Article
Immunology
Yi Zhai, Yanli Pang
Summary: PCOS is a common disorder related to endocrine/reproductive/metabolic systems, and it is associated with low-grade chronic inflammation. Patients with PCOS have higher levels of inflammatory cells and factors, as well as lower levels of anti-inflammatory cytokines. This systemic inflammation is thought to interact with obesity, insulin resistance, and hyperandrogenism.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Congshun Ma, Qianru Xiang, Ge Song, Xuefei Wang
Summary: Polycystic ovary syndrome (PCOS) is a reproductive endocrine disease with no specific drug treatment. Quercetin (QUR), a flavonoid, has potential therapeutic effects for PCOS patients. However, the mechanisms of QUR in PCOS patients remain unclear.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Necati Hancerliogullari, Aytekin Tokmak, Gurhan Guney, Meryem Kuru Pekcan, Esin Merve Koc, Tuba Candar, Yaprak Engin Ustun
Summary: Polycystic ovary syndrome (PCOS) is a common endocrine and metabolic disorder, and inflammation is believed to play a crucial role in its pathogenesis. This study found that serum calprotectin levels were higher in women with PCOS, and were correlated with insulin resistance, hyperandrogenism, and chronic inflammation.
Review
Endocrinology & Metabolism
Kexin Wang, Yanhua Li
Summary: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder among women of reproductive age. The etiologies of this syndrome are complex and involve prenatal factors, genetic variation, epigenetic mechanisms, unhealthy lifestyles, and environmental toxins. This review examines the molecular mechanisms underlying PCOS pathogenesis at the level of signaling pathways and discusses potential therapies including exosome therapy, gene therapy, and drugs based on traditional Chinese medicine and natural compounds.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Medicine, Research & Experimental
Si-wei Zhang, Jing Zhou, Hans-Jurgen Gober, Wing Ting Leung, Ling Wang
Summary: PCOS is a common disorder in women of reproductive age, affecting their physiology and metabolism, and often leading to metabolic syndrome and insulin resistance; Berberine can intervene in the development of PCOS in multiple ways, including alleviating insulin resistance, reducing androgen levels, regulating lipid metabolism, and reducing inflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
Ewa Rudnicka, Katarzyna Suchta, Monika Grymowicz, Anna Calik-Ksepka, Katarzyna Smolarczyk, Anna M. Duszewska, Roman Smolarczyk, Blazej Meczekalski
Summary: Polycystic ovary syndrome (PCOS) is characterized by chronic anovulation, hyperandrogenism, and polycystic ovarian morphology, often leading to health issues like obesity and insulin resistance. Studies suggest a link between PCOS and chronic inflammation, which may contribute to cardiovascular diseases and other complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Maryam Rostamtabar, Sedigheh Esmaeilzadeh, Mehdi Tourani, Abolfazl Rahmani, Masoud Baee, Fatemeh Shirafkan, Kiarash Saleki, Sajedeh S. Mirzababayi, Soheil Ebrahimpour, Hamid Reza Nouri
Summary: PCOS is the most common hormonal imbalance disease in reproductive-aged women, characterized by ovulatory dysfunction and ovarian overproduction of androgens. Recent studies have shown that inflammation processes are involved in ovulation and play a key role in ovarian follicular dynamics.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Yuanyuan Peng, Hongyue Yang, Jiahui Song, Di Feng, Zhijing Na, Hongyu Jiang, Yaxin Meng, Bei Shi, Da Li
Summary: This study analyzed the association between leptin and polycystic ovary syndrome (PCOS). The results showed that serum leptin levels were significantly higher in patients with PCOS and were associated with multiple metabolic markers. Combined detection of leptin and anti-Mullerian hormone (AMH) had high accuracy in diagnosing PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Hosna Mohammad Sadeghi, Ida Adeli, Daniela Calina, Anca Oana Docea, Taraneh Mousavi, Marzieh Daniali, Shekoufeh Nikfar, Aristidis Tsatsakis, Mohammad Abdollahi
Summary: PCOS is an endocrine-gynecology disorder affecting women of childbearing age, with incomplete understanding of its etiology and pathophysiology. Lifestyle modifications and alternative medicines are the preferred first-line therapy, and certain medications have shown potential for repurposing in PCOS. Further research and well-designed clinical trials are needed, as the current evidence is limited.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Antonio Mancini, Carmine Bruno, Edoardo Vergani, Claudia d'Abate, Elena Giacchi, Andrea Silvestrini
Summary: The pathophysiology of PCOS involves complex mechanisms such as obesity, insulin-resistance, oxidative stress, and low-grade inflammation, which may lead to obesity, insulin resistance, vitamin D deficiency, and immune dyscrasia. These factors can interact and exacerbate each other's effects, suggesting an inverse interaction from the traditional understanding.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Hui He, Jiaxing Feng, Shike Zhang, Yu Wang, Jian Li, Jingshu Gao, Jing Cong, Yi Gong, Xiaoke Wu
Summary: The study found that there is a positive association between the ApoB/ApoA1 ratio and metabolic and endocrine parameters in women with PCOS. Higher ratios were also associated with increased risk of MetS and IR. The ratio could be a useful tool for screening MetS and IR in PCOS patients.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Maryam Abolghasemi, Soleiman Mahjoub
Summary: PCOS is an endocrine disorder that affects 5-10% of reproductive-age women, characterized by chronic anovulation, polycystic ovaries, hyperandrogenism, hyperinsulinemia, and central obesity. Recent research has highlighted the potential involvement of long noncoding RNAs in the development of PCOS.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Endocrinology & Metabolism
Jin Yu, Yulai Zhou, Jie Ding, Danying Zhang, Chaoqin Yu, Hefeng Huang
Summary: This study aimed to investigate the metabolic characteristics of overweight women with PCOS and analyze the possible mechanisms. The results showed that overweight PCOS patients were prone to hypertension, diabetes, low gonadal levels, and insulin resistance. Inflammatory cytokines CXCL12/SDF-1, Serpin E1/PAI-1, and MIF were predicted to play a crucial role in inducing insulin resistance in overweight PCOS through various biological functions and signal transductions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Chemistry, Analytical
Anna Rajska, Magdalena Buszewska-Forajta, Szymon Macioszek, Renata Wawrzyniak, Pawel Wityk, Andrzej Berg, Agnieszka Kowalewska, Dominik Rachon, Michal J. Markuszewski
Summary: Despite numerous studies, the cause of PCOS remains unknown. To confirm the reliability of proposed metabolomics biomarkers, we conducted a validation study on serum and urine samples from PCOS patients and healthy controls. Our analysis identified a comprehensive set of altered metabolites in PCOS patients, indicating disruptions in hormone synthesis, lipid metabolism, and energy production.
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2023)
Review
Reproductive Biology
Yan-Nan Liu, Yi Qin, Bin Wu, Hui Peng, Ming Li, Hai Luo, Lin-Lin Liu
Summary: Polycystic ovary syndrome (PCOS) is closely related to epigenetic factors, and changes in DNA methylation are associated with the pathogenesis of PCOS.
REPRODUCTIVE TOXICOLOGY
(2022)
Letter
Endocrinology & Metabolism
Alicia R. Jones, Peter R. Ebeling, Helena Teede, Frances Milat, Amanda J. Vincent
CLINICAL ENDOCRINOLOGY
(2023)
Article
Rehabilitation
Clara C. Zwack, Rachael McDonald, Ainura Tursunalieva, Shradha Vasan, Gavin W. Lambert, Elisabeth A. Lambert
Summary: The study showed that adults with intellectual disabilities experience higher levels of perceived stress compared to those without disabilities, likely due to unique stressors they face. Stress is strongly associated with social isolation, obesity in females with mild intellectual disabilities, and arterial stiffness.
DISABILITY AND REHABILITATION
(2023)
Review
Cardiac & Cardiovascular Systems
Edgar M. Hidalgo, Leah Wright, Mats Isaksson, Gavin Lambert, Thomas H. Marwick
Summary: With advances in robotics and telecommunications, robot-assisted teleoperated ultrasound examination can help with medical diagnosis in remote areas, reducing health inequalities. Studies have shown that robots can safely perform ultrasound examinations by following the hand movements of sonographers and researchers. However, real-time transmission of video and ultrasound images requires high bandwidth, and improvements are needed in robot control and interface design.
JACC-CARDIOVASCULAR IMAGING
(2023)
Review
Biochemistry & Molecular Biology
Kate Rassie, Rinky Giri, Anju E. Joham, Helena Teede, Aya Mousa
Summary: Women with maternal pregestational diabetes mellitus or polycystic ovary syndrome are at increased risk of pregnancy complications and suboptimal lactation outcomes. Prolactin levels may be lower in pregnancies affected by type 1 diabetes mellitus, but data is limited for polycystic ovary syndrome or type 2 diabetes pregnancy. Lactation difficulties in women with pre-existing metabolic disease before pregnancy are well-described, but the relationship to prolactin remains unclear. Further well-designed studies are needed to clarify the associations between pre-existing maternal metabolic disease and prolactin dynamics in pregnancy and postpartum.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Peripheral Vascular Disease
Revathy Carnagarin, Janis M. Nolde, Jun Yang, Francine Z. Marques, Dean S. Picone, Gavin W. Lambert, Thomas Beaney, Neil R. Poulter, Aletta E. Schutte, Christopher M. Reid, Derrin Brockman, Markus P. Schlaich
Summary: The awareness, treatment, and control rates of hypertension in Australia are substantially lower than global and high-income country rates, indicating the need for collaborative efforts to improve the situation.
JOURNAL OF HYPERTENSION
(2023)
Article
Multidisciplinary Sciences
Fakir M. Amirul Islam, Mohammad Ariful Islam, Mohammad Arzan Hosen, Elisabeth A. Lambert, Ralph Maddison, Gavin W. Lambert, Bruce R. Thompson
Summary: Engaging in high physical activity and having a positive attitude towards physical activity are associated with lower blood pressure levels in rural Bangladesh. Awareness programs should be implemented to promote the benefits of physical activity and increase participation in high physical activity.
Article
Peripheral Vascular Disease
Gianni Sesa-ashton, Janis M. Nolde, Ida Muente, Revathy Carnagarin, Rebecca Lee, Vaughan G. Macefield, Tye Dawood, Yusuke Sata, Elisabeth A. Lambert, Gavin W. Lambert, Antony Walton, Marcio G. Kiuchi, Murray D. Esler, Markus P. Schlaich
Summary: Long-term follow-up studies on catheter-based renal denervation in patients with resistant hypertension show that the method can still effectively reduce blood pressure and decrease medication usage after nearly 9 years of follow-up, without any adverse effects on renal function.
Article
Cell Biology
Aeson Chang, Edoardo Botteri, Ryan D. Gillis, Lukas Lofling, Caroline P. Le, Alexandra I. Ziegler, Ni-Chun Chung, Matthew C. Rowe, Stewart A. Fabb, Brigham J. Hartley, Cameron J. Nowell, Sasagu Kurozumi, Sara Gandini, Elisabetta Munzone, Emilia Montagna, Nina Eikelis, Sarah E. Phillips, Chikako Honda, Kei Masuda, Ayaka Katayama, Tetsunari Oyama, Steve W. Cole, Gavin W. Lambert, Adam K. Walker, Erica K. Sloan
Summary: We found a relationship between beta-blocker use and anthracycline chemotherapy in protecting against TNBC progression, disease recurrence, and mortality. Beta-blockade improved the efficacy of anthracycline chemotherapy in TNBC mouse models by reducing metastatic development. Anthracycline chemotherapy increased sympathetic nerve fiber activity and norepinephrine concentration in mammary tumors, but this effect can be overcome by inhibiting beta 2-adrenergic signaling in the tumor microenvironment.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Margaret McGowan, Siew Lim, Sharleen L. O'Reilly, Cheryce L. Harrison, Joanne Enticott, Helena Teede, Stephanie Cowan, Lisa J. Moran
Summary: This study investigated the impact of 2020 COVID-19 restrictions on weight, physical activity, diet, and psychological distress for Australians with PCOS. The results showed that individuals with PCOS gained more weight, were less likely to meet physical activity recommendations, and had higher intake of sugar-sweetened beverages compared to those without PCOS, but there were no differences in psychological distress.
Review
Endocrinology & Metabolism
Johanna Melin, Maria Forslund, Simon Alesi, Terhi Piltonen, Daniela Romualdi, Poli Mara Spritzer, Chau Thien Tay, Alexia Pena, Selma Feldman Witchel, Aya Mousa, Helena Teede
Summary: This review evaluates the effectiveness of metformin and lifestyle modification compared with placebo in the management of PCOS and will inform the forthcoming, 2023 evidence-based PCOS guidelines. The results showed that metformin can reduce body mass index, insulin resistance, fasting glucose, waist-hip ratio, total cholesterol, low-density lipoprotein, and triglycerides in PCOS patients. Therefore, metformin should be considered as an efficacious adjunct to lifestyle interventions in adults with PCOS, especially for those with a higher BMI.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Chau Thien Tay, Deborah Loxton, Mahnaz Khomami, Helena Teede, Cheryce L. Harrison, Anju E. Joham
Summary: During the preconception period, women with PCOS had higher prevalence of medical conditions such as obesity, depression, anxiety, and infertility, as well as engaged in more unhealthy lifestyle behaviors compared to women without PCOS.
HUMAN REPRODUCTION
(2023)
Article
Health Care Sciences & Services
Sharleen L. O'Reilly, Rachel Laws, Helle Terkildsen Maindal, Helena Teede, Cheryce Harrison, Fionnuala M. McAuliffe, Aisling Geraghty, Cristina Campoy, Mercedes G. Bermudez, Laura Pirhonen, Christy Burden, Anna Davies, Ditte Hjorth Laursen, Timothy Skinner
Summary: This study aims to explore the feasibility and implementation of the B2B&Me intervention and investigate its effectiveness in women at risk of gestational diabetes.
JMIR RESEARCH PROTOCOLS
(2023)
Article
Health Care Sciences & Services
Mansi Patil, Radhika Prashant Hedaoo, Rohan Pravinbhai Shah, Syed Mohammad Tauseef, Roy Rillera Marzo, Siew Mooi Ching, Gavin Lambert
Summary: The burden of hypertension has been increasing, and besides the risk of stroke and cardiovascular disease, it also affects the quality of life (QoL) of individuals. This study aimed to assess the QoL of hypertensive men undergoing treatment in India. The results showed that patients with uncontrolled hypertension had significantly poorer QoL compared to those with controlled blood pressure.
INQUIRY-THE JOURNAL OF HEALTH CARE ORGANIZATION PROVISION AND FINANCING
(2023)
Review
Management
Mihirika Surangi de Silva Pincha Baduge, Mariam Mousa, Belinda Garth, Leanne Boyd, Helena J. Teede
Summary: This systematic review focuses on organizational strategies for advancing women nurses in healthcare leadership. The study found that there are barriers in leadership at the individual level, but organizational strategies such as mentorship, leadership training, career planning and coaching, networking opportunities, sponsorship, and targeted recruitment processes can promote women nurses in healthcare leadership.
JOURNAL OF NURSING MANAGEMENT
(2023)
Article
Obstetrics & Gynecology
Rhonda M. Garad, Mahnaz Bahri-Khomami, Maureen Busby, Tania S. Burgert, Jacky Boivin, Helena J. Teede
Summary: This review examines gender-sensitive language in sexual and reproductive health guidelines and highlights significant gaps in its usage. Recognizing the importance of gender diversity in research, clinical practices, and societal norms, it emphasizes the need to balance inclusivity and biological accuracy. Future research should focus on systemic approaches in the field of sexual and reproductive health.
SEMINARS IN REPRODUCTIVE MEDICINE
(2023)
