Microglial interactions with the neurovascular system in physiology and pathology

Activated microglia induce the production of reactive oxygen species and promote apoptosis of co-cultured retinal microvascular pericytes

(2017) Xinyi Ding et al.   GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY

Neuronal P2X7 Receptors Revisited: Do They Really Exist?

(2017) Peter Illes et al.   JOURNAL OF NEUROSCIENCE

Neuronal P2X7 Receptor: Involvement in Neuronal Physiology and Pathology

(2017) M. Teresa Miras-Portugal et al.   JOURNAL OF NEUROSCIENCE

A new fate mapping system reveals context-dependent random or clonal expansion of microglia

(2017) Tuan Leng Tay et al.   NATURE NEUROSCIENCE

Diverse Requirements for Microglial Survival, Specification, and Function Revealed by Defined-Medium Cultures

(2017) Christopher J. Bohlen et al.   NEURON

The biphasic function of microglia in ischemic stroke

(2017) Yuanyuan Ma et al.   PROGRESS IN NEUROBIOLOGY

TREM2, Microglia, and Neurodegenerative Diseases

(2017) Felix L. Yeh et al.   TRENDS IN MOLECULAR MEDICINE

Coupled Proliferation and Apoptosis Maintain the Rapid Turnover of Microglia in the Adult Brain

(2017) Katharine Askew et al.   Cell Reports

Developmental changes in microglial mobilization are independent of apoptosis in the neonatal mouse hippocampus

(2016) Ukpong B. Eyo et al.   BRAIN BEHAVIOR AND IMMUNITY

Glioma-mediated microglial activation promotes glioma proliferation and migration: roles of Na+/H+exchanger isoform 1

(2016) Wen Zhu et al.   CARCINOGENESIS

The Indispensable Roles of Microglia and Astrocytes during Brain Development

(2016) Kitty Reemst et al.   Frontiers in Human Neuroscience

Microglia-Neuron Communication in Epilepsy

(2016) Ukpong B. Eyo et al.   GLIA

Effects of interleukin-1ß on cortical spreading depolarization and cerebral vasculature

(2016) Frank Richter et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Deficiency in the voltage-gated proton channel Hv1 increases M2 polarization of microglia and attenuates brain damage from photothrombotic ischemic stroke

(2016) Dai-Shi Tian et al.   JOURNAL OF NEUROCHEMISTRY

Glioma-secreted soluble factors stimulate microglial activation: The role of interleukin-1β and tumor necrosis factor-α

(2016) Ji-Sun Hwang et al.   JOURNAL OF NEUROIMMUNOLOGY

Brain pericytes serve as microglia-generating multipotent vascular stem cells following ischemic stroke

(2016) Rika Sakuma et al.   Journal of Neuroinflammation

TAM receptors regulate multiple features of microglial physiology

(2016) Lawrence Fourgeaud et al.   NATURE

Microglial brain region−dependent diversity and selective regional sensitivities to aging

(2016) Kathleen Grabert et al.   NATURE NEUROSCIENCE

Cerebrovascular pathology during the progression of experimental Alzheimer's disease

(2016) Patrizia Giannoni et al.   NEUROBIOLOGY OF DISEASE

New tools for studying microglia in the mouse and human CNS

(2016) Mariko L. Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia and monocytes synergistically promote the transition from acute to chronic pain after nerve injury

(2016) Jiyun Peng et al.   Nature Communications

Spinal Microgliosis Due to Resident Microglial Proliferation Is Required for Pain Hypersensitivity after Peripheral Nerve Injury

(2016) Nan Gu et al.   Cell Reports

Correction: Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling

(2016) Oihane Abiega et al.   PLOS BIOLOGY

Resident microglia rather than peripheral macrophages promote vascularization in brain tumors and are source of alternative pro-angiogenic factors

(2015) Susan Brandenburg et al.   ACTA NEUROPATHOLOGICA

Microglia–blood vessel interactions: a double-edged sword in brain pathologies

(2015) Nevenka Dudvarski Stankovic et al.   ACTA NEUROPATHOLOGICA

Microglia: Multitasking Specialists of the Brain

(2015) Alessandra Maria Casano et al.   DEVELOPMENTAL CELL

Glia Open Access Database (GOAD): A comprehensive gene expression encyclopedia of glia cells in health and disease

(2015) Inge R. Holtman et al.   GLIA

Striatal Blood–Brain Barrier Permeability in Parkinson'S Disease

(2015) Madison T Gray et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Axon Initial Segment-Associated Microglia

(2015) K. Baalman et al.   JOURNAL OF NEUROSCIENCE

Modulation of Microglial Process Convergence Toward Neuronal Dendrites by Extracellular Calcium

(2015) U. B. Eyo et al.   JOURNAL OF NEUROSCIENCE

Parkinson's disease

(2015) Lorraine V Kalia et al.   LANCET

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

A Cellular Perspective on Brain Energy Metabolism and Functional Imaging

(2015) Pierre J. Magistretti et al.   NEURON

β-amyloid, microglia, and the inflammasome in Alzheimer’s disease

(2015) Maike Gold et al.   Seminars in Immunopathology

Dopamine induces growth inhibition and vascular normalization through reprogramming M2-polarized macrophages in rat C6 glioma

(2015) Tian Qin et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Astrocyte Regulation of Blood Flow in the Brain

(2015) Brian A. MacVicar et al.   Cold Spring Harbor Perspectives in Biology

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

Brain pericytes acquire a microglial phenotype after stroke

(2014) Ilknur Özen et al.   ACTA NEUROPATHOLOGICA

Perivascular microglia promote blood vessel disintegration in the ischemic penumbra

(2014) Valérie Jolivel et al.   ACTA NEUROPATHOLOGICA

Microglia Development and Function

(2014) Debasis Nayak et al.   Annual Review of Immunology

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

Neuronal Hyperactivity Recruits Microglial Processes via Neuronal NMDA Receptors and Microglial P2Y12 Receptors after Status Epilepticus

(2014) U. B. Eyo et al.   JOURNAL OF NEUROSCIENCE

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

(2014) Marco Prinz et al.   NATURE REVIEWS NEUROSCIENCE

Tumor necrosis factor-α-stimulated brain pericytes possess a unique cytokine and chemokine release profile and enhance microglial activation

(2014) Junichi Matsumoto et al.   NEUROSCIENCE LETTERS

The Evolving Biology of Microglia in Alzheimer’s Disease

(2014) Tarja M. Malm et al.   Neurotherapeutics

Chemokine expression profile of freshly isolated human glioblastoma-associated macrophages/microglia

(2014) KIRSTEN HATTERMANN et al.   ONCOLOGY REPORTS

Interleukin-1β Induces Blood–Brain Barrier Disruption by Downregulating Sonic Hedgehog in Astrocytes

(2014) Yue Wang et al.   PLoS One

Microglia Modulate Wiring of the Embryonic Forebrain

(2014) Paola Squarzoni et al.   Cell Reports

Surveillance, Phagocytosis, and Inflammation: How Never-Resting Microglia Influence Adult Hippocampal Neurogenesis

(2014) Amanda Sierra et al.   NEURAL PLASTICITY

Angiogenesis in multiple sclerosis and experimental autoimmune encephalomyelitis

(2014) Francesco Girolamo et al.   Acta Neuropathologica Communications

Microglia Promote Learning-Dependent Synapse Formation through Brain-Derived Neurotrophic Factor

(2013) Christopher N. Parkhurst et al.   CELL

Adaptive phenotype of microglial cells during the normal postnatal development of the somatosensory “Barrel” cortex

(2013) Isabelle Arnoux et al.   GLIA

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Radiation Therapy-Induced Tumor Invasiveness Is Associated with SDF-1-Regulated Macrophage Mobilization and Vasculogenesis

(2013) Shu-Chi Wang et al.   PLoS One

Matrix Metalloproteinases, New Insights into the Understanding of Neurodegenerative Disorders

(2012) Yoon-Seong Kim et al.   Biomolecules & Therapeutics

Mechanisms of Mononuclear Phagocyte Recruitment in Alzheimers Disease

(2012) Suzanne E. Hickman et al.   CNS & Neurological Disorders-Drug Targets

Microglia and Inflammation in Alzheimers Disease

(2012) Shweta Mandrekar-Colucci et al.   CNS & Neurological Disorders-Drug Targets

Reciprocal Regulation between Resting Microglial Dynamics and Neuronal Activity In Vivo

(2012) Ying Li et al.   DEVELOPMENTAL CELL

Development of ramified microglia from early macrophages in the zebrafish optic tectum

(2012) Adam J. Svahn et al.   Developmental Neurobiology

Effects of oxygen-glucose deprivation on microglial mobility and viability in developing mouse hippocampal tissues

(2012) Ukpong Eyo et al.   GLIA

The “quad-partite” synapse: Microglia-synapse interactions in the developing and mature CNS

(2012) Dorothy P. Schafer et al.   GLIA

Inflammatory Cytokines in Experimental and Human Stroke

(2012) Kate Lykke Lambertsen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The voltage-gated proton channel Hv1 enhances brain damage from ischemic stroke

(2012) Long-Jun Wu et al.   NATURE NEUROSCIENCE

Microglia in development: linking brain wiring to brain environment

(2012) Rosa C. Paolicelli et al.   Neuron Glia Biology

Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation

(2012) Dimitrios Davalos et al.   Nature Communications

Tumor Microenvironment in the Brain

(2012) Mihaela Lorger   Cancers

Capillary blood flow around microglial somata determines dynamics of microglial processes in ischemic conditions

(2011) Tadashi Masuda et al.   GLIA

Evidence for angiogenesis in Parkinson’s disease, incidental Lewy body disease, and progressive supranuclear palsy

(2011) Brinda Desai Bradaric et al.   JOURNAL OF NEURAL TRANSMISSION

Angiogenesis is present in experimental autoimmune encephalomyelitis and pro-angiogenic factors are increased in multiple sclerosis lesions

(2011) Timothy J Seabrook et al.   Journal of Neuroinflammation

Microglial Cells Contribute to Endogenous Brain Defenses after Acute Neonatal Focal Stroke

(2011) J. V. Faustino et al.   JOURNAL OF NEUROSCIENCE

Alzheimer's disease

(2011) Clive Ballard et al.   LANCET

Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool

(2011) Bahareh Ajami et al.   NATURE NEUROSCIENCE

A Two-Way Communication between Microglial Cells and Angiogenic Sprouts Regulates Angiogenesis in Aortic Ring Cultures

(2011) Simin F. Rymo et al.   PLoS One

Characteristics of the Alternative Phenotype of Microglia/Macrophages and its Modulation in Experimental Gliomas

(2011) Konrad Gabrusiewicz et al.   PLoS One

Tissue macrophages act as cellular chaperones for vascular anastomosis downstream of VEGF-mediated endothelial tip cell induction

(2010) A. Fantin et al.   BLOOD

Hematopoietic Origin of Pathological Grooming in Hoxb8 Mutant Mice

(2010) Shau-Kwaun Chen et al.   CELL

Microglia Shape Adult Hippocampal Neurogenesis through Apoptosis-Coupled Phagocytosis

(2010) Amanda Sierra et al.   Cell Stem Cell

Microglial ablation and lipopolysaccharide preconditioning affects pilocarpine-induced seizures in mice

(2010) Martine M. Mirrione et al.   NEUROBIOLOGY OF DISEASE

Human Microglia Transplanted in Rat Focal Ischemia Brain Induce Neuroprotection and Behavioral Improvement

(2010) Dashdemberel Narantuya et al.   PLoS One

Astrocyte-Derived Vascular Endothelial Growth Factor Stabilizes Vessels in the Developing Retinal Vasculature

(2010) Andrew Scott et al.   PLoS One

Microglial Interactions with Synapses Are Modulated by Visual Experience

(2010) Marie-Ève Tremblay et al.   PLOS BIOLOGY

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

Inflammatory cytokines in vascular dysfunction and vascular disease

(2009) Alexander H. Sprague et al.   BIOCHEMICAL PHARMACOLOGY

Neurovascular development uses VEGF-A signaling to regulate blood vessel ingression into the neural tube

(2009) J. M. James et al.   DEVELOPMENT

M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis

(2009) Yoshiaki Kubota et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Resting Microglia Directly Monitor the Functional State of Synapses In Vivo and Determine the Fate of Ischemic Terminals

(2009) H. Wake et al.   JOURNAL OF NEUROSCIENCE

An empirical analysis of the precision of estimating the numbers of neurons and glia in human neocortex using a fractionator-design with sub-sampling

(2009) Lise Lyck et al.   JOURNAL OF NEUROSCIENCE METHODS

Inflammation, microglia, and alzheimer's disease

(2009) Brent Cameron et al.   NEUROBIOLOGY OF DISEASE

Cortical microinfarcts in Alzheimerʼs disease and subcortical vascular dementia

(2009) Yoko Okamoto et al.   NEUROREPORT

Gliomas induce and exploit microglial MT1-MMP expression for tumor expansion

(2009) D. S. Markovic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Temporal and Spatial Dynamics of Cerebral Immune Cell Accumulation in Stroke

(2009) Mathias Gelderblom et al.   STROKE

A leaky blood-brain barrier, fibrinogen infiltration and microglial reactivity in inflamed Alzheimer’s disease brain

(2008) Jae K. Ryu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Role of CX3CR1 (Fractalkine Receptor) in Brain Damage and Inflammation Induced by Focal Cerebral Ischemia in Mouse

(2008) Ádám Dénes et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Developmental Neuronal Death in Hippocampus Requires the Microglial CD11b Integrin and DAP12 Immunoreceptor

(2008) S. Wakselman et al.   JOURNAL OF NEUROSCIENCE

Block of purinergic P2X7 receptor is neuroprotective in an animal model of Alzheimerʼs disease

(2008) Jae K. Ryu et al.   NEUROREPORT

Inflammation as a causative factor in the aetiology of Parkinson's disease

(2007) P S Whitton   BRITISH JOURNAL OF PHARMACOLOGY

Neocortical glial cell numbers in human brains

(2007) D.P. Pelvig et al.   NEUROBIOLOGY OF AGING