The International Mouse Phenotyping Consortium (IMPC): a functional catalogue of the mammalian genome that informs conservation

High-throughput mouse phenomics for characterizing mammalian gene function

(2018) Steve D. M. Brown et al.   NATURE REVIEWS GENETICS

Identification of genetic elements in metabolism by high-throughput mouse phenotyping

(2018) Jan Rozman et al.   Nature Communications

Placentation defects are highly prevalent in embryonic lethal mouse mutants

(2018) Vicente Perez-Garcia et al.   NATURE

A Gene Implicated in Activation of Retinoic Acid Receptor Targets Is a Novel Renal Agenesis Gene in Humans

(2017) Patrick D. Brophy et al.   GENETICS

Analysing the outcome of CRISPR-aided genome editing in embryos: Screening, genotyping and quality control

(2017) Joffrey Mianné et al.   METHODS

Disease model discovery from 3,328 gene knockouts by The International Mouse Phenotyping Consortium

(2017) Terrence F Meehan et al.   NATURE GENETICS

Comparative genomics reveals convergent evolution between the bamboo-eating giant and red pandas

(2017) Yibo Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Using ALoFT to determine the impact of putative loss-of-function variants in protein-coding genes

(2017) Suganthi Balasubramanian et al.   Nature Communications

Prevalence of sexual dimorphism in mammalian phenotypic traits

(2017) Natasha A. Karp et al.   Nature Communications

A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction

(2017) Michael R. Bowl et al.   Nature Communications

Identifiers for the 21st century: How to design, provision, and reuse persistent identifiers to maximize utility and impact of life science data

(2017) Julie A. McMurry et al.   PLOS BIOLOGY

A Gene Implicated in Activation of Retinoic Acid Receptor Targets Is a Novel Renal Agenesis Gene in Humans

(2017) Patrick D. Brophy et al.   GENETICS

Mapping Complex Traits in a Diversity Outbred F1 Mouse Population Identifies Germline Modifiers of Metastasis in Human Prostate Cancer

(2017) Jean M. Winter et al.   Cell Systems

No evidence of inbreeding depression in a Tasmanian devil insurance population despite significant variation in inbreeding

(2017) Rebecca Gooley et al.   Scientific Reports

Recovery of gene diversity using long-term cryopreserved spermatozoa and artificial insemination in the endangered black-footed ferret: response to commentaries

(2016) D. E. Wildt et al.   ANIMAL CONSERVATION

High-throughput discovery of novel developmental phenotypes

(2016) Mary E. Dickinson et al.   NATURE

The Human Phenotype Ontology in 2017

(2016) Sebastian Köhler et al.   NUCLEIC ACIDS RESEARCH

Massive dysregulation of genes involved in cell signaling and placental development in cloned cattle conceptus and maternal endometrium

(2016) Fernando H. Biase et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rewinding the process of mammalian extinction

(2016) Joseph Saragusty et al.   ZOO BIOLOGY

Integrating Genomic Data Sets for Knowledge Discovery: An Informed Approach to Management of Captive Endangered Species

(2016) Kristopher J. L. Irizarry et al.   International Journal of Genomics

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

(2015) Traver Hart et al.   CELL

Using genome-wide measures of coancestry to maintain diversity and fitness in endangered and domestic pig populations

(2015) Mirte Bosse et al.   GENOME RESEARCH

Targeted capture and resequencing of 1040 genes reveal environmentally driven functional variation in grey wolves

(2015) Rena M. Schweizer et al.   MOLECULAR ECOLOGY

Genetic subdivision and candidate genes under selection in North American grey wolves

(2015) Rena M. Schweizer et al.   MOLECULAR ECOLOGY

Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics

(2015) Martin Hrabě de Angelis et al.   NATURE GENETICS

PhenStat: A Tool Kit for Standardized Analysis of High Throughput Phenotypic Data

(2015) Natalja Kurbatova et al.   PLoS One

Mountain gorilla genomes reveal the impact of long-term population decline and inbreeding

(2015) Y. Xue et al.   SCIENCE

Gene essentiality and synthetic lethality in haploid human cells

(2015) V. A. Blomen et al.   SCIENCE

Identification and characterization of essential genes in the human genome

(2015) T. Wang et al.   SCIENCE

Expanding the mammalian phenotype ontology to support automated exchange of high throughput mouse phenotyping data generated by large-scale mouse knockout screens

(2015) Cynthia L Smith et al.   Journal of Biomedical Semantics

Population Genomics Reveal Recent Speciation and Rapid Evolutionary Adaptation in Polar Bears

(2014) Shiping Liu et al.   CELL

A Mouse Geneticist's Practical Guide to CRISPR Applications

(2014) P. Singh et al.   GENETICS

Strong Artificial Selection in Domestic Mammals Did Not Result in an Increased Recombination Rate

(2014) Violeta Muñoz-Fuentes et al.   MOLECULAR BIOLOGY AND EVOLUTION

A 660-Kb Deletion with Antagonistic Effects on Fertility and Milk Production Segregates at High Frequency in Nordic Red Cattle: Additional Evidence for the Common Occurrence of Balancing Selection in Livestock

(2014) Naveen Kumar Kadri et al.   PLoS Genetics

Genome-wide Generation and Systematic Phenotyping of Knockout Mice Reveals New Roles for Many Genes

(2013) Jacqueline K. White et al.   CELL

Bloomsbury report on mouse embryo phenotyping: recommendations from the IMPC workshop on embryonic lethal screening

(2013) D. Adams et al.   Disease Models & Mechanisms

What the Inbred Scandinavian Wolf Population Tells Us about the Nature of Conservation

(2013) Jannikke Räikkönen et al.   PLoS One

PhenoDigm: analyzing curated annotations to associate animal models with human diseases

(2013) D. Smedley et al.   Database-The Journal of Biological Databases and Curation

Heterozygosity-Fitness Correlations and Inbreeding Depression in Two Critically Endangered Mammals

(2012) MarÍA JOSÉ Ruiz-López et al.   CONSERVATION BIOLOGY

An integrated map of genetic variation from 1,092 human genomes

(2012)   NATURE

A Systematic Survey of Loss-of-Function Variants in Human Protein-Coding Genes

(2012) D. G. MacArthur et al.   SCIENCE

Animal models and conserved processes

(2012) Ray Greek et al.   Theoretical Biology and Medical Modelling

A conditional knockout resource for the genome-wide study of mouse gene function

(2011) William C. Skarnes et al.   NATURE

100 years of Drosophila research and its impact on vertebrate neuroscience: a history lesson for the future

(2010) Hugo J. Bellen et al.   NATURE REVIEWS NEUROSCIENCE

Evolutionary Characters, Phenotypes and Ontologies: Curating Data from the Systematic Biology Literature

(2010) Wasila M. Dahdul et al.   PLoS One

Genetic Restoration of the Florida Panther

(2010) W. E. Johnson et al.   SCIENCE

Congenital bone deformities and the inbred wolves (Canis lupus) of Isle Royale

(2009) Jannikke Räikkönen et al.   BIOLOGICAL CONSERVATION

Practical application of ontologies to annotate and analyse large scale raw mouse phenotype data

(2009) Tim Beck et al.   BMC BIOINFORMATICS

Genetic rescue guidelines with examples from Mexican wolves and Florida panthers

(2009) Philip W. Hedrick et al.   CONSERVATION GENETICS

Conserved developmental processes and the formation of evolutionary novelties: examples from butterfly wings

(2008) S. V Saenko et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES