Review
Plant Sciences
Kobra Ziyaei, Fatemeh Abdi, Majid Mokhtari, Mohammad Ali Daneshmehr, Zahra Ataie
Summary: Phycocyanin, a protein compound with antidiabetic properties, can be used as a nutraceutical. Animal studies showed that phycocyanin positively affected biochemical parameters related to diabetes, such as increased fasting insulin serum and decreased fasting blood glucose. Cellular studies demonstrated that phycocyanin exerted its antidiabetic effect through various molecular pathways. Overall, targeting these pathways by phycocyanin may offer benefits in the management of diabetes.
Review
Endocrinology & Metabolism
Safaet Alam, Md. Moklesur Rahman Sarker, Taposhi Nahid Sultana, Md. Nafees Rahman Chowdhury, Mohammad A. Rashid, Nusrat Islam Chaity, Chao Zhao, Jianbo Xiao, Elsayed E. Hafez, Shah Alam Khan, Isa Naina Mohamed
Summary: Diabetes is a chronic condition that significantly impacts people's lives worldwide. The development of resistance and side effects to current antidiabetic drugs necessitates the search for novel treatments. Increasingly, scientists, researchers, and pharmaceutical companies are turning to plants and herbal sources to discover potential bioactive compounds for targeted and less side-effect prone antidiabetic drugs. This review highlights prospective candidates, including isolated phytochemicals and/or plant extracts, that have demonstrated significant antidiabetic potential in in vitro, in vivo, and clinical studies. The mechanisms of action for these bioactive compounds are also discussed, emphasizing their potential for further investigation in the discovery and development of novel antidiabetic therapeutics.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Stefania Chiappini, Alessio Mosca, Andrea Miuli, Francesco Maria Semeraro, Gianluca Mancusi, Maria Chiara Santovito, Francesco Di Carlo, Mauro Pettorruso, Amira Guirguis, John Martin Corkery, Giovanni Martinotti, Fabrizio Schifano, Massimo Di Giannantonio
Summary: This study reviewed the misuse of centrally acting anticholinergics, highlighting its widespread and popular nature. Healthcare professionals should be vigilant and monitor potential misusing issues due to the associated adverse effects.
Review
Neurosciences
Ana Vazquez-agredos, Fernando Gamiz, Milagros Gallo
Summary: Adolescence is a crucial developmental period marked by brain network reorganization and epigenetic mechanisms. Behaviors like alcohol and drug abuse are common during adolescence and are associated with increased susceptibility to stress. Exposure to stress, alcohol, or drugs disrupts the epigenetic mechanisms mediated by miRNAs, which modify gene expression involved in neurodevelopmental processes. The expression patterns of miRNAs in the adolescent rodent brain are influenced by stress and drug abuse, indicating their significant role in regulating brain development during adolescence.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Dermatology
Justin D. Lu, Asfandyar Mufti, Muskaan Sachdeva, Shamina Rahat, Rafael Paolo Lansang, Jensen Yeung
Summary: Porokeratosis is a rare skin disorder characterized by atrophic macules or patches, potentially associated with drug use. The most common therapies linked to porokeratosis development are biologic use, phototherapy, and radiotherapy, suggesting that drug reactions may trigger porokeratosis. Large-scale studies are needed to confirm these findings and explore the pathogenesis of drug-induced porokeratosis further.
DERMATOLOGIC THERAPY
(2021)
Review
Polymer Science
Wedja Timoteo Vieira, Maria Vitoria Silva Nicollini, Meuris Gurgel Carlos da Silva, Laura de Oliveira Nascimento, Melissa Gurgel Adeodato Vieira
Summary: Multiparticulate drug delivery systems (MDDS) are gaining interest for their therapeutic benefits and technological advantages. This review investigates the use of polysaccharides and/or polyacid proteins in MDDS for anti-inflammatory drug delivery. The study found that polysaccharide materials are widely used in MDDS due to their biodegradability, biocompatibility, nontoxicity, and availability. The encapsulation efficiency and drug release profile in MDDS are influenced by various factors such as polymer/active pharmaceutical ingredient ratio, crosslinking agent type and concentration, and process parameters.
EUROPEAN POLYMER JOURNAL
(2022)
Review
Immunology
Elizabeth M. Rabold, Hammad Ali, Danielle Fernandez, Martha Knuth, Karl Schenkel, Rana Jawad Asghar, Mirza Amir Baig, Saqib Shaikh, Oliver Morgan
Summary: Multiple HIV outbreaks in Pakistan since 2003 have been linked to unsafe injection practices and injection drug use. A systematic review identified 7 outbreaks from 2000 to 2019, with more than half occurring during 2016-2019. The primary sources of transmission were iatrogenic transmission, injection drug use, and a combination of both.
EMERGING INFECTIOUS DISEASES
(2021)
Review
Endocrinology & Metabolism
Alvin Kuate Defo, Veselko Bakula, Alessandro Pisaturo, Christopher Labos, Simon S. Wing, Stella S. Daskalopoulou
Summary: The aim of this umbrella review and meta-analysis was to evaluate the impact of diabetes on the risk of dementia and the effectiveness of antidiabetic treatments. The study found that metformin, thiazolidinediones, pioglitazone, GLP1RAs, and SGLT2is were associated with a reduced risk of dementia. However, further longitudinal studies are needed to determine their relative benefits in different populations.
DIABETES OBESITY & METABOLISM
(2023)
Review
Biochemistry & Molecular Biology
Anna Gumieniczek, Anna Berecka-Rycerz
Summary: This paper is the second part of a review on the metabolism and chemical degradation of new antidiabetic drugs from glutides, gliflozins and gliptins. The paper discusses the importance of metabolism data for determining safe levels of degradation impurities and their toxicological aspects. It also summarizes analytical tools, including liquid chromatography (LC) and liquid chromatography coupled with mass spectrometry (LC-MS or LC-MS/MS), for conducting modern drug metabolism and degradation experiments. The paper focuses on the analytical approaches used to examine the metabolism and degradation pathways of gliptins, specifically DPP-4 inhibitors.
Review
Endocrinology & Metabolism
Ashley S. Cha, Yilin Chen, Katherine Fazioli, Matthew B. Rivara, Emily Beth Devine
Summary: The study focused on the impact of new antidiabetic medications on diabetic kidney disease, with findings suggesting that dapagliflozin and empagliflozin, among others, have the most significant reduction in the risk of developing composite kidney outcomes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Nutrition & Dietetics
Sepideh Alasvand Zarasvand, Amy P. Mullins, Bahram Arjmandi, Vivian Haley-Zitlin
Summary: This systematic review investigates the antidiabetic properties of different parts of the mango plant in managing type 2 diabetes mellitus in animal models and humans. The results support the glucose-lowering properties of mango and propose multiple mechanisms of action for its antidiabetic effects. Although promising, more observational studies and randomized control trials are needed to further validate these findings.
NUTRITION RESEARCH
(2023)
Review
Multidisciplinary Sciences
Rayah Asiri, Anna Robinson-Barella, Anum Iqbal, Adam Todd, Andy Husband
Summary: This review explores the barriers to and facilitators of adherence to antidiabetic medication among ethnic minority groups in high-income countries. The study identifies cultural, communication, and management-related factors as the main themes influencing medication adherence. Interventions targeting these barriers may improve diabetes outcomes in these communities.
Review
Endocrinology & Metabolism
Pierre-Emmanuel Cailleaux, Andre Luis Porporatti, Martine Cohen-Solal, Natacha Kadlub, Amelie E. Coudert
Summary: The aim of this systematic review was to determine if there exists an efficacious drug treatment for cherubism. The review identified three types of drugs used for cherubism management: calcitonin, immunomodulators, and anti-resorptive agents. However, due to the heterogeneity in case reports and the lack of standardized outcomes, no effective treatment for cherubism could be identified.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Anna Gumieniczek, Anna Berecka-Rycerz
Summary: The article discusses the possible links between metabolic and degradation pathways for new antidiabetic drugs, focusing on glutides, gliflozins, and gliptins. It highlights the importance of metabolism data in determining safe levels of degradation impurities and improving product quality. Various analytical approaches, including chromatographic methods and radioactive labeling, are mentioned for examining the metabolism and degradation pathways.
Review
Infectious Diseases
Jean Eduardo Meneguello, Leticia Sayuri Murase, Joao Vitor Perez de Souza, Cheila Guimaraes de Oliveira, Luciana Dias Ghiraldi-Lopes, Jorge Juarez Vieira Teixeira, Regiane Bertin de Lima Scodro, Katiany Rizzieri Caleffi Ferracioli, Vera Lucia Dias Siqueira, Paula Aline Zanetti Campanerut-Sa, Rosilene Fressatti Cardoso
Summary: The objective of this systematic review was to examine published studies on the treatment of bacterial infections using disulfiram. The review highlighted the potential of disulfiram as a non-antibiotic drug in the treatment of bacterial diseases and suggested further investigation into its combination with other drugs and its immunomodulatory effects.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Eberhard Blind, Pieter A. de Graeff, Illiana Meurs, Frank Holtkamp, Ania Baczynska, Heidi Janssen
EUROPEAN HEART JOURNAL
(2016)
Editorial Material
Endocrinology & Metabolism
E. Blind, K. Dunder, P. A. de Graeff, E. Abadie
Article
Endocrinology & Metabolism
Steven Boonen, Fernando Marin, Barbara Obermayer-Pietsch, Maria E. Simoes, Clare Barker, Emmett V. Glass, Peyman Hadji, George Lyritis, Heide Oertel, Thomas Nickelsen, Eugene V. McCloskey
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2008)
Editorial Material
Medicine, General & Internal
Amy G. Egan, Eberhard Blind, Kristina Dunder, Pieter A. de Graeff, B. Timothy Hummer, Todd Bourcier, Curtis Rosebraugh
NEW ENGLAND JOURNAL OF MEDICINE
(2014)
Review
Pharmacology & Pharmacy
Theresa Kehoe, Eberhard Blind, Heidi Janssen
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2019)
Letter
Cardiac & Cardiovascular Systems
Kristina Dunder, Pieter A. de Graeff, Eberhard Blind
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2017)
Article
Surgery
Vasiliy Moskalenko, Karin Ulrichs, Andreas Kerscher, Eberhard Blind, Christoph Otto, Wulf Hamelmann, Yurij Demidchik, Stephan Timm
TRANSPLANT INTERNATIONAL
(2007)
Article
Biochemistry & Molecular Biology
Asif Ali, Paul T. Christie, Irina V. Grigorieva, Brian Harding, Hilde Van Esch, S. Faisal Ahmed, Maria Bitner-Glindzicz, Eberhard Blind, Catherine Bloch, Patricia Christin, Peter Clayton, Jozef Gecz, Brigitte Gilbert-Dussardier, Encarna Guillen-Navarro, Anna Hackett, Isil Halac, Geoffrey N. Hendy, Fiona Lalloo, Christoph J. Mache, Zulf Mughal, Albert C. M. Ong, Choni Rinat, Nicholas Shaw, Sarah F. Smithson, John Tolmie, Jacques Weill, M. Andrew Nesbit, Rajesh V. Thakker
HUMAN MOLECULAR GENETICS
(2007)
Article
Endocrinology & Metabolism
J Bösel, M John, M Freichel, E Blind
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES
(2003)
Article
Endocrinology & Metabolism
IA Hansen, O Jakob, S Wortmann, T Arzberger, B Allolio, E Blind
JOURNAL OF ENDOCRINOLOGY
(2002)
Article
Endocrinology & Metabolism
MR John, H Wickert, K Zaar, KB Jonsson, A Grauer, P Ruppersberger, H Schmidt-Gayk, H Murer, R Ziegler, E Blind
Article
Medicine, General & Internal
E Blind, M Fassnacht, C Körber, N Körber-Hafner, C Reiners, B Allolio
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT
(2001)
Article
Endocrinology & Metabolism
MR John, J Bösel, S Breit, H Wickert, R Ziegler, E Blind
Article
Medical Laboratory Technology
Eberhard Blind
CLINICAL LABORATORY
(2008)