Review
Biochemistry & Molecular Biology
Sona Ciernikova, Aneta Sevcikova, Lubos Drgona, Michal Mego
Summary: Treatment resistance and adverse effects are important issues in cancer patient management. The use of microbiome in oncology is showing promising results. Favorable bacterial species and gut diversity are associated with increased treatment efficacy, while alterations in gut microbiome contribute to intestinal dysbiosis and treatment-induced toxicity.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2023)
Article
Gastroenterology & Hepatology
Kosuke Fujimoto, Yasumasa Kimura, Jessica R. Allegretti, Mako Yamamoto, Yao-Zhong Zhang, Kotoe Katayama, Georg Tremmel, Yunosuke Kawaguchi, Masaki Shimohigoshi, Tetsuya Hayashi, Miho Uematsu, Kiyoshi Yamaguchi, Yoichi Furukawa, Yutaka Akiyama, Rui Yamaguchi, Sheila E. Crowe, Peter B. Ernst, Satoru Miyano, Hiroshi Kiyono, Seiya Imoto, Satoshi Uematsu
Summary: This study found that FMT alters the characteristics of intestinal microbiomes and viromes in recipients after FMT compared to before, and the coordinated action of phages and their host bacteria restores the recipients' intestinal flora. Additionally, distinctive pathways in bacterial and viral gene functions before and after FMT were significantly represented.
Review
Biochemistry & Molecular Biology
Natalia Vallianou, Gerasimos Socrates Christodoulatos, Irene Karampela, Dimitrios Tsilingiris, Faidon Magkos, Theodora Stratigou, Dimitris Kounatidis, Maria Dalamaga
Summary: Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide, often starting as a benign liver fat accumulation that can progress to non-alcoholic steatohepatitis (NASH) and increase the risk of cirrhosis and hepatocellular carcinoma (HCC). Recent studies have highlighted the role of gut dysbiosis, which can lead to increased gut permeability and the release of toxic bacterial products and proinflammatory cytokines, causing and sustaining inflammation. The composition of the gut microbiota and various metabolites may vary during different stages of NAFLD and among population groups, and further research is needed to determine the causal relationship between gut microbiota profiles and NAFLD in patients. Additionally, multiple metabolites may contribute to the pathogenesis of NAFLD.
Article
Immunology
Bhupinder Kapoor, Monica Gulati, Reena Gupta, Rajeev K. Singla
Summary: Dysregulated immune system, in which self-antigens are not recognized properly, is a common pathogenesis in autoimmune diseases. Environmental factors, such as disturbed gut microbiota, have been found to play a crucial role. Recent studies have shown that dysbiosis of gut microbiota is associated with the development of myasthenia gravis (MG), a rare autoimmune disease of the neuromuscular junction. The modulation of gut microbiota through interventions like probiotics, prebiotics, and fecal microbiota transplantation (FMT) is considered a promising approach for the management of MG.
AUTOIMMUNITY REVIEWS
(2023)
Article
Immunology
Elizabeth S. Aby, Byron P. Vaughn, Eva A. Enns, Radha Rajasingham
Summary: This study assessed the cost-effectiveness of fecal microbiota transplantation (FMT) for first recurrent Clostridioides difficile infection (CDI). The findings indicate that FMT is a cost-effective treatment strategy for first recurrent CDI.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Gastroenterology & Hepatology
Maribeth R. Nicholson, Suchitra K. Hourigan, Maire Conrad, Alka Goyal, Kyle Jensen, Judith Kelsen, Melissa Kennedy, Madison Weatherly, Stacy A. Kahn
Summary: The impact of the 2019 US FDA safety alert and the COVID-19 pandemic on the use of FMT in children has led to changes in practices for many pediatric gastroenterologists, with a majority of programs being halted as a result.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Nutrition & Dietetics
Binhui Pan, Xiujie Liu, Jiangmin Shi, Yaoxuan Chen, Zhihua Xu, Dibang Shi, Gaoyi Ruan, Fangyan Wang, Yingpeng Huang, Changlong Xu
Summary: The meta-analysis showed that microbial therapy significantly improved metabolic indicators in patients with MetS, such as waist circumference, blood glucose, cholesterol, and triglycerides. However, there was no significant effect on BMI, blood pressure, and HbA1c levels.
FRONTIERS IN NUTRITION
(2021)
Review
Medicine, General & Internal
Honglin Jiang, Yan Peng, Wei Zhang, Yue Chen, Qingwu Jiang, Yibiao Zhou
Summary: This study aims to comprehensively assess the effects of microbiome-targeted therapies (MTTs), including probiotics, prebiotics, synbiotics, and fecal microbiota transplantation (FMT), in patients with liver cirrhosis. The study will include randomized controlled trials and evaluate the therapeutic effects and mechanisms of MTTs through subgroup analysis and sensitivity analysis.
SYSTEMATIC REVIEWS
(2022)
Article
Medicine, General & Internal
Pei-Chang Lee, Tien-En Chang, Yen-Po Wang, Kuei-Chuan Lee, Yi-Tsung Lin, Jen-Jie Chiou, Chi-Wei Huang, Ueng-Cheng Yang, Fen-Yau Li, Hui-Chun Huang, Chun-Ying Wu, Yi-Hsiang Huang, Ming-Chih Hou
Summary: This study aimed to investigate the efficacy of FMT for treating rCDI and its association with microbial changes. The research found that successful FMT was related to treatment outcomes and led to dynamic changes in fecal microbial composition.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Review
Microbiology
Chun-Wei Chiu, Pei-Jane Tsai, Ching-Chi Lee, Wen-Chien Ko, Yuan-Pin Hung
Summary: Oral vancomycin and metronidazole, the therapeutic choices for CDIs, disrupt microbiota and lead to a loss of colonization resistance to C. difficile. Alternatives like probiotics and FMT have been studied extensively for preventing and treating rCDIs by aiming to preserve microbiota.
Article
Microbiology
Craig Haifer, Sudarshan Paramsothy, Thomas J. Borody, Annabel Clancy, Rupert W. Leong, Nadeem O. Kaakoush
Summary: Oral lyophilized fecal microbiota transplantation (FMT) is effective in treating Clostridioides difficile infection (CDI), improving microbial diversity and resulting in durable engraftment up to 6 months post-treatment, with better efficacy observed in primary CDI compared to recurrent cases. Changes in bacterial and fungal communities are associated with therapy outcomes.
Article
Multidisciplinary Sciences
Olle Bjorkqvist, Ignacio Rangel, Lena Serrander, Cecilia Magnusson, Jonas Halfvarson, Torbjorn Noren, Malin Bergman-Jungestrom
Summary: The study found that FMT can increase the relative abundance of Faecalibacterium prausnitzii in patients with recurrent CDI, and this microbial shift persists for several months later. Further research is needed to determine whether Faecalibacterium prausnitzii actively contributes to the resolution of CDI.
Review
Food Science & Technology
Chen Wang, Junying Bai, Xiaoyong Chen, Jiajia Song, Yu Zhang, Hongwei Wang, Huayi Suo
Summary: Host health and disease are affected by changes in intestinal flora. Strategies such as probiotics, prebiotics, diet, fecal microbiota transplantation, antibiotics, and phages can regulate the structure and abundance of microflora. Diets and prebiotics have reduced risk and high security, while phages have high specificity for targeted regulation. Individual variability in microflora and metabolic response should be considered, and future studies should use artificial intelligence and multi-omics to develop personalized intervention strategies.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Gastroenterology & Hepatology
Anna Maria Seekatz, Nasia Safdar, Sahil Khanna
Summary: The composition of the human gut microbiota is important for overall health, and disruptions in this microbiome can lead to various diseases. In the case of Clostridioides difficile infection, standard treatments and monoclonal antibodies do not address the underlying dysbiosis. Fecal microbiota transplantation (FMT) is an effective strategy in preventing recurrent infections, but there are challenges in screening and standardizing the acquisition and processing of donor stool. Newer biotherapeutic formulations are being developed to improve gut microbiome restoration and prevent CDI recurrence.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2022)
Review
Nutrition & Dietetics
Margherita Prosperi, Elisa Santocchi, Letizia Guiducci, Jacopo Frinzi, Maria Aurora Morales, Raffaella Tancredi, Filippo Muratori, Sara Calderoni
Summary: Although the findings are promising, the results are still partial due to the variability in treatments, sample sizes, treatment durations, and evaluation tools used in the trials. It is yet to be determined the conclusive beneficial effect of probiotics and other interventions on ASD symptoms, including the optimal species, subspecies, and dosages. Double-blind, randomized, controlled trials tailored to ASD characteristics and host-microbiota are recommended.
Article
Gastroenterology & Hepatology
Allen A. Lee, Krishna Rao, Henry P. Parkman, Richard W. McCallum, Irene Sarosiek, Linda A. Nguyen, John M. Wo, Michael Schulman, Baharak Moshiree, Satish Rao, Braden Kuo, William L. Hasler
Summary: The study found that gender, stool hardness, and functional dyspepsia were predictive factors for more severe upper gastrointestinal symptoms, while delayed gastric emptying and abnormal gastrointestinal contractility were also associated with more severe symptoms and worse quality of life scores.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Article
Immunology
D. Alexander Perry, Daniel Shirley, Dejan Micic, C. Pratish Patel, Rosemary Putler, Anitha Menon, Vincent B. Young, Krishna Rao
Summary: None of the published CDI severity scores showed stable and good predictive ability for adverse outcomes across multiple centers. The existing scoring systems have poor predictive ability for CDI severity.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Gastroenterology & Hepatology
Matthew K. Schnizlein, Vincent B. Young
Summary: Clostridioides difficile infection is a significant burden on health and economy worldwide. This review provides insights into the physiology of C. difficile, its survival mechanisms in the gut environment, and the relationships between host-microorganism and microorganism-microorganism.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2022)
Review
Microbiology
Madeline R. Barron, Vincent B. Young
Summary: The relationship between the gut environment and bacterial colonization is of great significance. The complex interactions between multiple factors in the gut environment make it difficult to uncover the characteristics of the system using reductionist methods. The systems biology approach provides a more comprehensive perspective. This article explores the relationship between the gut environment and bacterial colonization from the perspective of systems biology, and provides guidance for future research.
Article
Microbiology
Madeline R. Barron, Kelly L. Sovacool, Lisa Abernathy-Close, Kimberly C. Vendrov, Alexandra K. Standke, Ingrid L. Bergin, Patrick D. Schloss, Vincent B. Young
Summary: Patients with inflammatory bowel disease (IBD) have an increased risk of developing C. difficile infection (CDI), even in the absence of antibiotic treatment. The mechanisms regulating C. difficile colonization in IBD patients remain unclear. In this study, a mouse model was used to demonstrate that intestinal inflammation alters microbiota composition, leading to susceptibility to C. difficile colonization. Treating inflammation with an anti-p40 monoclonal antibody restores colonization resistance. Microbiota transfer experiments confirm that the microbiota shaped in the setting of IBD is the primary driver of susceptibility to C. difficile colonization.
Article
Multidisciplinary Sciences
Jay Vornhagen, Emily K. Roberts, Lavinia Unverdorben, Sophia Mason, Alieysa Patel, Ryan Crawford, Caitlyn L. Holmes, Yuang Sun, Alexandra Teodorescu, Evan S. Snitkin, Lili Zhao, Patricia J. Simner, Pranita D. Tamma, Krishna Rao, Keith S. Kaye, Michael A. Bachman
Summary: This study identifies several genes reproducibly associated with progression to infection in patients colonized by diverse Klebsiella. Patient variables, such as comorbidities, partially explain which patients will progress to Klebsiella infection, with colonization of the gut acting as a reservoir. Little is known, however, regarding Klebsiella genes that may increase risk of disease in colonized individuals.
NATURE COMMUNICATIONS
(2022)
Article
Public, Environmental & Occupational Health
Meghana Kamineni, Erkin Otles Meng, Jeeheh Oh, Krishna Rao, Vincent B. Young, Benjamin Y. Li, Lauren R. West, David C. Hooper, Erica S. Shenoy, John G. Guttag, Jenna Wiens, Maggie Makar
Summary: This article presents the prospective and retrospective evaluations of two CDI infection risk prediction models and discusses their robustness to data-set shifts.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Anna S. C. Conlon, Zoey Chopra, Shannon Cahalan, Sandro Cinti, Krishna Rao
Summary: This study aims to describe the natural course of procalcitonin (PCT) in COVID-19 patients and its correlation with antimicrobial prescribing, providing insights into PCT data utilization in antimicrobial stewardship. The results show that PCT trends are associated with antibiotic initiation and duration of treatment, independent of pneumonia status and comorbidities.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Editorial Material
Nursing
Jeremy Mills
ISSUES IN MENTAL HEALTH NURSING
(2023)
Article
Public, Environmental & Occupational Health
John P. P. Mills, Julia Mantey, Marco Cassone, Keith S. S. Kaye, Lona Mody
Summary: Resistant gram-negative bacteria (R-GNB) colonization in nursing home patients can lead to clinical infection and intrafacility transmission. Limited data exist on the roles of age and function on R-GNB colonization. Persistent R-GNB colonization is associated with younger age, functional disability, and prolonged length of nursing home stay.
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY
(2023)
Review
Obstetrics & Gynecology
Malavika Prabhu, Gianna Wilkie, Mark MacEachern, Dana LaBuda, Jasmine Purtell, Krishna Rao, Laura E. E. Riley, Matthew Fuller, Morgan Rosser, Ashraf S. S. Habib, Melissa E. E. Bauer
Summary: The study aims to determine the mean procalcitonin levels in different groups of pregnant women and evaluate its usefulness in identifying infection.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
Editorial Material
Nursing
Jeremy Mills, C. Chime Karkhang
ISSUES IN MENTAL HEALTH NURSING
(2023)
Article
Gastroenterology & Hepatology
Patricia P. Bloom, Krishna Rao, Christine Bassis, Borko Nojkov, Vincent B. Young, Anna S. F. Lok
Summary: Patients with cirrhosis have higher duodenal epithelial permeability and lower mucosal bacteria alpha diversity compared to controls, while no such differences are seen in the ileum or colon. Specific bacteria are associated with epithelial permeability and future hepatic decompensation.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Veronica Azcutia, Matthias Kelm, Seonyoung Kim, Anny-Claude Luissint, Sven Flemming, Lisa Abernathy-Close, Vincent B. Young, Asma Nusrat, Mark J. Miller, Charles A. Parkos
Summary: This study used real-time intravital microscopy and a new distal colon loop model to investigate PMN migration dynamics in response to acute colonic injury models. The results revealed different migratory patterns of PMNs under various conditions, suggesting potential mechanisms for regulating PMN migration and providing insights for future anti-inflammatory and pro-repair therapies.