Harpagoside suppresses IL-6 expression in primary human osteoarthritis chondrocytes

Emerging targets in osteoarthritis therapy

(2015) Mary B Goldring et al.   CURRENT OPINION IN PHARMACOLOGY

Biologic basis of osteoarthritis

(2015) Charles J. Malemud   CURRENT OPINION IN RHEUMATOLOGY

The Role of Inflammatory and Anti-Inflammatory Cytokines in the Pathogenesis of Osteoarthritis

(2014) Piotr Wojdasiewicz et al.   MEDIATORS OF INFLAMMATION

Immunopathogenesis of osteoarthritis

(2013) Abdul Haseeb et al.   CLINICAL IMMUNOLOGY

Delphinidin inhibits IL-1 -induced activation of NF- B by modulating the phosphorylation of IRAK-1Ser376 in human articular chondrocytes

(2013) A. Haseeb et al.   RHEUMATOLOGY

Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations

(2013) Jeremy Sokolove et al.   Therapeutic Advances in Musculoskeletal Disease

The role of synovitis in osteoarthritis pathogenesis

(2012) Carla R. Scanzello et al.   BONE

Devil's Claw—A review of the ethnobotany, phytochemistry and biological activity of Harpagophytum procumbens

(2012) Nontobeko Mncwangi et al.   JOURNAL OF ETHNOPHARMACOLOGY

Interleukin-6 is elevated in synovial fluid of patients with focal cartilage defects and stimulates cartilage matrix production in an in vitro regeneration model

(2012) Anika I Tsuchida et al.   ARTHRITIS RESEARCH & THERAPY

Matrix metalloproteinase-13 expression in IL-1β-treated chondrocytes by activation of the p38 MAPK/c-Fos/AP-1 and JAK/STAT pathways

(2011) Hyun Lim et al.   ARCHIVES OF PHARMACAL RESEARCH

Interleukin-6 plays an essential role in hypoxia-inducible factor 2α-induced experimental osteoarthritic cartilage destruction in mice

(2011) Je-Hwang Ryu et al.   ARTHRITIS AND RHEUMATISM

Osteoarthritis: an update with relevance for clinical practice

(2011) Johannes WJ Bijlsma et al.   LANCET

Molecular targets of natural health products in arthritis

(2011) Sarah Khalifé et al.   ARTHRITIS RESEARCH & THERAPY

IL-6 and IL-1 synergistically enhanced the production of MMPs from synovial cells by up-regulating IL-6 production and IL-1 receptor I expression

(2010) Miho Suzuki et al.   CYTOKINE

Inhibitory effects of devil’s claw (secondary root of Harpagophytum procumbens) extract and harpagoside on cytokine production in mouse macrophages

(2010) Kazunori Inaba et al.   Journal of Natural Medicines

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

Circulating levels of IL-6 and TNF-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults

(2010) O. Stannus et al.   OSTEOARTHRITIS AND CARTILAGE

Effect of isolated fractions of Harpagophytum procumbens D.C. (devil's claw) on COX-1, COX-2 activity and nitric oxide production on whole-blood assay

(2010) Maria Cecilia Anauate et al.   PHYTOTHERAPY RESEARCH

Desirable effect of combination therapy with high molecular weight hyaluronate and NSAIDs on MMP production

(2009) M. Hashizume et al.   OSTEOARTHRITIS AND CARTILAGE

Treatment of arthritis with a selective inhibitor of c-Fos/activator protein-1

(2008) Yukihiko Aikawa et al.   NATURE BIOTECHNOLOGY

New horizons and perspectives in the treatment of osteoarthritis

(2008) Francis Berenbaum   ARTHRITIS RESEARCH & THERAPY