.
Article
Biology
Judith Nicolas, Bradley R. King, David Levesque, Latifa Lazzouni, Emily Coffey, Stephan Swinnen, Julien Doyon, Julie Carrier, Genevieve Albouy
Summary: Targeted memory reactivation during sleep can enhance motor memory consolidation, and the coordination between slow and sigma oscillations plays a crucial role in memory reinstatement or protection against irrelevant information.
Article
Clinical Neurology
Alexandre Lafreniere, Jean-Marc Lina, Jimmy Hernandez, Maude Bouchard, Nadia Gosselin, Julie Carrier
Summary: This study compared the sleep slow-wave (SW) transition speed and other characteristics between older adults with amnestic mild cognitive impairment (aMCI) and cognitively normal (CN) controls, and examined their associations with memory and cognitive changes. The results showed that aMCI participants had a slower SW transition speed and a higher proportion of slow-switchers. Additionally, the transition speed of fast-switchers was slower in participants with obstructive sleep apnea (OSA). These SW measures were correlated with memory decline in aMCI and cognitive improvements in CN participants.
Article
Clinical Neurology
Anna-Francesca Boatswain-Jacques, Charlotte Dusablon, Catherine Cimon-Paquet, Elie YuTong Guo, Rosalie Menard, Celia Matte-Gagne, Julie Carrier, Annie Bernier
Summary: This study examines the sleep trajectories and developmental changes in pre- and early adolescents. The research shows significant changes in sleep-wake cycles, including delayed sleep onset, offset, and midpoint, and decreased total sleep time. Weekend-weekday differences in sleep offset and midpoint become more pronounced over time. Intra-individual variability in sleep increases with age. Important between-person and sex differences are also observed.
